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RECOMMENDATION 1: Research should continue into the physiological effects of synthetic and plant-derived cannabinoids and the natural function of cannabinoids found in the body.  Because different cannabinoids appear to have different effects, cannabinoid research should include, but not be restricted to, effects attributable to THC alonc

Scientific data indicate the potential therapeutic value of cannabinoid drugs for pain relief, control of nausea and vomiting, and appetite stimulation.  this value would be enhanced by a rapid onset of drug effect.

RECOMMENDATION 2:  Clinical trials of cannabinoid drugs for symptom management should be conducted with the goal of developing rapid-onset, reliable, and safe delivery systems.

The psychological effects of cannabinoids are probably important determinants of their potential therapeutic value.  they can influence symptoms indirectly which could create false impressions of the drug effect or be beneficial as a form of adjunctive therapy.

RECOMMENDATION 3: Psychological effects of cannabinoids such as anxiety reduction and sedation, which can influence medical benefits, should be evaluated in clinical trials.

Numerous studies suggest that marijuana smoke is an important risk factor in the development of respiratory diseases, but the data that could conclusively establish or refute this suspected link have not been collected.

RECOMMENDATION 4:  Studies to define the individual health risks of smoking marijuana should be conducted, particularly among populations in which marijuana use is prevalent

Because marijuana is a crude THC delivery system that also delivers harmful substances, smoke marijuana should generally not  be recom-

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