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ON ASSI:SS - NT OF THI: I - LTI1 RISES OF
SEVEN PESTICIDES USED FOR TE—ITE CONTROL
prepared by the
COMMITTEE ON TORI COLOGY
Board on Toxicology and Enviro~enta1 }lealth "carafe
Co~ission on Life Sciences
National Academy Press
Washington, D. C.
Angus t l9B2
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NOTICE: The project that is the subject of this report was approved
by the Governing Board of the N.tione1 Research Council, whose members
are drawn from the Councils of the National A`:ate" of Sciences, the
Nations1 Academy of Engineering, and the Institute of Medicine. The
members of the committee responsible.for the report were chosen for
their special competences and with regard for appropriate balance.
This report has been reviewed by a group other than the authors
according to procedures approved by a Report Review Committee
consisting of members of the National Academy of Sciences, the
National Academy of Engineering, and the Institute of Medicine.
The National Research Council was estate! ished by the National
Academy of Sciences in 1916 to associate the broad community of
science and technology with the Academy's purposes of furthering
knowledge and of advising the federal government. The Council
operates in accordance with general policies determined by the Academy
under the authority of its Congress tonal charter of 1863, which
establishes the Academy as ~ private, nonprofit, self-governing
comb ership corporation. The Counc it has become the principal
operating agency of both the Nat tonal Academy of Sc fences and the
National Academy of Engineering in the conduc t of their services to
the government, the publ ic, and the ac ientif ic and engineering
cc,~un~1es . it [s arms tered jointly by both Academies and the
Institute of Medicine. The National Academy of Engineering and the
Institute of Medicine were establiabed in 1964 and 1970, respectively,
under the charter of the National Academy of Sciences.
Prepared under Contract 1400014-SO~C-0161 between
the Natio~1 Academy of Sciences and the Office
of Neve1 Research.
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Subcommittee to A88e88 the Hazards of Termiticides
Wendell W. Kilgore, University of Cal if ornia, Davis, California,
Cha irman
David W. Gaylor, National Center for Toxicological Research,
Jef f erson, Arkansas
Leonard T. Kurland, Mayo C1 inic, Rochester, Minnesota
Howard I. Maibach, University of California, San Francisco, California
Edward A. Smuckler, University of California, San Francisco, California
COMMITTEE ON TOXI COLOGY
Roger 0. McClellan, Lovelace Inhalation Toxicology Research Institute,
Albuquerque, New Mexico, Chairman
Donald Ecobichon, McGi 1 1 Univers ity, Montreal, Quebec, Canada
David W. Gaylor, National Center for Toxicological Research,
Jef ferson, Arkansas
Peter Greenwald, National Cancer Institute, Bethesda, Maryland
Ian T. Higgins, University of Michigan Medical Center, Ann Arbor,
Michigan
Wendell W. Kilgore, University of California, Davis, California
Leonard T. Kurland, Mayo Clinic, Rochester, Minnesota
Howard I. Maibach, University of California, San Francisco, California
H. George Handel, George Washington University School of Medicine,
Washington, I).C.
Joseph V. Rodricks, Environ Corporation, Washington, D.C.
Ronald C. Shank, University of California, Irvine, California
Edward A. Smuckler, University of California, San Francisco, California
Robert Snyder, Rutgers University College of Pharmacy, Piscataway, New
Jer sey
Peter Spencer, Al bert Einstein Cal lege of Medicine, Bronx, New York
Phil ip G. Watanabe , Dow Chemical U. S .A., Hitland , Michigan
Na t tonal Re search Counc it S ~ af f
Gary R. Keilson, Staff Scientist
Gordon W. Newell, Staff Scientis t
Norman Groseblatt, Editor
Bre nda S pears, Secre tory
. · .
_ zzz _
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BOARD ON TOXICOLOGY AND ENVIRONMENTAL llEALTlI HAZARDS
Ronald W. Estabrook, University of Texas Medical School (Southwestern),
Dallas , Texas, Chairman
Philip Landrigan, National Institute for Occupational Safety and
HeaLth, Cincinnat i, Ohio, Vice~Chairman
Edward Breenick, University of Vermont, Burl ington, Vermont
Theodore Cairns, DuPont Chemical Co. (retired), Greenville, Delaware
Victor Cohn, George Washington University Medical Center, Washington,
D.C.
A. Myrick Freeman, Bowdoin College, Brunswick, Maine
Ronald W. Hart, National Center for Toxicological Research, Jefferson,
Arkansas
Michael Liebenman, Washington University School of Medicine, St. Louis,
Missouri
Richard Merrill, University of Virginia Law School, Charlottesville,
Virginia
Robert A. Neal, Chemical Industry Institute of Toxicology, Research
Triangle Park, North Carolina
Ian Niabet, Clement Associates, Inc., Arlington, Virginia
John Peters, University of Southern Cal if ornia School of Medicine, Los
Angeles, Cal if ornia
Liane Russell, Oak Ridge National Laboratory, Oak Ridge, Tennessee
Charles R. Schuster, Jr., University of Chicago, Chicago, Illinois
Na t tonal Research Counc it S tat f
Robert G. Tardiff, Executive Director
Gordon W. Newell, Associate Executive Director
— z~
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CONTENTS
EXE CUTI VE SUMMARY .
CHLORDANE. ~ ~ ~ e
HEPTACHLOR . . .
ALDRINtDI ELDRIN .
LINI)AIJE . . . . .
PE NTACHLOROP HENOL.
CHLORP YRIFO S . . .
CONCLUSIONS AND RECOMMENDATIONS. .
Comparison of Carcinogenic Risk
Overal 1 As sesoment o f Rinks . . . .
Recommends t ion
TABLES . . . . .
REFERENCES .. ~ .... ~ e · - - ~ ~ ~
BIOGRAPHIC SKETCHES OF COMMITTEE EMBERS
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