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ON ASSI:SS - NT OF THI: I - LTI1 RISES OF SEVEN PESTICIDES USED FOR TEITE CONTROL prepared by the COMMITTEE ON TORI COLOGY Board on Toxicology and Enviro~enta1 }lealth "carafe Co~ission on Life Sciences National Academy Press Washington, D. C. Angus t l9B2

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NOTICE: The project that is the subject of this report was approved by the Governing Board of the N.tione1 Research Council, whose members are drawn from the Councils of the National A`:ate" of Sciences, the Nations1 Academy of Engineering, and the Institute of Medicine. The members of the committee responsible.for the report were chosen for their special competences and with regard for appropriate balance. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The National Research Council was estate! ished by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and of advising the federal government. The Council operates in accordance with general policies determined by the Academy under the authority of its Congress tonal charter of 1863, which establishes the Academy as ~ private, nonprofit, self-governing comb ership corporation. The Counc it has become the principal operating agency of both the Nat tonal Academy of Sc fences and the National Academy of Engineering in the conduc t of their services to the government, the publ ic, and the ac ientif ic and engineering cc,~un~1es . it [s arms tered jointly by both Academies and the Institute of Medicine. The National Academy of Engineering and the Institute of Medicine were establiabed in 1964 and 1970, respectively, under the charter of the National Academy of Sciences. Prepared under Contract 1400014-SO~C-0161 between the Natio~1 Academy of Sciences and the Office of Neve1 Research.

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Subcommittee to A88e88 the Hazards of Termiticides Wendell W. Kilgore, University of Cal if ornia, Davis, California, Cha irman David W. Gaylor, National Center for Toxicological Research, Jef f erson, Arkansas Leonard T. Kurland, Mayo C1 inic, Rochester, Minnesota Howard I. Maibach, University of California, San Francisco, California Edward A. Smuckler, University of California, San Francisco, California COMMITTEE ON TOXI COLOGY Roger 0. McClellan, Lovelace Inhalation Toxicology Research Institute, Albuquerque, New Mexico, Chairman Donald Ecobichon, McGi 1 1 Univers ity, Montreal, Quebec, Canada David W. Gaylor, National Center for Toxicological Research, Jef ferson, Arkansas Peter Greenwald, National Cancer Institute, Bethesda, Maryland Ian T. Higgins, University of Michigan Medical Center, Ann Arbor, Michigan Wendell W. Kilgore, University of California, Davis, California Leonard T. Kurland, Mayo Clinic, Rochester, Minnesota Howard I. Maibach, University of California, San Francisco, California H. George Handel, George Washington University School of Medicine, Washington, I).C. Joseph V. Rodricks, Environ Corporation, Washington, D.C. Ronald C. Shank, University of California, Irvine, California Edward A. Smuckler, University of California, San Francisco, California Robert Snyder, Rutgers University College of Pharmacy, Piscataway, New Jer sey Peter Spencer, Al bert Einstein Cal lege of Medicine, Bronx, New York Phil ip G. Watanabe , Dow Chemical U. S .A., Hitland , Michigan Na t tonal Re search Counc it S ~ af f Gary R. Keilson, Staff Scientist Gordon W. Newell, Staff Scientis t Norman Groseblatt, Editor Bre nda S pears, Secre tory . . _ zzz _

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BOARD ON TOXICOLOGY AND ENVIRONMENTAL llEALTlI HAZARDS Ronald W. Estabrook, University of Texas Medical School (Southwestern), Dallas , Texas, Chairman Philip Landrigan, National Institute for Occupational Safety and HeaLth, Cincinnat i, Ohio, Vice~Chairman Edward Breenick, University of Vermont, Burl ington, Vermont Theodore Cairns, DuPont Chemical Co. (retired), Greenville, Delaware Victor Cohn, George Washington University Medical Center, Washington, D.C. A. Myrick Freeman, Bowdoin College, Brunswick, Maine Ronald W. Hart, National Center for Toxicological Research, Jefferson, Arkansas Michael Liebenman, Washington University School of Medicine, St. Louis, Missouri Richard Merrill, University of Virginia Law School, Charlottesville, Virginia Robert A. Neal, Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina Ian Niabet, Clement Associates, Inc., Arlington, Virginia John Peters, University of Southern Cal if ornia School of Medicine, Los Angeles, Cal if ornia Liane Russell, Oak Ridge National Laboratory, Oak Ridge, Tennessee Charles R. Schuster, Jr., University of Chicago, Chicago, Illinois Na t tonal Research Counc it S tat f Robert G. Tardiff, Executive Director Gordon W. Newell, Associate Executive Director z~ - -

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CONTENTS EXE CUTI VE SUMMARY . CHLORDANE. ~ ~ ~ e HEPTACHLOR . . . ALDRINtDI ELDRIN . LINI)AIJE . . . . . PE NTACHLOROP HENOL. CHLORP YRIFO S . . . CONCLUSIONS AND RECOMMENDATIONS. . Comparison of Carcinogenic Risk Overal 1 As sesoment o f Rinks . . . . Recommends t ion TABLES . . . . . REFERENCES .. ~ .... ~ e - - ~ ~ ~ BIOGRAPHIC SKETCHES OF COMMITTEE EMBERS V Page 9 19 23 29 33 37 43 43 45 46 51 59 73

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