Fitted exposure response model (left side) and relative risk (RR) of lung cancer (right side) in all 11 cohorts of miners for all exposures, and for exposures < 600 WLM (Lubin and others 1995).
- factor) gives rise to larger risk. Because this is how the model parameters are derived, it gives rise to the reason for the so-called inverse-exposure effect.
- There is a higher lung-cancer risk per unit of 222Rn exposure for smokers than for nonsmokers.
The two models derived from the joint analysis are considered equally likely to fit the observations.
- TSE/AGE/WL model (time since exposure, age, and concentration):
w5-12, W15-24 = exposure in WLM 5-14 years before the end of mining, and so on.
- TSE/AGE/DUR model (time since exposure, age, and duration):
The estimated parameter values derived for these two models are given in table 5.6. The combined effect of smoking and 222Rn exposure could not be