Figure 5.8

Fitted exposure response model (left side) and relative risk (RR) of lung cancer (right side) in all 11 cohorts of miners for all exposures, and for exposures < 600 WLM (Lubin and others 1995).

  • factor) gives rise to larger risk. Because this is how the model parameters are derived, it gives rise to the reason for the so-called inverse-exposure effect.
  • There is a higher lung-cancer risk per unit of 222Rn exposure for smokers than for nonsmokers.

The two models derived from the joint analysis are considered equally likely to fit the observations.

  • TSE/AGE/WL model (time since exposure, age, and concentration):

where

w5-12, W15-24 = exposure in WLM 5-14 years before the end of mining, and so on.

  • TSE/AGE/DUR model (time since exposure, age, and duration):

The estimated parameter values derived for these two models are given in table 5.6. The combined effect of smoking and 222Rn exposure could not be



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement