TABLE 6-2 Epidemiologic Studies—Environmental Exposure

Reference

Study Design

Description

Study Group (N)

Comparison Group (N)a

SEVESO

New Studies

Bertazzi et al., 1997

Cohort

Study of cancer incidence among Seveso residents in contaminated zones (A, B, R) after 15 years of follow-up through 1991

45,373 total:

805 in zone A;

5,943 in zone B;

38,625 in zone R

232,747

Mocarelli et al., 1996

Cohort

Study of sex ratio among the offspring of Seveso residents born in zone A from (1) 1977-1984 and (2) 1985-1994

(1) 74 births (28 male,

48 female)

(2) 124 births (60

male, 48 female)

Studies Reviewed in Update 1996

Bertazzi et al., 1993

Cohort

Study of cancer incidence in Seveso residents (aged 20 to 74 years) in contaminated zones (A, B, R) exposed to TCDD on July 10, 1976, compared to neighboring residents in unexposed areas

724 zone A

4,824 zone B

31,647 zone R

181,579

Pesatori et al., 1993

Cohort

Evaluation of cancer incidence in Seveso residents aged 1-19 years m the first post-accident decade compared to age-matched residents of neighboring unexposed areas

Approximately

20,000

167,391

Studies Reviewed in VAO

Bertazzi et al., 1992

Cohort

Comparison of mortality of children (1976-1986) exposed during Seveso accident compared to children in uncontaminated areas

306 zone A

2,727 zone B

16,604 zone R

95,339



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