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Biographical Sketches SUBCOMM ITTEE ON DNA ADDUCTS DAVID if. BRUSICK received his Ph.D. in microbial genetics from Illinois State University in 1970 and did postdoctoral research as a National Academy of Sciences research associate at the Food and Drug Administra- tion's Genetic Toxicology Branch. A past president of the U.S. Environ- mental Mutagen Society (1978-79), Dr. Brusick is adjunct professor of microbiology and genetics at the schools of medicine of both Howard and George Washington universities. He is the author of numerous scientific publications, including a textbook, Principles of Genetic Toxicology. He was a committee member contributing to the NRC report Toxicity Testing: Strat- egies to Determine Needs and Priorities for the National Toxicology Program and has also served on numerous other NRC committees. He is a member of the International Commission for the Protection against Environmental Mutagens and Carcinogens and a member of the Steering Committee for the Environmental Protection Agency's Gene-Tox Program. Dr. Brusick's in- terests include basic and applied research in mutagenic and carcinogenic mechanisms and the application of biotechnology techniques to the devel- opment of safety testing methods. GAIL T. ARCE is a genetic toxicologist at the Haskell Laboratory for Toxicology and Industrial Medicine, E. I. du Pont de Nemours & Company, in Newark, Delaware. She received her Ph.D. from Yale University in 1978 from the Department of Molecular Biophysics and Biochemistry and did postdoctoral work at New York University's Department of Environmental 89

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90 DRINKING WATER AND HEALTH Medicine and Columbia University's Institute of Cancer Research. Her re- search has focused on the evaluation of DNA-adduct dosimetry in in vitro mutation and transformation assays. JOHN C. BAILAR III is a statistician and physician at McGill University in Montreal. Since 1980 he has been a statistical consultant for the New England Journal of Medicine. His research interests center on the processes of health risk assessment, whether they are applied to chemicals, radiation, microorganisms, or other hazards. He also has a strong interest in scientific communication, and in 1987-88 served as the president of the Council of Biology Editors. He has been a member of many National Academy of Sciences/National Research Council studies concerned with health risks. RAMESH C. GUPTA holds degrees from Agra, Meerut, and Roorkee Universities in India. He is an associate professor in the Department of Pharmacology at Baylor College of Medicine in Houston, Texas. Conducting research in sensitive techniques for sequencing of RNA, he is also one of the developers of the 32P-postlabeling assay for DNA adducts. His research interests include DNA damage and repair in animal and human cells. Dr. Gupta is a member of the American Society of Biological Chemists, the American Society of Cancer Research, the American Society for Cell Bi- ology, and the American Association for the Advancement of Science. ROBIN HERBERT is a Charles A. Dana Foundation Fellow in Envi ronmental Epidemiology and an instructor in the Division of Environmental and Occupational Medicine of the Department of Community Medicine at Mount Sinai Medical Center in New York, New York. An internist and specialist in occupational medicine, Dr. Herbert's principal area of interest is in the use of biologic markers of exposure to carcinogens in occupationally and environmentally exposed populations. She is currently studying DNA adducts and other markers of exposure among roofing workers exposed to polycyclic aromatic hydrocarbons. Dr. Herbert is a member of the American College of Physicians, the Society for General Internal Medicine, and the American Public Health Association. PAUL H. M. LOHMAN is a professor and director of the laboratory of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands. Dr. Lohman is an expert is the field of DNA repair and the relation between the induction of DNA damage, DNA repair, and mu- tagenesis in cells of mammalian origin. Currently, he is heading one of the largest research institutions in Europe in the filed of environmental muta- genesis and genetic toxicology. He is scientific secretary of the International

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Biographical Sketches 91 Commission for Protection against Environmental Mutagens and Carcinogens and a past president of the European Environmental Mutagen Society. CAROL W. MOORE received degrees from Ohio State University and Pennsylvania State University and performed postdoctoral research at the University of Rochester School of Medicine. She received a fellowship to conduct research in the Interdisciplinary Programs in Health and Environ- mental Health Policy and Management Program from the Harvard University School of Public Health and School of Business. Dr. Moore is currently associate professor of microbiology at City University of New York Medical School, Sophie Davis School of Biomedical Education City College, New York City. She has conducted research in genetics, molecular biology, ge- netic toxicology, cancer biology, radiobiology and biochemistry, including the genetic control of cellular responses in yeast and human cells to radiation and the radiomimetic bleomycins. ROBERT F. MURRAY is a graduate of the University of Rochester School of Medicine, an internist whose subspecialty is medical genetics. A military tour of duty in the U.S. Public Health Service at the National Institutes of Health sparked an interest in genetic markers which might in- dicate inherited susceptibility to disease. He received a master's degree and a fellowship in medical genetics at the University of Washington in Seattle. After joining the Faculty of Medicine at Howard University in Washington, D.C., he continued studies of developmental variation in human liver alcohol dehydrogenase and genetic markers indicating the clonal origins of breast tumors. He also became involved in programs of genetic screening, coun- seling and prenatal diagnosis (with special emphasis on sickle cell disease), and the use of genetic markers to identify individuals highly susceptible to potentially toxic compounds in the work environment, as well as the effects of these compounds on the human genome. A major research interest has been the study of the psychological aspects of genetic counseling. He is currently chief of the Division of Medical Genetics in the Department of Pediatrics and Child Health, directing an active program of teaching and patient service, and chairman of the Graduate Department of Genetics and Human Genetics. He is an active member of the Institute of Medicine and he has served on its governing council and also on several NRC and IOM task forces and working groups. MIRIAM C. POIRIER is a research chemist in the Laboratory of Cellular Carcinogenesis and Tumor Promotion at the National Cancer Institute, NIH. Her graduate studies were carried out at the McArdle Laboratories at the University of Wisconsin, and the Department of Biology at the Catholic University of America. She was among the first to elicit antisera specific for

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92 DRINKING WATER AND HEALTH carcinogen-DNA adducts and investigate mechanisms of chemical carcino- genesis utilizing quantitative immunoassays and immunohistochemistry. For development of this methodology she received the NIH Merit Award. More recently Dr. Poirier has pioneered efforts to validate the use of immunoassays for human exposure biomonitoring. She has served in an advisory capacity to the Harvard School of Public Health, the Department of Health and Human Services Panel on Application of Biologic Markers in Risk Assessment, and the Health Effects Institute. GARY A. SEGA received graduate degrees from the University of Texas and Louisiana State University. He has been a research staff member in the Biology Division of Oak Ridge National Laboratory for the past 15 years. Dr. Sega's principal research interest is studying the molecular mechanisms that give rise to mutations in mammalian germ cells, including chemical binding to DNA and proteins, and DNA repair in the germ cell. He is a member of the Environmental Mutagen Society and is presently a member of the editorial board of Molecular and Environmental Mutagenesis. RICHARD B. SETLOW was educated in the field of physics (Ph.D., Yale University, 19471. He is a senior biophysicist at- Brookhaven National Laboratory on Long Island and is the Laboratory's Associate Director for Life Sciences. His research deals with DNA repair mechanisms in numerous biological systems, the roles of such repair mechanisms in ameliorating the effects of carcinogenic chemicals, variations in repair among people, and the association of such mechanisms with aging. He is a member of the National Academy of Sciences. JAMES A. SWENBERG is head of-the Department of Biochemical Toxicology and Pathobiology at the Chemical Industry Institute of Toxicology and an adjunct professor of pathology at the University of North Carolina and Duke University. Dr. Swenberg is on the editorial boards of several cancer- and toxicology-related journals; served as a member and chairperson of the National Toxicology Program Board of Scientific Counselors; is a member of the EPA FIFRA Science Advisory Panel; and the Board of Sci- entific Counselors, Division of Biometry and Risk Assessment of the National Institute for Environmental Health Sciences. Dr. Swenberg's research inter- ests address the role of DNA adducts, repair and replication in carcinogenesis, experimental neuroncology and the scientific basis of quantitative risk as- sessment. He is a diplomat in the American College of Veterinary Pathol- ogists.