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AIdrin Chemical name: 1,2,3,4,10,10-Hexachloro-1,4,4a,5,B,Ba- hexahydro-l, 4 , 5 , 8~dime thanonaphthal ene Molecular weight: 365 Molecular formula: C12HgCl6 Physical state: Brown to white crystalline solid Melting point: 104C Vapor pressure: 0.000006 mm Ilg (at 20C) Soluble in most organic solvents Insoluble in water Ch lordane Chemical name: Molecular weight: Molecular formula: Phys ical ~ tate: Vapor pre ssure: Specif ic gravity: Soluble in many organic Solubility in water Chlorgyrifos 1,2,4,5,6,7,d,8-Octachloro-4, 7-methano~ 3a ,4, 7, 7a-tetrabydroindane 410 ClOH6C18 Colorless, odorles a, viscous 1 iquid 0.0(~)001 ~ Hg (at 2~)C) 1 .57-1 .67 olvenes 9 ~g/L Chemical name: D,O-Diethyl 0-~3,5,6-trichloro~2- pyridy 1 ~ phosphorothioat e Mol ecul a r wei ght: 3 51 Ho 1 ecul ar f ormul a: C9lll 1Cl 3NO3PS Physical state: Mite crystalline sol it Mel tiny point: 42. 5-43C Vapor pressure: 1.87 x 10-5 ~ Hg (at 25C) Soluble in most organic solvents Solubility in water: 0.0002 g/100 g Dieldrin Chemical name: 1,2,3,4,10,10-Hexachloro-6,7-epoxy- 1,4,4a,5,6,7,B,8a-octabydro-1,4,5,8- d~methanonaphthalene Molecular weight: 381 Molecular formula: cl248cl6o Physical state: Light-tan, flaked, odorless solid Hel tiny point: 175-176C Vapor pressure: 1.8 x 10-7 mm Ilg (at 2~)C) Moderately soluble in aromatic hydrocarbons, halogenated solvents, esters, and ketones Insolubl e in water, methanol, ant al iphatic hydrocarbons - 51 -

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Heptachlor Chemical name: Molecular weight: Ho l ecul ar f onoul a: Phys ice 1 ~ tat e: Mel tiny point: Boiling point: Vapor pressure: Spec if ic gravity: Soluble in xylene and alcohol Insoluble in water Lindane Chemica 1 name: Molecular weight: Molecular formula: Phys ice l ~ tate: 1,4,5,6, 7,A,Ba-Heptachloro~3a,4, 7, 7a- te trahydro-4, 7~ethano indane 373 Cloll5Cl 7 Mite to light tan, waxy solid with a mild camphoraceous odor 9 5-96C 175C (at 2 mmHg) 0.0003 mm H8 (at 20C) 1.5 7-1 .5 9 Hexach l o rocyc 1 ohexane 291 C6116C1 6 Wni te c rye tat 1 ice subs tanc e wi th a ~ ~ ight mus ty odor Melting point: 112.5C Vapor pressure: 0.14 mm Hg (at 40C) Soluble in chloroform, alcohol, acetone, ether, and benzene Insoluble in water Penta chl oro phenol Ma 1 ecul ar we ight: Molecular formula: Phys ice 1 ~ tat e: Mel ring point: Boiling point: Vapor pressure: 266 C6HCisO Wnite crystal or powder with a phenol ic odor and a pungent taste 190C 310 C 0.00017 ~ Hg (at 20C) Specific gravity: 1.978 (at 20C) Soluble in alcohol, acetone, ether, pine oil, and benzene Slightly soluble in water 52

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Table 3. Standard Mortality Ratiosa in WE ~ ~:~ Deaths Deatbe Minimal Periods from from Deaths from Deathe from of Employment All Causes Cancer Heart Disease All Other Causes 3 ma 1 yr 5 yr 10 yr 15 yr 20 ye 0.84C 0.84d 0.90 0.86 0.87 0.87 0.79 0.87 0.97 1.03 1.12 1.06 1.02 0.98 1.04 0.99 0.92 0.83 0.65 0.65 0.68 0.56 0.62 0.78 aStandard mortality ratio ~ ratio of observed to expected, i.e., (no. observed Marshal 1 deathe)/(no. calculated expected deatha) bReprinted with permission from Shindell and Associates, 1980. CStatistically significant, EN ~ 0.01. dStatistically significant, ~ < 0.05. 54

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- - Table 4. Su~ry Data on Seven Pestic ites BIOLOGIC END POINTS Oral LD,o Observet Observed Critical for Rats, Critical Effects EDlo for Target Site for Peacicide mg/kg in Animale Mice, ppm iluman Exposure A1 drina 46-63 CNS sympto~, 3. 1 Central nervous hepatoma system Dieldrina 38-52 CNS s~rmptom~, 3.6 Central nervous hepatoma system Chlordanea 335-430 CNS symptoms, 16 Central nervous hepatoma sys tem Heptachlora 100-1 60 CNS symptoms , 5 Central nervous hepatoma system Lindaneb 125-230 CNS symptome, 103 Central nervous . . . 1 tver tox~c tty sys tem Pentachlorophenolb 146-174 CNS symptoms, -- Central nervous embryotoxicity system Ch 1 orpyri f Oac 138-245 Chol inesterase -- P1 asma inhibition chol ines terase ENV IRONMENTAL EtID POINTS Reported Amount of Airborne Ac t ive Pers is fence Volatil ity, Concentrations, Ingredient,d Af ter Pesticide mm Hg tlg/~3 lb/gal Application, yr Aldrina 0.000006 e 0.04 20 (at 20C) Dieldrina 0.00000018 e 0.024 20 (at 20C) Chlordanea 0.00001 <1-264 0.08 20 (at 20C) IleptachloP 0.0003 e 0.04 20 (at 20C) Lindaneb 0.14 e 0.064 10 (at 40C) Pentachloropenolb 0.00017 e 0.4 3 (at 20C) ChlorpyrifocC 0.0000187 e 0.08 4-10 (at 25C) ash 1 orina ted c yc lodiene . bCh 1 orinated hydrocarbon. COrganophosphate . dEstimated amount applied for subelab injection in preexisting structures. eNone reported in the 1 iterature. 55 ~

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Table 5. Proportio" of Mele B6C3~! Mice with Bepatocellular Carcico~ afeer Pesticide Feedin8. Dietary No. Ani~le Pesticide Concentration, ppe with Tumore AIdrin 0 17 92 4 16 49 8 25 46 Chlordane 0 17 92 30 16 48 56 43 49 Dieldrin 0 17 92 2.5 12 50 5.0 16 45 Heptachlor 0 17 92 6 11 46 14 34 4 7 Lintane 0 5 49 80 19 49 160 9 46 Data from NCI, 1977s,b,c; 1978~. - 56 - No. Animal ~ Examined

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Table 6. Esti~tes in Male 86C3~1 Mice After Pesticide Feeding EDlo, Pesticide ppe . 95 Percent Conf idence Limit ~ Al drin 3. 1 1. 5-6 .5 Chl ortane 16 Dieldrin 3.6 Heptachlor 5 .0 14-20 2.0-6.6 4.1-6.2 Lindane 103 47-225 57

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Table 7. Upper Bounde on Carcinogenic Riek of Pesticides Consumed in Drinking Waters Upper 95 Percent Conf idence Estima te of Pesticide Lifetime Cancer Risk per Microgram per Liter Dieldrin Heptach1 or Chl octane Lindane aDats from NRC, 1977b. 260 x 10-6 42 x 10-6 18 x 10-6 9.3 x 10-6 58