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Arsenic in Drinking Water (1999)

Chapter: Addendum to Chapter 10

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Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
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Page 307

Addendum to Chapter 10

Table A10-1 Internal Cancer Data From Arsenic-exposure Studies Conducted In Taiwan Region Endemic To Blackfoot Disease

Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
×

Page 308

TABLE A10-1 Internal Cancer Data from Arsenic-Exposure Studies Conducted in Taiwan Region Endemic to Blackfoot Diseasea

 

No. of

   

Person-Years

Bladder

Liver

Lung

Village

Wells

Arsenic Concentration, ppm

Median

M

F

M

F

M

F

M

F

3-H

1

0.010

0.010

4,159

4,043

1

6

3

1

3

5

2-1

1

0.011

0.011

3,529

3,194

0

0

0

0

0

1

0-G

5

0.010, 0.010, 0.030, 0.259, 0.770

0.030

5,388

4,861

3

2

3

3

4

5

3-5

1

0.032

0.032

7,851

7,033

3

3

5

2

6

2

3-N

1

0.032

0.032

2,689

2,392

4

3

1

1

3

1

4-7

1

0.042

0.042

10,629

10,227

0

0

4

0

0

0

6-A

1

0.045

0.045

7,716

6,820

0

0

1

1

0

0

0-J

2

0.020, 0.080

0.050

6,501

5,888

1

0

2

2

0

0

3-L

2

0.053, 0.058

0.056

6,238

5,094

3

4

3

0

5

7

4-D

1

0.060

0.060

10,107

9,227

1

2

1

1

1

2

3-P

1

0.065

0.065

6,574

5,927

0

0

3

0

2

5

6-C

1

0.073

0.073

12,767

11,937

0

1

2

0

2

0

4-8

1

0.080

0.080

11,307

10,332

1

0

3

1

2

2

0-0

1

0.100

0.100

6,895

6,392

0

0

2

2

3

1

O-E

5

0.010, 0.085, 0.110, 0.288, 0.686

0.110

5,753

5,310

6

3

3

1

4

5

0-I

7

0.020, 0.050, 0.110, 0.110, 0.190, 0.580, 0.590

0.110

4,249

3,833

0

2

1

3

3

2

4-N

2

0.073, 0.172

0.123

4,709

4,291

0

0

3

1

1

2

4-J

1

0.126

0.126

6,508

6,026

0

1

6

1

2

2

2-D

1

0.256

0.256

9,702

8,869

0

2

2

1

7

1

0-D

1

0.256

0.256

3,872

3,412

1

3

2

3

5

2

3-Q

6

0.148, 0.198, 0.242, 0.276, 0.291, 0.458

0.259

5,580

5,079

2

0

4

2

5

4

4-M

1

0.307

0.307

2,953

2,758

1

0

0

0

2

3

6-6

1

0.307

0.307

5,364

4,505

3

0

3

1

4

1

4-E

2

0.340, 0.360

0.350

3,942

3,586

0

0

1

0

0

1

4-L

2

0.310, 0.485

0.398

3,069

2,723

1

1

1

0

0

1

Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
×

Page 309

 

No. of

   

Person-Years

Bladder

Liver

Lung

Village

Wells

Arsenic Concentration, ppm

Median

M

F

M

F

M

F

M

F

4-F

11

0.120, 0.170, 0.229,0.260, 0.260, 0.406,0.469, 0.485, 0.595, 0.779, 0.819

0.406

4,482

3,886

2

3

1

0

5

1

3-1

1

0.448

0.448

4,551

4,259

2

3

5

1

4

3

5-G

1

0.467

0.467

3,179

5,298

7

5

2

3

7

1

4-P

1

0.504

0.504

5,843

5,397

1

0

1

1

1

1

0-H

5

0.050, 0.394, 0.520, 0.610,1.752

0.520

4,390

4,313

3

2

4

0

4

5

4-1

47

0.020, 0.020, 0.030, 0.090, 0.100, 0.110, 0.120, 0.5200.120, 0.160, 0.190, 0.230, 0.240, 0.250, 0.270, 0.270, 0.290, 0.290, 0.350, 0.370, 0.410, 0.430, 0.450, 0.510, 0.520, 0.540, 0.560, 0.660, 0.700, 0.730, 0.740, 0.760, 0.760, 0.760, 0.780, 0.810, 0.810, 0.840, 0.840, 0.850, 0.850, 0.850, 0.870, 0.880, 0.900, 0.930, 0.940, 0.970

0.520

4,870

4,432

2

2

1

0

3

5

3-J

2

0.529, 0.529

0.529

8,454

8,689

4

8

3

1

6

5

3-S

2

0.480, 0.595

0.538

4,287

3,667

4

3

7

0

8

4

3-9

1

0.544

0.544

3,655

3,413

0

1

1

1

1

0

2-2

10

0.560, 0.580, 0.580, 0.590, 0.597, 0.600, 0.618, 0.620, 0.650, 0.704

0.599

9,059

7,977

2

2

9

5

8

5

4-G

2

0.620, 0.680

0.650

2,425

2,108

2

0

0

0

2

2

5-4

2

0.630, 0.735

0.683

3,155

2,983

1

1

2

1

5

2

2-M

2

0.435, 0.950

0.693

11,123

11,263

9

9

6

4

14

4

0-F

5

0.415, 0.660, 0.694, 0.720, 0.749

0.694

7,010

5,720

5

1

8

3

2

9

3-R

5

0.397, 0.440, 0.698, 0.750,1.010

0.698

4,310

3,576

3

6

3

2

6

7

3-M

4

0.221, 0.329, 1.105,1.411

0.717

5,815

4,877

0

1

2

0

0

0

2-N

3

0.560, 0.934, 0.960

0.934

8,341

8,342

7

10

8

2

4

4

aData from Wu et al. 1989; Chen et al. 1992.

Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
×

Page 310

References

Chen, C.J., C.W. Chen, M.M. Wu, and T.L. Kuo. 1992. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br. J. Cancer 66:888-892.

Wu, M.M., T.L. Kuo, Y.H. Hwang, and C.J. Chen. 1989. Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Am. J. Epidemiol. 130:1123-1232.

Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
×
Page 307
Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
×
Page 308
Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
×
Page 309
Suggested Citation:"Addendum to Chapter 10." National Research Council. 1999. Arsenic in Drinking Water. Washington, DC: The National Academies Press. doi: 10.17226/6444.
×
Page 310
Arsenic in Drinking Water Get This Book
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The U.S. Environmental Protection Agency (EPA) has been considering a more stringent regulation of arsenic in water. A significant reduction in the maximum contaminant level (MCL) could increase compliance costs for water utilities. This book discusses the adequacy of the current EPA MCL for protecting human health in the context of stated EPA policy and provides an unbiased scientific basis for deriving the arsenic standard for drinking water and surface water.

Arsenic in Drinking Water evaluates epidemiological data on the carcinogenic and noncarcinogenic health effects of arsenic exposure of Taiwanese populations and compares those effects with the effects of arsenic exposure demonstrated in other countries—including the United States.

The book also reviews data on toxicokinetics, metabolism, and mechanism and mode of action of arsenic to ascertain how these data could assist in assessing human health risks from arsenic exposures. This volume recommends specific changes to improve the toxicity analyses and risk characterization. The implications of the changes for EPA's current MCL for arsenic are also described.

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