TABLE 1.1 Overview of the TOXNET Databases

Database

Sponsoring Agencies

Factual or Bibliographic

Subject Content

CCRIS

NCI

Factual

Results of carcinogenicity, mutagenicity, tumor production, tumor inhibition studies

DART

NLM, NIEHS, FDA, EPA

Bibliographic

Literature on teratology and many aspects of reproductive toxicology

EMIC

NLM, EPA, NIEHS

Bibliographic

Literature since 1991 published on substances tested for genotoxic activity

EMICBACK

NLM, EPA, NIEHS

Bibliographic

Pre-1950 through 1991 literature on substances tested for genotoxic activity

ETICBACK

NLM

Bibliographic

Teratology literature from 1950–1989, continued by DART

GENE-TOX

EPA

Factual

Results from expert review of scientific literature on chemicals tested for mutagenicity

HSDB

NLM (previously ATSDR)

Factual

Peer-reviewed summaries of the toxicology of potentially hazardous substances

IRIS

EPA

Factual

EPA health risk and regulatory information, includes carcinogenic and noncarcinogenic risk assessment data

RTECS

NIOSH

Factual

Toxic effects including skin and eye irritation, carcinogenicity, mutagenicity, and reproductive consequences

TRI

EPA

Factual

Annual estimated releases of toxic chemicals to the environment

NOTE: ATSDR = Agency for Toxic Substances and Disease Registry; CCRIS = Chemical Carcinogenesis Research Information System; DART = Developmental and Reproductive Toxicology; EMIC = Environmental Mutagen Information Center; EMICBACK = EMIC Back File; EPA = Environmental Protection Agency; ETICBACK = Environmental Teratology Information Center Backfile; FDA = Food and Drug Administration; GENE-TOX = Genetic Toxicology Data Bank; HSDB = Hazardous Substances Data Bank; IRIS = Integrated Risk Information System; NCI = National Cancer Institute; NIEHS = National Institute of Environmental Health Sciences; NIOSH = National Institute for Occupational Safety and Health; RTECS = Registry of Toxic Effects of Chemical Substances; TRI = Toxic Chemical Release Inventory.



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