PAUL ROATH: It seemed most of your talk centered on gram negatives. Is there any expectation of gram positives to have an iron uptake system because the membranes would conserve it differently?
GERALD KEUSCH: There are parallels in the gram positives. Most of the information has really come from the paradigm organism, E. coli. But Corynebacterium diphtheriae is a gram positive organism in which toxic production is closely regulated by iron. There is a good source of information on the gram positive bacteria and iron in the monograph Iron and Infection, edited by Bullen and Griffiths (1987).
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15 Iron Metabolism, Microbial Virulence, and Host Defenses ."
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