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Marijuana and Medicine: Assessing the Science Base (1999)
Institute of Medicine (IOM)

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. "Appendix E Recommendations Made in Recent Reports on the Medical Use of Marijuana." Marijuana and Medicine: Assessing the Science Base. Washington, DC: The National Academies Press, 1999.

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mit careful analysis and is not summarized here. It is available on the Internet at: www.parliament.uk.

General Recommendations

Health Council of the Netherlands

In order to assess the efficacy of marijuana and cannabinoids, the committee studied literature published during the past 25 years. Based on those findings, the committee concluded that there was insufficient evidence to justify the medical use of marijuana.

AMA House of Delegates

Adequate and well-controlled studies of smoked marijuana should be conducted in patients who have serious conditions for which preclinical, anecdotal, or controlled evidence suggests possible efficacy, including AIDS wasting syndrome, severe acute or delayed emesis induced by chemotherapy, multiple sclerosis, spinal cord injury, dystonia, and neuropathic pain.

British Medical Association

Research on the clinical indications for medical prescription of cannabinoids should be undertaken. For all indications listed below (antiemetics, pain, epilepsy, glaucoma, asthma, immunological effects, multiple sclerosis, spinal cord injury, and other spastic disorders) further research is required to establish suitable methods of administration, optimal dosage regimens, and routes of administration. A central registry should be kept of patients prescribed cannabinoids so that the effects can be followed up over the long term.

National Institutes of Health

For at least some potential indications, marijuana looks promising enough to recommend that new controlled studies be done. The indications in which varying levels of interest were expressed are the following: appetite stimulation and wasting, chemotherapy-induced nausea and vomiting, neurological and movement disorders, analgesia, [and] glaucoma. Until studies are done using scientifically acceptable clinical trial design and subjected to appropriate statistical analysis, the question concerning the therapeutic utility of marijuana will likely remain largely un-

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