Table 12-1 Potential Scientific Needs for Poxviruses and Their Components

Research Area

Other Orthopoxvirus

Variola Vires DNA Clones

Orthopoxviruses with One or More Variola Genes

Replication-Defective Variola Virus

Live Variola Virus in Tissue Culture

Live Variola Virus Animal Models*

Variability of Variola (Chapters 8, 9)

Useful for comparison

Essential

Helpful

Not required

Essential until overlapping and repetitive clones from many isolates are available

Not required

Antivirals (Chapter 6)

Helpful

Helpful

Helpful

Helpful

Essential for development steps

Essential for full verification

Tissue Culture Vaccines (Chapter 7)

Essential

No use

Helpful

Possible verification

Not required

Essential for full verification

Novel Vaccines (Chapter 7)

Helpful

May be used to develop immunogens

Not applicable

Helpful

Helpful for development

Essential for full verification

Environmental Detection (Chapter 8)

Essential for early phases

Essential for assessing variola variability

Helpful for field testing

Partial verification

Helpful but not essential

Helpful but not essential

Diagnosis of Infection (Chapter 8)

Helpful for determining specificity

Essential

Essential for in vitro or in vivo testing

Helpful but not essential

Helpful but not essential

Helpful but not essential

Virus-Cell Interactions (Chapter 10)

Helpful

Helpful

Helpful

Helpful

Essential for some targets

Helpful but not essential

Virus-Host Interactions (Chapter 10)

Helpful

Helpful

Helpful

Helpful

Helpful for some targets

Essential for some targets

* Currently unavailable.



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