• Front Matter R1-R18

• Executive Summary 1-4

• Part I. Introduction 5-6

• 1 Introduction 7-14

• Part II. Smallpox and Its Control 15-16

• 2 Variola Virus and Other Orthopoxviruses 17-24

• 3 Clinical Features of Smallpox 25-32

• 4 Epidemiology 33-36

• 5 Variola Virus Stocks Following Eradication of Smallpox 37-44

• Part III. Scientific Needs for Variola Virus 45-46

• 6 Development of Antiviral Agents 47-52

• 7 Development of Vaccines 53-58

• 8 Detection and Diagnosis 59-62

• 9 Bioinformatics 63-68

• 10 Understanding of the Biology of Variola Virus 69-72

• 11 Research on the Expressed Protein Products of Variola 73-76

• Part IV. Findings 77-78

• 12 Summary and Conclusions 79-86

• References 87-92

• Appendix A Glossary 93-98

• Appendix B Acronyms 99-100

• Appendix C Committee and Staff Biographies 101-108

" Part I. Introduction ." Assessment of Future Scientific Needs for Live Variola Virus . Washington, DC: The National Academies Press, 1999 .

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