Biologic Markers in Reproductive Toxicology (1989)

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References Abel, E. L. 1980. Fetal alcohol syndrome: Behavioral teratology. Psychol. Bull. 87:29-50. Abraham, G. E., G. B. Maroulis, and J. R. Marshall. 1974. Evaluation of ovulation and corpus luteum function using measurements of plasma progesterone. Obstet. Gynecol. 44:522-525. Al~yholm, T., J. Kofstad, K Molne, and S. Stray-Pedersen. 1981. Seminalplasma fructose, zinc, magnesium and acid phosphatase in cases of male infertility. Int. J. Androl. 4:75-81. AcoK, T. S., D. J. Johnson, H. Brandt, and D. D. Hoskins. 1979. Sperm forward motility protein: Tissuedistribu- tion and species cross reactivity. Biol. Reprod. 20:247- 252. ACS (American Chemical Society), Committee on En- vironmental Improvement and Subcommittee on EnvironmentalAnalyticalChemisby. 1980. Guidelines for data acquisition and data quality evaluation in environmental chemistry. Anal. Chem. 52:2242-2249. Adams, J. 1986. Clinical relevance of experimental be- havioral teratology. NeuroToxicology 7:19-34. Adams,J.,andJ.Buelke-Sam. 1981. Behavioralasses~ ment of the postnatal animal: Testing and methods development, pp. 233-258. In C. A. Kimmel and J. Buelke-Sam,Eds. DevelopmentalToxicology. New York: Raven Press. Adams, M. J., Jr., G. C. Windham, L. M. James, F. Green- berg, J. A. Clayton-Hopkins, C. B. Reimer, and G. P. Oakley, Jr. 1984. Clinical interpretation of maternal serum alpha-fetoprotein concentrations AN J. Obstet. Gynecol. 148:241-254. Adams, N. R. 1976. Pathological changes in the tissue of infertile ewes with clover disease. J. Comp. Pathol. 86:29-35. Adams, N. R 1977. Morphological changes in the organs of ewes glazing oestrogenic subterranean clover. Res. Vet. Sci. 22:21~221. 319 Adams, N. R. 1983. Sexual behavior of ewes with clover disease treated repeatedly with oestradiol benzoate or testosterone propionate after ovariectomy. J. Reprod. Fertil. 68:113-117. Adam$ N. R., and G. B. Martin. 1983. Effects of oestra- diol on plasma concentrations of lutein~ng hormone in ovariectomized ewes with clover disease. Aust. J. Biol. Sci. 36:295-303. Adams, N. R., H. Hearnshaw, and C. M. Ol&am. 1981. Abnormal function of the corpus luteum in some ewes with phyto-oestrogenic infertility. Aust. J. Biol. Sci. 34:61-65. Adams, S. O., S. P. Nissley, S. Handwerger and M. M. Rechler. 1983. Developmental patterns of insulin- like growth factor-I and-II synthesis and regulation in rat f~broblasts. Nature 302:150-153. Aedo, A.-R., P. H. Pedersen, S. C. Pedersen, and E. Di~falusy. 1980. Ovarian steroid secretionin normally menstruating women. II. The contribution of the corpus luteum. Acta Endocrinol. 95:222-231. Ahlgren, L., B. Haeger-Aronsen, S. Mattsson, and A. Schutz. 1980. In-vivo determination of lead in the skeleton after occupational exposure to lead. Br. J. Ind. Med. 37:109-113. Aitken, R. J. 1977. Changes in the protein content of mouse uterine flushings during normal pregnancy and delayed implantation, and after ovariectomy and oestradiol administration. J. Reprod. Fertil. 50:29- 36. Alanen, A. 1984. Serum IgE and smooth muscle an- tibodies in Gamma Acta Obstet. G'ynecoL Sand 63:S81-582. Alavi, A., R. Dann, J. Chawluk, J. Alavi, M. Kushner, and M. Reivich. 1986. Positron emission tomography imaging of regional cerebral glucose metabolism. Semin. Nucl. Med. 16:2-34. Albertini, R. J. 1985. Somatic gene mutations in viva

320 as indicated by the ~thioguanine resistant T-tmpho- cytes in human blood. Mutat. Res. 150:418422. Albertini, RJ. , K. L. Castle, and W .R . Borcherding. 1982. T-cell cloning to detect the mutant ~thiogua- nine-resistant Lymphocytes present in human peripheral blood. Proc. Natl. Acad. Sci. USA 79:6617 6621. Albertini, RJ., L.M. Sullivan, J.K. Berman, CJ. Greene, J A. Stewart, J. M. Silveira, and J.P. O'Neill. 1988. Mutagenicity monitoring in humans by autoradio- graphic assay for mutant T lymphocytes. Mutat. Res. 204:481492. Albro, P.W., W.B. Crummet, A.E. Dupuy, Jr., M.L. Gross, M. Hanson, R.L. Harless, R.D. Hileman, D. Hilker, C. Jason, and J. L. Johnson. 1986. Methods for the quantitative determination of multiple, specific polychlorinated dibenzo-p-dioxin and dibenzofuran isomers in human adipose tissue in the parts-per- tr~lion range. An interlaboratory stu~y. Anal. Chem. 57:2717-2725. Alexander, NJ. 1973. Ultrastructural changes in rat epididymis after vasectomy. Z. Zellforsch. Mikrosk. Anat. 136:177-182. Alexander, N. J. 1982. Male evaluation and semen analysis. Clin. Obstet. Gynaecol. 25:463482. Allan, L.D., D.C. Crawford, R.H. Anderson, and MJ. Tynan. 1984. Echocardiographic and anatomical correlations in fetal congenital heart disease. Br. Heart J. 52:542-548. Allen, K.S., H.Y. Kressel, P.H. Arger, and H.M. Pol- lack. 1989. Age-related changes of the prostate: Evaluation by MR imaging. Am. J. Roentgenol. 152:77-81. Altland, K., M. Kaempher, M. Forssbohm, and W. Wer- ner. 1982. Monitoring for changing mutation rates using blood samples submitted for PKU screening. Prog. Clin. Biol. Res. 103(Pt. A):277-287. Altman, J. 1966. Autoradiographic and histological studies of postnatal neurogenesis. II. A longitudinal investigation of the kinetics, migration and transforma- tion of cells incorporating tntiated tlymidine in infant rats, with special reference to postnatal neurogenesis in some brain regions. J. Comp. Neurol. 128:431- 474. Altman, J. 1986. An animal model of minimum brain dysfunction,pp.241-304. InM.Lewis,Ed. Learning Disabilities and Prenatal Risk. Urbana, Ill.: University of Illinois Press. Altman, J. 1987. MorphoIogical and behavioral markers of environmentally induced retardation of brain de- velopment: An animal model. Environ. Health Per- spect. 74:153-168. Altman, J., and S. A. Bayer. 1978. Prenatal development of the cerebellar system in the rat. I. Cytogenesis and histogenesis of the deep nuclei and the cortex of the cerebellum. J. Comp. Neurol. 179:2348. Altman, J., and G. P. Das. 1966. Autoradiographic and histologicalstudiesofpostnatalneurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated REFERENCES thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions. J. Comp. Neurol. 126:337-389. Altman, J., W. J. Anderson, and K. A. Wright. 1969. Reconstitution of the external granule layer of the cerebellar cortex in infant rats after low-level x-irradia- tion. Anat. Rec. 163:453472. Altshuller, L. F., D. B. Halak, B. H. Landing, and R. A. Kehoe. 1962. Decidous teeth as an index of body burden of lead. J. Pediatr. 60:224-29. Altstatt, L. B. 1965. Transplacental hyponatremia in the newborn infant: Report of 4 cases. J. Pediatr. 66:985-988. Amann, R. P. 1970a. Sperm production rates, pp. 433- 482. In A. D. Johnson, W. R. Gomes, and N. L. VanDemark, Eds. The Testis, Vol.1. Development, Anatomy, and Physiology. New York: Academic Press. Amann, R. P. 1970b. The male rabbit. IV. Quantitative testicular histology and comparisons between daily sperm production as determined histologically and daily sperm output. Fertil. Steril. 21:662~72. Amann, R. P. 1981. A critical review of methods for evaluation of qmmatogenesis from ~al cha~teris tics. J. Androl. 2:37-58. Amann, R. P. 1986. Detection of alterations in testicular and epididymal function in laboratory animals. En- viron. Health Perspect. 70:149-158. Amann, R. P. 1987. Function of the epididymis in bulls and rams. J. Reprod. Fertil. Suppl. 34:115-131. Amann, R. P., and J. O. Almquist. 1962. Reproductive capacity of dairy bulls. VI. Effect of unilateral vasec- tomy and ejaculation frequency on sperm reserves: Aspects of epididymal physiolo~r. J. Reprod. Fertil. 3:26~268. Amann, R. P., and W. E. Berndtson. 1986. Assessment of procedures for screening agents for effects on male reproduction: Effects of dibromochloropropane (DBCP) on the rat. Fundam. Appl. Toxicol. 7:244- 255. Amann, R. P., and S. S. Howards. 1980. Daily sper- matozoal production and epididymal spermatozoa! resetves of the human male. J. Urol. 124:211-215. Amann, R. P., and J. T. Lambiase, Jr. 1969. The male rabbit. 3. Deterniination of daily sperm production by means of testicular homogenates. J. Anim. Sci. 28:369-374. Amann, R. P., G. J. Killian, and A. W. Benton. 1973. Differences in the electrophoretic characteristics of bovine rete testis fluid and plasma from the cauda epididyrnidis. J. Reprod. Fertil. 35:321-330. Amann, R. P., S. R. Hay, and R. H. Hammerstedt. 1982. Yield, characteristics, motility and cAMP content of sperm isolated from seven regions of ram epididyrnis. Biol. Reprod. 27:723-733. Amelar, R. D., and L. Dubin. 1977. Semen analysis, pp. 105-140. In R. D. Amelar, L. Dubin, and P. C. Walsh. MaleInfertility. Philadelphia: W. B. Saunders. Ames, B. M., J. Mccann, and E. Yamasaki. 1975. Meth-

REFERENCES oafs for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31:347-364. Ammer, H., A. Henschen, and C. H. Lee. 1986. Isolation and amino-acid sequence analysis of human sperm protamines PI and P2. Occurrence of two forms of protamine P2. Biol. Chem. Hoppe Seyler 367:515- 522. Amoroso, E. C. 1981. Viviparity, pp. 3-25. In S. R. Glasser and D. W. Bullock, Eds. Cellular and Molecu- lar Aspects of Implantation. New York: Plenum Press. Anderson, D. C. 1974. Sex-hormone-binding globulin. Clin. Endocrinol. 3:69-96. Anderson, G. G., and T. M. Hanson. 1974. Chronic fetal bradycardia: Possible association with hypokale- mia. Obstet. Gynecol. 44:896-898. Andrews, L. B. 1984a. Legal issues raised by in vitro fertilization and embryo transfer, pp. 11-36. In D. P. Wolf and M. M. Quigley, Eds. Human In Intro Fertilization and Embryo Transfer. New York: Plen- um Press. Andrews, L. B. 1984b. Ethical considerations in in vitro fertilization and embryo transfer, pp. 403-423. In D. P. Wolf and M. M. Quigley, Eds. Humanin Vitro Fertilization and Embryo Transfer. New York: Plen- um Press. Angell, R. R., R. J. Aitken, P. F. A. van Look, M. A. Lumsden, and A. A. Templeton. 1983. Chromosome abnormalities in human embryos after in vitro fertiliza- tion. Nature 303:336-338. Annest, J. L., J. L. Pirkle, D. Makuc, J. W. Neese, D. D. Bayse, and M. G. Kovar. 1983. Chronological trend in blood lead levels between 1976 and 1980. N. Engl. J. Med. 308:1373-1377. Anthony, C. T., B. J. Danzo, and M.C. Orgebin-Crist. 1984. Investigations on the relationship between sperm fertilizing ability and androgen-binding protein in the restricted rat. Endocrinology 114:1413-1418. Apgar, V. 1953. A proposal for a new method of evalua- tion of the newborn infant. Curr. Res. Anesth. Analg. 32:26~267. Aragona, C., and H. G. Friesen. 1975. Specific prolactin binding sites in the prostate and testis of rats. En- docrinology 97:677 684. Archer, P. G., M. Bender, A. D. Bloom, J. G. Brewen, A. V. Carrano, and R. J. Preston. 1981. Guidelines for cytogenetic studies in mutagen-exposed human populations, pp.1-35. In A. D. Bloom, Ed. Guidelines for Studies of Human Populations Exposed to Muta- genic and Reproductive Hazards. New York: March of Dimes Birth Defects Foundation. Ardito, G., L. Lamberti, E. Ansaldi, and P. Ponzetto. 1980. Sister-chromatid exchanges in cigarette-smoking human females and their newborns. Mutat. Res. 78:209-212. Armstrong, D.T. 1968. Hormonal control of human uterine fluid retention in the rat. Am. J. Physiol. 214:764 771. 321 Armstrong, E. G., P. H. Ehrlich, S. Birken, J. P. Schlat- terer, E. Siris, W. C. Hembree, and R. E. Canf~eld. 1984. Use of a highly sensitive and specific immuno- radiometric assay for detection of human chorionic gonadotropin in urine of normal, nonpregnant, and pregnant individuals. J. Clin. Endocrinol. Metab. 59:867-874. Arora, R., Dinakar, N., and M. R. N. Prasad. 1975. Biochemical changes in the spermatozoa and luminal contents of different regions of the epididymis of the rhesus monkey, Macaca mulatto Conha - lion 11:689 700. Aschheim, S., and B. Zondek. 1928. Die schwanger- schaftsdiagnose aus dem ham durch nachweis des hypophysenvorderlappenhormons. II. Pracktische wed theoretische ergebnisse aus den harnuntersuchun- gen. Klin. Wschr. 7:1453-1457. Ashford, N. A. 1986. Policy considerations for human monitoringin the workplace. J. Occup. Med.28:563- 568. Ashford, N. A., C. J. Spadafor, and C. C. Caldart. 1984. Human monitoring: Scientific, legal and ethical con- siderations. Harvard Environ. Law Rev. 8:263-363. Ashley-Montague, M. F. 1957. The Reproductive De- velopment of the Female with Special Reference to the Period of Adolescent Sterility. New York: Julian Press. 234 pp. Atland, K., M. Kaempfer, M. Forszbohm et al. 1982. Monitoring for changing mutation rates using blood samples submitted for PKU screening, pp. 277-287. In Human Genetics, Part A: The Unfolding Genome. New York: Alan R. Liss. Attramadal, A., C. W. Bardin, G. L. Gunsalus, N. A. Musto, and V. Hansson. 1981. Itrununocytochemical localization of androgen binding protein in rat Sertoli and epididymal cells. Biol. Reprod. 25:983-988. Auroux, M., C. Collin, and M. L. Couvillers. 1985. Do nonspermatozoal cells mainly stem from spermiogene- sis? Study of 106 fertile and 102 subfertile men. Arch. Androl. 14:73-80. Austin, C. R., and R. V. Short, Eds. 1982. Reproduction in Mammals, Vol. 1: Germ Cells and Fertilization, 2nd ed. New York: Cambridge University Press. Awa, A. A., S. Honda, S. Nerlishi, H. Shimba, T. Amano, and H. B. Hamilton. 1981. An interim report of the c ytogenetic study of the offspring of atomic bomb survivors in Hiroshima and Nagasaki. Abstract for the 6th International Congress of Human Genetics, held September 13-18, 1981 in Jerusalem, Israel. Axelrod, L., R. M. Neer, and B. Kliman. 1979. Hypogo- nadism in a male with immunologically active, biolog- ically inactive luteinizing hormone: An exception of a venerable rule. J. Clin. Endocrinol. Metab. 48:279- 287. Ayala, A. R., B. C. Nisula, H. C. Chen, G. D. Hodgen, and G. T. Ross. 1978. Highly sensitive radioimmuno- assay for chorionic gonadotropin in human urine. J. Clin. Endocrinol. Metab. 47:767-773. Ayd, F. J., Jr. 1961. A survey of druginduced extra~Ta-

322 midal reactions. J. Am. Med. Assoc.175:1054-1060. Babich, H., D. L. Davis, and G. Stotzky. 1981. Dibromo- chloropropane (DBCP): A review. Sci. Total Environ. 17:207-221. Bailey, R. E. 1950. Inhibition with prolactin of light- induced gonad increase in white-crowned sparrows. Condor 52:247-251. Baird, D. D., end A.J. Wilcox. 1985. Cigarette smoking associated with delayed conception. J. Am. Med. Assoc. 253:2979-2983. Baird, D. D., A. J. Wilcox, and C. R. Weinberg. 1986. Use of time to pregnancy to study environmental pp. exposures. Am. J. Epidemiol. 124:470-480. Baker, H. W., H. G. Burger, D. M. de Kretser, D. W. Lording, P. McGowan, and G. C. Rennie. 1981. Factors affecting the variability of semen analysis results in infertile men. Int. J. Androl. 4:609-622. Baker, T. G. 1971. Radiosensitivity of mammalian oo- cyteswith particular reference to the human female. Am. J. Obstet. Gynecol. 110:74~761. Baker, T. S., K. M. Jennison, and A. E. Kellie. 1979. She direct ra~oimmunoa~y of own glucL~onides in human female urine. Biochem. J. 177:729-738. Bamforth, S. J., and P. A. Baird. 1989. Spina bifida and hydrocephalus: A population study over a 35- year period. Am. J. Hum. Genet. 44:225-232. Barbieri, R. L., J. A. Canick, A. Makris, R. B. Todd, I. J. Davies, and K. J. Ryan. 1977. Danazol inhibits steroidogenesis. Fertil. Steril. 28:809-813. Barfield, A., J. Melo, E. Coutinho, F. Alvarez-Sanchez, A. Faundes, V. Brache, P. Leon, J. Frick, G. Bartsch, W. H. Weiske, P. Brenner, D. Mishell, Jr., G. Bern- stein, end A. Ortiz. 1979. Pregnancies associated with sperm concentrations below 10 million/ml in clinical studies of a potential male contraceptive meth- od, monthly depot medroxyprogesterone acetate and testosterone esters. Contraception 20:121-127. Barlow, P. W., and M. I. Sherman. 1972. The biochem- istry of differentiation of mouse trophoblast: Studies on polyploidy. J. Embryol. Exp. Morphol. 24:447- 465. Barlow, P., and C. G. Vosa. 1970. The Y chromosome in human spermatozoa. Nature 226:961-962. Barnes, A. B. 1979. Menstrual history of young women exposed in utero to diethylstilbestrol. Fertil. Steril. 32:14~153. Barros, C., J. Gonzelez, E. Herrera, and E. Bustos- Obregon. 1978. Fertilizing capacity of human sper- matozoa evaluated by actual penetration of foreign eggs. Contraception 17:87-92. Bartsch, G., and H. P. Rohr. 1977. Ultrastructural sterology. A new approach to the study of prostatic function. Invest. Urol. 14:301-306. Bartsch, G., H. R. Muller, M. Oberholzer, and H. P. Rohr. 1979. Light microscopic sterological analysis of the normal human prostate of benign prostatic hyperplasia. J. Urol. 122:487-491. Bartsch, G., G. Egender, H. Hubscher, and H. Rohr. 1982. Somometricsof the prostate. J.Urol.127:1119- REFERENCES 1121. Battistin, L., and F. Gerstenbrand, Eds. 1986. Pet and NMR: New Perspectives in Neuroimaging and in Clinical Neurochemistry. New York: Liss. 518 PP. Bayer, S. A., R. L. Brunner, R. Hine, and J. Altman. 1973. Behavioural effects of interference with the postnatal acquisition of hippocampal granule cells. Nature 242:222-224. Bayley, N. 1969. Manual for the Bayley Scales of Infant Development. New York: Psychological Corp. 178 Baukloh, V., H. G. Bohnet, M. Trapp, W. Heeschen, W.Feichtinger,andP.Kemeter. 1985. Biocidesin human follicular fluid. Ann. N.Y.Acad. Sci.442:240 250. Beazley, J. M., and B. Alderman. 1984. Neonatal hyper- bilirubinaemia following the use of ceytocin in labour. Br. J. Obstet. Gynecol. 82:265-271. Bedford, J. M. 1966. Development of the fertilizing ability of spennatozoa in the epidi~ymis of the rabbit. J. Exp. Zool. 163:319-329. Bedford, J. M. 1967. Effects of duct ligation on the fertilizing ability of spermatozoa from different regions of the rabbit epididymis. J. Exp. Zool. 166:271-281. Bedford, J. M. 1975. Maturation, transport, and fate of spermatozoa in the epididymis, pp. 303-317. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physiology, Section 7: Endocrinology. Volume V. Male Reproductive System. Washington, D.C.: American Physiological Society. Bedford, J. M. 1976. Adaptations of the male reprodu~ tive tract and the fate of spennatozoa following vasec tomy in the rabbit, rhesus monkey, hamster and rat. Biol. Reprod. 14:118-142. Bedford,J. M. 1977. Evolution of the scrotum: The epididymis as the prime mover, pp. 171-182. In J. H. Calaty and C. H. Tyndale Biscoe, Eds. Reprodu~ tion and Evolution. Canberra City: Australian Aca- demy of Science. Bedford, J. M. 1978a. Anatomical evidence for the epididymis as the prime mover in the evolution of the scrotum. Am. J. Anat. 152:483-507. Bedford, J. M. 1978b. Influence of abdominal tempera- ture on epididymal function in rat and rabbit. Am J. Anat. 152:509-521. Bedford, J. M. 1979. Evolution of the sperm maturation and sperm storage functions of the epididymis, pp. 7-21. In D. W. Fawcett and J. M. Bedford, Eds. The Spermatozoon. Maturation, Motility, Surface Properties and Comparative Aspects. Baltimore, Md.: Urban & Schwarzenberg. Bedford, J. M., and G. W. Cooper. 1978. Membrane fusion events in the fertilization of vertebrate eggs, pp. 65-125. In G. Poste and G. L. Nicolson, Eds. Membrane Fusion. Cell Surface Reviews, Vol. 5. Amsterdam: Elsevier North-Holland. Bedford, J. M., and R. P. Millar. 1978. The character of sperm maturation in the epididymis of the ascrotal

REFERENCES hyrax, Proca~via capensis and armadillo, Da~pus novewcinctus. Biol. Reprod. 19:396 406. Bedford, J. M., and L. Nicander. 1971. Ultrastructural changes in the acrosome and sperm membranes during maturation of sperTnatozoa in the testis and epidi~Ths of the rabbit and monkey. J. Anat. 108:527-543. Bedford, J. M., H. Calvin, and G. W. Cooper. 1973. The maturation of spermatozoa in the human epididy- mis. J. Reorod. Fertil. (SUT)01. 18):199-213. 323 Bergquist, H., and B. K5L~n. 1954. Notes on the early histogenesis and morphogenesas of the central nervous system in vertebrates. J. Comp. Neurol. 100:627- 659. Bland, C. G. 1986. Alphafetoprotein in pacdi~ics. Acta Paediatr. Scand. 75:1-9. Bland, C. G., and B. Czar. 1957. Paper electrophor- etic study of human fetal serum proteins with demon- stration of a new protein fraction. Scand. J. Clin. Beer, A. E., J. F. Quebbeman, J. W. Ayers, and R. F. Lab. Invest. 9:277-286. Haines. 1981. Major histocompatibility complex Berndtson,W.E. 1977. Methodsforquantif~ingmam- antigens, maternal and paternal immune responses malian spermatogenesis: A review. J. Anim. Sci. and chronic habitual abortions in humans. Am. J. 44:818-833. Obstet. Gynecol. 141:987-999. Beer, A. E., J. F. Quebbeman, and X. Zhu. 1986. Non- paternal leucocvte immunization in women previously immunized with paternal leucocytes: Immune re- sponses and subsequent pregnancy outcome, pp. 261- 268. In D. A. Clark and B. A. Croy, Eds. Reproduc- t~ve Immunology 1986: Proceedings of the3rd Interna- tional Congress of Reproductive Immunology Held in Toronto, Canada, 1-5 July 1986. Amsterdam: Elsevier Science. Beier, H. M., and K. Beier-Hellwig. 1973. Specific secretory proteins of the female genital tract. Acta. Endocrinol. 180(Suppl.~:404 425. Bell, J. L. 1969. Comparative study of immunological tests for pregnancy diagnosis. J. Clin. Pathol. 22:79- 83. Bell, S. C. 1979. Protein synthesis during deciduoma morphogenesis in the rat. Biol. Reprod. 20:811- 821. Bellinger, D. C., H. L. Needleman, A. Leviton, C. Water- naux, M. B. Rabinowitz, and M. L. Nichols. 1984. Early sensory-motor development and prenatal ex- posure to lead. Neurobehav. Toxicol. Teratol.6:387- 402. Bellisario, R., R. B. Carlsen, and O. P. Bahl. 1973. Human chorionic gonadotropin: Linear amino acid sequence of the alpha subunit. J. Biol. Chem. 248:6796009. Belsey, M. A., R. Eliasson, A. H. Gallegos, K S. Melissa C. A. Paulsen, and M. R. N. Prasad. 1980. Laboratory Manual for the Examination of Human Semen and Semen-Ce~vicalMucusInteraction. Singapore: Press Concern. Benoit,J. 1926. Recherchesanatomiques,cytologiques et histophysiologiques sur les voles excretrices du testicule chez les mammiferes. Arch. Anat. Histol. Embryol. 5:175-412. Benziger, D. P., and J. Edelson. 1983. Absorption from the vagina. Drug Metabol. Rev. 14:137-168. Bergman, A., A. Amit, M. P. David, Z. T. Homonnai, and G. F. Paz. 1981. Penetration of human ejaculated spermatozoa into human and bovine cervical mucus. I. Correlation between penetration values. Fertil. Steril. 36:363-367. Bergquist, H. 1964. The formation of the front part of the neural tube. Experientia 20:92-93. Burly, M., and J. T. Eayrs. 1966. The effects of x-irradia- tion on the development of the cerebral cortex. J. Anat. 100:707-722. Berry, S. J., R. Sterner, D. S. Coffey, and L. L. Ewing. 1985. Methods for monitoring canine prostate size: Internal and external Wiper no=. Prostate 6:303-314. Beverley, P. C. L. 1985. The functional significant of the human E rosette receptor (CD2), pp. 93-104. In F. Ellendorff and E. Koch, Eds. Early Pregnancy Factors. Ithaca, N.Y.: Perinatology Press. Beyler, S. A., and L. J. Zaneveld. 1979. The role of acrosin in spermpenetration through human cervical mucus. Fertil. Steril. 32:671~75. Bibbo, M., W. B. Gill, F. Azizi, R. Though, V. S. Fang, R. L. Rosenf~eld, G. F. B. Schumacher, K. Sleeper, M. G. Sonek, and G. L. Wied. l9T7. Follo~v-up study of male and female offspring of DE - posed mothers. Obstet. Gynecol. 49:1~. Bigbee, W. L., R. G. I~nglois, M. Swift, and R H. Jensen. 1989. Evidence for an elevated frequency of in viva somatic cell mutations in ataxia telangiectasia. Am. J. Hum. Genet. 44:402 408. Bigbee, W. L., A. J. Wyrobek, R. G. Langlois, R. H. Jensen, and R. B. Everson. In press. The effects of chemotherapy on in vivo frequency of glycophorin a "null" variant erythrocytes. Mutat. Res. Bigsby, R. M., and G. R. Cunha. 1986. Estrogen stimula- tion of deoxyribonucleic acid synthesis in uterine epithelial cells which lack estrogen receptors. En- docrinology 119:39~396. Billington, W. D. 1985. Pregnancy proteins, earb,rpreg~ nancy factor and maternal immune responses. A summary and an assessment of their relationships, pp. 267-272. In F. Ellendorff and E. Koch, Eds. F~rtr Pregnancy Factors. Ithaca, N.Y.: Perinatology Press. Birgersson, L., and E. D. B. Johansson. 1983. Inhibition of progesterone synthesis by Win 32,729 in women. Acta Endocrinologia. 103(Suppl. 256~:145. Birken, S., and R. E. Canfield l7T7. Isolation and amino acid sequence of COOH-terminal fragments from the beta subunit of human choriogonadotropin. J. Biol. Chem. 252:5386 5392. Birken, S., R. Canfield, G. Agosto, and J. Lewis. 1982. Preparation and characterization of an improved beta- COOH-terminal immunogen for generation of specific

324 and sensitive antisera to human chorionic gonadotro- pin. Endocrinology 110: 1555-1563. Birken, S., E. G. Armstrong, M.A. G. Kooks, L.A. Cole, G. M. Agosto, A. Krichevsky, J. L. Vaitukaitis, and R. E. Canf~eld. 1988. Structure of the human chori- onic gonad Subunit filament from p£egnan cy urine. Endocrinology 123:572-583. Birnberg, C. H., R. Ku~zrok end A. Laufer. 1958. Simple test for determining owlation time. J. Am. Med. Assoc. 166:1174-1175. Bitman, J., H. C. Cecil, S. J. Harris, and G. F. Fries. 1968. Estrogenic activity of o,p'-DDT in the mam- malian uterus and avian oviduct. Science 162:371- 372. Bjersing, L., and H. Carstensen. 1967. Biosynthesis of steroids by granulosa cells of the porcine ovary in vi - . J. Reprod. Fertil. 14:101-111. Black, I. B., J. E. Adler, C. F. Dreyfus, G. M. Jonakait, D. M. Katz, E. F. La Gamma, and K. M. Markey. 1984. Neurotransmitter plasticity at the molecular level. Science 225:1266 1270. Blandau, R. J., and R. E. Rumery. 1964. The relationship of swimming movements of epididymal spermatozoa to their fertilizing capacity. Fertil. Steril. 15:571- 579. Blaquier, J. A. 1971. Selective uptake and metabolism of androgens by rat epididymis. The presence of a cytoplasmic receptor. Biochem. Biophhys. Res. Com- mun. 45:1076-1082. Blaquier, J. A., M. S. Cameo, D. Stephany, A. Piazza, J. Tezon, and R. J. Sherins. 1987. Abnormal distribu- tion of epididymal antigens on spermatozoa from infertile men. Fertil. Steril. 47:302-309. Blatt, J., R. J. Sherins, and D. G. Poplack. 1981. Evi- dence of normal testicular function in boys following chemotherapy for acute lymphoblastic leukemia. Presented at Seventy-second Annual Meeting of the American Association for Cancer Research/Seven- teenth Annual Meeting of the American Society of Clinical Oncology, 27 April-2 May, 1981, in Washing- ton, D.C. Abstracts (Eng.) 22(Mar.~: Paper No. C- 303. (Abstract.) Bloch, P., G. Garavaglia, G. Mitchell, and I. M. Shapiro. 1977. Measurement of lead content of ch~dren's teeth in situ by x-ray fluorescence. Phys. Med. Biol.20:5 63. Block, E. 1952. Quantitative morphological investigations of the follicular system in women. Variations at different ages. Acta Anat. 14:108 123. Bloom, A. D., Ed. 1981. Guidelines for Studies of Human Populations Exposed to Mutagenic and Repro- ductive Hazards: Proceedings of a Conference on the Evaluation of Human Populations Exposed to Potential Mutagenic and Reproductive Hazards, Wash- ington, D.C., Jan. 2~27, 1981. White Plains, N.Y.: March of Dimes Birth Defects Foundation. 163 pp. Blum, M. D., R. R. Bahnson, C. Lee, T. W. Deschler, and J. T. Grayhack. 1985. Estimation of canine prostatic size by in viva ultrasound and volumetric REFERENCES measurement. J. Urol. 133:1082-1086. Bochkov, N. P., N. P. Kuleshov, A. N. Chebotarev, V. I. Alekhin, and S. A. Midian. 1974. Population cyto- genetic inwestigation of newborns in Moscow. Hu- mangenetik 22:139-152. Bohmer, T., S. C. Weddington, and V. Hansson. 1977. Effect of testosterone propionate on levels of carnitine and testicular androgen binding protein (ABP) in rat epididymis. Endocrinology 100:835-838. Bohn, H. 1985. Biochemistry of pregnancy proteins: An overview, pp. 127-139. In F. Ellendorff and E. Koch,Eds. Early Pregnancy Factors. Ithaca,N.Y.: Perinatology Press. Boime, L., M. Boothby, M. Hoshima, S. Daniels-Mc- Queen, and R. Darnell. 1982. Expression and struc- ture of human placental hormone genes as a function of placental development. Biol. Reprod. 26:73-91. Boisselle, A., and R. R. Tremblay. 1979. New therapeutic approach to the hirsute patient. Fertil. Steril.32:276- 279. Boitani, C., C. L. C. Chen, A. N. Margioris, I. Gerendai, P. L. Morris, and C. W. Bardin. 1986. Pro-opiome- lanocortin-derived peptides in the testis: Evidence for a possible role in Leydig and Sertoli cell function. Med. Biol. 63:251-258. Bondareff, W. 1973. Age changes in the neuronal en- vironment, pp. 1-18. In M. Rockstein and M. L. Sup Eds Devela~nent and Aging in the Nervous System. New York: Academic Press Bondy, S. 1985. Especial considerations for neurotoxi- cological research. CRC Crit. Rev. Toxicol. 14:381- 402. Bordy, M. J., J. H. Shaper, and L. L. Ewing. 1984. Trophic influences of lutcini~ng hormone on steroido- genesis by Percoll-separated rat Leydig cells in culture. Ann. N.Y. Acad. Sci. 438:329-345. Bostofte, E., J. Serup, and H. Rebbe. 1982a. Relation between sperm count and semen volume, andpregnan- cies obtained during a twenty-year follow-up period. Int. J. Androl. 5:267-275. Bostofte, E., J. Serup, and H. Rebbe. 1982b. Relation between morphologically abnormal spermatozoa and pregnancies obtained during a twenty-year follow- up period. Int. J. Androl. 5:379-386. Botero-Ruiz, W., N. Laufer, A. H. DeCherney, M. L. Polan, F. P. Haseltine, and H. R. Behrman. 1984. The relationship between follicular fluid steroid con- centration and suaver fertilization of human oodles in vi=. Fertil. Steril. 41:82(~826. Bouckaert, P. X., J. L. H. Evers, W. H. Doesburg, L. A. Schellekens, and R. Rolland. 1986. Patterns of changes in glycoproteins, polypeptides, and steroids in the peritoneal fluid of women during the periodic tory phase of the Mensa cycle. J. Clin Endo~inoL Metab. 62:293-299. Bou6, A., J. Bou6, and A. Gropp. 1985. Cytogenetics of pregnancy wastage. Adv. Hum. Genet. 14:1-57. Bournia~Vardiabasis, N. 1985. Use of amniotic fluid cells for testingteratogens, pp. 31~331. In A. M.

REFERENCES Golf Ed. In H~ Toxicology A Progress Report from the Johns Hopkins Center for Alternatives to Animal Testing. Alternative Methods in Toxicity, Vol. 3: In Vitro Toxicology. New York: Liebert. Boveris, A., E. Cadenas, R. Reiter, M. Filipkowski, Y. Nakase, and B. Chance. 1980. Organ chemilumin- esence: Noninvasive essay for oxidative radical reac- tions. Proc. Natl. Acad. Sci. USA 77:347-351. Bower, P. A., P. C. Yelick, and N. B. Hecht. In press. Both protamine 1 and 2 are expressed in mouse, hamster, and rat. Biol. Reprod. Boyar, R. M., J. W. Finkelstein, H. Roffwarg, S. Kapen, D. Weitzman, and L. Hellman. 1973. Twenty-four- hour luteinizing hormone and follicle-stimulating hormone secretory patterns in gonadal dysgenesis. J. Clin. Endocrinol. Metab. 37:521-525. Bradley, M. O., and G. Dysart. 1985. DNA single- strand breaks, double-strand breaks, and crosslinks in rat testicular germ cells: Measurements of their formation and repair by alkaline and neutral filter elusion. Cell Biol. Toxicol. 1:181-195. Brandriff, B., L. Gordon, L. Ashworth, G. Watchmaker, A. Carrano, and A. Wyrobek. 1984. Chromosomal abnormalities in human sperm: Comparisons among four healthy men. Hum. Genet. 66:193-201. Brandriff, B. F., L. A. Gordon, D. Moore II, and A. V. Carrano. 1988a. An analysis of structural aberrations in human sperm chromosomes Cytogenet. Cell Genet. 47:29-36. Brandriff, B. F., L. A. Gordon, L. K. Ashworth, and A. V. Carrano. loo. Chromosomal aberrations induced by in vitro irradation: Comparisons between human sperm and lymphocytes. Environ. Mol. Mutagen. 12:167-177. Brandt, H., T. S. Acott, D. J. Johnson, and D. D. Hoskins. 1978. Evidence for epidi~ymal onion of bovine sperm forward motility protein. Biol. Reprod. 19:830-835. Branton, C., and G. W. Salisbury. 1947. Morphology of spermatozoa from different levels of the reproduce live tract of the bull. J. Anim. Sci. 6:154-160. Braun, A. G., D. J. Emerson, and B. B. Nichinson. 1979. Teratogenic drugs inhibit tumour cell attachment to lectin-coated surfaces. Nature 282:507-509. Braun, A. G., C. A. Buckner, D. J. Emerson, and B. B. Nichinson. 1982. Quantitativecorrespondencebe- tween the in viva and in vitro activity of teratogenic agents. Proc. Natl. Acad. Sci. USA 79:2056-2060. Brawer, J. R., and F. Naftolin. 1979. The effects of oestrogen exposure on hypothalamic tissue, pp. 19- 33. In Sex, Hormones and Behaviour. CIBA Founda- tion Symposium 62 (New Series). Amsterdam: Ex- cerpta Medical Brawer, J. R., H. Schipper, and B. Robaire. 1983. Effects of long term androgen and estradiol exposure on the hypothalamus. Endocrinology 112:194-199. Brewen, J. G., R. J. Preston, and N. Gengozian. 1975. Analysis of x-ray-induced chromosomal translocations in human and marmoset spe'~atogonial stem cells. Nature 253:468 470. 325 Brinsmead, M. W., B. J. Bancroft, G. D. Thorburn, and M. J. Waters. 1981. Fetal and maternal ovine placen- tal lactogen during hyperglycaemia, hypoglycaemia and fasting. J. Endocrinol. 90:337-343. Brooks, D. E. 1979a. Influence of androgens on the weights of the male accessory reproductive organs and on the activities of mitochondrial enzymes in the epididymis of the rat. J. Endocrinol. 82:293-303. Brooks, D. E. 1979b. Carbohydrate metabolism in the rat epididymis: Evidence that glucose is taken up by tissue slices and isolated cells by a process of facili- tated transport. Biol. Reprod. 21:19-26. Brooks, D. E. 1980. Carnitine in the male reproductive tract and its relation to the metabolism of the epididy- mis and spermatozoa, pp. 219-235. In R. A. Frankel and J. D. McGarry, Eds. Carnitine Biosynthesis, Metabolism, and Functions. New York: Academic Press. Brooks, D. E. 1981. Metabolic activity in the epididymis and its regulation by androgens. Physiol. Rev. 61:516- 555. Brooks, D. E. 1982. Epididymal functions and their hormonal regulation. Aust. J. Biol. Sci. 36:205-221. Brooks, D. E. 1983. Effect of androgens on protein synthesis and secretion in various regions of the rat epididymis, as analysed lay two~imensional gel electro- phoresis. Mol. Cell. Endocrinol. 29:255-270. Brooks, D. E., and K. Tiver. 1984. Analysis of surface proteins of rat spermatozoa during epididymal transit and identification of antigens common to spermatozoa, rete testis fluid and cauda epididymal plasma. J. Reprod. Fertil. 71:249-257. Brown, C. R., K. I. von Glos, and R. Jones. 1983. Changes in plasma membrane glycoproteins of rat spermatozoa during maturation in the epididymis. J. Cell Biol. 96:25~264. Bruce, W. R., R. Furrer, and A. J. Wyrobek. 1974. Abnormalities in the shape of murine sperm after acute testicular x-irradiation. Mutat. Res. 23:381- 386. Brusick D., F. J. de Serres, R. B. Everson, M. L. Mendel- sohn, J. V. Neel, M. D. Shelby, and M. D. Waters. 1981. Monitoring the human population for mutagenic effects: Detection of gene mutations and dna damage. In A. D. Bloom, Ed. Guidelines for Studies of Human Populations Exposed to Mutagenic and Reproductive Hazards. New York: March of Dimes Birth Defects Foundation, Bryce, T. H., and J. H. Teacher. 1908. Contributions to the Study of Early Development and Imbedding of the Human Ovum. Glasgow: MacLehose. 93 PP. . Budnick, I. S., S. Leikin, and L. E. Hoeck. 1955. Effect in the newborn infant of reserpine administered an- tepartum. A.M^. Am. J. Dis. Child. 90:286 289. Buelke-Sam, J., C. A. Kimmel, J. Adams, C. J. Nelson, C. V. Vorhee$ D. C. Wright, V. St. Omer, B. A. Korot R. E. Butcher, M. A. Geyer, J. F. Holson, C. Kutscher, and M. J. Wayner. 1985. Collaborative behavioral

326 REFERENCES teratology study: Results. Neurobehav. Toxicol. Teratol. 7:591-624. Bulbrook, R. D., J. L. Hayward, and C. C. Spicer. 1971. Relation between urma~y and and oortiocid Acre lion and subsequent breast cancer. Lancet 2:395- 398. Burkhart, J. G., J. Benzinger, K. Svensson, and H. V. Mailing. 1985. An evaluation of heterologous an- tibodies to lactate dehydrogenase-C in the detection of mutations. Mutat. Res. 148:135-149. Burmer, G., and L. Loeb. In press. Mutations in C- Ki-ras- oncogene during progressive stages of human colon carcinoma. Proc. Natl. Acad. Sci. USA. Burroughs, C. D., H. A. Bern, and E. L. R. Stokstad. 1985. Prolonged vaginal certification and other changes in mice treated neonatally with coumestrol, a plant estrogen. J. Toxicol. Environ. Health 15:51- 61. Bush, T. L., and E. Barrett-Connor. 1985. Noncontracep- tive estrogen use and cardiovascular disease. Epidem- iol. Rev. 7:89-104. Bushnell P. J., R. E. Bowman, J. R. Allen, and R. J. Marlar. 1977. Scotopoic vision deficits in young monkeys exposed to lead. Science 196:333-335. Bussolino, F., C. Benedetto, M. Massobrio, and G. Camus- si. 1980. Maternal vascular prostacyclin activity in pre-eclampsia (letter). Lancet 2:702. Bygdeman, M., and R. Eliasson. 1969. Distribution of pros~andins, fructose and acid phosphatase in human seminal plasma. Andrologie 1:5-10. Callen, P. W. 1983. Ultrasonography in Obstetrics and Gynecology. Philadelphia: W. B. Saunders Co. 346 PP. Caine, D. B., J. W. Kingston, W. R. Martin, A. J. Stoesst T. J. Ruth, M. J. Adam, B. D. Pate, and M. Schulzer. 1985. Positron emission tomography after MPTP: Observations relating to the cause of Parkinson's disease. Nature 317:246-248. Caine, D. B., A. Eisen, E. McGeer, and P. Spencer. 1986. Alzheimer's disease, Parkinson's disease and motoneurone disease: A biotropic interaction between ageing and environment? Lancet 2:1067-1072. Calvin, H. I., and J. M. Bedford. 1971. Formation of disulphide bonds in the nucleus and accessory struc- tures of mammalian spermatozoa during maturation in the epididymis. J. Reprod. Fertil. (Suppl. 13~:65- 75. Campbell, K. L. 1985. Methods of monitoring ovarian function and predicting ovulation: Summary of a meeting. Res. Frontiers Fertil. Regulation 3:1-16. Campbell, M. E., S. P. Spielberg, and W. Kalow. 1987. A urinary metabolite ratio that reflects systemic caf- feine clearance. Clin. Pharmacol. Ther.42:157-165. CanDleld, R. E., S. Birken, P. Ehrlich, and G. Armstrong. 1984. Immunochemistry of human chorionic gonado- tropin. Adv. Exp. Med. Biol. 176:199-215. Caulfield, R. E., J. F. O'Connor, S. Birken, A. Krichevsky, and A. J. Wilcox. 1987. Development of an assay for a biomarker of pregnancy and early fetal loss. Environ. Health Perspect. 74:57 66. Carey, S. W., N. W. Klein, W. T. Frederickson, G. Seakett, R. M. Greenstein, P. Sehgal, and M. Elliott. 1984. Analysis of sera from monkeys with histories of fetal wastage and the identification of teratogenicity in sera from human chronic spontaneous aborters using rat embryo cultures. Trophoblast Res. 1:347-360. Carr, D. W., and T. S. Acott. 1984. Inhibition of bovine spermatozoa bycaudal epididymidalfluid: I. Studies of a sperm motility quiescence factor. Biol. Reprod. 30:913-925. Carrano, A. V., L. H. Thompson, P. A. Lindl, and J. L. Minkler. 1978. Sister chromatic exchange as an indicator of mutagenesis. Nature 271:551-553. Carrano, A. V., J. L. Minkler, D. G. Stetka, and D. H. Moore, II. 1980. Variation in the baseline sister chromatic exchange frequency in human lymphocytes. Environ. Mutag. 2:325-337. Carreau, S., M. A. Drosd~Lcy, C. Pisselet, and M. Cour- ot. 1980. Hormonal regulation of androgen-binding protein in lamb testes. J. Endocrinol. 85:443~48. Carreau, S., M. A. Drosdowsky, and M. Courot. 1984. Androgen-binding proteins in sheep epididymis: Characterization of a cytoplasmic androgen receptor in the ram epididymis. J. Endocnnol. 103:273-279. Carson, D. D., J.-Y. Tang, J. A. Julian, and S. R. Glasser. 1988. Vectorial secretion of proteoglycansbypolar~zed rat uterine epithelial cells. J. Cell Biol. 107:2425- 2435. Casillas, E. R., and S. Chaipayungpan. 1979. The dis- tn~ution of carnitine and acetylcarnitine in the rabbit epididymis and the carnitine content of rabbit sper- matozoa during maturation. J. Reprod. Fertil. 56:439- 444. Casslen, B., and K Ohlsson. 1981. Alpha 1-antittypsin— complexation and inactivation in the uterine fluid of IUD-users. Acta Obstet. Gynecol. Scand. 60: 103-107. Cate, R.L., RJ. Mattaliano, C. Hession, R. Tizard, N. M. Farber, A. Cheung, E.G. Ninfa, A.Z. Frey, D. J. Gash, E.P. Chow, R. A. Fisher, J.M. Bertonis, G. Torres, B.P. Wallner, K.L. Ramachandran, R.C. Ragin, T.F. Mangonaro, D.T. MacLaughlin, and P.K Donahoe. 1986. Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells. Cell 45:685-698. Catt, K. J., M. L. Dufau, and J. L. Vaitukaitis. 1975. Appearance of hCG in pregnancy plasma following the initiation of implantation of the blastocyst. J. Clin. Endocrinol. Metab. 40:537-540. Catz, C., and S. J. Yaffe. 1968. Barbiturate enhancement of bilirubin conjugation and excretion in young and adult animals. Pediat. Res. 2:361-370. Caudle, M. R., N. S. Rote, J. R. Scott, C. DeWitt, and M. F. Barney. 1983. Histocompatibility in couples with recurrent spontaneous abortion and normal fertility. Fertil. Steril. 39:793-798. Cavanagh, A. C., H. Morton, B. E. Rolfe, and A. A.

REFERENCES Gidley-Baird. 1982. Ovum factor: A first signal of pregnancy? Am. J. Reprod. Immunol. 2:97-101. Cavicchia, J. C. 1979. Fine structure of the monkey epididymis: A correlated thin-section and freeze- cleave study. Cell Tissue Res. 201:451458. Chandley, A. C. 1984. Infertility and chromosomal abnor- mality. Oxford Rev. Reprod. Biol. 6:1 46. Chandley, A. C., P. Edmond, S. Christie, L. Gowans, J. Fletcher, A. Franckiewicz, and M. Newton. 1975. Cytogenetics and infertility in man. I. Karyote and seminal analysis: Results of a five-year sunrey of men attending a subfertility clinic. Ann. Hum. Genet. 39:231-254. Chandra, R. K, and P. M. Newberne. 1977. Nutrition, Immunity and Infection. New York: Plenum Press. 246 pp. Chang, T. S. K, and P. C. Albertsen. 1984. Interpretation and utilization of the zone pellucida-free hamster egg penetration test in the evaluation of the infertile male. Sem. Urol. 2~2~:124 130. Chang, T. S. K., and B. R. Zirkin. 1978. Distribution of sulfhydryl oxidase activity in the rat and hamster male reproductive tract. Biol. Reprod. 18:745-748. Channing, C. P., and S. P. Coudert. 1976. Contribution of granulosa cells and follicular fluid to ovarian estro- gen secretion in rhesus monkeyin vivo. Endocrinology 98:59~597. Chapman, R. M. 1983. Gonadal iniun resultin~ from chemotherapy. Am. J. Ind. Med. 4:149-161. Chard, T. 1985. Biological and clinical signif~cance of pregnancy proteins, pp. 29-41. In F. Ellendorff and E. Koch, Eds. Early Pregnancy Factors. Ithaca, N.Y.: Perinatology Press. Chasnoff, I. J., W. J. Burns, S. H. Schnoll, and K. A. Burns. 1985. Cocaine use in pregnancy. N. Engl. J. Med. 313:666 669. Chatot, C. L., N. W. Klein, J. Piatek, and L. J. Pierro. 1980. Successful culture of rat embryos on human serum: Use in the detection of teratogens. Science 207:1471-1473. Chellman, G. J., J. S. Bus, and P. K. Working. 1986. Role of epididymal inflammation in the induction of dominant lethal mutations in Fischer 344 rat sperm by methyl chloride. Proc. Natl. Acad. Sci. USA 83:8087 8091. Chen, P. H., K. T. Chang, and Y. D. Lu. 1981. Poly- chlorinated biphenyls and poh,rchlorinated d~benzofur- ans in the toxic rice bran oil that caused PCB poisoning inTaichung. Bull. Em~ron. Contamin. Toxicol.26:489- 495. Chervenak, F. A., M. A. Farley, L. Walters, J. C. Hobbins, and M. J.Mahoney. 1984. When is termination of pr~nancy dur~g the third t~mester mora~ justiSable? N. Eng. J. Med. 310:501-504. Chervenak F. A., G. Isaacson, J. C. Hobbins, U. Chitkara, M. Tortora, and R. L. Berkowitz. 1985. Diagnosis and management of fetal holoprosencephaly. Obstet. Gynecol. 66:322-326. Chew, W. C., and I. L. Swan. 1977. Influence of simul- 327 taneous low amniotomy and oxytocin infusion and other maternal factors on neonatal jaundice: A pro~ pective study. Br. Med. J. 1:72-73. Chilton, B. S., S. V. Nicosia, and D. P. Wolf. 1981. Separation and characterization of endocen~cal cells, pp. 464~66. In S. R. Glasser and D. W. Bullock, Eds. Cellular and Molecular Aspe~s of Iinplantation. New York: Pergamon Press. Chisolm, J. J., and E. K. Silbergeld. 1981. Increased excretion of homovanillic acid (HVA) in urine by young children with increased lead absorption, pp. 565-568. In Proceedings ofInternationalConference on Heavy Metals in the Environment. Edinburgh: CEP Consultants. Christensen, A. K., and K. C. Peacock. 1980. Increase in L~ydig cell number in testes of adult rats treated chronicall~r with an excess of human chorionicgonado- tropin. Biol. Reprod. 22:383-391. Chubb, C., and C. Desiardins. 1982. Vasculature of the mouse, rat, and rabbit testis-epididymis. Am. J. Anat. 165:357-372. Chubb, C., and C. Nolan. 1985. Animal models of male infertility Mice bearing single-gene mutations that induce infertility. Endocrinology 117:33~346. Chulavatnatol, M., S. Panyim, and D. Wititsuwannakul. 1982. Companson of phosphotylated proteins in intact rat spermatozoa from caput and cauda epididy~nidis. Biol. Reprod. 26:197-207. Church, G. M, and W. Gilbert. 1984. Genomic sequen~ ing. Proc. Natl. Acad. Sci. USA 81:1991-1995. Cicero, T. J., R. D. Bell, W. G. Wiest, J. H. Allison, K. Polakoski, and E. Robins. 1975. Function of the male sex organs in heroin and methadone users. N. Engl. J. Med. 292:882 887. Clark, D. A., A. Chaput, and D. Tutton. 1986. Active suppression of host-v~t reaction in pregnant mice. VII. Spontaneous abortion of allogeneic CBA/J x DBA/2 fetuses in the uterus of C1lA/J mice correlates with deficient non-T suppressor cell activity. J. Im- munol. 136:1668 1675. Clark, R. V. 1988. Male hypogonadism, pp. 51~516. In J. W. Hurst, Ed. Medicine for the Practiang Physi- cian, 2nd ed. Boston: Butterworths. Clark, R. V., and R. J. Sherins. 1986. Use of semen analysis in the evaluation of the infertile couple, pp. 253-266. In R. J. Santen and R. S. Swerdloff, Eds. Male Reproductive Dysfunction: Diagnosis and Man- agement of Hypogonadism, Infertility, and Impotence. New York: Marcel Del~er. Clarkson, T. W. 1987. The role of biomarkers in repro- ductive and developmental to~ncology. Emiron. Health Perspect. 74:103-107. Clarren, S. K., and D. W. Smith. 1978. The fetal alcohol syndrome. N. Engl. J. Med. 298:1063-1067 Clemetson, C. A. B., J. D. Kim, T. P. S. De Jesus, V. R. Mal~ca Juneswara, and J. H. Wilds. 1973. Human uterine fluid potassium and the menstrual cycle. J. Obstet. Gynecol. Br. Comm. 80:553-561. Clermont, Y. 1972. Kinetics of ppermatogenesis in mam-

328 mars: Seminiferous epithelium cycle and spermato- gonial renewal. Physiol. Rev. 52:198-236. Clift,A. F. 1945. Observations on certain theological properties of human cervical secretion. Proc. R. Soc. Med. 39:1-9. Clifton, D. K., and W. J. Bremner. 1983. The effect of testicular x-irradiation on spermatogenesis in man. J. Androl. 4:387-392. Clifton, R. K., and M. N. Nelson. 1976. Developmental study of habituation in infants: The importance of paradigm, response system, and state, pp. 159-205. In T. J. Tighe and R. N. Leaton, Eds. Habituation: Perspectives from Child Development, Animal Be- havior,andNeurophysiology. Hillsdale,NJ.: Law- rence Erlbaum. Clifton, D. K., and R.A. Steiner. 1983. Cycle detection: A technique for estimating the frequency and ampli- tude of episodic fluctuations in blood hormone and substrate concentrations. Endocrinology 112:1057- 1064. Coffey, D. S. 1986. The biochemistry and physiology of the prostate and seminal vesicles, pp. 233-274. In P. C. Walsh, R. F. Gittes, A. D. Perlmutter, and T. A. Stamey, Eds. Campbell's Urology, 5th edition. Vol. 1. Philadelphia: W. B. Saunders. Coffey, D. S., and J. T. Isaacs. 1981. Control of prostate growth. Urology 17(Suppl.3~:17-24. Cohen, J., M. P. Ooms, and J. T. M. Vreeburg. 1981. Reduction of fertilizing capacity of epididymal sper- matozoa by Salpha-steroid reductase inhibitors. Ex- perientia 37:1031-1032. Cohen, J. S., R. H. Knop, G. Navon, and D. Foxall. 1983. Nuclear magnetic resonance in biology and medicine. Life Chem. Repts. 1:281 457. Cohn, D. F., Z. T. Homonnai, and G. P. Paz. 1982. Diphenylhydantoin excretion in the semen of treated epileptics. Isr. J. Med. Sci. 8:509-511. Cole, K. D., J. C. Kandala, and W. S. Kistler. 1986. Isolation of the gene for the testi~specific H1 histone variant Hlt. J. Biol. Chem. 261:7178-7183. Cole, R. J., J. Cole, L. Henderson, N. A. Taylor, C. F. Arlett, and T. Regan. 1983. Short-term tests for transplacentally active carcinogens. A comparison of sister-chromatic exchange and the micronucleus test in mouse foetal liver e~ythroblasts. Mutat. Res. 113:61-75. Collea, J. V., and W. M. Holls. 1982. The contraction stress test. Clin. Obstet. Gynecol. 25:707-717. Collins, J. A., W. Wrixon, L. B. Janes, and E. H. Wilson. 1983. Treatment-independent pregnancy among infer- tile couples. N. Engl. J. Med. 309:1201-1206. Collins, W. P., P. O. Collins, M. J. Kilpatrick, P. A. Man- ning, J. M. Pike, and J. P. P. Tyler. 1979. The con- centrations of urinary oestrone-3-glucuronide, LH and pregnanediol-3alpha-glucuronide as indices of ovarian function. Acta Endocrinol. 90:33~348. Committee on Biological Markers of the National Re- search Council. 1987. Biological markers in environ- mental health research. Environ. Health Perspect. REFERENCES 74:3-9. Connell, C. J., and A. M. Donjacour. 1985. A morpho- logical study of the epididyrnides of control and estra- diol-treatedprepubertal dogs. Biol. Reprod. 33:951- 969. Cooke, B. A., and M. H. F. Sullivan. 1985. Review the mechanism of LHRH agonist action in gonadal tissues. Mol. Cell. Endocrinol. 41:115-122. Cooper, T. G. 1986. The Epididymis, Sperm Maturation, end Fertilization. Berlin: SprengerVerlag. 281 pp. Cooper, T. G., and D. E. Brooks. 1981. Entry of glycerol into the rat epidi~mis and its utilization by epidi~9mal spermatozoa. J. Reprod. Fertil. 61:163-169. Cooper, T. G., and D. W. Hamilton. 1977. Phagocytosis of spermatozoa in the terminal region and gland of the vas deferens of the rat. Am. J. Anat. 150:247- 267. Cooper, T. G., C. H. Yeung, D. Nashan, and E. Nieschlag. 1988. Epididymal markers in human infertility. J. Androl. 9:91-101. Copp, A. J. 1979. Interaction between inner cell mass and trophectoderm of the mouse blastocyst. II. The fate of the polar trophectoderm. J. Embryol. Exp. Morphol. 51:109-120. Corliss, C. E., and G. G. Robertson. 1963. The pattern of mitotic density in the early chicle neural epithelium. J. Exp. Zool. 153:125-140. Cowol, P., A. Michaud, J. Menard, M. Freifeld, and J. Mahoudeau. 1975. Antiandrogenic effect of spirola~ tones: Mechanism of action. Endocrinology97:52- 58. Cosentino, M. J., H. Takihara, J. W. Burhop, and A. T. K Codcett. 1984. Regulation of rat caput epididy- niidis contractility ~y prostaglandins. J. Androl. 5:21 222. Cottrill, C. M., R. G. McAllister, Jr., L. Gettes, and J. A. Noonan. 1977. Propranolol therapy during preg- nancy, labor and deliveIy. Evidence for transplacental drug transfer and impaired neonatal drug disposition. J. Pediatr. 91:812-814. Coulam, C. B. 1981. The diagnosis and treatment of infertility, Chapter 50. In J. J. Sciarra, Ed Gynecology and Obstetrics. Hagerstown, Md.: Harper & Row. Coulam, C. B., T. L Wasmoen, R. Creapy, P. Siiteri, and G. Gleich. 1987. Major basic protein as a predictor of preterm labor: A preliminary report. Am. J. Ob- stet. Gynecol. 156:79~796. Courot, M. 1964. Some results obtained in the irradiation with x-rays of testes of lambs, pp. 279-286. In W. Carlson and F. Gassner, Eds. Effects of Ionizing Radiation on the Reproductive System. New York: Pergamon Press. Courot, M. 1981. Transport and maturation of sper- matozoa in the epididymis of mammals. Prog. Reprod. Biol. 8:67-79. Cowan, W. M., B. B. Stanfield, and K. Kishi. 1980. The development of the dentate gyrus. Curr. Top. Dev. Biol. 15:103-157. Crabo, B. 1965. Studies on the composition of epididy-

REFERENCES mat content in bulls and boars. Acta Vet. Scand. 6(Suppl. 5~:1-94. Crabo, B., and B. Gustafsson. 1964. Distribution of sodium and potassium and its relation to sperm con- centration in the epididymal plasma of the bull. J. Reprod. Fertil. 7:337-345. Crain, J. L., and A. A. Luciano. 1983. Peritoneal fluid evaluation in infertility. Obstet. Gynecol. 61:159- 164. Crandall, B. F. 1981. Alpha-fetoprotein: A review. CRC Cnt. Rev. Clin. Lab. Sci. 15:127-185. Cree, J. E., J. Meyer, and D. M. Halley. 1973. Diazepam in labour: Its metabolism and effect on the clinical condition and thermogenesis of the newborn. Br. Med. J. 4:251-255. Croxatto, H. B., M. E. Ortiz, S. Diaz, R. Hess, J. Bal- maceda, and H. D. Croxatto. 1978. Studies on the duration of egg transport by the human oviduct. II. Ovum location at various intervals following lutein~ng hormone peak. Am. J. Obstet. Gynecol. 132:629- 634. Csapo, A. I., M. O. PuL~inen, B. Ruttner, J. P. Sauvage, and W. G. Wiest. 1972. The significance of the human corpus luteum in pregnancy maintenance. I. Prelim- inary studies. Am. J. Obstet. Gynecol. 112:1061- 1067. Cumming, D. C., J. C. Yang, R. W. Rebar, and S. S. C. Yen. 1981 Treatment of hirsutism with spironola~ tone. J. Am. Med. Assoc. 247:1295-1298. Cummins, J. M. 1976. Effects of epididymal occlusion on sperm maturation in the hamster. J. Exp. Zool. 197:183-190. Cunha, G. R., L. W. K. Chung, J. M. Shannon, and B. A. Reese. 1980. Stromal-epithelial interactions in sex differentiation. Biol. Reprod. 22:19-42. Cunha, G. R., R. M. Bigsby, P. S. Cooke, and Y. Sugi- mura. 1985. Stromal-epithelial interactions in adult organs. Cell Different. 17:137-148. Curtis, G., and M. Fogel. 1970. Creatinine excretion: Diurnal variation and variability of whole and part- day measures. A methodologic issue in psychoen- docrine research. Psychosom. Med. 32:337-350. Cutler, G. B., Jr., and D. L. Loriamc. 1980. Adrenarche and its relationship to the onset of puberty. Fed. Proc. 39:2384 2390. Czeizel, A. 1982. Epidemiological follow-up study on mutagenic effects in self-poisoning persons, pp. 639- 646. In T. Sugimura, S. Kondo, and H. Takebe, Eds. Environmental Mutagens and Carcinogens New York and Tokyo: Liss and University of Tokyo Press. Czekala, N. M., J. K Hodges, and B. L. Lasley. 1981. Pregnancy monitoring in diverse spades by estrogen and bioactive luteinizing hormone determinations in small volumes of urine. J. Med. Primatol. 10:1- 15. Dacheux, J. L. 1977. Reinvestigation of the variation in total phospholipid content of the spermatozoa of the rat and the ram during epididymal transport. IRCS Medical Science 5:18. 329 Dacheux, J. L., and J. K. Voglmayr. 1983. Sequence of sperm cell surface differentiation and its relationship to exogenous fluid proteins in the ram epidic~mis. Biol. Reprod. 29:1033-1046. Dacheux, J. L., T. O'Shea, and M. Paquignon. 1979. Effects of osmolality, bicarbonate and buffer on the metabolism and motility of testicular, epidi~ymal and ejaculated spermatozoa of boars. J. Reprod. Fertil. 55:287-296. da Cunha, M. F., M. L. Meistrich, M. M. Haq, L. A. Gordon, and A. J. Wyrobek. 198Z Temporary effects of AMSA (4'-~9-acridinylamino~methane sulfon-m- anisidide) chemotherapy on spermatogenes~s. Cancer 49:2459-2462. Daffo$ F., M. CapeLla-Pavlavsky, and F. Forestier. 1985. Fetal blood sampling during pregnancy with use of a needle guided by ultrasound: A study of 606 con- secutive cases. Am. J. Obstet. Gynecol. 153:655- 660. Dahl, K. D., N. M. Czekala, P. Lim, and A. J. Hsueh. 1987. Monitoring the menstrual cycle of humans and lowland gorillas based on urinary profiles of bioactrve follicle-stimulating hormone and steroid metabolites. J. Clin. Endocrinol. Metab. 64:486 493. Daly, D. C., I. A. Maslar, and D. H. Riddick. 1983a. Prolactin production during in vitro decidualization of proliferative endometrium. Am. J. Obstet. GynecoL 145:672-678. Daly, D. C., I. A. Maslar, and D. H. Riddick. 1983b. Term decidua response to estradiol and progesterone. Am. J. Obstet. Gynecol. 145:679 683. Danzo, B. J., and B. C. Eller. 1975. Androgen binding to cytosol prepared from epididymides of smoaLly mature castrated rabbits: Evidence for a cytoplasmic receptor. Steroids 25:507-524. Danzo, B. J., and B. C. Eller. 1979. The presence of a cytoplasmic estrogen receptor in sexually mature rabbit epidictmides: Comparison with the estrogen receptor in immature rabbit epidid~nnal c~rtosol. Endocrinology 105:1128 1134. Danzo, B. J., M.~. Orgebin-Crist, and D. O. Toft. 1973. Characterization of a protoplasmic receptor for Scr- dibydrotestosterone in the caput epidipyrnidis of intact rabbits. Endocrinology 92:31~317. Danzo, B. J., T. G. Cooper, and M.-C. Orgebin-Cnst. 1977. Androgen binding protein (ABP) in fluids collected from the rete testis and cauda epidi~ymidis of sexually mature and hnmawe rabbits and obsena lions on morphological changes in the epidi~mis following ligation of the ductuli efferentes. Biol. Reprod. 17:64 77. David, G., J. P. Bisson, F. Cyglik, P. Jouannet, and C. Genugon. 1975. Anomalies mo~phologiques du sper- matozolde humain. 1. Propositions pour un systime de classification. J. Gynecol. Obstet. Biol. Reprod. 4:17-36. Davies, J., and S. R. Glasser. 1968. Histological and fine structural observations on the placenta of the rat. Acta Anat. (Baser) 69:542r608.

330 Davies, M. 1985. Antigenic analysis of immune com- plexes formed in normal human pregnancy. Clin. Em. Immunol. 61:406 415. Davies, M., and C. M. Browne. 1985. Anti-trophoblast antibody responses during normal human pregnancy. J. Reprod. Immunol. 7:285-297. Davis, M. 1984. The mammalian startle response, pp. 287-351. In R C. Eaton. Ed. Neural Mecca r s of Startle Behavior. New York: Plenum Press. Davis, M., and G. K. Aghajanian. 1976. Effects of apo- morphine and haloperidol on the acoustic startle re- sponse. Psychopharmacology 47:217-223. Davis, M., and D. I. Astrachan. 1981. Spinal modulation of acoustic startle: Opposite effects of clonidine and d-amphetamine. Psychopharmacology75:219-225. Davis, M., and M. H. Sheard. 1976. p-Chloroampheta- m~ne (PCA): Acute and chronic effects on habituation and sensitization of the acoustic startle response in the rat. Eur. J. Pharmacol. 35:261-273. Davison, J. M., and F. E. Hytten. 1974. Glomerular filtration during and after pregnancy. J. Obstet. Gynae- col. Br. Commonw. 81:5~595. de Ikonicoff, L. K. and L. Cedard. 1973. Localization of human chorionic gonadotropin and somatomam- motropic hormones by the peroxidase immunohistoen- ymologic method in villi and amniotic epithelium of human placentas (from six weeks to term). Am. J. Obstet. Gynecol. 116:1124-1132. deJong, F. H. 1979. Inhibin-fact or artifact. Mol. Cell. Endocrinol. 13:1-10. de Jong, F. H. 1987. Inhibin—its nature, site of produc- tion and function. Oxford Rev. Reprod. Biol. 9:1- 53. DeKlerk, D. P., D. S. Coffey, L. L. Ewing, I. R. McDer- mott, W. G. Reiner, C. H. Robinson, W. W. Scott, J. D. Strandber~ P. Talalay, P. C. Walsh, L. G. Whea- ton, and B. R. Zirkin. 1979. Comparison of spon- taneous and experimentally induced canine prostatic hyperplasia. J. Clin. Invest. 64:842-849. DeLap, L. W., S. S. Tate, and A. Meister. 1977. Gamma- glutamyl uar~tidase and related enzyme activities in the reproductive system of the male rat. Life Sci. 20:673 680. Delehanty, J., R L. White and M. L. Mendelsohn. 1986. Approaches to determining mutation rates in human DNA. Mutat. Res. 167:215-232. Delongeas, J. L., J. L. Gelly, R. Hatier, and G. Gngnon. 1984. Postnatal evolution of Sedative metabolism of the epidi~mis in rats. C.R. Acad Sci. [m] 298:19- 22. (In French) Del Rio, A. G., and R. Raisman. 1978. cAMP in sper- matozoa taken from different segments of rat epididy- mis. Experientia 34:67~671. De Luca, H. F. 1978. The hormonal nature of vitamin D function, pp.249-270. In J. Dumont and J. Nunez, Eds. Hormones and Cell Regulation, Volume 2. Amsterdam: Elsevier/North-Holland. Del Zompo, M., F. Bernardi, U. Bonuccelli, R. Maggio, M. Bajorek, M. Arnone, and G. U. Corsini. 1986. REFERENCES Properties of [3H]-MPrD binding sites in human blood platelets. Life Sci. 39:1855-1891. Dempsey, J. L., R. S. Seshadri, and A. A. Morley. 1985. Increased mutation frequency following treatment with cancer chemotherapy. Cancer Res. 45:2873- 2877. Denison, M. S., and C. F. Wilkinson. 1985. Identification of the Ah receptor in selected mammalian species and induction of aryl hydrocarbon hydrox rlase. Eur. J. Biochem. 147:429-435. Denison, M. S., L. M. Vella, and A. B. Okey. 1986. Structure and function of the Ah receptor for 2,3,7,8- tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols. J. Biol. Chem. 261:3987- 3995. Denomme, M. A., K. Homonko, T. Fujita, T. Sawyer, and S. Safe. 1986. Substituted polychlorinated diben- rector binding affinities and alyl hydrocubon hydroxylase induction potencies—a QSAR analysis. Chem. Biol. Interact. 57:175-187. De Rosis, F., S. P. Anastasio, L. Salvage, A. Beltrame, and G. Morianio. 1985. Female reproductive health in two lamp factories: Effects of exposure to inorganic mercury vapour and stress factors. Br. J. Ind. Med. 42:488 494. Derue, G. J., H. G. Englert, E. N. Harris, A. E. Gharavi, S. H. Morgan, and R. G. Hull. 1985. Fetal loss in systemic lupus: Association with anticardiolipin an- tibodies. J. Obstet. Gynaecol. 5:207-209. Desmond, M. M., R. P. Schwanecke, G. S. Wilson, S. Yasunaga, and I. Burgdorff. 1972. Maternal bar- titurate utilization and neonatal withdrawal symptoma- tology. J. Pediatr. 80:190-197. DeVore, G. R., and J. C. Hobbins. 1984. Antenatal diagnosis of congenital structural anomalies with ultrasound, pp. 1-55. In R. W. Beard and P. W. Na- thaniels~, Eds. Fetal Physiology and Medicine, 2nd ed. New York: Marcel Dekker. DeWitte, D. B., M. K. Buick, S. E. Cyran, and M. J. Maisels. 1984. Neonatal pancytopenia and severe combined immunodeficiengy associated with antenatal administration of azathioprine and prednisone. J. Pediatr. 105:625~28. Dick Mann, Z., and S. K. Dey. 1974. Steroidogenesis in peimplantabon rat embryo and its possible influence on morula-blastocyst transformation and implantation. J. Reprod. Fertil. 37:91-93. Dixon, R. L. 1985. Reproductive Toxicology. New Yorlc: Raven Press. 350 pp. diZerega, G. S., and G. D. Hodgen. 1980. The primate ovarian cycle: Suppression of human menopausal gonadotropin-induced follicular growth in the presence of the dominant follicle. J. Clin. Endocrinol. Metab. 50:819-825. Dobson, R. L., and J. S. Felton. 1983. Female germ cell loss from radiation and chemical exposures. Am. J. Ind. Med. 4:175-190. Donnez, J., S. I~ngerock, and K Thomas. 1982. Periton-

REFERENCES eel fluid volume and 17 be~hadiol and progesterone concentrations in ovulatory, anavulato~y, and postmeno- pausal women. Obstet. Gynecol. 59:687-692. Dorfman, R. I., and R. A. Shipley. 1956. Androgens: Biochemistry, Physiology and Clinical significance. New York: John Wiley & Sons. 590 pp. Dornngton, J. H., Y. S. Moon, and D. T. Armstrong. 1975. Estradiol-17 beta biosynthesis in cultured granu- losa cells from hypophysectomized immature rats: Stimulations follicle-stimulating hormone. Endocrin- ology 97:1328-1331. Doshi, M. L. 1986. Accuracy of consumer performed in-home tests for early pregnancy detection. Am. J. Public Health 76:512-514. Dott, H. M., and J. T. Dingle. 1968. Distribution of lysosomal enzymes in the spermatozoa and cytoplasmic droplets of bull and ram. Exp. Cell Res. 52:523- 540. Dougherty, R. C., M. J. Wl~itaker, S.-Y. Tang, R. BoKcher' M. Keller, and D. W. Kuehl. 1981. Sperm density and toxic substances: A potential key to environmental health hazards, pp. 263-278. In J. D. McKinney, Ed. Environmental Health Chemistry: The Chemistry of Environmental Agents as Potential Human Hazards. Ann Arbor, Mich.: Ann Arbor Science. Douglas, C. P., J. S. Garrow, and E. W. Pugh. 1970. Investigation into the sugar content of endometrial secretion. J. Obstet. Gynaecol. Br. Commonw.77:891- 894. Doull, J. 1980. Factors influencing toxicology, pp. 7 83. In J. Doull, C. D. Klaassen, and M. O. Amdur, Eds. Casarett and Doull's Toxicology: The Basic Science of Poisons, 2nd ed. New York: Macmillan. Dreskin, R. B., S. S. Spicer, and W. B. Greene. 1970. Ultrastructural localization of chorionic gonadotropin in human term placenta. J. Histochem. Cytochem. 18:862-874. Due, H. T., A. Masse, P. Bobe, R. G. Kinsky, and G. A. Voisin. 1985. Deviation of humoral and cellular alloimmune reactions by placenta! extracts. J. Reprod. Immunol. 7:27-39. Dudley, K., J. Potter, M. F. Lyon, and K. R. Willison. 1984. Analysis of male sterile mutations in the mouse using haploid stage expressed cDNA probes. Nucleic Acids Res. 12:4281~293. Dym, M., H. G. M. Raj, and H. E. Chemes. 1977. Response of the testis to selective withdrawal of LH or FSH using antigonadotropic sera, pp. 97-124. In P. Troen and H. R. Nanldn, Eds. The Testis in Normal and Infertile Men. New York: Raven Press. Dyson, A. L., and M.-C. Orgebin-Crist. 1973. Effects of hypophysectomy, castration and androgen replace- ment upon the fertilizing ability of rat epididymal spermatozoa. Endocrinology 93:391402. Eddy, E. M., R. B. Vernon, C. H. Muller, A. C. Hahnel, and B. A. Fenderson. 1985. Immunodissection of sperm surface modifications during epididymal matura- tion. Am. J. Anat. 174:225-237. Eddy, E. M. 1987. The spermatozoon. In E. Knobil 331 and J. D. Neill. The Physiology of Reproduction. New York: Raven Press. Edmonds, D. K., K. S. Lindsay, J. F. Miller, E. William- son, and P. J. Wood. 1982. Early embryonic mortality in women. Fertil. Steril. 38:447453. Edward$ O. M., R. I. S. Bayliss, S. Millen. 1969. Urinary creatinine excretion as an index of the completeness of manhour urine collections. Lancet 2:1165-1166. Edwards, R. G., P. C. Steptoe, and J. M. Purdy. 1980. Establishing full term human pregnancies using clearing embryos growin Lion. Br. J. Obstet. Gynaecol.87:737- 756. Egozcue, J., C. Templado, F. Vidal, J. Navarro, F. Morer- Fargas, and S. Marina. 1983 Meiotic .cturliec in ~ _. _ series of 1100 infertile and sterile males. Hum. Genet. 65:185-188. Ehrenberg, L. 1988. Dose monitoring and cancer risk, pp. 23-31. In H. Bartsch, K. Hemminki, and I. K. O'Neill, Eds. Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiol- ogy and Prevention. IARC Scientific Publications, No. 89. Lyon: InternationalAgency for Research on Cancer. Ehrenberg, L., and S. Osterman-Golkar. 1980. Adulation of macromolecules for detecting mutagenic agents. Teratogenesis Carcinog. Mutagen. 1:105-127. Ehrhardt, A. A., and H. F. L. Meyer-Bahlburg. 1979. Psychosexual development: An examination of the role of prenatal hormones, pp. 41-50. In Sex, Hor- mones and Behaviour. CIBA Foundation Symposium 62 (New Series). Amsterdam: Excerpta Medical Ehrlich, P. H., W. R. Moyle, Z. A. Moustafa, and R. E. Canfield. 1982. Mung two monoclonal antibodies yields enhanced affinity for antigen. J. Immunol. 128:2709-2713. Ehrlich, P. H., Z. A. Moustafa, A. Krichevsky, S. Birken, E. G. Armstrong, and R. E. Canfield. 1985. Charac- terization and relative orientation of epitopes for monoclonal anubo~es and an isera to human chononic gonadotropin. Am. J. Reprod. Immunol. Microbiol. 8:48 54. Ehrstrom, C. 1987. Fetal movement monitoring in nomal and high-risk pregnancy. Acta. Obstet. Gynecol. 80(Suppl.~:1-32. Elce, J. S., E. J. Graham, G. Zboril, L. Lemon, E. Perez, H. B. Croxatto, and A. de Ioannes. 1986. Monoclonal antibodies to bovine and human acrosin. Biochem. Cell Biol. 64:1242-1248. E1 Etreby, M. F. 1980. The role of contraceptive steroids in the pathogenesis of pituitary tumours in various experimental animals and in man, pp. 211-2212. In G. Faglia, M. A. Giovanelli, and R. M. MacLeod, Eds. Pituitary Microadenomas. Proceedings of the Serono Symposia, Vol. 29. New York: Academic Press. Eliasson, R. 1975. Analysis of semen, pp. 691-713. In S. J. Behrman and R. W. Kistner, Eds. Progress in Infertility, 2nd ed. Boston: LiKle, Brown ~ Company. Eliasson, R. 1981. Analysis of semen, pp. 381-399. In

332 H. Burger and D. de Kretser, Eds. The Testis. New York: Raven Press. Elias.con, R. 1982. Biochemical analysis of human semen. Int. J. Androl. (Suppl. 5~:109-119. Eliasson, R. 1983. Morphological and chemical methods of semen analysis for quantitating damage to male reproductive function in man, pp. 263 275. In V. B. Vouk and P. J. Sheehan, Eds. Methods for Assessing the Effects of Chemicals on Reproductive Function. SC<:)PE 20. New York: John Wiley & Sons. Eliasson, R., and N. Verdi. 1985. LDH-C4 in human seminal plasma and its relationships to testicular function. II. Clinical aspects. Int. J. Androl. 8:201- 214. Elinder, C.-G., G. Oberdorster, and L. Gerhardscon. In press. In T. W. Clarkson, L. Frieberg, G. Nordberg, and P. R. Sager, Eds. Biological Monitoring of Metals. New York: Plenum Press. Ellis, G. B., and C. Desjardins. 1984. Mapping episodic fluctuations in plasma LH in orchidectomized rats. Am. J. Physiol. 247:E13~E135. Enders, A. C. 1965. Formation of syncytium from cyto- trophoblast in the human placenta. Obstet. Gynecol. 25:378-386. Enders, A. C., D. J. Chavez, and S. Schlafke. 1981. Comparison of implantation in utero and in vitro, pp. 365-~82 In ~ R (iln.ccer anti n w R''llr`~k Eds. Cellular and Molecular Aspects of Implantation. New York: Plenum Press. Eng, L. A., and G. Oliphant. 1978. Rabbit sperm rever- sible decapacitation by membrane stabilization with a highly purified glycoprotein form seminal plasma. Biol. Reprod. 19:1083-1094. Evans, H. J. 1982. Sister chromatic exchanges and disease states in man, pp. 183-228. In S. Wolff, Ed. Sister Chromatid Exchange. NewYork: John Wiley & Sons. Evans, R. W., and B. P. Setchell. 1979. Lipid changes during epididymal maturation in ram spermatozoa collected at different times of the year. J. Reprod. Fertil. 57:197-203. Evans, W. E., J. J. Schentag, and W. J. Jusko. 1986. Applied Pharmacokinetics, Principles ofTherapeutic Drug Monitoring. 2nd ed. Spokane, Wash.: Applied Therapeutics. 1272 pp. Evenson, D. P., Z. Darzynkiewicz, and M. R. Melamed. 1980. Relation of mammalian sperm chromatin het- erogeneitytofertility. Science210~4474~:1131-1133. Everson, R. B. 1987. A review of approaches to the detection of genetic damage in the human fetus. Environ. Health Perspect. 74:109-117. Everson, R. B., E. Randerath, R. M. Santella, R. C. Cefalo, T. A. Avitts, K. Randerath. 1986. Detection of smoking~related covalent DNA adducts in human placenta. Science 231:54-57. Everson, R. B., E. Randerath, T. A. Avitts, H. A. J. Schut, end K.Randerath. 1987. Preliminaryinvestigations of tissue specificity, species specificity, and strategies for identifying chemicals causing DNA adducts in REFERENCES human placenta. Prog. Exp. Tumor Res. 31:8~103. Everson, R. B., E. Randeratl~, R. M. Santella, T. A. Avitts, I. B. Weinstein, and K Randerath. 1988. Quantitative associations between DNA damage in human placenta and maternal smoking and birth weight. J. Natl. Cancer Inst. 80:567-576. Ewing, L. L., and B. R. Zirkin. 1983. L~ydig cell struc- ture and steroidogenic function. Recent Prog. Horm. Res. 39:599-635. Ewing, L. L., C. Desiardins, D. C. Irby, and B. Robaire. 1977. Syne~ic interaction of testosterone and oestra- diol inhibits spe~matogenesis in rats. Nature 269:44)9- 411. Ewing, L. L., J. C. Davis, and B. R. Zirkin. 1980. Regula- tion of testiscular function: A spatial and temporal view. Int. Rev. Physiol. 22:41-115. Ewing, L. L., B. R. Zirkin, and C. Chubb. 1981. Asses~ ment of testicular testosterone production and L~ydig cell structure. Environ. Health Perspect. 38:19-27. Fabre, F., S. Carreau, and M. A. Drosdowsky. 1979. Androgen binding protein (ABP) was demonstrated in testicular and epidid~nal cytosols of adult guinea pig. Ann. Endocrinol. 40:15-16. Fabro, S., and A. R. Scialli. 1986. Drug and Chemical Action in Pregnancy Pharmacologic and Taqacologic Principles. New York: Marcel Dekker. 524 pp. Fain-Maurel, M. A., J. P. Dadoune, and J. F. Reger. 1983. Surface changes in monkey spermatozoa during epididymal maturation and after ejaculation, pp. 15~ 162. In J. Andrd, Ed. The Sperm Cell: Fertilizing Power, Surface Properties, Motility, Nucleus and Acrosome, Evolutiona~yAspeas. The Hague: Nijhoff. Falck, B. 1959. Site of production of oestrogen in rat ovary as studied in micro-transplants. Acta Physiol. Scand. 47(Suppl. 163~:1-101. Faulk, W. P. 1983. Idiopathic spontaneous abortion [editorial]. Am. J. Reprod. Immunol. 3:4~49. Faulk, W. P., and B.-L. Hsi. 1983. Immunobiology of human trophoblast membrane antigens, pp. 535- 570. In Y. W. Loke and A. Whyte, Eds. Biology of Trophoblast. Amsterdam: Elsevier. Faulk, W. P., and E. McCrady. 1983. Role of the ex- traemb~yonic membranes in transplantation analogies of human pregnancy, pp. 215-227. In R. Duncan and M. Weston Smith, Eds. The En~yclopedia of Ignor- ance, Vol. 3. Oxford: Perzamon Press. c' Faulk, W. P., and J. A. McIntyre. 1981. Trophoblast survival. Transplantation 32:1-5. Faulk, W. P., and J. A. McIntyre. 1983. Immunological studies of human trophoblast: Markers, subsets and functions. Immunol. Rev. 75:139-175. Faulk, W. P., and J. A. McIntyre. 1986. Role of anti- ~IXL antibody in human pregnangy, pp. 106 114. In D. A. Clark and B. A. Croy, Eds. Reproductive Im- munology. Proceedings of the 3rd International Con- gress of Reproduct~ve Immunology held in Toronto, Canada, 1-5 July 1986. Amsterdam: Elsevier Sci- ence. Faulk, W. P., M. Jeannet, W. D. Creighton, and A. Car-

REFERENCES bonara. 1974. Immunological studies of human pla- centa Chala~erization of immuna~obul~s on tropho- blastic basement membranes. J. Clin. Invest. 54:1011- 1019. Faulk, W. P., A. Temple, R. E. Lovins, and N. Smith. 1978. Antigens of human trophoblast: A working hypothesis for their role in normal and abnormal pregnancies. Proc. Natl. Acad. Sci. USA 75:1947- 1951. FauIk, W. P., C. Yeager, J. A. McIntyre, and M. Ueda. 1979. Oncofetalantigensof human trophoblast. Proc. R. Soc. Lond. (B) 206:163-182. Faulk, W. P., J. A. McIntyre, and B. L. B. Hsi. 1980. Transplantation analogies of the materno-fetal relation- ship in human pregnancy, pp. 143-150. In J. L. Tou- raine, J. Traeger, H. BetueL J. Brochier, J. M. Duber- nard, J. P. Revillard, and R. Triau, Eds. Transplanta- tion and Clinical Immunology, Vol. ll. Amsterdam: Excerpta Medical Faulk, W. P., B. L. Hsi, J. A. McIntyre, C. J. G. Yeh, and A. Mucchielli. 1982. Antigens of human extra- emb~onic membranes. J. Reprod. Fertil. (Suppl. 31):181-199. Faulk, W. P., C. B. Coulam, and J. A. McIntyre. 1987. Reproductive Immunology: Biomarkers of compro- mised pregnancies. Environ. Health Perspect. 74:119- 127. Faulk, W. P., D. S. Torry, and J. A. McIntyre. 1988a. Effects of serum versus plasma agglutination of an- tibody-coated indicator cells by human rheumatoid factors. Clin. Immunol. Immunopathol.46:169-176. Faulk, W. P., B. L. Hsi, C. J. G. Yeh, J. A. McIntyre, and P. J. Stevens. 1988b. Epidermolysis bullosa letalis: An immunogenetic disease of extraembryonic ecto- derm? Am. J. Obstet. Gynecol. 158:15~157. Fawcett, D. W. 1975. Ultrastructure and function of the Sertoli cell, pp. 21-55. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physiology, Section 7: Endocrinology. Volume V. Male Reproductive System. Washington, D.C.: American Physiological Society. Fawcett, D. W., and R. D. Hollenberg. 1963. Changes in the acrosome of guinea pig spermatozoa during passage through the epididymis. Z. Zellforsch. Mik- rosk. 60:276-292. Fawcett, D. W., and D. M. Phillips. 1969. Observations on the release of spermatozoa and on changes in the head during passage through the epidigylT is. J. Re- prod. Fertil. (Suppl. 6~:405418. Fechter, L. D. 1974. Central serotonin involvement in the elaboration of the startle reaction in rats. Pharmacol. Biochem. Behav. 2:161-172. Federation CECOS (Federation des Centres d'Etude et de Conse~vation de Sperme Humain), D. Schwar~, and M. J. Mayaux. 1982. Female fecundity as a function of age. Results of artificial insemination in 2193 nulliparous women with azoospermic husbands. N. Engl. J. Med. 306:404406. Felicio, L. S., J. F. Nelson, and C. E. Finch. 1986. Pro- 333 longation and cessation of estrous cycles in aging C57BL/6J mice are differentially regulated events. Biol. Reprod. 34:849-858. Fenech, M., end A.A. Morley. 1986. Cytokinesi~block micronucleus method in human lymphocytes: Effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161:193-198. Ferguson-Smith, M. A. 1983. Prenatal chromosome analysis and its impact on the birth incidence of chro- mosome disorders. Br. Med. Bull. 39:355-364. Ferrari C., and P. G. Crosignani.1986. Medical treatment of hypaprolactinemic disorders. Hum. Reprod.1:507- 514. Feuers, R. J., and J. B. Bishop. 1986. The response of kinetic parameters from selected enymes to variant loci in congenic mice and implications for in vivo biochemical mutation tests, pp.37~382 In C. RameL B. Lambert, and J. Magnusson, Eds. Genetic Toxicol- ogy of Environmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis. Proceedings of the Fourth International Conference on Em~ironmental Mutagens held in Stockholm, Sweden, June 24 28, 1985. New York: Liss. Fiddes, J. C., and H. M. Goodman. 1981. The gene encoding the common alpha subunit of the four human glycoprotein hormones. J. Mol. Appl. Genet. 1:3- 18. Finch, C. E. 1976. The regulation of physiological changes dunng mammalian aging. Q. Rev. Biol.51:49- 83. Finch, C. E. 1980. The relationships of aging changes in the basal gang ia to manifestations of Huntington's chorea. Ann. Neurol. 7:406 411. Finch, C. E. 1981. Neural and endocrine mechanisms in aging: A synopsis, pp.537-557. In R. T. Schmike, Ed. Biological Mechanisms in Aging. NIH Publ. No. 81-2194. Washington, D.C.: U.S. National In- stitutes of Health. Finch, C. E., and R. G. Gosden. 1986. Animal models for the human menopause, pp.3-34. In L. Mastroianni, Jr., and C. A. Paulsen, Eds. Aging, Reproduction, and the Climacteric. New York: Plenum Press. Finch, C. E., L. S. Felicio, C. V. Mobbs, and J. F. Nelson. 1984. Ovarian and steroidal influences on neuroendo- crine aging processes in female rodents. Endrocnnol. Rev. 5:467~97. Fink, E., W. B. Schill, F. Fiedler, F. Krassnig~ R. Geiger, and K Shimamoto. 1985. Tissue kall~rein of human seminal plasma is secreted by the prostate gland. Biol. Chem. Hoppe Seyler 366:917-924. Firestone, P., and A. N. Prabhu. 1983. Minor physical anomalies and obstetrical complications: Their rela- tionship to hyperactive, psychoneurotic and normal children and their families. J. Abnorm. Child Psychol. 11:207-216. Fischer, S. G., and L. S. Lerman. 1983. DNA fragments differing ty single base pair substitutions are separated in denatunng gradient gels: Correspondence with melting theo~y. Proc. Natl. Acad. Sci. USA 80:1579-

334 1583. Fishel, S. B. 1979. Analysis of mouse uterine proteins at pro-oestrus during early pregnancy and after ad- ministration of exogenous steroids. J. Reprod. Fertil. 55:91-100. Flickinger, C. J. 1972. Alterations in the fine structure of the rat epididymis after vasectomy. Anat. Rec. 173:277-299. Flickinger, C. J. 1982. The fate of sperm after vasectomy in the hamster. Anat. Rec. 202:231-239. Foote, R. H. 1969. Research techniques to study repro- ductive physiology in the male, pp.81-110. In Tech- niques and Procedures in Animal Science Research. Albany, N.Y.: American Society of Animal Science. Forest, M. G., and J. Bertrand. 1972. Studies of the protein binding of dihydrotestosterone (17-beta-hy- droxy-5 alpha-androstan-3 one) in human plasma in different physiological conditions and effect of medrox- yprogesterone (17-hydroxy-6 alpha-methyl-4 pregnene- 3,20 dione 17-acetate). Steroids 19:197-214. Fournier-Delpech, S., G. Colas, M. Courot, R. Ortavant, and G. Brice. 1979. Epididymal sperm maturation in the ram: Motility, fertilizing ability and embryonic survival after uterine artificial insemination in the ewe. Ann. Biol. Anim. Biochim. Biophys. 19:597- 605. Fournier-Delpech, S., G. Colas, and M. Courot. 1981. The first cleavage of tubal sheep eggs after fertilization with epididymal or ejaculated spermatozoa. C.R. Acad. Sci. III 292:515-517. (In French) Fowle, J. R., III. 1984. Workshop Proceedings: Ap- proaches to Improving the Assessment of Human Genetic Risk—Human Biomonitoring. Report No. EPA 600/9~016. Washington, D.C.: Office of Health and Environmental Assessment, U.S. Environ- mental Protection Agency. 40 pp. Fowler, R. E., R. G. Edwards, D. E. Walters. S. T. H. Chan, and P. R. Steptoe. 1978. Steroidogenesis in preovulatory follicles of patients given human meno- pausal and chorionic gonadotropins as judged by the radioimmuneassay of steroids in follicular fluid. J. Endocrinol. 77:161-169. Fox, D. A., and A. Wright. 1982. Evidence that low level developmental lead exposure produces toxic amblyopia. Soc. Neurosci. Abs. 8:81. Fox, D. A., J. P. Lewkowski, and G. P. Cooper. 1977. Acute and chronic effects of neonatal lead exposure on development of the visual evoked responses in rats. Toxicol. Appl. Pharmacol. 40:449 461. Fox, D. A., J. P. Lewkowski, and G. P. Cooper. 1979. Persistent visual cortex excitability alterations produced by neonatal lead exposure. Neurobehav. Toxicol. 1:101-106. Franchimont, P., U. Gaspard, A. Reuter, and G. Heynen. 1972. Polymorphism of protein end polypeptide hor- mones. Clin. Endocrinol. (Oxford) 1:315-336. Frankel, A. I., and K B. Eik-Nes. 1970. The metabolism of steroids in the rabbit epididymis. Endocnnology 87:644652. REFERENCES Franks, P. A., N. K. Laughlin, D. J. Dierschke, R. E. Bowman, and P. A. Meller. 1986. Effects of lead on luteal function in rhesus monkeys. Biol. Reprod. 34(Suppl. 1~:186. Fredricsson, B. 1979. Morphologic evaluation of sper- matozoa in different laboratories. Andrologia 11:57- 61. Freeman, J. M., Ed. 1985. Prenatal and Perinatal Factors Associated with Brain Disorders. NIH Pub.85-1149. [Bethesda, Md.~: U.S. Department of Health and Human Services, National Institutes of Health. Freemark M., and S. Handwerger. 1982. Ovine placental lactogen stimulates amino acid transport in rat dia- phragm. Endocnnology 110:2201-2203. Frenkel, G. P., R. Kaplan, G. Yedwab, Z. T. Homonnai, and P. F. Kraicer. 1978. The effect of caffeine on rat epididymal spermatozoa: Motility, metabolism and fertilizing capacity. Int. J. Androl. 1:145-152. Freund, M. 1966. Standards for the rating of human sperm morphology. A cooperative study. Int. J. Fertil. 11:97-180. Freund, M. 1968. Semen analysis, pp. 593~27. In S. J. Behrman and R. W. Kistner, Eds. Progress in Infertility. Boston: Little, Brown and Company. Friberg, L. 1983. Quality control in laboratories testing for environmental pollution, pp.811-829. In T. W. Clarkson, G. F. Nordberg, and P. R. Sager, Eds. Reproductive and Developmental Toxicity of Metals. New York: Plenum Press. Fricker, H. S., and S. Segal. 1978. Narcotic addiction, pregnan~r, and the newborn. Am. J. Dis. Child 132:36~366. Fned, P. A. 1980. Marihuana use by pregnant women: Neurobehavioral effects in neonates. Drug Alcohol Depend. 6:415424. Friedman S. J., and P. Skehan. 1979. Morpholog~cal differentiation of human choriocarcinoma cells induced by methotrexate. Cancer Res. 39: 196~1967. Friend, D. S., and N. B. Gilula. 1972. Variations in tight and gap junctions in mammalian tissues. J. Cell Biol. 53:75~776. Fnes, H., S. J. Nillius, and F. Pettersson. 1974. Epidemi- ology of seconda~y amenorrhea. II. A retrospective evaluation of etiology with special regard to psycho- genic factors and weight loss. Am. J. Obstet. Gynecol. 118:473479. Fnesen, H. G. 1966. Lactation induced by human placental lactogen and cortisone acetate in rabbits. Endocrinology 79:212-215. Frigas, E., and G. J. Gleich. 1986. I~e eoesinophil and the pathophysiology of asthma. J. Allergy Clin. Im- munol. 77:527-537. Frisch, R. E. 1980. Pubertal adipose tissue: Is it nece~ sary for normal sexual maturation? Evidence from the rat and human female. Fed. Proc. 39:2395-2400. Frisch, R. E. 1985. Fatness, menarche, and female fertility. Perspect. Biol. Med. 28:611~3. Frommer, D. J. 1~4. Chan~ng aged of the menopause. Br. Med. J. 54()5:349-351.

REFERENCES Frost,J. K. 1974. Gynecologic and obstetric cytopathol- ogy, pp. 634 728. In E. R. Novak and J. D. Woodruff, Eds. Novak's Gynecologic and Obstetric Pathology, 7th ed. Philadephia: W. B. Saunders. Fuccillo, D. A. 1985. Application of the Avidin-Biotin Technique in microbiology. Biotechniques 3:494- 501. Fujii, T., H. N~an~ S. Morimoto, and N. Hard 1987. Pharmacological assessment of the functional effects of maternal exposure to drugs: Transmission of the effects to the offspring of subsequent generations, pp. 159-174. In T. Fujii and P. M. Adams, Eds. FunctionalTeratogenesis: Functional Effects on the Offspring After Parental Drug Exposure. Tokyo: Teikyo University Press. Fujimoto, H., R. P. Erickson, M. Quinto, and M. P. Rosenberg. 1984. Post-meiotic transcription in mouse testes defected with spermatid cDNA clones. Biosci. Rep. 4:1037-1044. Fujino, T., K. Gottlieb, D. K. Manchester, S. S. Park, D. West, H. L. Gurtoo, R. E. Tarone, and H. V. Gelboin. 1984. Monoclonal antibody phenotyping of interindividual differences in cytochrome P-45 dependent reactions of We and twin human plan Cancer Res. 44:3916-3923. Fujita, S., M. Horii, T. Tanimura, and H. Nishimura. 1964. H3-~midine autoradiographic studies on cyan kinetic responses to x-ray irradiation and to thio- TEPA in the neural tube of mouse embryos. Anat. Rec. 149:3748. Fune~Cravioto, F., C. Zapata-Gayon, B. Kolmodin- Hedman, B. Lambert, J. Lindsten, E. Norberg, M. Nordenskjold, R. Olin, and A. Swesson. 1977. auk Radons and ~ster~natid exd~ange in workers in chemical laboratories and a rotoprinting factory and in children of women laboratory workers. Lancet 2:322-325. Gabel, C. A., E. M. Eddy, and B. M. Shapiro. 1979. After fusion, sperm surface components remain as a patch in sea urchin and mouse embryos. Cell 18:207-215. Gagnon, C., R. J. Sherins, D. M. Phillips, and C. W. Bardin. 198Z Deficiency ofprotein~ylmethylase in immotile spermatozoa of infertile men. N. Engl. J. Med. 306:821~25. Gagnon, C., D. HaIbour, E. De I~irande, C. W. Bardin, and J.-L. Dacheux. 1984. Sensitive assay detects protein methylesterase in spermatozoa: Decrease in enzyme activity during epididymal maturation. Biol. Reprod. 30:953-958. Gagnon, C., E. de Lamirande, and R. J. Sherins. 1986. Positive correlation between the level of protein- ~ Ease in spermatozoa and sperm motility. Fertil. Steril. 45:847~53. Galen, R. S., and S. R. Gambino. 1975. Beyond Nor- mality The Predictive Value end efficiency of Medical Diagnoses. New York: John Wiley & Sons. 237 PP. Gallager, D. W., J. H. Kehne, E. A. Wakeman, and M. 335 Davis. 1983. Development changesin pharmacological responsivity of the acoustic startle reflex: Effects of picrotoxin. Psychopharmacology 79:87-93. Ganjam, V. K., and R. P. Amann. 1976. Steroids in fluids and sperm entering and leaving the bovine epididymis, epididymidal tissue, and accessory sex Hand secretions. Endocrinology 99:1618-1630. Gardiner, M. R., and M. E. Narin. 1969. Studies on the effect of cobalt and selenium in clover disease of ewes. Aust. Vet. J. 45:215-222. Gastel, B., J. E. Haddow, J. C. Fletcher, and A. Neale, Eds. 1980. Maternal Serum Alpha-Fetoprotein: Issues in the Prenatal Screening and Diagnosis of NeuralTube Defects. Rockville,Md.: U.S. Public Health Service, Of fice of Health Research, Statistics, and Technology. 201 pp. Gaunt, S. J. 1983. Spreading of a sperm surface antigen within the plasma membrane of the egg after fertiliza- tion in the rat. J. Emb~yol. Exp. Morphol. 75:259- 270. Gay, V. L., and N. W. Dever. 1971. Effects of testoster- one propionate and estradiol benzoate—alone or in combination—on serum LH and FSH in orchidec- tomized rats. Endocrinology 89:161-168. Generoso, W. M., K. T. Cain, M. Krishna, and S. W. Huff. 1979. Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg. Proc. Natl. Acad. Sci. USA 76:435-437. Generoso, W. M., J. C. Rutledge, K. T. Cain, L. A. Hughes, and P. W. Braden. 1987. Exposure of female mice to ethylene Ride within hours after mating leads to fetal malformation and death. Mutat. Res. 176:269- 274. Gerencer, M., A. Drazancic, I. Kuvacic, Z. Tomaskovic, end A. Kastelan. 1979. HtA antigen studies in women with recurrent gestational disorders. Fertil. Steril. 31:401-404. Gibaldi, M., and D. Perrier. 1982. Pharmacokinetics, 2nd ed. New York: Marcel Dekker. 494 pp. Gill, T. G., ad. 1983. Immunogenetics of spontaneous abortions in humans. Transplantation 35:1~. Gillbc~ C. 1977. FloppyInfant Syndrome and maternal diazepam [letter]. Lancet 2:244. Ginsburg, K. A., K. S. Mothissi, and E. L. Abel. 1988. Computer-assisted human semen analysis. Sampling errors and reproducibility. J. Androl. 9:82-90. Gizang-G~ E., and D. J. Wolgemuth. 1985. Local- ization of mRNAs in mouse testes by in situ hybridiza- tion: Distribution of c'-tubulin and developmental stage specificity of pro-opiomelanocortin transcripts. Dev. Biol. 111:293-305. Glasser, S. R. 1972. The uterine environment in implan- tation and decidualization, pp. 776~33. In H. A. Balin and S. R. Glasser, Eds. Reproductive Biology. Ams- terdam: Excerpta Medical Glasser, S. R 1975. A molecular bioassay for progester- one and related compounds, pp. 45~465. In B. W. O~Ialley and J. Hardman, Eds. Methods in Enymol- ogy, Vol. 36. Hormone Action, Part A, Steroid Hor-

336 manes. New York: Academic Press. Glasser, S. R. 1985. Laboratory models of implantation, pp.219-238. In R. L. Dixon, Ed. Reproduct*eToxi- cology. New York: Raven Press. Glasser, S. R. 1986. Current concepts of implantation and decidualization, pp. 127-154. In G. Huszar, Ed. The Physiology and Biochemistry of the Uterus in Pregnancy and Labor. Boca Raton, Fla.: CRC Press. Glasser, S. R., and J. H. Clark. 1975. A determinant role for progesterone in the development of uterine sensitivity to decidualizaton and ovo-implantation, pp.311-345. In C. L. Markert end d. Papaconstantinou, Eds. The Developmental Biology of Reproduction. New York: Academic Press. Glasser, S. R., and J. A. Julian. 1986. Intermediate filament of the midgestation rat trophoblast giant cell. Dev. Biol. 113:356-363. Glasser, S. R., and J. A. Julian. In press. UCLA Sym- posium on Early Emb~yogenesis and Paracnne Signals. New York: Liss. Glasser, S. R., and S. A. McCormack. 1979. Estrogen- modulated uterine gene transcription in relation to decidualization. Endocrinology 104: 1112-1121. Glasser, S. R., and S. A. McCormack. 1980. Functional development of rat trophoblast and decidual cells during establishment of the hemochorial placenta. Adv. Biosci. 25:165-197. Glasser, S. R., and S. A. McCormack. 1981. Separated cell types as analytical tools in the study of decidualiza- tion and implantation, pp. 217-239. In S. R. Glasser and D. W. Bullock, Eds. Cellular and Molecular Aspects of Implantation. New York: Plenum Press. Glasser, S. R., and S. A. McCormack. 1982. Cellular and molecular aspects of decidualization and implanta- tion, pp. 245-310. In H. M. Beier and P. Karlson, Eds. Proteins and Steroids in Early Pregnancy. New York: Springer-Verlag. Glasser, S. R., J. A. Julian, M. I. Munir, and M. J. Soares. 1987a. Biological markers during early pregnancy: Trophoblastic signals of the pert-implantation period. Environ. Health Perspect. 74:129-147. Glasser, S. R., S. Lampelo, M. I. Munir, and J. Julian. 1987b. Expression of desmin, laminin and fibronectin during in situ differentiation (decidualization) of rat uterine stromal cells. Differentiation 35:132-142. Glasser, S. R., J. A. Julian, G. L. Decker, J.-Y. Tang, and D. D. Carson. 19~. Development of morpholog- ical and functional polarity in primary cultures of immaturae rat uterine epithelial cells. J. Cell Biol. 107:2409-2423. Gleich, G. J., E. Frigas, D. A. Loegering, D. L. Wassom, and D. Steinmuller. 1979. Cytotoxic properties of the eopsinophil major basic protein. J. Immunol. 123:2925-2927. Glover, T. D. 1969. Some aspects of function in the epidigymis. Experimental occlusion of the epidi~ymis in the rabbit. Int. J. Fertil. 14:215-221. Glover, T. D. 1982. The epididymis, pp. 544-555. In G. D. Chisholm and D. I. Williams, Eds. Scientific REFERENCES Foundations of Urology, 2nd ed. London: Heinemann Medical Books Ltd. Gloyna, R. E., and J. D. Wilson. 1969. A comparative study of the conversion of testo$erone to 17beta- hydrmy-Salpha-androstan-3-one (dibydrotestosterone) l~prostate and epididyrnis. J. Clin. Endocnnol. Metab. 29:97~977. Gold, B., H. Fujimoto, J. M. Kramer, R. P. Erickson, and N. B. Hecht. 1983. Haploid accumulation and translational control of phosphoglycerate kinasm2 messenger RNA during mouse sp~natogenesis. Dev. Bio. 98:392-399. Goldberg, E. 1977. Iso~mes in testes and spermatozoa, pp. 79-124. In M. C. Rattazi, J. C. Scandalios, and G. S. Whitt, Eds. Iso~mes. Current Topics in Biolog- ical and Medical Research, Vol. 1. New York: Liss. Goldberg, E., D. Sberna, T. E. Wheat, G. J. Urbanski, end E.Margoliash. 1977. Cytochrome c: Immuno- fluorescent localization of the testis-specific form. Science 196:101~1012. Golditch, I. M. 1972. Post contraceptive amenorrhea. Obstet. Gynecol. 39:903-908. Goldman, R., R. Woodcock, and M. Fristoe. 1970. Test of Auditory Discrimination. Circle Pines, Minn.: American Guidance Service Corporation. Gonder, J. C., R. A. Proctor, and J. A. Will. 1985. Genetic differences in oxygen toxicity are correlated with cytochrome P-450 induability. Proc. Natl. Acad. Sci. USA 82:6315-6319. Gonzalez Echeverria, F., P. S. Cuasnicu, A. Piazza, L. Pineiro, and J. A. Blaquier. 1984. Addition of an androgen-free epididymal protein extract increases the abilibr of ~nah~ ham~er spennatozoa to fertilize in vivo and in vitro. J. Reprod. Fertil. 71:433~37. Goodman, A. L., and G. D. Hodgen. 1977. Systemic versus intraovarian progesterone replacement after luteectomyin rhesus monkeys: Differential patterns of gonadotropins and follicle growth. J. Clin. En- docrinol. Metab. 45:837-840. Goodman, A. L., W. E. NLxon, D. K. Johnson, and G. D. Hodgen. 1977. Regulation of folliculogenesis in the pycling rhesus monkey Selection of the dominant follicle. Endocrinology 100:155-161. Gordon, D. L., D. J. Moore, T. Thorslund, and C. A. Paulsen. 1965. The determination of size and con- centration of human sperm with an electronic particle counter. J. Lab. Clin. Med. 65:506 512. Gordon, D. L., J. E. Herrigel, D. J. Moore, and C. A. Paulsen. 1967. Efficacy of Couler Counter in deter- mining low sperm concentrations. Am. J. Clin. Pathol. 47:22~228. Gorer, P. A., Z. B. Mikulska, and P. O'Gorman. 1959. The time of appearance of isoantibodies during the homograft res~nse to mouse tumours Immunology 2:211-218, Gorski, R. A. 1968. Influence of age on the response to paranatal adrninimation of a low dose of androgen. Endocrinolog;y 82:1001-1004.

REFERENCES Goriki, R. A. 1971. Gonadal hormones and the perinatal development of neuroendocrine function, pp. 237- 290. In L. Martini and W. F. Ganong, Eds. Frontiers in Neuroendocrinology, 1971. New York: Oxford University Press. Gosden, R. G. 1985. The Biology of Menopause: The Causes and Consequences of Ovarian Aging. Orlando, Fla.: Academic Press. 188 pp. Gosden, R. G., S. C. Laing, L. S. Felicio, J. F. Nelson, and C. E. Finch. 1983. Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J mice. Biol. Reprod. 28:255-260. Goulieb, K A., and D. K Manchester. 1986. Twin study methodology and variability in xenobiotic placental metabolism. Teratogenesis Carcinog. Mutagen. 6:253- 263. Gougeon, A. 1982. Rate of follicular growth in the human ovary, pp. 155-163. In R. Rolland, E. V. Van Hall, S. G. Hillier, K P. McNatty, and J. Schoemaker, Eds. FollicularMaturation and Ovulation: Proceed- ings of the IVth Reinier de Graaf Symposium, Nij- megen, Aug. 2~22, 1981. International Congress Series, 560. Amsterdam: Excerpta Medical Gravanis, A., J. R. Zorn, G. Tanguy, C. Nessmann, L. Cedard, and P. Robel. 1984. The "dysharmonic luteal phase" syndrome: Endometrial progesterone receptor and estradiol dehydrogenase. Fertil. Steril. 42:73 736. Green, B. B., J. R. Daling, N. S. Weiss, J. M. Liff, and T. Koepsell. 1986. Exercise as a risk factor for infer- tility with ovulato~y dysfunction. Am. J. Public Health 76:1432-1436. Green, J. E., A. Dorfmann, S. Jones, S. Bender, L. Patton, and J. D. Schulman. 1988. Chorionic villus sampling Experience with an initial 940 cases. Obstet. Gynecol. 71:208-212. Greenberg, J., and W.-G. Forssmann. 1983. Studies of the guinea pig epidi~ymis. II. Intercellular junctions of principal cells. Anat. Embryol. 168:195-209. Griffin, J. E., III, and J. D. Wilson. 1987. Disorders of the testis, pp. 1907-1818. In Harrison's Principles of Internal Medicine, 11th ed. New York: McGraw Hill. Grinnell, F., J. R. Head, and J. Hoffpauir. 1982. Fibro- nectin and cell shape invivo: studies on the endometri- um during pregnancy. J. Cell Biol. 94:597 606. Griswold, M. D. 1988. Protein secretion of sertoli cells. Int. Rev. Cytol. 110:133-1S6. Groll-Knoff, E., M. Haider, H. Hoeller, H. Jenkner, and H. G. Stidl. 1978. Neurm and psychophysiological effects of moderate carbon monoxide exposure, pp. 424~430. In D. A. Otto, Ed. Multidisciplinary Per~ fives in Event Related Brain Potential Research. EPA600/9-77~43. Washington, D.C.: U.S. Er~ron- mental Protection Agency. Grollman, S. 1967. The Human Body. Its Structure and Physiology. New York: Macmillan. 543 pp. Grumbach, M. M., J. C. Roth, S. L. Kaplan, and R. P. 337 Kelch. 1974. Hypothalamic-pituitary regulation of puber~ in man: Evidence and concepts derived from clinical research, pp. 11~166. In M. M. Grumbach, G. D. Grave, and F. E. Mayer, Eds. Control of the Onset of Puberty. New York: John Wiley & Sons. Guerrero, R., T. Aso, P. F. Brenner, Z. Cekan, B. M. Landgren, K. Hagenfeldt, and B. Diczfalusy. 1976. Studies in the pattern of circulating steroids in the normal menstrual cycle. I. Simultaneous assays of progesterone, pregnenolone, dehydroepiandrosterone, testosterone, dihydrotestosterone, androstenedione, oestradiol and oestrone. Acta Endocrinol. 81:133- 149. Guesdon, J. L., C. Jouanne, and S. Avrameas. 1983. Use of antibody conjugates in enz~ne and erythro- irnmuneassay, pp. 197-205. In S. Avrameas, P. Druet, R. Masseyeff, and G. Feldmann, Eds. Irnmunoen- ymatic Techniques. Proceedings of the Second Inter- national Symposium on hnmunoen~maticTechniques held in Cannes, France, 1~18 March 1983. Amster- dam: Elsevier. Guillebaud, J., I. S. Fraser, G. D. Thorburn, and G. Jenken. 1977. Endocrine effects of danazol in men- struating women. J. Int. Med. Res. 5(Suppl. 3~:57- 66. Gunsalus, G. L., N. A. Musto, and C. W. Bardin. 1980 Bidirectional release of a Sertoli cell product, androgen binding protein, into the blood and seminiferous tubule, pp. 291-297. In A. Steinberger and E. Stein- berger, Eds. Testicular Development, Structure, and Function. New York: Raven Press. Gupta, C., and S. J. Yaffe. 1981. Reproductive dysfunc~ tion in female offspring after prenatal exposure to phenobarbital: Critical period of action. Pediatr. Res. 15:1488 1491. Gu~ta, R. C., M. V. Reddy, and K. Randerath. 1982. P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts. Carcinogenesis 3:1081- 1092. Gurney, M. E., B. R Apatoff, G. T. Spear, M. J. Baumel, J. P. Antel, M. B. Bania, and A. T. Reder. 1986a. Neuroleukin: A lymphokine product of lectin-stimu- lated T cells. Science 234:57~581. Gurney, M. E., S. P. Heinnch, M. R. Lee, and H. S. Yin. 1986b. Moleallar cloning and e~pression of neuroleu- kin, a neurotrophic factor for ~pinal and senso~y neur- ons Science 234:566 574. Gurtoo, H., C. J. Williams, K. Gottlieb, A. I. Mulhern, L. Caballes, J. B. Vaught, A. J. Marinello, and S. K. Bansal. 1983. Population distribution of placental benzo~a)F'rrene metabolism in smokers. Int. J. Cancer 31:29-37. Gusella, J. F., R. E. Tanzi, M. A. Anderson, W. Hobbs, K. Gibbons, R. Raschtchian, T. C. Gilliam, M. R. Wallace, N. S. Wexler, and P. M. Conneally. 1984. DNA markers for newous system diseases. Science 225:1320 1326. Guyda, H. J., and H. G. Friesen. 1973. Serum prolactin levels in humans from birth to adult life. Pediatr.

338 Res. 7:534 540. Haas, G. G., Jr., D. B. Cines, end A. D. Schreiber. 1980. Immunologic infertility Identification of patients with antisperm antibody. N. Engl. J. Med. 303:72 727. Haddock, L., G. Lebron, R. Martinex, J. F. Cordero, L. W. Freni-Titulaer, F. Carrion, C. Cintron, and L. Gonzalez. 1985. Premature sexual development in Puerto Rico: Background and current status, pp. 358-379. In J. A. McLachlan, Ed. Estrogens in the Environment II: Influences on Development. New York: Elsevier. Hafez, E. S. E., and M. R. N. Prasad. 1976. Functional aspects of the epidi~mis, pp. 3143. In E. S. E. Hafez, Ed. Human Semen and Fertility Regulation in Men. St. Louis: C. V. Mosby. Hahn, J., R. H. Foote, and E. T. Cranch. 1969. Tonome- ter for measuring testicular consistency of bulls to predict semen quality. J. Anim. Sci. 29:483~89. . Hales, B. F., C. Hachey, and B. Robaire. 1980. The presence and longitudinal distribution of the glutathi- one S-transferases in rat epididymis and vas deferens. Biochem. J. 189:135-142. Hales, B. F., S. Smith, and B. Robaire. 1986. Cyclophos- phamide in the seminal fluid of treated males: Trans- mission to females by mating and effect on pregnancy outcome. Toxicol. Appl. Pharmacol. 84:423-430. Hall, J. L. 1981. Relationship between semen quality and human sperm penetration of zone-free hamster ova. Fertil. Steril. 35:457463. Halperin, D. S., and P. C. Sizonenko. 1983. Prepubertal gynecomastia following topical inunction of estrogen- containing ointment. Helv. Paediatr. Acta 38:361- 366. Halpern, B. N., T. Ky, and B. Robert. 1967. Clinical and immunological study of an exceptional case of reaginic type sensitization to human seminal fluid. Immunology 12:247-258. Halvorson, C. F., Jr., and J. B. Victor. 1976. Minor physical anomalies end problem behaviorin elementa~y school children. Child Dev. 47:281-285. Hamilton, D. W. 1972. The mammalian epidi~ is, pp. 268 337. In H. Balin and S. Glasser, Eds. Repro- ductive Biology. Amsterdam: Excerpta Medical Hamilton, D. W. 1975. Structure and function of the epithelium lining the ductuli efferentes, ductus epididy- midis, and ductus deferens in the rat, pp. 259-301. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physiology, Section 7: Endocrinology. Volume V. Male Reproductive System. Washington, D.C.: American Physiological Society. Hamilton, D. W. 1981. Evidence for alpha-lactalbumin- ldce activity in reproductive tract fluids of the male rat. Biol. Reprod. 25:385-392. Hamilton, D. W., and D. W. Fawcett. 1970. In vitro synthesis of cholesterol and testosterone from acetate by rat epididymis and vas deferens. Proc. Soc. Exp. Biol. Med. 133:693-695. Handelsman, D. J., and S. Staraj. 1985. Testicular size: REFE:RENCES The effects of aging, malnutrition and illness. J. Androl. 6:144 151. Handley, S. L., and K V. Thomas. 1979. Potentiation of startle response by d- and 1-amphetamine: The possible involvement of pre- and postsynaptic alpha- adrenoreceptors and other transmitter systems in the modulation of a tactile startle response. Psychophar- macology 64:105-111. Hanew, K, A. Sasaki, S. Sato, M. Goh, and K Ym}~ 1987. Growth hormone inhibitory and stimulatory action of L-dopa in patientswith acromegaly. J. Clin. Endocrinol. Metab. 64:255-260. Haney, A. F., W. S. Maxon, and D. W. Schombe~ 1986. Compartmental ovarian steroidogenesis in polycystic ovary syndrome. Obstet. Gynecol. 68:63~644. Hansen, P. J., F. W. Bazer, and R. M. Roberts. 1985. Appearance of B-hexosanunidase and other Iysosomal- ldce en~mes in the uterine lumen of gilts, ewes and mares in response to progesterone and oestrogens. J. Reprod. Fertil. 73:411-424. Hanson, J. W., H. J. Hoffman, and G. T. Ross. 1975. Monthly gonadotropin cycles in premenarcheal girls. Science 190:161-163. Hanson, J. W., N. C. Myrianthopoulos, M. A. Harvey, and D. W. Smith. 1976. Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. J. Pediatr. 89:662 668. Hansson, V., and O. Djoseland. 1972. Prelirnina~ chara~ terization of the 5`x-dihydrotestosterone binding protein in the epididymal cytosol fraction. In vivo studies. Acta Endocrinol. 71:61~624. Hansson, V., E. M. Ritzin, F. S. French, and S. N. Nay- feh. 1975. Androgen han~ort and receptor mechan- isms in testis and epididymis, pp. 173-201. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physio- logy, Section7: Endocrinology. Volume V. Male Reproductive System. Washington,D.C.: American Physiological Society. Harada,M. 1978. CongenitalMinamata disease: In- trauterine methylmercwy poisoning. Teratology 18:285-288. Harada, Y. 1976. Intrauterine poisoning. Clinical and epidemiolo~cal studies and ~ifi~ce of the p~blen~ Bull. Inst. Constit. Med., Kumamoto Univ. (Suppl. 25~:1 60. Harada, Y. 1977. Congenital minamata disease, pp. 209-239. In T. Tsubaki and K. Ir~kayama, Eds. Minamata Disease: Methylmercu~y Poisoning in Minamata and Niigata Japan. Tolyo: Kodansha. Hargreave, T. B., and R. A. Elton. 1983. Is conventiona1 sperm analysis of any use? Br. J. Urol. 55:775-779. Hargreave, T. B., and S. Nilson. 1983. Seminology, pp. 56 74. In T. B. Hargreave, Ed. Male Inferdlit~r. New York: Springer-Verlag. Harrington, J. M., G. F. Stein, R. O. Rivera, and A. V. de Morales. 1978. The occupational hazards of for- mulating oral contraceptives: A survey of plant em- ployees. Arch. Environ. Health 33:12-15.

REFERENCES Harris, H., D. A. Hopkinson, and E. B. Robson. 1974. The incidence of rare alleles determine electrophore- tic variants: Data on 43 enzyme loci in man. Ann. Hum. Genet. 37:237-253. Harry, G. J., J. F. Goodrum, M. R. Krigman, and P. Morell. 1985. The use of synapsin I as a biochemical marker for neuronal damage by trimethyltin. Brain Res. 326:9-18. Hassold, T. J. 1985. The origin of aneuploidy in humans, pp. 103-115. In V. Dellarco, P. Voytek, and A. Hol- laender, Eds. Aneuploidy Etiology and mechanisms. New York: Plenum. Hatcher, N. H., and E. B. Hook. 1981a Somatic chromo- some breakage in low birth weight newborns. Mutat. Res. 83:291-299. Hatcher, N. H., and E. B. Hook. 1981b. Sister chromatic exchange in newborns. Hum. Genet. 59:389-391. Hatzalds, A., A. Kokkevi, K Katsouyanni, K Maravelias, J. F. Salaminios, A. Kalandidi, and A. Koutselinis. 1987. Psychometric intelligence and attentional perfor- mance deficits in lead-exposed children, pp. 204 209. In S. E. Lindberg and T. C. Hutchinson, Eds. Heavy Metals in the Environment, Vol.1. New Orleans/Edinburgh: CEP Consultants. Healy, D. L., G. P. Chrousos, H. M. Schulte, R. F. Wil- liams, P. W. Gold, E. E. Baulieu, and G. D. Hodgen. 1983. Pituita~y and adrenal responses to the anti- progesterone and anti-glucocorticoid steroid RU 486 in primates. J. Clin. Endocrinol. Metab. 57:863- 865. Heap, R. B., A. P. F. Flint, and J. E. Gadsby. 1981. Emb~yonic signals and maternal reco~ition, pp. 311- 326. In S. R. Glasser and D. W. Bullock Eds. Cellular and Molecular Aspects of Implantation. New York: Plenum Press. Hecht, N. B. 1987a. Gene expression dunng spermato- genesis, pp. 9~101. In M. C. Orgebin-Crist and B. J. Danzo, Ed. Cell Biology of the Testis and Epididy- mis. Annals of the New York Academy of Sciences, Vol.513. New York New York Academy of Sciences. Hecht, N. B. 1987b. Detming the effects of t~ic agents on spermatogenesis using DNA probes. Environ. Health Perspect. 74:31-40. Hecht, N. B. 1987c. Regulation of gene expression during mammalianspermatogenesis,pp.151-193. In J. Ros- sant and R. Peders=, Eds. E~perimental Approaches to Mammalian Embryonic Development. New York: Cambridge University Press. Hecht, N. B. In press. Mamma~ protamines and their expression, pp. 347-373. In G. Stein, J. Stein, and L. Hnilica, Eds. Histones and Other Basic Nuclear Proteins. Boca Raton, Fla.: CRC Press. Hecht, N. B., K C. Kleene, R. J. Distel, and L. M. Silver. 1984. The differential expression of the actins and tubulins during spermatogenesis in the mouse. Exp. Cell Res. 153:275-280. Hecht, N. B., K C. Kleene, P. C. Yelick, P. A. Johnson, D. D. Pravtcheva, and F. H. Ruddle. 1986a Mapping of haploid expressed genes: Genes for both mouse 339 protamines are located on chromosome 16. Somatic Cell Mol. Genet. 12:203-208. Hecht, N. B., P. A. Bower, S. H. Waters, P. C. Yelick, and R. J. DisteL 1986b. Evidence for haploid expre~ sion of mouse testicular genes. Exp. Cell Res. 164:183-190. Heinnchs, W. L., R. J. Gellert, J. L. Bakke, and N. L. Lawrence. 1971. DDT admini~ered to neonatal rats induces persistent estrus syndrome. Science 173:642- 643. Heller, C. G., and Y. Clermont. 1964. Kinetics of the germinal epithelium in man. Rec. Prog. Horm. Res. 20:545-575. Hemeida, N. A., W. O. Sack, and K. McEntee. 1978. Ductuli efferentes in the epididymis of boar, goat, ram, bull, and stallion. Am. J. Vet. Res. 39:1892- 1900. Henneberry, M., M. F. Carter, and H. L. Neiman. 1979. Estimation of prostatic size by suprapubic ultrasonog- raphy. J. Urol. 121:615~16. Hennig, B. 1975. Change of cytochrome c structure during development of the mouse. Eur. J. Biochem. 55:167-183. Henry, J. P. 1980. Present concept of stress theory, p. 557-571. In E. Usdin, R. Kvetnansly, and I. J. Kopin, Eds. Catecholamines and Stress: Recent Advances. Developments in Neuroscience, Vol. 8. New York: Elsevier-North Holland. Henzl, M. R. 1986. Contracept~ve hormones and their clinical use, pp. 643 682. In S. S. C. Yen and R. B. Jaffe, Eds. Reproductnre Endocrinologg Physiology, Pathophysiology and Clinical Management. 2nd ed. Philadelphia: W. B. Saunders Company. Herbst, A. L., and H. A. Bern. 1981. Developmental Effects of Diethylstilbestrol (DES) in Pregnancy. New York: Thieme-Stratton. 203 pp. Herb$, A. L., S. J. Robboy, R. E. ScuLl~r, and D. C. Poskanzer. 1974. Clear-cell adenocarcinoma of the vagina and cerv~ in girls: Anal~rsis of 170 registry cases. Am. J. Obstet. Gynecol. 119:713-724. Herbst, A. L., M. M. Hubby, R. R. Blouglt, and F. Azizi. 1980. A comparison of pregnancy ay~aience in DE~ exposed and DES-unexposed daughters. J. Reprod. Med. 24:62-69. Hernberg, S. 1972. Biological effects of low lead doses, pp.617-629. InInternationalSymposium: Environ- mental Health Aspects of Lead Luxembourg Com- mission of the European Communities, Directorate General for Dissemination of Knowledge, Center for Information and Documentation. Hernberg,S. 1980. Biochemicaland clinical effects end responses as indicated by blood concentration, pp. 367-399. In R. L. Singhal and J. A. Thomas, Eds. Lead Toxicity. Baltimore: Urban&Schwa~zenberg. Hertig, A. T., and J. Rock. 1945. Two human ova of the pre-villous stage having developmental age of about seven and nine days reppectively. Contnb. Em~yrol. 31:65 84. HiLks, S. P. 1953. Developmental malformations pro-

340 duced Or radiation. A timetable of their development. Am. J. Roentgenol. 69:272-293. Hicks, S. P. 1959. Radiation as an experimental tool in mammalian developmental neurology. Physiol. Rev. 38:337-356. Hicks, S. P., and C. J. D'Amato. 1963. Low dose radia- tion of the developing brain. Science 141:903-905. Hicks, S. P., and C. J. D'Amato. 1966. Effects of ionizing radiations on mammalian development, pp. 195-250. In D. H. M. Woollam, Ed. Advances in Teratology, Vol. 1. London: Logos Press. Hicks, S. P., C. J. D'Amato, M. A. Coy, E. D. O'Brien, J. M. Thurston, and D. L. Joftes. 1961. Migrating cells in the developing nervous system studied by their radiosensitivity and tritiated thymidine uptake, pp. 2`K261. In Fundamental Aspens of Radiosensitivity. Brookhaven Symposia in Biology, No. 14. Upton, N.Y.: Brookhaven National Laboratory. Hicks, S. P., C. J. D'Amato and J. L. Falk. 1962. Some effects of radiation on structural and behavioral devel- opment. Int. J. Neurol. 3:535-548. Hilf, G., and W. E. Merz. 1985. Influence of cyclic nucleotides on receptor birding, immunological activity and microheterogeneity of human choriogonadotropin synthesized in placental tissue culture. Mol. Cell En- docrinol. 39:151-159. Hill, R. M., W. M. Verniaud, M. G. Horning, L. B. Mc- Culley, end N. F. Morgan. 1974. Infants exposed in utero to antiepileptic drugs. Prospective study. Am. J. Disab. Child 127:645~53. Hinton, B. T. 1980. The epididymal microenvironment: A site of attack for a male contraceptive? Invest. Urol. 18:1-10. Hinton, B. T. 1985. The blood-epididymis barrier, pp. 371-382. In T. J. Lobl and E. S. E. Hafez, Eds. Male Fertility and Its Regulation. Boston: MTP Press. Hinton, B. T., and S. S. Howards. 1982. Micropuncture and microperfusion techniques for the study of tes- ticular physiology. Ann. N.Y. Acad. Sci. 383:29-43. Hinton, B. T., and D. A. Keefer. 1985. Binding of [3H] aldosterone to a single population of ceils within the rat epididymis. J. Steroid Biochem. 23:231-233. Hinton, B. T., and B. P. Setchell. 1980a. Concentrations of glycerophosphocholine, phosphocholine and free inorganic phosphate in the luminal fluid of the rat testis and epididymis. J. Reprod. Fertil. 58:401~06. Hinton, B. T., and B. P. Setchell. 1980b. Concentration and uptake of carnitine in the rat epididymis A micro- puncture study, pp. 237-249. In R. A. Frankel and J. D. McGarry, Eds. Carnitine Biosynthesis, Metabol- ism, and Functions. New York: Academic Press. Hinton, B. T., R. W. White, and B. P. Setchell. 1980. Concentrations of myo-inositol in the luminal fluid of the mammalian testis and epididymis. J. Reprod. Fertil. 58:395-399. Hinton, B. T., D. E. Brooks, H. M. Dott, and B. P. Set- chell. 1981. Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymis. J. Reprod. Fertil. 61:59-64. REFERENCES Hirsch, P. J., I. L. C. Fergusson, and R. J. B. King. 1977. Protein composition of human endometrium and its secretions at different stages of the menstrual cycle. Ann. N.Y. Acad. Sci. 286:233-248. Hoar, R. M., and I. W. Monie. 1981. Comparative development of specific organ systems, pp. 13-33. In C. A. Kimmel and J. Buelke-Sam, Eds. Develop- mental Toxicology. New York: Raven Press. Hobbins, J. C., P. A. Grannum, R. Romero, E. A. Reece, and M. J. Mahoney. 1985. Percutaneous umbilical blood sampling. Am. J. Obstet. Gynecol. 152: 1~. Hodgson, B. J., and C. J. Pauerstein. 1976. Comparison of oviductal transport of fertilized and unfertilized ova after hCG or coitus-induced ovulation in rabbits. Biol. Reprod. 14:377-380. Hoffer, A. P., and D. W. Hamilton. 1974. Phagocytosis of sperm by the epithelial cells in ductuli efferentes of experimental rats. Anat. Rec. 178:376-377. Hoffer, A. P., and B. T. Hinton. 1984. Morphological evidence for a blood epididymis barrier and the effects of gospel on its integrity. Biol. Reprod. 30:991- 1004. Hoffer, A. P., D. W. Hamilton, and D. W. FawceK. 1973. The ultrastructural pathology of the rat epididymis after administration of alpha-chlorhydrin (U-5897~. I. Effects of a single high dose. Anat. Rec. 175:203- 229. Hoffer, A. P., D. W. Hampton, and D. W. FawceK. 1975. Phago~rtosis of spermatozoa by the epithelial cells of the ductuli efferentes after epididymal obstruction in the rat. J. Reprod. Fertil. 44:1-9. Hoffer, B., L. Olson, H. Bjorklund, A. Henschen, and M. Palmer. 1984. Some toxic effects of lead and other metals in the nervous system: In oculo experi- mental models, pp. 141-152. In T. Narahashi, Ed. Cellular and Molecular Neurotoxicology. New York: Raven Press. Hoffer, B. J., L. Olson, and M. R. Palmer. 1987. Toxic effects of lead in the developing nervous system. In oculo experimental models. Environ. Health Perspect. 74:169-175. Hoffman, H. S. 1984. Methodological factors in the behavioral analysis of startle: the use of reflex modiDca- tion procedures and the assessment of threshold, pp. 267-285. In R. C. Eaton, Ed. NeuralMechanisms of Startle Behavior. New York: Plenum Press. Hoffman, R. E., P. A. Stehr-Green, K. B. Webb, R. G. Evans, A. P. Knutsen, W. F. Schramm, J. L. Staake, B. B. Gibson, and K. K. Steinberg. 1986. Health effects of long-term exposure to 2,3,7,~tetrachlorodi- benzo-p-dioxin. J. Am. Med. Assoc. 255:2031-2038. Holinka, C. F., Y. C. Tseng, and C. E. Finch. 1979. Reproductive aging in C57BL/6J mice: Plasma progeny terone, viable embryos and resorption frequency during pregnancy. Biol. Reprod. 20:1201-1211. Holson, R. R., J. Adams, J. Buelke-Sam, B. Gough, and C. A. Kimmel. 1985. d-Amphetamine as a behavioral teratogen: Effects depend on dose, sex, age, and task. Neurobehav. Toxicol. Teratol. 7:753-758.

REFERENCES Holstein, A. F. 1978. Spermatophagy in the seminiferous tubules and excurrent ducts of the testis in Rhesus monkey and in man. Andrologia 10:331-352. Homonnai, Z. T., G. Paz, J. N. Weiss, and M. P. David. 1980a. Quality of semen obtained from 627 fertile men. Int. J. Androl. 3:217-228. Homonnai Z. T., G. F. Paz, J. N. Weiss, and M. P. David. 1980b. Relation between semen quality and fate of pregnancy: Retrospective study on 534 pregnancies. Int. J. Androl. 3:574-584. Hook, E. B. 1981. Prevalence of chromosome abnor- malities during human gestation and implications for studies of environmental mutagens. Lancet 2:169- 172. Hopper, B. R., and S. S. C. Yen. 1975. Circulating con- cen~ations of delydroep~ndrosterone and dehydro~ androsterone sulfate curing puberty. J. Clin. Endocrin- ol. Metab. 40:45~461. Home, C. H., and A. D. Nisbet. 1979. Pregnancy pro- teins: A review. Invest. Cell. Pathol. 2:217-231. Horning, S. J., R. T. Hoppe, H. S. Kaplan, and S. A. Rosenbert. 1981. Female reproductive potential after treatment for Hod~kin's disease. N. Engl. J. Med. 304:1377-1382. Hoshina, M., R. Hussa, R. Pattillo, H. M. Camel, and I. Boime.1982. The role of trophoblast differentiation in the control of the hCG and hPL genes. Adv. Exp. Med. Biol. 176:290-312. Hoshina, M., M. Boothby, R. Hussa, R. Pattillo, H. M. Camel, and I. Boime. 1985. Linkage of human chori- onic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis. Placenta 6:163-172. Hoskins, D. D., and E. R. Casillas. 1975. Function of cyclic nucleotides in mammalian spermatozoa, pp. 453-460. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physiology, Section 7: Endocrinology. Volume V. Male Reproductive System. Washing :on, D.C.: American Physiological Society. Hoskins, D. D., H. Brandt, and S. Acott. 1978. Initiation of sperm motility in the mammalian epididymis. Fed. Proc. 37:2534-2542. Hotchkiss, R. S., E. K. Brunner, and P. Grenley. 1938. Semen analyses of 200 fertile men. Am. J. Med. Sci. 196:362-384. Houck, P. R., C. F. Reynolds, 3d., U. Kopp, and I. Hanin. 1988. Red blood cell/plasma choline ratio in elderly depressed and demented patients. Psychiat~y Res.(Ire- land) 24:109-116. Hougie, C. 1985. Circulating anticoagulants. Recent Adv. Blood Coag. 4:63. Howards, S. S. 1983. The epididymis, sperm maturation, and capacitatiorl, pp.121-134. In L. I. Lipshultz and S. S. Howards, Eds. Infertility in the Male. New York: Churchill Livingstone. Howards, S. S., S. J. Jessee, and A. L. Johnson. 1976. Micropuncture studies of the b~ tubule barrier. Biol. Reprod. 14:264-269. Hsi, B.-L., C.-J. G. Yeh, and W. P. Faulk. 1982. Human 341 amniochorion: Tissue-speciB~c markers, transferrin receptors and histocompatibility antigens. Placenta 3:1-11. Hsi, B.-L., C.-J. G. Yeh, and W. P. Faulk. 1984a. Class I antigens of the major histocompatibility complex on cytotrophoblast of human chorion laeve. hnmunol- ogy 52:621-629. HSi B.-L., C.-J. G. Yeh, and W. P. Faulk. 1984b. Chara~ terization of antibodies to antigens of the human amnion. Placenta 5:513-521. Hsu, A. F., and P. Troen. 1978. An androgen-binding protein in the testicular cytosol of human testis: Com- parison with human testosterone estrogen binding globulin. J. Clin. Invest. 61:1611-1619. Hsu, T. C., F. Elder, and S. Pathak. 1979. Method for improving the yield of spermatogonial and meiotic metaphases in mammalian testicular preparations. Environ. Mutatgen. 1:291-294. Hsueh, A. J. W., and J. M. Schaeffer. 1985. Gonadotro- pin-releasing hormone as a paracrine hormone and neurotransmitter in extra-pituitary sites. J. Steroid Biochem. 23:757-764. Hudec, T., J. Thean, D. Kuehl, and R. C. Dougherty. 1981. Tris~dichloropropyl~phosphate, a mutagenic flame retardant: Frequent cocurrence in human seminal plasma. Science 211~4485~:951-952. Hughes, J. A., and S. B. Sparber. 1979. d-Amphetamine unma~ postnatal oonsequences of mposure to me~ mercu~y in utero: Methods for studying behavioral teratogenesis. Pharmacol. Biochem. Behav. 8:365- 375. Huhtanemi, I. T., C. C. Korenbrot, and R. B. Jaffe. 1977. HCG binding and ~imulation of testosterone biosyn- thesis in the human fetal testis. J. Clin. Endocrinol. Metab. 44:963-967. Hulten, M. N. Saadallah, B. M. N. Wallace, and D. J. Cockburn. 1985. Meiotic investigations of aneuploidy in the human, pp. 75-90. In V. L. Dellarco, P. E. Voytek, andA. Hollaender, Eds. Aneuploidy: Etiol- ogy and Mechanisms. New York: Plenum. Hunter, J., M. A. Urbanowi=, W. Yule, and R. I~nsdown. 1985. Automated testing of reaction time and its association with lead in children. Int. Arch. Occup. Environ. Health 57:27-34. Huret, J. L. 1986. Nuclear chromatin decondensation of human sperm: A review. Arch. Androl. 16:97- 109. Hurley, T. W., C. M. Kuhn, S. M. Schanberg, and S. Handwerger. 1980. Differential effects of placental lactogen, growth hormone and prolactin on rat liver ornithine decarbo~ylase activity in the perinatal period. Life Sci. 27:2269-2275. Hutchings, D. E. 1983. Behavioral teratology: A new frontier in neurobehavioral research, pp. 207-235. In E. M. Johnson and D. M. Kochar, Eds. Teratogene- sis and Reproductive Toxicology. Handbook of Ex- perimental Pharmacology, Vol. 65. Berlin: Springer- Verlag. IARC (International Agenc~r for Research on Cancer).

342 1984. Monitoring Human Exposure to Carcinogenic and Mutagenic Agents. IARC Scientific Publications, No. 59. Lyon: International Agency for Research on Cancer. 457 pp. Ilgren, E. B. 1983. Control of trophoblastic growth. Placenta 4:307-328. Inano, H., A. Machino, and B.-I. Tamaoki. 1969. In vitro metabolism of steroid hormones by cell-free homogenates of epididyTnides of adult rats. Endocrin- ology 84:997-1003. Inskeep, P. B., and R. H. Hammerstedt. 1982. Changes in metabolism of ram sperm associated with epididymal transit or induced by exogenous carnitine. Biol. Re- prod. 27:735-743. Invin, M., N. Nicholson, J. T. Haywood, and G. R. Pour- ier. 1983. Immunoflourescent localization of a murine seminal vesicle proteinase inhibitor. Biol. Reprod. 28:1201-1206. Isaacs, W. B., and D. S. Coffey. 1984. The predominant protein of canine seminal plasma is an enzyme. J. Biol. Chem. 259:1152~11526. Isaacs, W. B., and J. H. Shaper. 1983. Isolation and characterization of the major androgen-dependent glycoprotein of canine prostatic fluid. J. Biol. Chem. 258:6610~615. Isaacs, W. B., and J. H. Shaper. 1985. Immunological localization and quantitation of the androgen-depen- dent secretory protease of the canine prostate. En- docrinology 117:1512-1520. Ismail, A. A. A., P. Astley, W. A. Burr, K. Wakelin, and M. J. Wheeler. 1986. The role of testosterone meas- urement in the investigation of androgen disorders. Ann. Clin. Biochem. 23:113-134. Ison, J. R. 1984. Reflex modification as an objective test for sensory processing following toxicant e~posure. Neurobehav. Toxicol. Teratol. 6:437445. Israel, R., D. R. Mishell, Jr., S. C. Stone, I. H. Thorney- croft, and D. L. Moyer. 1972. Single lutealphase serum progesterone assay as an indicator of ovulation. Am. J. Obstet. Gynecol. 112:1043-1046. Iversen, P., L. Kjaer, C. Thomsen, and O. Henriksen. 1988. Magnetic resonance imaging of the prostate. Scand. J. Urol. Nephrol. Suppl. 107:14-18. Iwata, K. 1980. Neuroophthalmologic indices of Mina- mata Disease in Nigata, pp.165-185. In W. H. Meri- gan and B. Weiss, Eds. Neurotoxicity of the Visual System. New York: Raven Press. Jaakkola, U. M. 1983. Regional variations in transport of the luminal contents of the rat epididymis in vivo. J. Reprod. Fertil. 68:465470. Jaakkola, U. M., and A. Talo. 1981. Effects of oxytocin and vasopressin on electrical and mechanical activity of the rat epididyrnis in vi=. J. Reprod. Fertil. 63:47- 51. Jaakkola, U. M., and A. Talo. 1983. Movements of the luminal contents in two different regions of the caput epididymidis of the rat in vitro. J. Physiol. 336:453- 463. Jackson, L. 1985. Prenatal genetic diagnosis by chorionic REFERENCES villus sampling (CVS). Semin. Perinatol.9:209-218. Jacob, M. P., T. Fulop, Jr., G. Foris, and L. Robert. 1987. Effect of elastin peptides on ion fluxes in mono- nuclear cells, f~broblasts, and smooth muscle cells. Proc. Natl. Acad. Sci. USA 84:995-999. Jacobs, H. S., U. A. Knuth, M. G. R Hull, and S. Franks. l9T7. Post-"pill" amenorrhea: Cause or coincidence? Br. Med. J. 2:94~942. Jacobson, J. L., S. W. Jacobson, G. G. Fein, P. M. Sc}~, and J. K Dowler. 1984. Prenatal exposure to an environmental toxin: A test of the multiple effects model. Develop. Psychol. 20:523-532. Jacobson, M. A. 1978. Developmental Neurobiology, 2nd ed. New York: Plenum Press. Jacobson, S. W., G. G. Fein, J. L. Jacobson, P. M. Schwartz, and J. K. Dowler. 1985. The effect of intrauterine PCB exposure on visual reco~tion mem- ory. Child Devel. 56:853 860. Jaffe, R. B. 1986. Protein hormones of the placenta, decidua, and fetal membranes, pp. 758-769. In S. S. C. Yen and R. B. Jaffe, Eds. Reproductive En- docrinology: Physiology, Pathophysiology, and Clinical Management, 2nd ed. Philadelphia: W. B. Saunders Co. Jagiello, G., and S. J. Lin. 1974. Oral contraceptive compounds and mammalian oocyte meiosis. Am. J. Obstet. Gynecol. 120:390406. Jagiello, G., M. Ducayen, J-S. Fang, and J. Graffeo. 1975. Cytogenetic obsenrations in mammalian oopytes. Chromosomes Today 5:43~3, Jaiswal, A. K., F. J. Gonzalez, and D. W. Nebert. 1985a. Human dimon-inducible cytochrome P~450: Compli- mentary DNA and amino acid sequence. Science 228:8~82. Jaiswal,A. K., F. J. Gonzalez, and D. W. Nebert. 1985b. Human P-450 gene se~ence and mrrelabon of n~ with genetic differences in benzotaipyrene metabolism. Nucleic Acid Res. 13:4503-4520. Jeannet, M., P. Bischof, B. Bourrit, and P. Vuagnat. 1985. Sharing of HLA antigens in fertile, subfertile and infertile couples. Transplant Proc. 17:903. Jenderny, J., and G. Rohrborn. 1987. Chromosome analysis of human sperm. I. First results with a modified method. Hum. Genet. 76:385-388. Jenkins, A. D., C. P. Lechene, and S. S. Howards. 1980. Concentrations of seven elements in the intraluminal fluids of the rat seminiferous tubules, rete testis, and epididymis. Biol. Reprod. 23:981-987. Jenkins, A. D., C. P. Lechene, and S. S. Howards. 1983. The effect of spironolactone on the elemental composi- tion of the intraluminal fluids of the seminiferous tubules, rete testis and epididymis of the rat. J. Urol. 129:851~54. Jensen, J. C., and W. G. Thilly. 1986. Spontaneous and induced chromosomal aberrations and gene mutations in human imphoblast~; Miorrycin C, m~r- ea, and ethylnitrosourea. Mutat. Res. 160:95-102. Jensen, R. H., W. L. Bigbee, and R. G. Langlois. 1987. In vivo somatic mutations in the glycophorin A locus

REFERENCES of human erythroid cells, pp. 149-159. In M. M. Moore, D. M. Demarini, and K. R. Tindall, Eds. Banbury Report 28: Mammalian Cell Mutagenesis. Cold Spring Harbor, N.Y.: Cold Spring Harbor Labor- atory Press. Jequier,A. M. 1986. Infertilityin the Male. Edinburgh: Churchill Livingston. 154 pp. Jeyendran, R. S., H. H. Van der yen, M. Perez-Pelaez, B. G. Crabo, and L. J. D. Zaneveld. 1984. Develop- ment of an assay to assess the functional integrity of the human sperm membrane and its relationship to other semen characteristics. J. Reprod. Fertil. 70:219-228. Jick, H., end d. Porter. 1977. Relation between smoking and age of natural menopause. Lancet 1:1354-1355. Johnson, A., and L. Godmilaw. 1988. Genetic amniocen- tenesis at 14 weeks or less. Clin. Obstet. Gynceol. 31:345-352. Johnson, A. L., and S. S. Howards. 1976. Intratubular hydrostatic pressure in testis and epididyniis before and after long-term vasectomy in the guinea pig. Biol. Reprod. 14:371-376. Johnson, I. R., E. M. Symonds, D. M. Kean, B. S. Wor- thington, F. Broughton Pipkin, R. C. Hawkes, and M. Gyngell. 1984. Imaging the pregnant human uteruswith nuclear magnetic resonance. Am. J. Ob- stet. Gynecol. 148:1136-1139. Johnson, L. 1982. A re evaluation of daily sperm output of men. Fertil. Steril. 37:811-816. Johnson, L. 1986. A new approach to quantification of Sertoli cells that avoids problems associated with the irregular nuclear surface. Anat. Rec. 214:231- 237. Johnson, L., C. S. Petty, and W. B. Neaves. 1980a. The relationship of biopsy evaluations and testicular mea~ urements to over-all daily sperm production in human testes. Fertil. Steril. 34:36~0. Johnson, L., R. P. Amann, and B. W. Pickett. 1980b. Maturation of equine epididymal spermatozoa. Am. J. Vet. Res. 41:119~1196. Johnson, L., R. S. Zane, C. S. Petty, and W. B. Neaves. 1984a. Quantif~cation of the human Sertoli cell popula- tion: Its distribution, relation to germ cell numbers, and age-related decline. Biol. Reprod.31:785-795. Johnson, L., C. S. Petty, and W. B. Neaves. 1984b. Influence of age on sperm production and testicular weights in men. J. Reprod. Fertil. 70:211-218. Johnson, M. H., and J. Rossant. 1981. Molecular studies on cells of trophectodermal lineage of the postimplan- tation mouse embryo. J. Embryol. Exp. Morphol. 61:103-116. Johnson, M. H., H. P. M. Pratt, and A. H. Handyside. 1981. The generation and recognition of positional information in the preimplantation mouse embryo, pp. 55-74. In S. R. Glasser and D. W. Bullock, Eds. Cellular and Molecular Aspe~s of Implantation. New York: Plenum Press. Jones, E. C., and P. L. Krohn. 1961. The relationships between age, numbers of oopytes and fertility in virgin 343 and multiparous mice. J. Endocnnol. 21:469 495. Jones, G. S., S. Aksel, and A. C. Wentz. 1974. Serum progesterone values in the luteal phase def~c E!ffect of chorionic gonadotropin. Obstet. Gynecol. 44:26- 34 . Jones, K L., and G. F. Chetnoff. 1984. Effects of chemi- cal and environmental agents, pp. 189-200. In R. K Creasy and R Resnik, Eds. Matetnal Fetal Medicine: Principles and Practice. Philadelphia W. B. Saunders Jones, K L., D. W. Smith, C. N. Ulleland, and A. P. Strassguth. 1973. PaKern of malfonr~on in offspring of chronic alcoholic mothers. Lancet 1:1267-1271. Jones, L. S., and W. E. Berndtson.1986. A quantitat~ve study of Sertoli cell and germ cell populations as related to sexual development and ag ng in the stallion. Biol. Reprod. 35:13~148. Jones, R. C. R Br~m, K I. Von Glos, end M. G. Parker. 1980. Hormonal regulation of protein synthesis in the rat epididyrnis. Characterization of androgen- dependent and testicular fluid-dependent proteins. Biochem. J. 188:667-676. Jones, R., C. Pholpramool, B. P. Setchell, and C. R. Brown. 1981. Labellingof membrane glycoproteins on rat spermatozoa collected from different regions of the epidic~rnis. Biochem. J. 200:457460. Jones, R., K. I. von Glos, and C. R. Brown. 1983. Changes in the protein oomposition of rat spermatozoa dunng maturation in the epidi~mis. J. Reprod. Fertil. 67:299-306. Joseph, A. M., J. R. Gosden, end A. C. Chandley. 1984. Estimation of aneuploidy levels in human spermatozoa using chromosome specific probes andin situ }~bndisa- tion. Hum. Genet. 66:23~238. Joshi, S. G. 1983. A progestagen-associated protein of the human endome~ium Basic studies and poten- tial clinical applications. J. Steroid Biochem.19:751- 757. Josimovich, J. B. 1983. Placental lactogen and pituitary prolactin, pp. 144 160. In F. Fuchs and A. Klopper, Eds. Endocrinology of Pregnancy, 3rd ed. Philadel- phia: Harper & Row. Juchau, M. R. 1980. Drug transformation in the placenta. Pharmacol. Ther. 8:501-524. Kajino, T., J. A. McIntyre, W. P. Faulk, D. S. Cai, and W. D. Billington. 1988. Antibodies to trophoblast in normal pregnant and secondary aborting women. J. Reprod. Immunol. 14:267-282. Kaler, L. W., and W. B. Neaves. 1978. Attrition of the human I~ydig cell population with advancing age. Anat. Rec. 192:513-518. Kallen, B. 1965. Degeneration and regeneration in the vertebrate central nervous system during emb~yogene- sis, pp. 77-96. In M. Singer and J. P. Schadd, Eds. Degeneration Patterns in the Nervous System. Prog: ress in Brain Research, Vol. 14. Amsterdam: Elsevier. Kandala, J.C., M. K. Kistler, R. P. Lawther, and W. S. Kistler. 1983. Characterization of a genomic clone rat seminal vesicle secreto~y protein IV. Nucleic Acids Res. 11:3169-3186.

344 Kandel, R. E., and J. H. Schwartz. 1981. Principles of Neural Science. New York: Elsevier North-Holland. Kaplan, M., L. D. Russelt R. N. Peterson, and J. Martan. 1984. Boar sperm cytoplasmic droplets: Their ultra- structure, their numbers in the epididymis and at ejaculation and their removal during isolation of sperm plasma membranes. Tissue Cell 16:455 468. Kaplan, S., and M. Grumbach. 1981. Chorionic somatom- motropin in primates: Secretion and physiology, pp. 127-139. In M. J. Novy and J. A. Resko, Eds. Fetal Endocrinology. New York: Academic Press. Kapp, R. W., Jr., and C. B. Jacobson. 1980. Analysis of human spermatozoa for Y chromosomal nondisQun~ tion. TeratogenesisCarcinog.Mutagen.1:193-211. Kapp, R. W., Jr., D. J. Picciano, and C. B. Jacobson. 1979. Y-chromosomal nondisjunction in dibromochlor- opropane-exposedworkmen. Mutat.Res.64:47-51. Kapp, W. W., Jr. 1979. Detection of aneuploidy in human sperm. Environ. Health Perspect. 31:27-31. Karkun, T., M. Rajalakshmi, and M. R. N. Prasad. 1974. Maintenance of the epidic ymis in the castrated golden hamster by testosterone and dihydrotestosterone. Contraception 9:471485. Karp, W. B., A. F. Robertson, and H. C. Davis. 1984. Relationship of unbound bilirubin concentration to reserve albumin-binding concentration for bilirubin in human neonatal plasma. Biol. Neonate 46:105- 109. Karp, W. B., S. B. Subramanyam, C. K. Ho, and A. F. Robertson. 1985. Drugs affecting bilirubin uptake by human erythrocyte ghosts. Am. J. Med. Sci. 289:236-239. Karr, J. P., R. Y. Kirdani, G. P. Murphy, and A. A. Sandberg. 1974. Effects of testosterone and estradiol on ventral prostate and body weights of castrated rats. Life Sci. 15:501-513. Kashimoto, T., H. Miyata, S. Kunita, T.-C. Tung, S.- T. Hsu, K.-J. Chang, G. Ohi, J. Nakagawa, and S.- I. Yamamoto. 1981. Role of potrchlorinated diben- zofuran in Yusho (PCB poisoning). Arch. Environ. Health 36:321-326. Kasson, B. G., E. Y. Adashi, and A. J. W. Hsueh. 1986. Arginine vasopressin in the testis: An intra-gonadal peptide control system. Endocrine Rev. 7:1~168. Katayama, K. P., and M. R. Roesler. 1986. 500 cases of amniocentensis without Uoody tap. Obstet. Gyne- col. 68:70-73. Katz, D. F., end d. W. Overstreet. 1981. Sperm motility assessment byvideomicrography. Fertil. SteriL 35:188- 193. Katz, D. F., J. W. Overstreet, and F. W. Hanson. 1980. A new quantitative test for sperm penetration into cervical mucus. Fertil. Steril. 33:179-186. Katz, D. F., J. W. Overstreet, and F. W. Hanson. 1981. Variations within and amongst normal men of move- ment chractenstics of ~ninal spaTnat~oa J. Reprod Fertil. 62:221-2~. Katz, D. F., L. Diel, and J. W. Overstreet. 1982. Dif- ferences in the movement of morphologicallynormal REFERENCES and abnormal human seminal spermatozoa. Biol. Reprod. 26:566 570. Kaufman, D. W., D. Slone, L. Rosenberg, O. S. Mieit- tinen, and S. Shapiro. 1980. Cigarette smoking and age at natural menopause. Am. J. Public Health 70:42~422. Kaufmann, S. L. 1966. An autoradiographic study of the generation cycle in the ten~ay mouse neural tube. Exp. Cell Res. 42:67-73. Kaul, B., G. Slavin, and B. Davidow. 1983. Free eryth- ropyte protoporphyrin and zinc protoporp}yrin mea~ urements compared as prima~y screening methods for detection of lead poisoning. Clin. Chem. 29:1467- 1470. Kavlock, R. J., and C. T. Grabowski, Eds. 1983. Abnor- mal Functional Development of the Heart, Lungs, and Kidneys: Approaches to FunctionalTeratology. New York: Liss. Kawamoto J. C., S. R. Overmann, D. E. Woolley, and V. K. VijayJan. 1984. Morphometnc effects of pre- weaning lead e~posure on the hippommpal formation of adult rats. NeuroToxicology 5:125-148. Kawata, M., J. R. Parnes, and L. A. He~zenberg. 1984. Transcriptional control of HIA-A,B,C, antigens in human placental ~totrophoblast isolated using tropho- blast- and HLA-specific monoclonal antibodies and the fluorescenc~activated cell sorter. J. Exp. Med. 160:633~51. Kay, H. H., and D. R. Mattison. 1986. Nuclear magnetic resonance spec trosoopy and ilT—ng in perinatal medi- cine, pp. 269-323. In P. W. Nathaniels~, Ed. Animal Models in Fetal Medicine ~. Parturition. Mono- graphs in Fetal Physiology, Vol. 6. Ithaca: Pennatol- ogy Press. Keegan, K. A., Jr., and R. H. Paul. 1980. Antepartum fetal heart rate testing. IV. ~e nonstress test as a primary approach. Am. J. Obstet. Gynecol. 136:75- 80. Kellermann, G., M. Luyten-Kellermann, and C. R Shawl 1973a Genetic variation of agri hydrocarbon hydrmy- lase in human lympho~rtes. Am. J. Hum. Genet. 25:327-331. Kellermann, G., C. R Sh~v, and hI. byten-Kellamanr~ 1973b. AIY1 hydrocarbon hydraylase induclbilky and bronchogenic carcinoma. N. Engl. J. Med. 289:93 937. Kelly, P. A., R. P. C. Shiu, M. C. Robertson, and H. G. Fnesen. 1975. Characterization of rat chorionic mammotropin. EndoGrinology 96:1187-1195. Kenagy, G. J. 1979. Rapid surgical technique for mea~ urement of testis size in small mamma~ J. ManunaL 60:636 638. Kennedy, A. R., A. H. M. Heagerty, J. P. Ortonne, B. L. H!;i, C. J. G. Yeh, and R ~ J. Ea~y. 1985. Abnor- mal binding of an anti-amnion antl~od`,r to epidermal basement membrane prc~vides a novel di~ostic probe for junctional epidermolysis bullosa Br. J. D=natoL 113:651-659. Kennedy, G. L., Jr. 1986. Biological effects of acetamide,

REFERENCES fonnarnide, and tar monk and ~ derive fives. CRC Cnt. Rev. Toxicol. 17:129-182. Kephart, G. M., G. J. Gleich, D. A. Conner, D. W. Gib- son, and S. Ackerman. 1984. Deposition of eosinophit granule major basic protein onto microfilar- iae of onchocerca volvulus in the skin of patients treated with diethylcarbamazine. Lab. Invest.50:51- 61. Kessler, M. J., M. S. Reddy, R. H. Shah, and O. P. Bahl. 1979. Structures of N-glycosidic carbohydrate units of human chorionic gonadotropin. J. Biol. Chem. 254:79~)1-7908. Kidroni, G., R. Har-Nir, J. Menezel, I. W. Frutkoff, Z. Patti, and M. Ron. 1983. Vitamin D3 metabolites in rat epididymis: High 24, 25-dibydroxy vitamin D3 levels in the cauda region. Biochem. Biophys. Res. Commun. 113:982-989. Kiger, N., G. Chaouat, J. P. Kolb, T. G. Wegmann, and J. L. Guenet. 1985. Immunogenetic studies of spon- taneous abortion in mice. Preimmunization of females with allogeneic cells. J. Immunol.134:2966 2970. Kimbrough, R. D. 1987. Human health effects of poly- chlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs). Annul Rev. Pharmacol. Toxicol. 27:87-111. KimmeL C. A., and J. Buelke Sam, Eds. 1981. Develop- mental Toxicology. New York: Raven Press. Kimmel, C. A, L. D. Grant, G. L. West, C. M. Martinez- Vargas, E. E. McConnell, B. A. Fowler, J. S. Woods, and J. L. Howard. 1978. Multidisciplinary approach to the assessment of development toxicity associated with chronic lead exposure, pp. 396 409. In D. D. Mahlum, M. R. Sikov, P. L. Hackett, and F. D. An- drew, Eds. Developmental Toxicology of Energy- Related Pollutants: Proceedings of the 17th Annual Hanford Biological Symposium at Richland, Wash., Oct.17-19, 1977. DOE Symposium Series47. Wash- ington, D.C.: U.S. Department of Energy,Technical Information Center. E~ M. T. and D. Wild. 1979. Transplacental mutagen- esis: The micronucleus test on fetal mouse blood. Hum. Genet. 51:18~194. King, M. T., D. Wild, E. Gocke, and K. Eckhardt. 1982. ~Bromod~urid~ne tabletswith improved depot effect for analysis in vivo of sister-chromatic exchanges in bone-marrow and spermatogonial cells. Mutat. Res. 97:117-129. Kirton, K. T., C. Desiardins, and H. D. Hafs. 1967. Distnbution of ~perm in male rabbits after various ejaculation frequencies. Anat. Rec. 158:287-292. Klawans, H. L., Jr., G. W. Paulson, S. P. Ringel, and A. Barbeau. 1972. Use of L-dopa in the detection of presymptomatic Huntington's chorea. N. Engl. J. Med. 286:1332-1334. Kleene, K C" R. J. Distel, and N. B. Hecht. 1983. cDNA clones encoding cytoplasmic poly(A) + RNAs which first appear at detectable levels in haploid phases of spermatogenesis in the mouse. Dev. Biol.98:455- 345 464. Kleene, K. C., R. J. Distel, and N. B. Hecht. 1984. Translational regulation and coordinate deadenylation of a protamine mRNA during spermiogenesis in the mouse. Dev. Biol. 105:71-79. Kleene, K. C., R. J. Distel, and N. B. Hecht. 1985. The nucleotide sequence of a cDNA clone en~ding mouse protamine 1. Biochemistry 24:719-722. Klein, N. W., M. A.~Vogler, C. L. Chatot, and L. J. Pierro. 1980. The use of cultured rat embryos to evaluate the teratogenic activity of serum: Cadmium and cyclophosphamide. Teratology 21:199-208. Klein, N. W., J. D. Plenefisch, S. W. Carey, W. T. Fred- rickson, G. P. Sackett, T. M. Burbacher, and R. M. Parker. 1982. Serum from monkeys with histories of fetal wastage causes abnormalities in cultured rat embryos. Science 215:6~69. Kleinberg, D. L. 1980. Lactation and galactorrhea, pp. 70 89. In J. J. Gold end d. B. Josimovich, Eds. Gyne- cologic Endocrinology, 3rd ed. Hagerstown, Md.: Harper & Row. Knobil, E. 1980. The neuroendocrine control of the menstrual cycle. Recent Prog. Horm. Res. 36:53- 88. Knochel, J. Q., T. G. Lee, M. G. Melendez, and S. C. Henderson. 1983. Fetal anomalies involving the thorax and abdomen, pp.61 80. In P. W. Callen, Ed. Ultra- sonographyin Obstetrics and Gynecology. Philadel- phia: W. B. Saunders. Koering, M. J., D. L. Healy, and G. D. Hodgen. 1986. Morphologic repponse of endometnum to a progester- one receptor antagonist, RU486, in monkeys. Fertil. Steril. 45:280 287. Kohama, S., P. C. May, and C. E. Finch. 1986. Oral admir~ation of estradiol induces ag~like reproductive acyclicity in CS7BL/6J mice. Soc. Neurosci. Abstr. 12:1466. Koizumi, A., L. Hasegawa, R. Walford, and T. Imamura. 1986. H-2, Ah, and aging: The immune response and the inducibility of P450 mediated monooxygenase activities, xanthine oxidase, and lipid peroxidation in H-2 congenic mice on C57BL/10, C3H, and A strain backgrounds. Mech. Ageing Dev. 37:119-136. Komlos, L., R. Zamir, H. Joshua, and I. Halbrecht. 1977. Common HIA antigens in couples with repeated abor- tions. Clin. Immunol. Immunopathol. 7:33~335. Koninckx, P. R., W. Heyns, G. Verhoeven, H. Van Baelen, W. D. Lissens, P. De Moor, and I. A. Brosens. 1986. Biochemical characterization of peritoneal fluid in women curing the menstrual cycle. J. Clin. Endoainol. Metab. 51:1239-1244. Konoeda, Y., P. Terasaki, A. Wakisaka, M. S. Park, and M. R. Mickey. 1986. Public determinants of HLA indicated by pregnangy antibodies. Transplantation 41:253-259. Koos, B. J. 1985. Central stimulation of breathing move- ments in fetal iambs byprostaglandin synthetase inhibi- tors. J. Physiol. 362:455-466. Koos, B. J., and L. D. Longo. 1976. Mercu~y toxicity

346 in the pregnant woman, fetus, and newborn infant. Am. J. Obstet. Gynecol. 126:39~9. Kopin, I. J., and S. P. Markey. 1988. Mm toxicity: Implications for research in PaA`inson's disease. Annul Rev. Neurosci. 11:91-96. Kopp, S. J., A. A. Daar, R. C. Prentice, J. P. Tow, and J. M. Feliksik. 1986. 31P NMR studies of the intact perfused rat heart: A novel analytical approach for deterrrun~ functional-metabolic correlates, temporal relationships, and intracellular actions of cardiotoxic chemicals nondestructively in an intact organ model. Toxicol. Appl. Pharmacol. 82:200 210. Koskimies, A. I., and M. Kormano. 1975. Proteins in fluids from different segments of the rat epididymis. J. Reprod. Fertil. 43:345-348. Koulischer, L., and R. Schoysman. 1974. Chromosomes and human infertility. I. Mitotic and meiotic chromo- some studies in 202 consecutive male patients. Clin. Genet. 5:116-126. Kouri, R. E., C. E. McKinney, A. S. Levine, B. K. Ed- wards, E. S. Vesell, D. W. Nebert, and T. L. Mc- Lemore. 1984. Variations in a~yl hydrocarbon hydrox- ylase activities in mitogen-activated human and non- human primate lymphocytes. Toxicol. Pathol.12:44 48. Kovacs, L., M. Sas, B. A. Resch, G. Ugocsai, M. L. Swahn, M. Bygdeman, and P. J. Rowe. 1984. Termination ofveryearlypregnancybyRU486: Anantiprogesta- tional compound. Contraception 29:399~10. Kram, D., G. D. Bynum, G. C. Senula, and E. L. Schneid- er. 1979. In utero sister chromatic exchange analysis for detection of transplacental mutagens. Nature 279:531. Kram, D., G. D. Bynum, G. C. Senula, C. K. Bickings, and E. L. Schneider. 1980. In utero analysis of sister chromatic exchange: Alterations in susceptibility to mutagenic damage as a function of fetal cell type and gestational age. Proc. Natl. Acad. Sci. USA 77:4784- 4787. Kramer, J. M., and R. P. Er~ckson. 1981. Developmental program of PGK-1 and PGK-2 ~sozymes in spermato- genic cells of the mouse: Specific activities and rates of synthesis. Dev. Biol. 15:37~5. Krauer, B., F. Krauer, F. E. Hytten, and E. del Pozo, Eds. 1984. Drugs and Pregnancy: Maternal Drug Handling-FetalDrug Exposure. London: Academi~ Press. 281 pp. Kreiss, K 1985. Studies on populations exposed to poly- chlorinated biphenyls. Environ. Health. Perspect. 60:193-199. Kremer, J. 1965. A simple sperm penetration test. Int. J. Fertil. 10:209-215. Krichevsky, A., E. G. Armstrong, J. Schlatterer, S. Birken, S. Silverberg, J. W. Lustbader, and R. E. Canfield. 1988. Preparation and character~zation of antibodies to the urina~y fragment of the human chononic gonad- otropin beta-subunit. Endocrinology 123:584-593. Kronenberg, M. S., and J. H. Clark. 1985. Changes in keratin expression during estrogen-mediated dif- REFERENCES ferentiation of rat vypnal epithelium. Endocrinology 117:148~1489. Kuchera, L. K. 1974. Postcoital contraception with diethyl-stilbesterol—updated. Contraception 10:47- 54. Kuemmerle, H. P., and K. Brendel, Eds. 1984. Clinical Pharmacologyin Pregnancy. Fundamentals and Ra- tional Pharmacotherapy. New York: Thieme- Stratton. 386 pp. Kuida, C. A., G. D. Braunstein, P. Shintaku, and J. W. Said. 1988. Human chorionic gonadotropin expression in lung, breast, and renal carcinomas. Arch. Path. Lab. Med. 112:282-285. Laehdetie,J., andM. Parvinen. 1981. Meioticmicronu- clei induced by X-rays in early spermatids of the rat. Mutat. Res. 81:103-115. Lambert, G. H., D. A. Schoeller, A. N. Kotake, C. Flores, and D. Hay. 1986. The effect of age, gender, and sexual maturation on the caffeine breath test. Devel. Pharmacol. Ther. 9:375-388. Lancranjan, I., H. I. Popescu, O. Gavanescu, I. Klepsch, and M. Serbanescu. 1975. Reproductive ability of workmen occupationally exposed to lead. Arch. En- viron. Health 30:396~01. Landrigan, P., E. L. Baker, Jr., R. G. Feldman, D. H. Cox, K. V. Eden, W. A. Orenstein, J. A. Mather, A. J. Yankel, and I. H. Von Lindern. 1976. Increased lead absorption with anemia and slowed nen~e condu~ tion in children near a lead smelter. J. Pediatr. 89:9~910. Langlois, R. G., W. L. Bigbee, and R. H. Jensen. 1986. Measurements of the frequency of human e~throoytes with gene expression loss phenotypes at the gIycophorin A locus. Hum. Genet. 74:353-362. I~nglois, R. G., W. L. Bigbee, S. Kyoizumi N. Nakamura, M. A. Bean, M. Akiyama, and R. H. Jensen. 1987. Evidence for increased somatic cell mutations at the glycophorin A loals in atomic bomb sunrivors. Science 236:445 448. Langlois, R. G., W. L. Bigbee, R. H. Jensen, and J. German. 1989. Evidence for increased invivo muta- tion and somatic recombination in Bloom's syndrome. Proc. Natl. Acad. Sci. USA 86:670 674. Langman, J., and C. C. Haden. 1970. Formation and migration of neuroblasts in the spinal cord of the chick emb~yo. J. Comp. Neurol. 138:419~32. Langman, J., and G. W. Welch. 1967. Lxcess vitamin A and development of the cerebral cortex. J. Comp. Neurol. 131:15-26. Langman, J., R. L. Guerrant, and B. G. Freeman. 1966. Behavior of neuro-epithelial cells during closure of the neural tube. J. Comp. Neurol. 127:399~11. I~on, J. W., P. Ballard, J. Tertud, and I. IIwin. 1983. Chronic Parkinsonism in humans due to a product of meperidine-analoa synthesis. Science 219:979- 980. Lasley, B. L., J. K. Hodges, and N. M. Czekala. 1980. Monitoring the female reproductive cycle of great apes and other primate species by oestrogen and LH O ,

REFERENCES in small volumes of urine. J. Reprod. Fertil. 28(Suppl.~:121-129. Latt, S. A., J. Allen, S. E. Bloom, A. Carrano, E. Falke, D. Kram, E. Schneider, R. Schreck, R. Tice, B. Whit- field, and S. Wolff. 1981. Sister-chromatid exchanges: A report of the GENE-TOX program. Mutat. Res. 87:17-62. Lauritsen, J. G., J. Jorgensen, and F. Kissmeyer-Nielsen. 1976. Significance of HLA end blo~group incompati- bility in spontaneous abortion. Clin. Genet. 9:575- 582. Lauwerys, R. R. 1983. Industrial Chemical Exposure: Guidelines for Biological Monitonng. Davis, Calif.: Biomedical Publications. 150 pp. Lavery, J. P. 1982. Nonstress fetal heart rate testing. Clin. Obstet~ Gynecol. 25:689-705. Lea, O. A., and F. S. French. 1981. Characterization of an acidic glycoprotein secreted by principal cells of the rat epididymis. Biochim. Biophys. Acta 668 37 376. Lea, O. A., P. Petrusz, and F. S. French. 1979. Pros- tatein. A major secretory protein of the rat ventral prostate. J. Biol. Chem. 254:619~6202. Leblond, C. P., and Y. Clermont. 1952. Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann. N.Y. Acad. Sci. 55:548-573. Leenders, K. L., A. J. Palmer, N. Quinn, J. C. Clark, G. Firnau, E. S. Garnett, C. Nahmins, T. Jones, and C. D. Marsden. 1986. Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography. J. Neurol. Neurosurg. Psychiatry 49:853 860. Legault, Y., M. Bouthillier, G. Bleau, A. Chapdelaine, and K D. Roberts. 1979. The sterol and sterol sulfate content of the male hamster reproductive tract. Biol. Reprod. 20:1213-1219. Lejeune, B., and F. Leroy. 1980. Role of the uterine epithelium in inducing the decidual cell reaction, pp. 92-101. In F. Leroy, C. A. Finn, and A. Psychoyos, Eds. Blastocyst-Endometrium Relationships. Progress in Reproductive Biology and Medicine, Vol. 7. Basel: S Karger AG. LeMaire, W. J., N. S. T. Yang, H. H. Behrman, and J. M. Marsh. 1973. Preovulatory changes in the con- centration of prostaglandins in rabbit Graafian follicles. Prostaglandins 3:367-376. Lemasters, G. K., A. Hagen, and S. J. Samuels. 1985. Reproductive outcomes in women exposed to solvents in 36 reinforced plastics companies. I. Menstrual dysfunction. J. Occup. Med. 27:49~494. Leridon, H. 1977. Human Fertility: TheBasicCom- ponents. Chicago: University of Chicago Press. 202 pp. Lerman, L. S. 1985. A Proposal for the Detection of Mutations in a Large-Scale Sampling of the Human Genome Using Two-Dimermonal D=ah~ Gradient Separations. Typescript, contract report prepared for the Office of Technology Assessment, U. S. Con- gress, Washington, D.C. 347 Levine, M. S., N. L. Fox, B. Thompson, W. Taylor, A. C. Darlington, J. Van der Hoeden, E. A. Emmett, and W. Rutten. 1986. Inhibition of esterase activity and an undercounting of circulating mono~tes in a population of production workers. J. Occup.Med. 28:207-211. Levine, N., and D. J. Marsh. 1971. Micropuncture studies of the electrochemical appects of fluid and electro~te transport in individual sem~ferous tubules, the epi- didymis and the vas deferens in rats. J. Physiol. 213:557-570. Levine, R. J. 1983. Methods for detecting occupational causes of male infertdity. Reproductive history versus semen ana~s. Scand. J. Work Environ. Health 9371- 376. Levine, R. J., M. J. Symons, S. A. Balogh, D. M. Arndt, N. R. Kamandik and J. W. Gentile. 1980. A method for monitoring the fertility of workers. I. Method and pilot studies. J. Occup. Med. 22:781-791. Levine, R. J., P. B. Blunden, R. D. DalCorso, T. B. Starr, and C. E. Ross. 1983. Superiority of reproductive histories to sperm counts in detecting infertility at a dibromochloropropane manufacturing plant. J. Occup. Med. 25:591-597. Lewin, L. M., R. Weissenberg, J. S. Sobel, Z. Marcus, and L. Nebel. 1979. Differences in concanavalin A-FITC binding to rat spermatozoa during epidi~mal maturation and capacitation. Arch. Androl. 2:279- 281. Lewis, E. L., M. O. Rasor, and J. W. Overstreet. 1985. Measurement of human testicular consistency by tonometry. Fertil. Steril. 43:911-916. Lewis, S. E., and F. M. Johnson. 1986. The nature of spontaneous and induced electrophoretically detected mutations in the mouse, pp. 359-365. In C. Ramel, B. Lambert, and J. Magnusson, Eds. Genetic T~q~icol- ogy of Environmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis. Proceedings of the Fourth International Conference on Emrironmental Mutagens held in Stockholm, Sweden, June 24 25, 1985. New York: Liss. Liber, H. L., S. L. Danheiser, and W. G. Thilly. 1985. Mutation in single-cell systems induced by low-level mutagen exposure. Basic Life Sci. 33:169-204. Lightfoot, R. J., K. P. Croker, and H. G. Neil. 1967. Failure of sperm tran~ort in relation to ewe infertility followingprolonged grazing on oestrogenicpastures. Aust. J. Agric. 18:755-765. Lilja, H., J. Oldbring, G. Rannevik, and C. B. Laurell. 1987. Seminal vesicle-secreted proteins and their reactions during "elation and liquefaction of human semen. J. Clin. Invest. 80:281-285. Limic, N., and V. Valkovic. 1986. Environmental in- fluence on trace element levels in human hair. Bull. Environ. Contam. Toxicol. 37:925-930. Lindquist, O., and C. Bengtsson. 1979. The effect of smoking on menopausal age. Maturitas 1:171-173. Livingston, G. K. 1984. An overvie~v of chromosomal, micronucleus, heritable effects, dominent lethal, hent-

348 able translocation, and specific locus tests. Prog. Clin. Biol. Res. 160:417427. Lloyd, C. W., J. Lobotsky, J. Weisz, D. T. Baird, J. A. McCracken, M. Pupldn, J. Zanartu, and J. Puga. 1971. Concentration of unconjugated estrogens, androgens and gestagens in ovarian and peripheral venous plasma of women: The normal menstrual cycle. J. Clin. En- docrinol. Metab. 32:155-166. Lodge, A. 1976. Developmental findings with infants born to mothers on methadone maintenance: A preliminary report, pp. 79-85. In G. Beschner and R. Brotman, Eds. Symposium on Comprehensive Health Care for addicted Families end their Children. Rockville, Md.: National Institute on Drug Abuse. Longo, L. D. 1972. Placental transfer mechanisms—an overview. Obstet. Gynceol. Annul 1:103-138. Longo, L. D. 1982. Some health consequences of mater- nal smoking: Issues without answers, pp. 13-31. In W. L. Nyhan and K. L. Jones, Eds. Prenatal Diagnosis and Mechanisms ofTeratogenesis. March of Dimes Birth Defects Foundation, OriginalArticle Series 18~3a). New York: Liss. Longo, L. D. 1983. Maternalblood volume and cardiac output during pregnancy A hypothesis of endocrinolic control. Am. J. Physiol. 245~5 Pt. 1~:R72~R729. Loumaye, E., J. Donnez, and K. Thoma~. 1985. Ovula- tion instantaneously modifies women's peritoneal fluid characteristics: A demonstration from an in m fertilization program. Fertil. Steril. 44:827~29. Lower, G. M., Jr., and M. S. Kanarek. 1982. Risk, susceptibility and the epidemiology of proliferative neoplastic disease: Descriptive vs. mechanistic ap- proaches. Med. Hypotheses 9:33-49. Lower, G. M., L. E. Stevens, J. S. Najarian, and K Reem- tsma. 1971. Problems from immunosupress~ves during pregnancy. Am. J. Obstet. Gynecol. 111:112~1121. Lu, L.-J. W., R. M. Disher, M. V. Reddy, and K Rander- ath. 1986. 32P-postlabelingassayin mice oftranspla- cental DNA damage induced by the environmental carcinogens safrole, ~aminobiphenyl, and ber~zota~py- rene. Cancer Res. 46:3046 3054. Lu, Y.-C., and P.-N. Wong. 1984. Dermatologic, medical, and laboratory findings of patients in Taiwan and their treatments. Am. J. Ind. Med. 5:81-115. Lubet, R. A., M. J. Brunda, D. Taramelli, D. Dansie, D. W. Nebert, and R. E. Kouri. 1984. Induction of immunotoxicity of polycyclic hydrocarbons: Role of the Ah locus. Arch. Toxicol. 56:1~24. Luciano, A. A., K. S. Hauser, F. K. Chapler, and B. M. Sherman. 1981. Danazol: Endocrine consequences in healthy women. Am. J. Obstet. Gynecol.141:723- 727. Lutwak-Mann, C. 1964. Obsewations on progeny of thalidomide~reated male rabbits. Br. Med. J. 1:1090 1091. Maathuis, J. B., and R. J.Aitken. 1978. Cycle variation in the concentrations of protein and harose in human uterine flushin~ collected by an improved technique. J. Reprod. Fertil. 52:289-295. REFERENCES Maathuis, J. B., P. F. A. Van Look, and E. A. Michie. 1978. Changes in volume, total protein and ovarian steroid concentrations of peritoneal fluid throughout the human menstrual cycle. J. Endocrinol. 76:123- 133. Macdonald, R. R. 1969. Cyclic changes in ce~vical mucus. 1. Cyclic changes in cervical mucus as an indication of ovanan function. J. Obstet. Gynaecol. Br. Com- monw. 76:1090 1094. MacLeod, J. 1964. Human seminal cytology as a sensitive indicator of the germinal epithelium. Int. J. Fertil. 9:281-295. MacLeod, J., and R. Z. Gold. 1951. The male factor in fertility and infertility Spermatozoon counts in 1000 men of known fertility and in 1000 cases of infertile marriage. J. Urol. 66:436449. MacI~od, J., and Y. Wang. 1979. Male fertility potential in terms of semen quality: A review of the past, a study of the present. Fertil. Steril. 31:103-116. MacLeod, S. M., and I. C. Radde. 1985. Textbook of Pediatric Clinical Pharmacology. Littleton, Mass.: PSG Publishing. 467 pp. MacMahon, B., and T. F. Pugh. 1970. Epidemiology: Principles and Methods. Boston: Little, Brown and Co. 376 pp. MacMahon, B., and J. Worcester. 1966. Age at meno- pause: United States, 1960 1962. Vital Health Stat. 11~19~:1-20. MacQueen, J. M., and F. P. Sanfi~po. 1984. l~e e~ect of parental HLA compatibility on the expression of paternal haplotypes in offspring. Hum. Immunol. 11:155-161. Maddox, D. E., J. H. Butterfield, S. J. Ackerman, C. B. Coulam, and G. J. Gleich. 1983. Elevated serum levels in human pregnangr of a molecule immuno~e~ ically similar to eosinophil granule major basic proteir~ J. Exp. Med. 158:1211-1226. Maddox, D. E., G. M. Kephart, C. B. Coulam, J. H. Butterfield, K. Benirschke, and G. J. Gleich. 1984. L~l~ation of a molealle immunothemically simdar to eosinophil major basic protein in human placenta. J. E~p. Med. 160:29 41. Magani, G., G. Chiodoni, F. Rgy, and J. P. Felber. 1986. Further evidence for the usefulness of the salivary testosterone radioimmuneassay in the assessment of androgenicity in man in basal and stimulated condi- tions. Horm. Res. 23:6~73. Mahesh, V. B., R B. Greenblatt, and R F. Coniff. 1968. Adrenal hyperplasia—a case report of delayed onset of the congenital form or an acquired form. J. Clin. Endocrinol. Metab. 28:619~23. Mahony, M. C., N. J. Alexander, and R. J. Swanson. 1988. Evaluation of semen parameters by means of automated sperm motion analyzers. Fertil. Steril. 49:876 880. Maier, D., and S. Kuslis. 1987. Utenne Umversal F-luid (ULF) Volume and Prolactin (UPRL3 in Normal Menstrual Cycles. Presented at the 34th Annual meeting of the Sonety for Gynecolo~cal ~est4 - on

REFERENCES held March 12-21, 1987 in Atlanta, Georgia. Abstract No. 251, p. 155. Mailhes, J. B., R. J. Preston, and K. S. Lavappa. 1986. Mammalian in viva assays for aneuploidy in female germ cells. Mutat. Res. 167:139-148. Makler, A., I. Zaidise, E. Palm and J. M. Brandes. 1979a. Factors affecting sperm motility. I. In vitro change in motility with time after ejaculation. Fertil. Steril. 31:147-154. Makler, A., J. Itskovitz, J. M. Brandes, and E. Paldi. 1979b. Sperm velocity and percentage of motility in 100 normospermic specimens analyzed by the multi- ple exposure photography (MEP) method. Fertil. Steril. 31:155-161. Malmborg, A. S. 1978. Antimicrobial drugs in human seminal plasma. J. Antimicrob. Chemother. 4:483- 485. Malone, J. D., M. Richards, and A. J. Kahn. 1986. Human peripheral monocytes egress putative receptors for neuroexcitatory amino acids. Proc. Natl. Acad. Sci. USA 83:3307-3310. Manchester, D., and E. Jacoby. 1984. Decreased placen- tal monoxygenase activities associated with birth de- fects. Teratology 30:31-37. Manchester, D. K., N. B. Parker, and C. M. Bowman. 1984. Maternal smoking increases xenobiotic metabol- ism in placenta but not umbilical vein endothelium. Pediatr. Res. 18:1071-1075. Manchester, D. K., S. K. Gordon, C. L. Golas, E. A. Roberts, and A. B. Okey. 1987. Ah receptor in human placenta: Stabilization by mo~ybdate and characteriza- tion of binding of 2,3,7,~tetrachlorodibenzo-p-dio~n, 3-methylcholanthrene, and benzota~pyrene. Cancer Res. 47:4861~. Maneely, R. B. 1959. Epididymal structure and function. A historical and critical review. Acta Zool. 40:1- 21. Mann, T., and C. Lutwalc-Mann. 1981. Male Reproduce live Function and Semen: Themes and Trends in Physiology, BiochemistIy and Investigative Andrology. New York: Springer-Verlag. 495 pp. Marcal, J. M., N. J. Chew, D. S. Salomon, and M. I. Sherman. 1975. ^5,3 B-hydro~ysteroid dehydrogenase activities in rat trophoblast and ovary during pregnancy. Endocrinology 96:1270-1279. Markkula-Viitanen, M., V. Nikkanen, and A. Talo. 1979. Electrical activity and intraluminal pressure of the cauda epididymidis of the rat. J. Reprod. Fertil. 57:431-435. Markoff, E., P. Zeitler, S. Peleg, and S. Handwerger. 1983. Characterization of the synthesis and release of prolactin by an enriched fraction of human decidual cells. J. Clin. Endocrinol. Metab. 56:962-968. Marshall, E. 1986. Immune system theories on trial. Science 334:1490 1492. Marshall, J. R., C. B. Hammond, G. T. Ross, A. Jacobsen, P. Rayford, and W. D. Odell. 1968. Plasma and urinary chorionic gonadotropin during early human pregnancy. Obstet. Gynecol. 32:760 764. 349 Marshall, J. F., M. C. Drew, and K. A. Neve. 1983. Recovery of function after mesotelencephalic dopamin- ergic injury in senescence. Brain Res. 259:249-260. Marshall, W. A., and J. M. Tanner. 1969. Variations in pattern of pubertal changes in girls. Arch. Dis. Child. 44:291-303. Martal, J., J. Djiane, and M. P. Dubois. 1977. Immuno- fluorescent localization of ovine placental lactogen. Cell Tissue Res. 184:424 433. Martin, R. H. 1983. Sperm chromosomal analysis after radiotherapy. Hum. Genet. 79:392-393. Martin, R. H., W. Balkan, K. Burns, A. W. Rademaker, C. C. Lin, and N. L. Rudd. 1983. The chromosome Motion of 1000 human q~ermatezoa Hum. Genet. 63:305-309. Martin, R. H., A. W. Rademaker, K Hildebrand, L. Long- Simpson, D. Peterson, and J. Yamamoto. 1987. Variation in the frequency and type of sperm chrome somal abnormalities among normal men. Hum. Genet. 77:108 114. Martin-Deleon, P. A., E. L. Shaver, and E. B. Gammal. 1973. Chromosome abnormalities in rabbit blastocysts resulting from spermatozoa aged in the male tract. Fertil. Steril. 24:212-219. Martz, F., C. Failinger, III, and D. A. Blake. 1977. Phenytoin teratogenesis: Correlation between embryo- pathic effect and covalent binding of putative arene oxide metabolite in gestational tissue. J. Pharmacol. Expt. Therap. 203:231-239. Maruo, T., S. J. Segal, and S. S. Koide. 1979. Studies on the apparent human chorionic gonadotropin-like factor in the crab Ovalipes ocellatus. Endocrinology 104:932-939. Maslar, I. A., and D. H. Riddick. 1979. Prolactin product tion by human endometrium during the normal men- strual cycle. Am. J. Obstet. Gynecol. 135:751-754. Maslar, I. A., P. Powers-Craddock, and R. Ansbacher. 1986: Decidual prolactin production by organ cultures of human endometrium: Effects of continuous and intermittment progesterone treatment. Biol. Reprod. 34:741-750. Mason, A. J., J. S. Hayflick, N. Ling, F. Esch, N. Ueno, S.-Y. Ying, R. Guillemin, H. Niall, and P. H. Seeburg. 1985. Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta. Nature 318:659~63. Masuda, Y., T. YamaIyo, K. Haraguchi, M. Kuratsune, and S.-T. Hsu. 1982. Comparison of causal agents in Taiwan and Fukuol~a PCB poisonings Chemosphere 11:199-206. Mathur, S., E. R. Baker, H. O. Williamson, F. C. Derrick, K. J. Teague, and H. H. Fudenberg. 1981. Clinical significance of sperm antibodies in infertility. Fertil. Steril. 36:486~95. Matsumoto, A. M. 1988. The testis, pp. 14041421. J. B. Wyngaarden and L. H. Smith, Jr., Eds. In Cecil Textbook of Medicine, 18th ed. Philadelphia: W. B. Saunders Company. ~

350 Matter, L., and Faulk, W. P. 1980. Fibrinogen degrada- tion products and Factor vm consumption in normal pregnancy and pre-eclampsia: Role of the placenta, pp. 357-369. In J. Bonnar, I. MacGillivray, and M. Symonds, Eds. Pregnancy Hypertension. Prigs of the First Congress of the International Society for the Study of Hypertension in Pregnancy, held at Uni- versity College, Dublin, on 27-29 September 1978. Lancaster, Eng.: MTP Press. Mattison, D. R. 1982. The effects of smoking on fertility from gametogenesis to implantation. Environ. Res. 28:410433. Mattison, D. R. 1985. Clinical manifestations of ovarian toxicity, pp.109-130. In R. L. Dixon, Ed. Reproduc- tive Toxicology. Target Organ Toxicology Series. New York: Raven Press. Mattison, D. R. 1986. Physiologic variations inpharmaco- kinetics during pregnancy, pp. 37-102. In S. Fabro and A. R. Scialli, Eds. Drug and Chemical Action in Pregnancy: Pharmacologic and Toxicologic Prin- ciples. Reproductive Medicine, Vol. 8. New York: Marcel Dekker. Mattison, D. R., and T. Angruaco. 1988. Magnetic reson- ance imaging in prenatal diagnosis. Clin. Obstet. Gyne- col. 31:353-389. Mattison, D. R., and S. S. Thorgeirsson. 1977. Genetic differences in mouse ovarian metabolism of benzo- (a~pyrene and oocyte toxicity. Biochem. Pharmacol. 26:909-912. Mattison, D. R., M. S. Nightingale, and K. Shiromizu. 1983. Effects of toxic substances on female reproduc- tion. Environ. Health Perspect. 48:43-52. Mattison, D. R., H. H. Kay, R. K Miller, and T. Angtua- co. 1988. Magnetic resonanceimagng: Anoninvasive tool for fetal and maternal physiology. Biol. Reprod. 38:39~9. Maurissen, J. P. 1985. Psychophysical testing in human populations exposed to neuroto,eicants. Neurobehav. Toxicol. Teratol. 7:309-317. Maurissen, J. P., and B. Weiss. 1980. Vibration sensitivity as an index of somatosensory function. In P. H. Spen- cer and H. H. Schaumberg, Eds. Experimental and Clinical Neurotoxicology. Baltimore: Williams & Wilkins. Maxam, A. M., and W. Gilbert. 1977. A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA 74:56~564. May, P. C., and S. G. Kohama. 1986. Systemic treatment of adult female C57BL/6J mice with the neuronal excitotoxin N-methyl-aspartic acid mimics the age- related lengthening of the estrous cycle, p. 233. In Endocrine Society 68th Annual Meeting. Anaheim, California. Program and Abstracts. Mayorga, L. S., and F. Bertini. 1982. Effect of androgens on the activity of acid hydrolases in rat epididymis. Int. J. Androl. 5:345-352. Mazurkiewicz, J. E., J. F. Bank, and S. G. Joshi. 1981. Immunocytochemical localization of a progestagen- associated endometrial protein in the human decidua. REFERENCES J. Clin. Endocrinol. Metab. 52:1006 1008. McCarthy, S., and F. Haseltine. 1987. Magnetic Reson- ance of the Reproductive System. Thorofare, NJ.: Slack. 230 pp. McConnachie, P. R., and J. A. McIntyre. 1984. Maternal antipaternal immunity in couples predisposed to re- peated pregnancy losses. Am. J. Reprod. Immunol. 5:145-150. McCormack, S. A., and S. R. Glasser. 1978. Ontogeny and regulation of a rat placental estrogen receptor. Endocrinology 102:273-280. McCormack S. A., and S. R. Glasser. 1980. Differential response of individual uterine cell types from immature rats treated with estradiol. Endocrinology 106:1634- 1649. McCullagh, D. R. 1932. Dual endocrine activity of the testes. Science 76:19-20. McDonough, P. G. 1985. Applications of molecular biology toperinatal medicine. Sem. Perinatol.9:25 256. McIlree, M. E., W. H. Price, W. M. Brown, W. S. Tulloch, J. E. Newsam, and N. Maclean. 1966. Chromosome studies on testicular cells from 50 subfertile men. Lancet 2~454~:69-71. McIntire, M. S., and C. R. Angle. 1972. Air lead: Relation to lead in blood of black school children deficient in glucose~phosphate dehydrogenase. Science 177:520-521. McIntyre, J. A., and W. P. Faulk. 1979a. Trophoblast modulation of maternal allogeneic reco~iition. Proc. Natl. Acad. Sci. USA 76:4029~032. McIntyre, J. A., and W. P. Faulk. 1979b. Antigens of human trophoblast: Effects of heterologous anti- trophoblast sera on lymphocyte responses in vitro. J. Exp. Med. 149:824-836. McIntyre, J. A., and W. P. FauLk. 1979c. Maternal blocking factors in human pregnancy are found in plasma not serum. Lancet 2~8147~:821-823. McIntyre, J. A, and W. P. Faulk. 1982. Allotypic tropho- blast-lymphocyte cross-reactive (,IIX) cell surface antigens. Hum. Immunol. 4:27-35. McIntyre, J. A., and W. P. Faulk. 1983. Recurrent spon- taneous abortion in human pregnancy: Results of immunogeneticaL cellular, and humoral studies. Am. J. Reprod. Immunol. 4:165-170. McIntyre, J. A., and W. P. Faulk. 1985. Laboratory and clinical aspects of research in chronic spontaneous abortion. Diagn. Immunol. 3:163-170. McIntyre, J. A., P. R. McConnachie, C. G. Taylor, and W. P. Faulk. 1984a. Clinical, immunologic, and genetic definitions of prima~y and secondary recurrent spontaneous abortions. Fertil. Steril. 42:849-855. McIntyre, J. A., W. P. Faulk, S. J. Verhulst, and J. A. Colliver. 1984b. Human trophoblast-lymphocyte cross reactive (TLX) antigens de6~ne a new alloantigen system. Science 222:1135-1137. McIntyre, J. A., W. P. Faulk, V. R. Nichols-Johnson, and C. G. Taylor. 1986. Immunologic testing and immunotherapy in recurrent spontaneous abortion.

REFERENCES Obstet. Gynecol. 67:169-175. McKay, D. J., B. S. Renaux, and G. H. Dixon. 1985. The amino acid sequence of human sperm protamine P1. Biosci. Rep. 5:383-391. McKay, D. J., B. S. Renaux, and G. H. Dixon. 1986. Human sperm protamines. Amino acid sequences of two forms of protamine P2. Eur. J. Biochem.156:5- 8. McKinlay, S. M., N. L. Bifano, and J. B. McKinlay. 1985. Smoking and age at menopause in women. Ann. Inter. Med. 103:35~356. McKusick, V. A. 1975. Mendelian Inheritance in Man, 4th ed. Baltimore, Md.: Johns Hopkins University Press. 837 pp. McNatty, K. P., and D. T. Baird. 1978. Relationship between follicle-stimulating hormone, androstenedione and oestradiol in human follicular fluid. J. Endocrinol. 76:527-531. McNatty, K. P., D. T. Baird, A. Bolton, P. Chambers, C. S. Corker, and H. McLean. 1976. Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle. J. Endocnnol. 71:77-85. McWilliams, D., and I. Boime. 1980. Cytological localiza- tion of placental lactogen messenger ribonucleic acid in syncytiotrophoblast layers of human placenta. Endocrinology 107:761-765. Meistrich, M. L. 1977. Separation of spermatogenic cells and nuclei from rodent testes, pp. 15-24. In D. M. Prescott, Ed. Methods in Cell Biology, Vol. XV. New York: Academic Press. Meistrich, M. L. 1982. Quantitative correlation between testicular stem cell survival, sperm production, and fertility in the mouse after treatment with different cytotoxic agents. J. Androl. 3:58~8. Meistrich, M. L. 1986. Critical components of testicular function and sensitivity to disruption. Biol. Reprod. 34:17-28. Me~trich, M. L. 1987. Comparative male gonadal toxicity from cytotoxic cancer therapies. In J. J. Mulvihill and R. H. Sherins, Eds. Reproduction and Cancer. New York: Raven. Meistrich, M. L., and C. C. Brown. 1983. Estimation of the increased risk of human infertility from altera- tions in semen characteristics. Fertil. Steril. 2:220- 230. Meistrich, M. L., T. H. Hughes, and W. R. Bruce. 1975. Alteration of epididymal sperm han~ort and matura- tion in mice by oestrogen and testosterone. Nature 258:145-147. Meistrich, M. L., P. K. Trostle, M. Frapart, and R. P. Erickson. 1977. Biosynthesis and localization of lactate dehydrogenase X in pachytene spermatocytes and spermatids of mouse testes. Dev. Biol. 60:42~441. Meistrich, M. L., L. S. Goldstein, and A. J. Wyrobek. 1985. Long-term infertility and dominant lethal muta- tions in male mice treated with adriamycin. Mutat. Res. 152:53~5. Memo, M., C. Missale, M. O. Carruba, and P. F. Spano. 351 1986. Pharmacology and biochemistry of dopamine receptors in the central nervous system and peripheral tissue. J. Neural Transm. 22(Suppl.~:19-32. Menken, J., J. Trussell, and U. Larsen. 1986. Age and infertility. Science 233:1389-1394. Mes, J., D. J. Davies, and D. Turton. 1982. Polychlorin- ated biphenyl and other chlorinated hydrocarbon residues in adipose tissue of Canadians. Bull. Emiron. Contam. Toxicol. 28:97-104. Metcalf, M. G., R. A. Donald, and J. H. Livesey. 1981. Pituitary-ovarian function in normal women during the menopausal transition. Clin. Endocrinol. (Oxf.) 14:245-255. Meyer-Bahlburg, H. F., A. A. Ehrhardt, J. F. Feldman, L. R. Rosen, N. P. Verdiano, and I. Zimmerman. 1985. Sexual activity level and sexual functioning in women prenatally exposed to diethylstilbestrol. Psy- chosom. Med. 47:497-511. Michelson, A. M., G. A. P. Bruns, C. C. Morton, and S. H. Orkin. 1985. The human phosphoglycerate kinase multigene family. HLA-associated sequences and an X-linked loa~s contain~ng a processed pseudm gene and its functional counte~part. J. Biol. Chem. 260:6982~992. Michnovicz, J. J., R. J. Hershcopf, H. Naganuma, H. L. Bradlow, and J. Fishman. 1986. Increased 2- hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N. Eng. J. Med. 315:1305-1309. Mikhail, G. 1970. Hormone accretion by the human ovaries. Gynecol. Invest. 1:5-20. Millan, J. L., C. E. Driscoll, K. M. Levan, and E. Gold- berg. 1987. Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence. Proc. Natl. Acad. Sci. USA 84:5311-5315. Miller, J. F., E. Williamson, J. Glue, Y. B. Gordon, J. G. Grudzinskas, and A. Sykes. 1980. Fetal loss after implantation: A prospective study. Lancet 2:554- 556. Miller, J. R. 1983. International Commission for Prote~ tion agpin~ En~rironmental Mutagens and Carcinogens. ICPEMC Working paper 5/4. Pc~e~ves in mut~on epidemiology. 4: General pnnciples and considera- tions. Mutat. Res. 114:425447. Miller, M. W. 1986. Effects of alcohol on the generation and migration of cerebral cortical neurons. Science 233:130~1311. Miller,R.K. 1983. Perinataltoxicology: Its recognition and fundamentals. Am. J. Ind. Med. 4:205-244. Miller, R. K, and C. K Kellogg. 1985. The pharmaco~- namics of prenatal chemical exposure. Natl. Inst. Drug Abuse Res. Mongr. Ser. 60:39-57. ~ller, R. K, and Z. Shaikh. 1983. Perinatal metabolism: Metals and metallothionein, pp. 151-204. In T. Clark- son, G. Nordberg, and P. Sager, Eds. Developmental and Reproductive Toxicity of Metals. New York: Plenum Press. Miller, R. K., T. R. Kos~alka, and R. L Brent. 1976. The transport of molecules across placental mem-

352 branes, pp.145-223. In G. Poste and G. L. Nicolson, Eds. The Cell Surface in Animal Embryogenesis and Development. Cell Surface Reviews, Vol. 1. Amster- dam: North-Holland. Miller, R. K., C. K. Kellogg, and R. A. Saltzman. 1987a. Reproductive and perinatal toxicology, pp.195-309. In T. J. Haley, and W. O. Berndt, Eds. Handbook of Toxicology. Washington, D.C.: Hemisphere. Miller, R. K., D. R. Mattison, M. Panigel, T. Ceckler, R. Bryant, and P. Thomford. 1987b. Kinetic assess- ment of manganese using magnetic resonance imaging in the dually perfused human placenta in vitro. Environ. Health Perspect. 74:81-91. Miller, R. K., D. Mattison, and D. Plowchalk. 1988. Biological monitoring of the human placenta, pp. 567- 602. In T. W. Clarkson, L. Freiberg, G. Nordberg, and P. Saeger, Eds. Biological Monitoring of Toxic Metals. New York: Plenum Press. Mills, J. L., and D.Alexander. 1986. Teratogens and "litogens." N. Engl. J. Med. 315:1234-1236. Mirmiran, M., E. Brenner, J. van der Gugten, and D. F. Swaab. 1985. Neurochemical and electrophysiolog- ical disturbances mediate developmental behavioral alterations produced by medicines. Neurobehav. Toxicol. Teratol. 7:677-683. Mishell, D. R., Jr. 1979. Oral steroids, pp. 487-523. In D. R. Mishell, Jr. and V. Davajan, Eds. Reproduo tive Endocrinology, Infertility, and Contraception. Philadelphia: F. A. Davis. Mizejewski, G. J., and I. H. Porter, Eds. 1985. Alpha- Fetoprotein and Congenital Disorders. Orlando, Fla.: Academic Press. 363 pp. Mj ones, H. 1949. Paralysis agitans: Clinical and genetic study. Acta Psychiatr. Neurol. Scand. (Suppl.54~:1- 195. Mobbs, C. V., K. F1urkey, D. M. Gee, K. Yamamoto, Y. N. Sinha, and C. E. Finch. 1984. Estradiol-induced adult anovulatory syndrome in female CS7BL/6J mice: Age-l~e neuroendocrine, but not ~ian, impairments. Biol. Reprod. 30:556-563. Mobbs, C. V., L. S. Kannegieter, and C. E. Finch. 1985. Delayed anovulatory syndrome induced by estradiol in female CS7BL/6J mice: Age-like neuroendocnne, but not ovarian, impairments. Biol. Repro.32:101 1017. Mocarelli, P., A. Marocchi, P. Brambilla, P. Gerthoux, D. S. Young, and N. Mantel. 1986. Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental di~ aster near Seveso, Italy. J. Am. Med. Assoc. 256:2687-2695. Moghissi, K. S. 1966. Cyclic changes of cervical mucus in normal and progestin-treated women. Fertil. Sterd. 17:663-675. Moghissi, K. S. 1973. Composition and function of cervical secretion, pp. 25-48. In R. O. Greep, Ed. Handbook of Physiology, Section 7: Endocrinology. Volume II. Female Reproductive System, Part 2. Washington, D.C.: Amencan Physiological Sonety. REFERENCES Moghissi, K. S. 1976. Postcoital test: Physiologic basis, technique and interpretation. Fertil. Steril. 27:117- 129. Moghissi, K. S., F. N. Syner, and T. N. Evans. 1972. A composite picture of the menstrual cycle. Am. J. Obstet. Gynecol. 114:405-418. Molinatti G. M., F. Massara, M. Messina, and G. Ansel- mo. 1964. Postpubertal adrenal virilism due to a defect in 21-hydrosylation. Folia Endrocnnol. 17:63~636. Moore, H. D. M. 1981. Effects of castration on specific gIycoprotein secretions of the epididymis in the rabbit and hamster. J. Reprod. Fertil. 61:347-354. Morgan, F. J., S. Birken, and R. E. Canfield. 1973. Human chorionic gonadotrop~n: A proposal for the amino acid sequence. Mol. Cell. Biochem. 2:79-99. Morgan, F. J., S. Birken, and R. E. Canf~eld. 1975. The amino acid sequence of human chorionicgonadotrop~n (The a subunit and B subunit). J. Biol. Chem. 250:5247-5258. Morgan, W. F., and S. Wolff. 1984. Effect of 5-bromo- deoxyuridine substitution on sister chromatic exchange induction~r chemicals. Chromosoma89:285 289. Mori, H., and A. K Christensen. 1980. Morphometric analysis of L~ydig cells in the normal rat testis. J. Cell Biol. 84:340 354. Mori, H., N. Hiromoto, M. Nakahara, and T. Shiraishi. 1982. Stereological analysis of I~ydig cell ultrastruc- ture in aged humans. J. Clin. Endocrinol. Metab. 55:634 641. Morley, A. A., K J. Trainor, R Seshadri, and R. G. Ryall. 1983. Measurement of in vivo mutations in human lymphocytes. Nature 302:155-156. Moms, N. M., J. R. Ud~y, F. Khan-Dawood, and M. Y. Dawood. 1987. Mantal seK frequen~y and midcy~le female testosterone. Arch. Sex Behav. 16:27-37. Mortimer, D., A. A. Templeton, E. A. Linton, and R. A. Coleman. 1982. Influence of abstinence and ejaculation-to-analysis dela,~ on semen ana~sis param~ ters of suspected infertile men. Arch. Androl. 8:251- 256. Morton, H., V. Hegh, and G. J. Clunie. 1976. Studies of the rosette inhl~ition test in pregnant mice: Evi- dence for immunosuppression? Proc. R. Soc. Lond. [Biol.] 193(1113):413~19. Morton, H., B. Rolfe, and G. J. A. Clunie. 1977. An early pregnancy factor detected in human serum py the rosette inhl~ition test. Lancet 1:39~397. Morton, H., C. D. Nancarrow, R. J. Smramuzzi, B. M. Evison, and G. J. A. Clunie. 1979. Detection of early pregnancy in sheep by the rosette inhl~ition test. J. Reprod. Fertil. 56:75 80. Morton, H., B. E. Rolfe, and A. L. Cavanaugh. 1982. Early pregnancy factor: Biology and clinical signifi- cance, pp. 391~05. In G. Grudzinslcas, B. Teisner, and M. Seppala, Eds. Pregnancy Proteins. Sydney Academic Press. Moru~, J. F., A. J. Wyrobek, B. H. Mayall, and B. L.

REFERENCES Gledhill. 1988. Quantification and classification of human sperm morphology by computer-assisted Triage analysis. Fertil. Steril. 50:142-152. Moses, M., and P. G. Prioleau. 1985. Cutaneous him tolog~c findings in chemical workers with and without chloracnewith past exposure to 2,3,7,~tetrachlorodi- benzo-para-dioxin. J. Am. Acad. Dermatol. 12:497- 506. Mosher, W. D. 1980. Reproductive impairments among currently married couples: United States, 1976, pp. 1-11. In Advance Data from Vital and Health Statistics of the National Center for Health Statistics. Rock~ille, Md.: U.S. Department of Health, Education, and Welfare. Mowbray, J. F. 1987. Genetic and immunological factors in human recurrent abortion. Am. J. Reprod. Im- munol. Microbiol. 15:138-140. Mowbray, J. F., and J. L. Underwood. 1985. Immunology of abortion. Clin. Exp. Immunol. 60:1-7. Mowbray, J. F., C. R. Gibbing, A. S. Sidgw~ck, M. Rusz- kiewicz, and R. W. Beard. 1983. Effects of transfusion in women with recurrent spontaneous abortion. Trance plant Proc. 15:896-899. Moyle, W. R., C. Lin, R. L. Corson, and P. H. Ehrlich. 1983a. Quantitative explanation for increased affinity shown by mixtures of monoclonal antibodies: hnpor- tance of a circular complex. Mol. Immunol. 20:439- 452. Moyle, W. R., D. M. Anderson, and P. H. Ehrlich. 1983b. A circular antibody-antigen complex is responsible for increased affinity shown by mixtures of monoclonal antibodies to human chorionic gonadotropin. J. Im- munol. 131:190~1905. Muller, H. J. 1927. Artificial transmutation of the gene. Science 66:84-87. Mulvihill, J. J., and J. Byrne. 1985. Offspring of long- time survivors of childhood cancer. Late Effects in Sucessfully Treated Children with Cancer, Clinics in Oncology 4~2~:333-343. Mulvihill, J.J., end A. Czeizel. 1983. Perspectives in mutations epidemiology 6: A 1983 view of sentinel phenotypes. Mutat. Res. 123:345-361. Mulvihill, J. J., and A. M. Yeager. 1976. Fetal Alcohol Syndrome. Teratology 13:345-348. Murakami, M., A. Sugita, and M. Hamasaki. 1982a. Scanning electron microscopic observations of the vas deferens in man and monkey with special reference to spermiophagy in its ampullary region. Scan. Elec- tron Microsc. 3:1333-1339. Murakami, M., A. Sugita, and M. Hamasaki. 1982b. The vas deferens in man and monkey Sp~miophagy in its ampulla, pp. 187-195. In E. S. E. Hafez and P. Kenemans, Eds. Atlas of Human Reproduction By Scanning Electron Microscopy. Lancaster, U.K.: MTP Press. Murakami, M., T. Nishida, S. Iwanaga, and M. Shiromoto. 1984. Smrmi~ and transmission electron microscopic evidence of phagocytosis of spermatozoa in the ter- minal region of the vas deferens of the cat. Experien- 353 tie 40:95~960. Murphy, D. L. 1976. Clinical, genetic, hormonal and drug influences on the activity of human platelet monoamine oxidase, pp. 341-353. In Monoamine Oxidase and Its Inhibition. CIBA Foundation Sym- posium 39 (New Series). Amsterdam: Elsevier. Murphy, J. B., R. C. Emmott, L. L. Hicks, and P. C. Walsh. 1980. Estrogen receptors in the human prow late, seminal vesicle, epidi~mis, testis, and genital skin: A marker for estrogen-responsive tissues? J. Clin. Endocnnol. Metab. 50:93~948. Murthy, Y. S., G. H. Arronet, and M. C. Parekh. 1970. Luteal phase inadequacy. Obstet. Gynecol. 36:75 761. Musto, N. A., F. Larrea, S.-L. Cheng, N. Kotite, G. Gun- salus, and C. W. Bardin. 1982. Intracellular androgen-binding proteins: Species comparison and structure-function relationships. Ann. N.Y. Acad. Sci. 383:343-359. Myers, R. M., Z. Larin, and T. Manias 1985. Detection of single base substitutions by nbonuclease cleavage at mismatches in RNA:DNA duplexes. Science 230: 124~1246. Myles, D. G., and P. Pnmakoff. 1984. Localized surface antigens of guinea pig sperm migrate to new regions prior to fertilization. J. Cell Biol. 99:163~1641. Myles, D. G., P. Primakoff, and A. R. Bellve. 1981. Surface domains of the guinea pig sperm defined with monoclonal antibodies. Cell 23:433-439. Myrianthopoulos, N. C., F. N. Waldrop, and B. L. Vincent. 1969. A repeat study of hereditary predisposition in drug-induced parkisonism, pp. 486 491. In A. Barbeau and J. R. Brunette, Eds. Progress in Neuro- genetics. International Congress Series, No. 175. Amsterdam Excerpta Medica Foundation. Naeye, R. L., W. Blanc, W. Leblanc, and M. Khatamee. 1973. Fetal complications ofmaternalheroin addiction: Abnormal growth, infections, and episodes of stress. J. Pediatr. 83:1055-1061. Nagao, T. 1987. Frequency of congenital defects and dominant lethals in the offspring of male mice treated with methylnitrosourea. Mutat. Res. 177:171-178. Nagl, W. 1978. Endopolyploidy and Politely in Differen- tiation and Evolution. Towards an Understanding of Quantitative and Qualitative Variation of Nuclear DNA in Ontogeny and Phylogeny. Amsterdam: North-Holland. 283 pp. Nahoul, K., L. V. Rao, and R. Scholler. 1986. Saliva testosterone time-course response to hCG in adult normal men. Comparison with plasma levels. J. Steroid Biochem. 24:1011-1015. Nancarrow, C. D., B. M. Evison, R. J. Scaramuzzi, and K. E. Turnbull. 1979. Detection of induced death of embryos in sheep by the rosette inhibition test. J. Reprod. Fertil. 57:385-389. Narod, S. A., G. R. Douglas, E. R. Nestmann, and D. H.Blakey. 1988. Human mutagens: Evidence from paternal exposure? Environ. Mol. Mutagen. 11:401- 415.

354 NCCLS (National Committee for Clinical Laboratory Standards). 1981. List of Standards. Villanova, Penn.: National Committee for Clinical Laboratory Standards. NCCLS (National Committee for Clinical Laboratory Standards3. 1985. List of Standards. Villantnra, Penn.: National Committee for Clinical Laboratory Standards. Neaves, W. H. 1975. Biological aspects of vasectomy, pp. 383404. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physiology, Section 7: Endocnnol- ogy. Volume V. Male Reproductive System. Wash- ington, D.C.: American Physiological Society. Nebert, D. W., and N. M. Jensen. 1979. The Ah locus: Genetic regulation of the metabolism of carcinogens, drugs, and other environmental chemicals by cyto- chrome P-45~ mediated monooxygenases. CRC Crit. Rev. Biochem. 6:401-437. Needleman, H. L. 1987. Introduction: Biomarkersin neurodevelopmental toxicology. Environ. Health Per- spect. 74:149-152. Needleman, H. L. 1988. The persistent threat of lead: Medical and sociological issues. Curr. Probl. Pediatr. 18:697-744. Needleman, H. L., O. C. Tuncay, and I. M. Shapiro. 1972. Lead levels in decidous teeth of urban and suburban American children. Nature 235:111. Needleman, H. L., I. Davidson, E. M. Sewell, and I. M. Shapiro. 1974. Subclinical lead ensure in Philadel- phia schoolchildren: Identification by dentine lead analysis. N. Engl. J. Med. 290:245-248. Needleman, H. L., C. Gunnoe, A. Leviton, R. Reed, H. Peresie, C. Maher, and P. Barrett. 1979. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N. Engl. J. Med. 300:689~95. Needleman, H. L., M. Rabinowitz, A. Leviton, S. Linn, and S. Schoenbaum. 1984. The relationship between prenatal exposure to lead and congenital anomalies. J. Am. Med. Assoc. 251:295~2959. Neel, J. V., H. W. Mohrenweiser, and M. H. Meisler. 1980. Rate of spontaneous mutation at human loci encoding protein structure. Proc. Natl. Acad. Sci. USA 77:6037041. Neel, J. V., H. Mohrenweiser, S. Hanash, B. Rosenblum, S. Sternbeq~, K-H. Wumnger, E. Rothmans C. Satoh, K Goriki, T. Krasteff, M. Long, M. Skolnick, and R. K~zesicki. 1983. Biochemical approaches to moni- toring human populations for germinal mutation rates. I: Electrophoresis, pp. 71-93. In F. J. de Serres and W. Sheridan, Eds. Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. New York: Plenum Press. Neel, J. V., B. B. Rosenblum, C. F. Sing, M. M. Skolnick S. M. Hanash, and S. Sternberg. 1984. Adapting two-dimenstional gel electrophoresis to the study of human germ-line mutation rates, pp. 259-306. In J. E. Celis and R. Bravo, Eds. Two-Dimensional Gel Electrophoresis of Proteins. Orlando: Academic Press. REFERENCES Neel, J. V., C. Satoh, K. Goriki, M. Fujita, N. Takahashi, J. Asakawa, and R. Hazama. 1986. The rate with which spontaneous mutation alters the electrophoretic mobility ofpolypeptides. Proc. Natl.Acad. Sci. USA 83:389-393. Nelson, J. F., and L. S. Felicio. 1987. Reproductive aging in the female: An etiological perspective up- dated. Rev. Biol. Res. Aging 3:359-381. Nelson, J. F., L. S. Felicio, P. K. Randall, C. Sims, and C. E. Finch. 1982. A longitudinal study of estrous cyclicity in aging C57BL/6J mice. I. Cycle frequency, length and vaginal cytology. Biol. Reprod. 27:327- 329. Nestor, A., and M. A. Handel. 1984. The transport of morphologically abnormal sperm in the female repro- ductive tract of mice. Gamete Res. 10:119-125. New, M. I. 1985. Premature thelarch and estrogen intoxication, pp. 349-357. In J. A. McLachlan, Ed. Estrogens in the Environment II: Influences on Devel- opment. New York: Elsevier. Newbold, R. R., and J. A. McLachlan. 1982. Vaginal adenosis and adenocarcinoma in mice exposed prena- tally or neonatally to diethylstilbestrol. Cancer Res. 42:2003-2011. Newman, C. G. 1985. Teratogen update: Clinical aspects of thalidomide embryopathy~ continuing preoccupa- tion. Teratology 32:133-144. Nichols, N. R., J. N. Masters, P. C. May, S. L. Millar, and C. E. Finch. 1986. Altered RNA abundance in rat hippocampus in response to corticosterone, p. 265. In Endocrine Society 68th Annual Meeting. Anaheim, California. Program and Abstracts. Nicoletti, O., F. Ambrosi, C. Giammartino, L. Fedeli, C. Mannarelli, and P. Filipponi. 1986. Catecholamines and pituitary function. V. Effect of low-dose die infusion on basal and gonado~p~rel~g hormone stimulated gonadotropin release in normal cycling women and patients with hyperprolactinemic amenorrhea. Horm. Metab. Res. 18:479~84. Nicolson, G. L., and R. Yana~machi. 1979. Cell surface changes associated with the epididymal maturation of mammalian spermatozoa, pp.l87-194. In D. W. Fawcett and J. M. Bedford, ED The Spermatozoon. Maturation, Motility, Surface Properties and Compara tine aspects. Baltimore: Urban&Schwarzenberg. NIEHS (National Institute for Environmental Health Sciences), Task Force 3. 1985. Biochemical and Cellular Markers of Chemical Eyesore and Preclinical Indicators ofDisease. Wathington,D.C.: US.DeEme- ment of Health and Human Services. Niendorf, van F. 1964. Po~;permie und spontanabort. G,rnaecologia 158:35~1. NBcolopoulou, M., D. A. Soucek, and J. C. Vaty. 1985. Changes in the lipid content of boar sperm plasma membranes curing epidipymalmaturation. Biochim. Biophys. Acta 815:4~498. Nilsson, O. 1970. Some ultrastructrual aspects of ovo- implantation, pp. 5~72. In P. O. Hubinont, F. Leroy, C. Robyn, and P. Leleux, Eds. Ov - Implantation,

REFERENCES Human Gonadotropins and Prolactin. Basel: S. Karger. Nishikawa, Y., and Y. Waida. 1952. Studies on the maturation of spermatozoa. I. Natl. Inst. Agr. Sci. B. Ser. G:Anim. Husb. 3:69-81. Nistal Martin de Serrano, M., and R. Paniagua Gomez- Alvarez. 1984. Testicular and Epididymal Pathology. New York: Thieme-Stratton. 358 pp. Norppa, H., M. Sorsa, H. Vainio, P. Grohn, E. Heinonen, L. Holsti, and E. Nordman. 1980. Increased sister chromatic exchange frequencies in lymphocytes of nurses handling cytostatic drugs. Scand. J. Work Environ. Health 6:299-301. Noyes, R. W., A. W. Hertig, and J. A. Rock. 1950. Dating the endometrial biopsy. Fertil. Steril. 1:3- 25. Noyes, R. W., Z. Dickmann, L. L. Doyle, end A. H. Gates. 1063. Ovum transfers, synchronous and asynchronous, in the study of implantation, pp. 197-212. In A. C. Enders, Ed. Delayed Implantation. Published for William Marsh Rice University by the University of Chicago Press. NRC (NationalResearch Council). 1982. Identifying and Estimating the Genetic Impact of Chemical Muta- gens. Washington, D. C.: National Academy Press. 316 pp. NRC (National Research Council). 1983. Risk Assess- ment in the Federal Government: Managing the Process. Washington, D.C.: National Academy Press. 191 pp. NRC (National Research Council). 1985. Epidemiology end Air pollution. Washington,D.C.: NationalAca- demy Press. 224 pp. NBC (National Research Council). 1986. Emironmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects. Washington,D.C.: NationalAcademy Press. 337 pp. NRC (National Research Council). In press. Drinking Water and Health, Volume 9. Washington, D.C.: National Academy Press. O'Brien, W. F. 1984. Midtrimesterzenetic amniocentesis: A review of the fetal risks. J. Reprod. Med. 29:59- 63. O'Callaghan, J. P., and D. B. Miller. 1983. Nervous- system specih~c proteins as biochemical indicators of neurotoxicity. Trends Phar. 4:338-390. O'Callaghan, J. P., and D. B. Miller. 1984. Neuron- specific phosphoproteins as biochemical indicators of neurotoxicity: Effects of acute administration of trimethyltin to the adult rat. J. Pharmacol. Exp. Ther. 231:73~743. O'Donnell, J. P., and M. Van Tuinan. 1979. Behavior problems of preschool children: Dimensions and congenital correlates. J. Abnorm. Child Psychol. 7:61- 75. Oakberg, E. F. 1975. Radiation response of spermato- gonial stem-cells in mouse. Radiat. Res. 59:43 44. (Abstract.) Oakberg, E. F. 1978. Differential spermatogonial stem- 355 cell sun~val and mutation frequency. Mutat. Res. 50:327-340. Ojeda, S. R., W. W. Andrews, J. P. Advis, and S. S. White. 1980. Recent advances in the endocrinology of puber- ty. Endocr. Rev. 1:22~257. Okey, A. B., E. A. Roberts, P. A. Harper, and M. S. Denison. 1986. Induction of drug-metabolizing en- zymes: Mechanisms and consequences. Clin. Biochem. 19:132-141. Olson, G. E. 1982. The human spermatozoon, pp. 72- 111. In D. Hamilton and F. Naftolin, Eds. Basic Reproductive Medicine. Volume 2: Reproductive Function in Men. Cambridge, Mass.: MIT Press. Olson, G. E., and M.-C. Orgebin-Crist. 1982. Sperm surface changes during epididymal maturation. Ann. N.Y. Acad. Sci. 383:372-392. Omenn, G. S. 1986. Susceptibility to occupational and environmental exposure to chemicals. Prog. Clin. Biol. Res. 214:527-545. Orentreich, N., J. L. Brind, R. L. Rizer, and J. H. Vogel- man. 1984. Age changes and sex differences in serum dehy~androsterone ~lfate concen~ations duw~ out adulthood. J. Clin. Endocrinol. Metab. 59:551- 555. Orgebin-Crist, M.-C. 1967a. Sperm maturation in rabbit epididymis. Nature 216:816-818. Orgebin-Crist, M.-C. 1967b. Maturation of spennatozoa in the rabbit epididymis: Fatiliz~g ability and embry- onic mortality in does inseminated with epidid!'rmal spermatozoa. Ann. Biol. Anim. Biochim. Biophys. 7:373-389. Orgebin-Crist, M.-C. 1968. Maturation of spermatozoa in the rabbit epididymis: Delayed fertilization in does inseniinated with epididymal spermatozoa. J. Reprod. Fertil. 16:29-33. Orgebin-Crist, M.-C. 1969. Studies on the function of the epididymis. Biol. Reprod. (Suppl. 1~:155-175. Orgebin-Crist, M.-C. 1981. Epididymal physiology and sperm maturation, pp. 80 89. In C. Bollack and A. Clavert, Eds. Epididymis and Fertility Biology and Pathology. Progress in Reproductive Biology, Vol. 8. Switzerland: S. Karger. Orgebin-Crist, M.-C. 1984. Physiologie de l'dpididyme, pp. 51~1. In G. Schaison, P. Bouchard, J. Mahoudeau, and F. Labrie, Eds. M6decine de la Reproduction Masculine. Paris: Flammarion. Orgebin~rist, M.-C., and J. Djiane. 1979. Properties of a prolactin receptor from the rabbit epididymis. Biol. Reprod. 21:135-139. Orgebin~rist, M.-C., and S. Fournier-Delpech. 1982. Sperm-egg interaction: Evidence for maturational changes during epididymal transit. J. Androl. 3:429- 433. Orgebin~rist, M.~., and G. E. Olson. 1984. Epididymal sperm maturation, pp. 80 102. In M. Courot, Ed. The Male in Farm Animal Reproduction. Amsterd~n: Martinus Nijhoof. Orgebin-Crist, M.-C., B. J. Danzo, and J. Davies. 1975. Endocnne oon~ol of the devel~nent and maintenance

356 of sperm fertilizing ability in the epididymis, pp.319- 338. In D. W. Hamilton and R. O. Greep, Eds. Hand- book of Physiology, Section 7: Endocrinology. Volume V. Male Reproductive System. Washington, D.C.: American Physiological Society. Orgebin-Crist, M.-C., B. C. Eller, and B. J. Danzo. 1983. The effects of estradiol, tamoxifen, and testosterone on the weights and histology of the epididymis and accessory sex organs of sexually immature rabbits. Endocrinology 113:1703-1715. Orr, W. C., and H. J. Hoffman. 1974. A Gamin cardiac biorhythm: Methodology and data analysis using modi- fied periodograms and complex demodulation. IEEE Trans. Biomed. Eng. 21:130-143. Orsini, L. F., S. Salardi, G. Pilu, L. Bovicelli, and E. Cacciari. 1984. Pelvic organs in premenarchael girls: Real-time ultrasonography. Radiology153:113-116. Orth, J. M., and G. L. Gunsalus. 1987. The Sertoli cell depleted rat: Relationship among Sertoli cell (SC) population size, spermatogenesis and ABP production, pp.61. In M.-C. Orgebin-Crist and B. J. Danzo, Eds. Cell Biology of the Testis and Epididymis. Annals of the New York Academy of Sciences, Vol. 513. New York: New York Academy of Sciences. Osterman-Golkar, S., and L. Ehrenberg. 1983. Dosimetry of electrophilic compounds by means of hemoglobin alkylation. Annul Rev. Public Health 4:397-402. Ostrowski, M. C., M. K. Kistler, and W. S. Kistler. 1979. Purification and cell-free synthesis of a maj or protein from rat seminal vesicle secretion. J. Biol. Chem. 254:383-390. Ostrowski, M. C., M. K. Kistler, and W. S. Kistler. 1982. Effect of castration on the synthesis of seminal vesicle secretory protein IV in the rat. Biochemist~y 21:35^ 3529. OTA (U.S. Congress, Office of Technology Assessment). 1986. Technologies for Detecting Heritable Mutations in Human Beings. OTA-H-298. Washington, D. C.: U.S. Government Printing Office. 144 pp. Otto, D., and L. Reiter. 1984. Developmental changes in slow cortical potentials of young children with elevated body lead burden. Neurophysiological con- siderations. Ann. N.Y. Acad. Sci. 425:377-383. Otto, D., V. A. Benignu$ K E. Muller, and C. N. Barton. 1981. Effects of age and body lead burden on CNS function in young children. I. Slow cortical potentials. Electroencephalogr. Clin. Neurophysiol.52:229-239. Otto, D., V. Benignus, K. Muller, C. Barton, K. Seiple, J. Prah, and S. Schroeder. 1982. Effects of low to moderate lead exposure on slow cortical potentials in young children: Two-year follow-up study. Neuro- behav. Toxicol. Teratol. 4:733-737. Otto, D., G. Robinson, S. Baumann, S. Schroeder, P. Mushak, D. Kleinbaum, and L. Boone. 1985. 5- year follow-up study of children with low-to-moderate lead absorption: Electrophysiological evaluation. Environ. Res. 38:168-186. Overstreet,J. W., R. Yanagmachi, D. F. Katz, K. Hayashi, and F. W. Hanson. 1980. Penetration of human sper- REFERENCES matozoa into the human zone pellucida and the zona- free hamster egg: A study of fertile donors and infer- tile patients. Fertil. Steril. 33:534-542. Overstreet, J. W., M. J. Price, W. F. Blazak, E. L. Lewis, and D. F. Katz. 1981. Simultaneous assessment of human sperm motility and morphology byvideomicro- graphy. J. Urol. 126:357-360. Owen, J. R., S. F. Irani, and A. W. Blair. 1972. Effect of diazepam administered to mothers during labour on temperature regulation of the neonate. Arch. Dis. Child. 47:107-110. Page, R. D., D. Kirkpatrick-Keller, and R. L. Butcher. 1983. Role of age and length of oestrous cycle in alteration of the oocyte and intrauterine environment in the rat. J. Reprod. Fertil. 69:23-28. Palm,J. 1974. Proceedings: Maternal-fetalhistoincom- patibility in rats: An escape from adversity. Cancer Res. 34:2061-2065. Pan, Y. C., F. S. Sharief, M. Okabe, S. Huang, and S. S. L. Li. 1983. Amino acid sequence studies on lactate dehydrogenase C4 isozymes from mouse and rat testes. J. Biol. Chem. 258:7005-7016. PanigeL M., G. Wolfe, and A. Zeleznick. 1988. Magnetic resonance imaging of the placenta in rhesus monkeys, Macaca mulatta. J. Med. Primatol. 17:3-18. Papanicolaou, G. N. 1933. The sexual cycle in the human female as revealed by vaginal smears. Am. J. Anat. [Suppl. 523:519~37. Paris, F. X., J. Henry-Suchet, L. Tesquier, T. Loysel, V. Loffredo, and J. P. Pez. 1984. Le traitement medical des grossesses extra-utetrines par le RU486. Un moyen d'eviter la chirugie. Presse Med. 13~19~:1219. Paris, F. X., J. Hen~y-Suchet, L. Tesquier, T. Loysel, J. P. Pez, V. Loffredo, M. Roger, and J. De Brux. 1986. Interet d'un steroide action antiprogesterone dans le trautenebt de la grissesse extra-uterine. [The value of an antiprogesterone steroid in the treatment of extra-uterine pregnancy. Preliminary results.] Rev. Fr. Gynecol. Obstet. 81:33-35. Parks, D. R., V. M. Bryan, V. T. Oi, and L. A. Herzen- berg. 1979. Antigen-specific identification and cloning of hybridomas with a fluorescence activated cell sorter. Proc. Natl. Acad. Sci. USA 76:1962-1966. Parks, J. S. 1988. Short stature and delayed puberty, pp. 531-534. In J. W. Hurst, Ed. Medicine for the Practicing Physician, 2nd ed. Boston: Butterworths. Parks, J. S., P. V. Nielsen, L. A. Sexton, and E. H. Jorgen- sen. 1985. A effect of gene dosage on production of human chorionic somatomammotropin. J. Clin Endocrinol. Metab. 60:994-997. Pedersen, R. A., and F. Mangia. 1978. Ultraviolet- light-induced unscheduled DNA synthesis by resting and growing mouse oopytes. Mutat. Res. 49:425- 429. Pellegrino, L. J., and J. Altman. 1979. Effects of differen- tial interference with postnatal cerebellar neurogenesis on motor performan=, ac~vity levet and maze leaniing of rats: A developmental study. J. Comp. Physiol.

REFERENCES Psychol. 93:1-33. Perera, F. 1986. New approaches in risk assessment for carcinogens. Risk Anal. 6:195-201. Perera, F. P., and I. B. Weinstein. 1982. Molecular epidemiology and carcinogen-DNA adduct detection: New approaches to studies of human cancer causation. J. Chronic Dis. 35:581 600. Perera, F., R. Santella, and M. Poirier. 1986. Biomonitor- ing of workers exposed to carcinogens: Immuneassays to benzo~a~pyrene-DNA adducts as a prototype. J. Occup. Med. 28:1117-1123. Peress, M. R., C. C. Tsai, R. S. Mathur, and H. O. Wil- liamson. 1982. Hirsutism and menstrual patterns in women exposed to diethylstilbestrol in utero. Am. J. Obstet. Gynecol. 144:135-140. Pert, C. B., M. R. Ruff, R. J. Weber, and M. Herkenham. 1985. Neuropeptides and their receptors: A psychoso- maticnetwork. J. Immunol.13542Suppl.~:820s-825s. Pert, C. B., J. Hill, M. R. Ruff, R. M. Berman, W. B. Robbery, L. O. Arthur, F. W. Ruscetti and W. L. Farrar. 1986. Octapeptides deduced from the neuropathic receptor-l~e pattern of antigen T-4 in brain potentially inhibit human immunodeficiencyvirus receptor binding and human T cell infectivity. Proc. Natl. Acad. Sci. USA 83:9254-9258. Peters, P. J., and R. L. Brunner. 1976. Increased running wheel activity and dyadic behavior of rats with hip- pocampal granule cell deficits. Behav. Biol. 16:91- 97. Peters, J., S. T. Ball, and S. J. Andrews. 1986. The detection of gene mutations by electrophoresis, and their analysis, pp.367-374. In C. Ramel, B. Lambert, and J. Magnusson, Eds. Genetic Toxicology of En- vironmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis. Proccedings of the Fourth International Conference on Em~ronmental Mutagens held in Stockholm, Sweden, June 24-28, 1985. New York: Liss. Peters, M. S., M. Rodriguez, and G. J. Gleich. 1986. L~ation of human eosinophil granule major basic protein, eosinophil cationic protein, and eosinophil- derived neurotoxin by immunoelectron microscopy. Lab. Invest. 54:656 666. Petit, L., D. P. Alfano, and J. C. LeBoutillier. 1983. Early lead exposure and the hippocampus: A review and recent advances. NeuroToxicology 4:79-94. Peto, R., F. J. Roe, P. N. Levy, and J. Clack. 1975. Cancer and ageing in mice and men. Br. J. Cancer 32:411~26. Peyser, M. R., D. Ayalon, A. Harell, R. Toaff, and T. Cardova. Stress induced delay of ovulation. Obstet. Gynecol. 42:667-671. Phadke, A. M. 1975. Spermiophage cells in man. Fertil. Steril. 26:76~774. Phillips, D. M. 1972. Comparative analysis of mammalian sperm motility. J. Cell Biol. 53:561-573. Phillips, D. M. 1975. Mammalian sperm structure, pp. 405419. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physiology, Section 7: Endocrinology. 357 Volume V. Male Reproductwe System. Washingron, D.C.: Amencan Physiological Society. Pholpramool, C., and N. Triphrom. 1984. Effects of cholinergic and adrenergic drugs on intraluminal pressures and contractility of the rat testis and epididy- mis in vivo. J. Reprod. Fertil. 71:181-188. Pholpramool, C., R. W. White, and B. P. Setchell. 1982. Influence of androgens on inositol secretion and sperm transport in the epididymis of rats. J. Reprod. Fertil. 66:547-553. Pholpramool, C., O. A. Lea, P. V. Burrow, H. M. Dott, and B. P. Setchell. 1983. l~e effects of acidic epididy- mal glycoprotein (AEG) and some other proteins on the motility of rat epididymal spermatozoa. Int. J. Androl. 6:24~248. PholpramooL C., N. Triphrom, and A. Din-Udom. 1984. Intraluminal pressures in the seminiferous tubules and in different regions of the epididynus in the rat. J. Reprod. Fertil. 71:173-179. Picard, J.-Y., C. Goulut, R. Bourrillon, and N. Josso. 1986. Biochemical analysis of bovine testicular anti- Mullerian hormone. FEBS Lett. 195:73-76. Pierce, J. G., and T. F. Parsons. 1981. Glycoprotein 12o''.~ones: Structure and function. Annul Rev. Bio- chem. 50:465~95. Pierce, J. G., T. Liao, S. M. Howard, B. Shome, and J. S. Cornell. 1971. Studies on the structure of thyrotro- pin: Its relationship to luteinizing hormone. Recent Prog. Horm. Res. 27:165-212. Pijnenborg, R., W. B. Robertson, and I. Brosens. 1985. Mo~phological a~s of placental ontogeny and p}ylo- geny. Placenta 6:155-162. Piomelli, S., B. Davidow, V. F. Guinee, P. Young, and G. Gay. 1973. The FEP (free erythropyte po~phryins3 test: A screening micromethod for lead poisoning. Pediatrics 51:254-259. Platt, L. D., C. A. Walla, R. H. Paul, M. E. Trujillo, C. V. Loesser, N. D. Jacobs, and P. M. Broussard. 1985. A prospective trial of the fetal biophysical profile versus the nonstress test in the management of high- risk pregnancies. Am. J. Obstet. Gynecol. 153:62 633. Pletscher, A. 1968. Metabolism, transfer, and storage of 5-hydroxytryptamine in blood platelets. Br. J. Phar- macol. 32:1-16. Pohl, C. R., D. W. Richardson, J. S. Hutchison, J. A. Germak, and E. Knobil. 1983. Hypophysiotropic signal frequency and the functioning of the pituita~y- ovarian system in the rhesus monk~y. Endocrinology 112:207~2080. Poland, A., end d. C. Knutson. 198Z 2,3,7,~tetrachlorodi- benz~a?nn and related halogenated aromatic hy~ carbons: Examination of the mechanism of toxicity. Annul Rev. Pharmacol. Toxicol. 22:517-554. Pommerrenke, W. T. 1946. Cyclic changes in the physical and chemical properties of cenrical mucus. Am. J. Obstet. Gynecol. 52:1023-1031. Ponzetto, C., and D. J. Wolgemuth. 1985. Haploid expression of a unique c-abl transcript in the mouse

358 male germ line. Mol. Cell Biol. 5:1791-1794. Porter, I. H. 1986. Genetic aspects of preventive medi- cine, pp. 1427-14~. In J. M. Last, Ed Maxcy-Rosen- au Public Health and Preventive Medicine. Norwalk, Conn.: Appleton-Century-Crofts. Porter, S. B., D. E. Ong, F. Chytil, and M. -C. Orgebin- Crist. 1985. Localization of cellular retinol-binding protein and cellular retinoic acid-binding protein in the rat testis and epididymis. J. Androl. 6:197-212. Poskanzer. D. C.. and R. S. Schwab 1961. Studies in , , the epidemiology of Parkinson's disease predicting its disappearance as a major clinical entity by 1980. Trans. Am. Neurol. Assoc. 86:234 235. Pratt, H. P. M. 1977. Utenne proteins and the activation of embryos from mice during delayed implantation. J. Reprod. Fertil. 50:1. Pratt, R., R. I. Grove, and W. D. Willis. 1982. Prescreen- ing for environmental teratogens using cultured mesen- chymal cells from the human embryonic palate. Ter- atogenesis Carcinog. Mutagen. 2:313-318. Pretsch, W. 1986. Protein-charge mutations in mice, pp.38~388. In C. Ramel, B. Lambert, and J. Magnus- son, Eds Genetic Toxicology of Environmental Chemist cars, Part B: Genetic Effects and Applied Mutagenesis. Proceedings of the Fourth International Conference on Environmental Mutagens held in Stockholm, Swe- den, June 24-28, 1985. New York: Liss. Ps~rchoyos, A. 1973. Endocrine control of egg implanta- tion, pp. 187-215. In R. O. Greep, Ed. Handbook of Physiology, Section 7: Endocrinology. Volume II. Female Reproductive System, Part 2. Washington, D.C.: American Physiological Society. Pulsinelli, W. A. 1985. Selective neuronal vulnerability: Morphological and molecular characteristics. Prog. Brain. Res. 63:29-37. Purvis, K., L. Cusan, H. Attramadal, A. Ege, and V. Hansson. 1982. Rat sperm engines during epididymal transit. J. Reprod. Fertil. 65:381-387. Quinn, P. O., and J. L. Rapoport. 1974. Minor physical anomalies and necrologic status in hyperactive boys. Pediatrics 53:742-747. Quinn, P. O., M. Renfield, C. Burg, and J. L. Rapoport. 1977. Minor physical anomalies: A newborn screening and 1-year follow-up. J. Am. Acad. Child Psychiatry 16:662 669. Rabinowitz, M. B., G. W. Wetherill, and J. D. Kopple. 1976. Kinetic analysis of lead metabolism in healthy humans. J. Clin. Invest. 58:260 270. Rabkin, J. G., and E. L. Struening. 1976. Life events, stress, and illness. Science 194:1013-1020. Radwanska, E., H. H. G. McGarrigle, and G. I. M. Swyer. 1976. Plasma progesterone and oestradiol estimations in the diagnosis and treatment of luteal insufficiency in menstruating infertile women. Acta Eur. Fertil. 7:39-47. Radwanska, E., J. Hammond, and P. Smith. 1981. Single midluteal progesterone assay in the management of ovulatory infertility. J. Reprod. Med. 26:85-89. Rakoff, A. E. 1961. Hormonal cytology in gynecology. REFERENCES Clin. Obstet. Gynecol. 4:1045-1061. Ramaley, J. A. 1978. The adrenal rhythm and puberty onset in the female rat. Life Sci. 23:2079-2~7. Randerath, K., M. V. Reddy, and R. C. Gupta. 1981. 32P-labeling test for DNA damage. Proc.Natl.Acad. Sci. USA 78:6126 6129. Randerath, K, E. Randerath, H. P. Agrawad, R. C. Gupta, M. E. Schurdak and M. V. Reddy. 1985. Postlabeling methods for =ogen-DNA adduct anal EN Health Perspect. 62:57-65. Randerath, K., M. V. Reddy, and R. M. Disher. 1986. Age- and tissue-related DNA modifications in un- treated rats: Detection by 32P-post labeling assay and possible significance for spontaneous tumor induce tion and aging. Carcinogenesis 7:1615-1617. Rannevik, G. 1979. Hormonal, metabolic and clinical effects of danazol in the treatment of endometnosis. Postgrad. Med. J. 55(Suppl. 5):14-20. Rapoport, J. L., P. O. Quinn, and F. Lamprecht. 1974. Minor physical anomalies and plasma dopamine- beta-hydroxylase activity in hyperactive boys. Am. J. Psychiatry 131:38~390. Rappold, G. A., T. Cremer, H. D. Hager, K. E. Davies, C. R. Mueller, and T. Yang. 1984. Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes. Hum. Genet. 67:317-325. Rastogi, R. K, M. Milone, M. Di Meglio, M. F. Caliendo, and G. Chieffi. 1979. Effects of castration, Salpha- d~ydrotestosterone and ~pqoterone acetate on enzyme activity in the mouse epididymis. J. Reprod. Fertil. 57:73-77. Ratcliffe, J. M., S. M. Schrader, K. Steenland, D. E. Clapp, T. Turner, and R. W. Hornung. 1987. Semen quality in papaya workers with long term exposure to ethylene dibromide. Br. J. Ind. Med. 44:317-326. Rebar, R. N. 1986. Practical evaluation of hormonal status, pp. 683-733. In S. C. C. Yen and R. B. Jaffe, Eds. Reproductive Endocrinology Physiology, Patho- physiology and Clinical Management. Philadelphia: W. B. Saunders Company. Reddy, M. V., and K Randerath. 1987. 32P-postlabeling assay for carcinogen-DNA adducts: Nuclease P~- mediated enhancement of its sensitivity and applica- tions. Environ. Health Perspect. 76:4147. Reddy, M. V., and K. Randerath. 1988. DNA adduct formation in white blood cells in relation to internal organs of mice given benzo~a)pyrene, d~benzo~c,g~car- bazole, safrole or cigarette smelling condensate. Proc. Annul Meet. Am. Assoc. Cancer Res. 29:A357. (A~ stract.) Reed, E., V. Bonagura, P. Kung, D. W. King, and N. Suciu-Foca. 1983. Anti-idiotypic antibodies to HLA- DR4 and DR2. J. Immunol. 131:289~2894. Reed, E., M. Hardy, C. Latter J. Brensilver, R. McCabe, K Reemtsma, and N. Suciu-Foca. 1985. Anti idiotypic antibodies and their relevance to transplantation. Transplant Proc. 17:735-738. Reeves, D. S., R. C. G. Rowe, M. E. Snell, and A. B. .

REFERENCES W. Thomas. 1973. Further studies on the secretion of antibiotics in the prostatic fluid of the dog, pp. 197-205. In W. Brumfitt, and A. W. Asscher, Eds. UrinaryTract Infection. London: Oxford University Press. Reff, M. E., and E. L. Schneider. 1982. Biologic Markers of Aging: Proceedings of Conference on Nonlethal Biological Markers of Physiological Aging, June 19- 20, 1981. NIH Publication No. 82-2~1. Washington, D.C.: National Institutes of Health. 252 pp. Reich, P. 1987. Medical aspects of sexuality, pp. 22 223. In Harrison's Principles of Internal Medicine, 11th ed. New York: McGraw Hill. Reiter, E. O., and M. M. Grumbach. 1982. Neuroen- docrine control mechanisms and the onset of puberty. Annul Rev. Physiol. 44:595~13. Reiter, L. W. 1982. Developmental neurotomcity of lead: Experimental studies, pp.43-54. In J. J. Chisolm, Jr. and D. M. O'Hara, Eds. Lead Absorption in Children. Management, ClinicaL and Environmental Aspects. Baltimore: Urban & Schwarzenberg. Remuz=, G., D. Marchesi G. Mecca, R. Misiani E. Rossi M. B. Donati, and G. de Gaetano. 1980. Reduction of fetal vascular prostacyclin activity in pre-eclampsia (letter). Lancet 2:310. Reuhl, K R., and L. W. Chang. 1979. Effects of methyl- mercury on the development of the nervous system: A review. NeuroToxicology 1:21-55. Rhoads, G. G., L. G. Jackson, S. E. Schlesselman, F. F. de la Cruz, R. J. Desnick, M. S. Golbus, D. H. Ledbetter, H. A. Lubs, M. J. Mahoney, E. Pergament, J. L. Simpson, R. J. Carpenter, S. Elias, N. A. Gins- berg, J. D. Goldberg, J. C. Hobbins, L. Lynch, P. H. Shiono, R. J. Wapner, and J. M. Zachary. 1989. The safety and efficacy of chorionic villus sampling for early prenatal diagnosis of cytogenetic abnormali- ties. N. Eng. J. Med. 320:609-617. Riad-Fahmy, D., G. F. Read, R. F. Walker, and K. Grif- fiths. 1982. Steroids in saliva for assessing endocrine function. Endocr. Rev. 3:367-395. Rich, K. A., and D. M. De Kretser. 1977. Effect of differing degrees of destruction of the rat ~miniferous epithelium on levels of serum follicle stimulating honnone and an~ binding proteirL Endo~inology 101:959-968. Richards, J. S., J. J. Ireland, M. C. Rao, G. A. Bernath, A. R. Midgley, Jr., and E. Reichert, Jr. 1976. Ovarian follicular development in the rat: Hormone receptor regulation by estradiol, follicle stimulating hormone and luteinizing hormone. Endocrinology 99:1562- 1570. Richardson, S. J., V. Senikas, and J. F. Nelson. 1987. Follicular depletion during the menopausal transition: Evidence for accelerated loss and ultimate exhaustion. J. Clin. Endocrinol. Metabol. 65:1231-1237. Riddick, D. H., and C. B. Hammond. 1975. Adrenal virilism due to 21-hydroxylase deficienc3r in the post- menarchial female. Obstet. Gynecol. 45:21-24.' Riley, E. P., and C. Vorhees, Eds. 1986. Handbook 359 of BehavioralTeratology. New York: Plenum Press. 522 pp. Riley, G. M., E. Dontas, and B. Gill. 1955. Use of serial vaginal smears in detecting time of ovulation. Fertil. Steril. 6:86-102. Ritzen, E. M., S. N. Nayfeh, F. S. French, and M. C. Dobbins. 1971. Demonstration of androgen-binding components in rat epidi~mis cytosol and comparison with binding components in prostate and other tissues. Endocrinology 89:143-151. Riva, M., S. Memet, J. Y. Micouin, J. Huet, I. Treich, J. Dassa, R. Young, J. M. Buhler, A. Sentenac, and P. Fromageot. 1986. Isolation of structural genes for yeast RNA po~merases by immunolo~cal screen- ing. Proc. Natl. Acad. Sci. USA 83:155~1558. Robaire, B., and B. F. Hales. 1982. Regulation of epidid- ymalglutathione S-transferases: Effects of orchidec- tomy and androgen replacement. Biol. Reprod.24:559- 565. Robaire, B., and L. Hermo. 1987. Efferent ducts, epidid- ymis end vas deferens: Structure, functions and their regulation. In E. Knob~ and J. NeilL Eds Physiology of Reproduction. New York: Raven Press. Robaire, B., and B. R. Zirkin. 1981. Hypophysectomy and simultaneous testosterone replacement: Effects on male rat reproduct*e tract and epididymal ^ 5~-reductase and 3cr-hydroxysteroid dehydrogenase. Endocrinology 109:1225-1233. Robaire, B., L. L. Ewing, B. R. Zirkin, and D. C. Irby. 1977. Steroid ^4-5~-reductase and 3~-hydroxysteroid dehydrogenase in the rat epidi~mis. Endocrinology 101:1379-1390. Robaire, B., L. L. Ewing, D. C. Irby, and C. Desjardins. 1979. Interactions of testosterone and estradiol- 17beta on the reproduct*e tract of the male rat. Biol. Reprod. 21:455~63. Robaire, B., H. Scheer, and C. Hachey. 1981. Regulation of epididymal steroid metabolizing en~mes, pp.487- 498. In G. Jagiello and H. J. Vogel, Eds. Bioregula- tors of Reproduction. New York: Academic Press. Roberts, E. A., N. H. Shear, A. B. Okey, and D. K. Manchester. 1985. The Ah receptor and dioxin toxi- city. Chemosphere 14:661~74. Roberts, G. P., J. M. Parker, and S. R. Henderson. 1976. Proteins in human uterine fluid. J. Reprod. Fertil. 48:153-157. Roberts, M. L., W. H. Scouten, and S. E. Nyquist. 1976. Isolation and characterization of the cytoplasmic droplet in the rat. Biol. Reprod. 14:421-424. Roberts, N. S., L. K. Dunn, S. Weiner, L. Godmilow, and R. Miller. 1983. Mid-trimester amniocentesis: Indications, technique, ri~s and potential for prenatal diagnosis. J. Reprod. Med. 28:167-188. Robertson, D. M., H. Suginami, H. H. Montes, C. P. Puri, S. K. Choi, and E. Diczfalusy. 1978. Studies on a human chorionic gonadotropin-l~e material present in non-pregnant subjects. Acta Endocrinol. 89:492-505. Robertson, M. C., B. Gillespie, and H. G. Friesen. 1982.

360 Characterization of the two forms of rat placental lactogen (rPL): rPL'I and rPL-II. Endocrinology 111:1862-1866. Robertson, M. C., R. E. Owens, J. Klindt, and H. G. Friesen. 1984. Ovariectomyleadsto arapidincrease in rat placental lactogen secretion. Endocrinology 114:1805-1811. Robison, A. K, W. A. Schmidt, and G. M. Stancel. 1985. Estrogenic activity of DDT: Estrogen-receptor profiles and the responses of individual uterine cell types following o,p'-DDT administration. J. Toxicol. En- viron. Health 16:493-508. Rocklin, R. E., J. L. Kitzmiller, and M. R. Garvoy. 1982. Maternal-fetal relation. II. Further characterization of an immunologic blocking factor that develops during pregnancy. Clin. Immunol. Immunopathol. 22:305- 315. Rodeck, C. H., and K. H. Nicolaides. 1983a. Fetoscopy and fetal tissue sampling. Br. Med. Bull. 39:332- 337. Rodeck, C. H., and K H. Nicolaides. 1983b. Ultrasound guided invasive procedures in obstetrics. Clin. Obstet. Gynaecol. 10:515-539. Rogan, W. J. 1982. PCBs and cola-colored babies: Japan, 1968, and Taiwan, 1979. Teratology 26:259- 261. Rogan, W. J., J. R. Reigart, and B. C. Gladen. 1986. Association of amino levulinate dehydratase and ferrochelatase inhibition in childhood lead exposure. J. Pediatr. 109:60 64. Rogers, B. J., H. Van Campen, M. Ueno, H. Lambert, R. Bronson, and R. Hale. 1979. Analysis of human spermatozoa! fertilizing ability using zone-free ova. Fertil. Steril. 32:664-670. Rolfe, B. E. 1982. Detection offetalwastage. Fertil. Steril. 37:655 660. Rolfe, B., H. Morton, A. Cavanagh, and R. A. Gardiner. 1983. Detection of an early pregnancy factor-like substance in sera of patients with testicular germ cell tumors. Am. J. Reprod. Immunol. 3:97-100. Rolfe, B., A. Cavanagh, C. Forde, F. Bastin, C. Chen, and H. Morton. 1984. Modified rosette inhibition test with mouse lymphocytes for detection of early pregnancy factor in human pregnancy serum. J. Im- munol. Methods 70:1-11. Roman-Franco, A. A., M. Turiello, B. Albini, E. Ossi, F. Milgrom, and G. A. Andres. 1978. Anti-basement antibodies and antigen-ant~bo~r complexes in rabbits injected with mercuric chloride. Clin. Immunol. Im- munopathol. 9:464~481. Romrell, L. J., A. R. Bellve, and D. W. Fawcett. 1976. Separation of mouse spermatogenic cells by sedimenta- tion velocity. A mo~phological characterization. Dev. Biol. 49:119-131. Rondell, P. 1974. Role of steroid synthesis in the process of ovulation. Biol. Reprod. 10:199-215. Roosen-Runge, E. C. 1969. Comparative aspects of spermatogenesis. Biol. Reprod. l(Suppl.~:24-31. Rosen, S. W. 1986. New placental proteins: Chemistry, REFERENCES physiology and clinical use. Placenta 7:575-594. Rosenberg, J. B., and G. M. Weller. 1973. Minor physical anomalies and academic performance in young school children. Dev. Med. Child Neurol. 15:131-135. Rosenberg, M. J., A. J. Wyrobek, J. Ratcliffe, L. A. Gordon, G. Watchmaker, S. Fox, D. Moore II, and R. W. Hornung. 1985. Sperm as an indicator of reproductive risk amongpetroleum refine~yworkers. Br. J. Ind. Med. 42:123-127. Rosenfeld, D. L., S. Chudow, and R. A. Bronson. 1980. Diagnosis of lutealphase inadequacy. Ob~stet. Gynecol. 56:193-196. Rosenfeld, R. S., B. J. Rosenberg, D. K. Fukushima, and L. Hellman. 1975. 24-Hour secretory pastern of delydroisoandrosterone and dehydroisoandrosterone sulfate. J. Clin. Endocrinol. Metab. 40:85~855. Rossant, J., and L. Ofer. 1977. Properties of extra- embryonic ectoderm isolated from postimplantation mouse emb~yos. J. Emb~ol. Exp. Morphol.39:183- 194. Rossant, J., and W. Tamura-Lis. 1981. Effect of culture conditions on diploid to giant-cell transformation in postimplantation mouse trophoblast. J. Embryol. Eyp. Morphol. 62:217-227. Rosvold, H. E., A. F. M~y, I. Sarason, E. D. Bransome, and L. H. Beck. 1956. A continuous performance test of brain damage. J. Consult. Psychol. 20:343- 350. Rothstein, P., and J. B. Gould. 1974. Born with a habit: Infants of drugaddicted mothers. Pediatr. Clin. North Am. 21:307-321. Rowley, M. J., F. Teshima, and C. G. Heller. 1970. Duration of transit of spermatozoa through the human male ductular system. Fertil. Steril. 21:390 396. Rowley, M. J., D. R. Leach, G. A. Warner, and C. G. Heller. 1974. Effect of graded doses of ionizing radiation on the human testis. Radiat. Res. 59:665- 678. Rudak, E., P. A. Jacobs, and R. Yanagimachi. 1978. Direct analysis of the chromosome constitution of human spermatozoa. Nature 274:911-913. Rugh, R. 1953. Vertebrate radiobiology: Emb~yology. Ann. Rev. Nuclear Sci. 3:271-302. Rugh,R. 1959. Vertebrate radiobiology~embryology). Ann. Rev. Nuclear Sci. 9:493-522. Rui, H., L. Morkas, and K. Pumis. 1986. Time- and temperature-related alterations in seminal plasma constituents after ejaculation. Int. J. Androl. 9:195- 200. Rumack, C. M., M. A. Guggenheim, B. H. Rumack, R. G. Peterson, M. L. Johnson, and W. R. Braithwaite. 1981. Neonatal intracranial hemorrhage and maternal use of aspirin. Obstet. Gynecol. 58:52S 56S. Rumke, P. 1968. Sperm agglutinating autoantibodies in relation to male infertility. Proc. R. Soc. Med. 61:275-278. Rumke, P., and G. Hellinga. 19S9. Autoantibodies against spermatozoa in sterile men. Am. J. Clin. Pathol. 32:357-363.

REFERENCES Rummo, J. H., D. K. Routh, N. J. Rummo, and J. F. Brown. 1979. Behavioral and neurological effects of symptomatic and asymptomatic lead exposure in children. Arch. Environ. Health 34:12~124. Russell, L. B. 1985. Experimental approaches for the detection of chromosomal malsegregation occuring in the germline of mammals, pp. 377-396. In V. L. Dellarco, P. E. Voytik, and A. Hollaender, Eds. Aneuploidy Etiology and Mechanisms. New York: Plenum Press. Russell, L. B., and W. L. Russell. 1954. An analysis of the changing radiation response of the developing mouse embryo. J. Cell. Comp. Physiol. 43(Suppl. 1):103-149. Russell, L. B., and M. D. Shelby. 1985. Tests for herit- able genetic damage and for evidence of aonadal exposure in mammals. Mutat. Res. 154:69-84. Russell, L. D., J. P. Malone, and S. L. Karpas. 1981. Morphological pattern elicited by agents affecting spermatogenesis by disruption of its hormonal stimula- tion. Tissue Cell. 13:369-380. Russell, M. J., G. M. Switz, and K. Thompson. 1980. Olfactory influences on the human menstrual cycle. Pharmacol. Biochem. Behav. 13:737-738. Ruder, M. 1980. Raised lead levels and impaired cogni- tive/behavioural functioning: A review of evidence. Dev. Med. Child Neurol. Suppl. 42:1-36. Sadovsky, E., and W. Z. Polishuk. 1977. Fetal movements in utero: Nature, assessment, prognostic value, tinting of delivery. Obstet. Gynecol. 50:49-55. Safe, S. H. 1986. Comparative toxicology and mechanism of action of polychlorinated dibenz~p-dioxins and d~benzofurans. Annul Rev. Pharmacol.To,cicol.26:371- 399. Safe, S., S. Bandiera, T. Sawyer, L. Robertson, L. Safe, A. Parkinson, P. E. Thomas, D. E. Ryan, L. M. Reik, W. Levin, M. A. Denomme, and T. Fujita. 1985. PCBs: Structure-function relationships and mechanism of action. Environ. Health Perspect. 60:47-56. Saling, P. M. 1982. Development of the ability to bind zonae pellucidae during epididymal maturation: Reversible immobilization of mouse spermatozoa by lanthanum. Biol. Reprod. 26:429436. Saling, P. M. 1986. Mouse sperm antigens that partici- pate in fertilization. IV. A monoclonal antibody prevents zone Formation Or inhibition of the acrosome reaction. Dev. Biol. 117:511-519. Saling, P. M., G. Irons, and R. Waibel. 1985. Mouse sperm antigens that participate in fertilization. I. Inhibition of sperm fusion with the egg plasma mem- brane using monoclonal antibodies. Biol. Reprod. 33:515-526. Salmon, S. E. 1982. Drugs & the immune system, pp. 712-728. In B. G. Katzung, Ed. Basic & Clinical Pharmacology, 2nd edition. LosAltos, Calif.: Lange Medical Publications. Samuels, S. W. 1986. Medical surveillance: Biological, social, and ethical parameters. J. Oca~p. Med.28:572- 577. 361 Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467. Sankaranarayanan, K 1982. Genetic Effects of Ionizing Radiation in Multicellular Eukaryotes and the Assess ment of Genetic Radiation Hazards in Man. Amster- dam: Elsevier Biomedical Press. 385 pp. Santella, R. M. 1987. In vitro testing for carcinogens and mutagens. State Art Rev. Occup. Med. 2~1~:39- 46. Sapolsly, R. M. 1985. A mechanism for glucocorticoid toxicityin the hippocampus: Increased neuronal vul- nerability to metabolic insults. J. Neurosci. 5:1228- 1232. Sapolsky, R. M. 1986. Glucocorticoid toxicity in the hippocampus: Reversal by supplementation with brain fuels. J. Neurosci. 6:2240-2244. Satoh, C., A. A. Awa, J. V. Neel, W. J. Schull, H. Kato, H. B. Hamilton, M. Otake, and K. Goriki. 1982. Genetic effects of atomic bombs. Prog. Clin. Biol. Res. 103(Pt. A.~:267-276. Saxena, B. B., S. H. Hasan, F. Haour, and M. Schmidt- Gollwitzer. 1974. Radioreceptor assay of human chorionic gonadotropin: Detection of early pregnancy. Science 184:793-795. Schacter, B., A. Muir, M. Gyves, and M. Tasin. 1979. HLA-A,B compatibility in parents of offspring with neural-tube defects or couples expressing involuntary fetal wastage. Lancet 1:79~799. Scheer, H., and B. Robaire. 1980. Steroid delta 4-5 alpha-reductase and 3 alpha-hydr~ysteroid debydro- genase in the rat epididymis during development. Endocrinology 107:94~953. Schipper, H., J. R. Brawer, J. F. Nelson, L. S. Felicio, and C. E. Finch. 1981. The role of gonads in the histologic aging of the hypothalamic arcuate nucleus. Biol. Repro. 25:413419. Schlafke, S., and A. C. Enders. 1975. Cellular basis of interaction between trophoblast and uterus at implantation. Biol. Reprod. 12:41~5. Schleicher, G., U. Drews, W. E. Stumpf, and M. Sar. 1984. Differential distribution of dihydrotestosterone and estradiol binding sites in the epididymis of the mouse. An autoradiographic studier. Histochemistry 81:139-147. Schmassmann, A., G. Mikuz, G. Bartsch, and H. Rohr. 1982. Spermiometrics: Objective and reproducible methods for evaluating Sperm morphology. Eur. Urol 8:27~279. Schomberg, D. W. 1979. Steroidal modulation of steroid secretion in vi=: An experimental approach to intra- follicular regulatory mechanisms. Adv. Exp. Med. Biol. 112:155-165. Schou, M., M. D. Goldfield, M. R. Weinstein, and A. Villeneuve. 1973. Lithium end pregnancy. I. Report from the Register of Lithium Babies. Br. Med. J. 2:135-156. Schrag, S. D., and R. L. Dixon. 1985. Occupational exposures associated with male reproductive dysfun~

362 lion. Annul Rev. Pharmacol. Toxicol. 25:567-592. Schull, W. J., M. Otake, and J. V. Neel. 1981a. Genetic effects of the atomic bombs: A reappraisal. Science 213:12~1227. Schull, W. J., M. Otake, and J. V. Neel. 1981b. Hiro- shima and Naga~: A reassessment of the mutagenic effect of exposure to ionizing radiation. In E. B. Hook and I. H. Porter, Eds. Population and Biological Aspects of Human Mutation. New York: Academic Press. Schwartz, D., A. Laplanche, P. Jouannet, and G. David. 1979. Within-subject variability of human semen in regard to sperm count, volume, total number of sper- matozoa and length of abstinence. J. Reprod. Fertil. 57:391-395. Schwartz, J., P. J. Landriga~ R. G. Feldman, E. K Silber- geld, E. L. Baker, Jr., and I. H. von Lindern. 1988. Threshold effect in lead-induced neuropathy. J. Pe- diatr. 112:12-17. Schwartz, M., and R. Jewelewicz. 1981. The use of gonadotropins for induction of copulation. Fertil. Steril. 35:3-12. Searle, A. G., and C. V. Beechey. 1974. Sperm-count, egg-fertilization and dominant lethality after X-irradia- tion. Mutat. Res. 22:63-72. Searle, A. G., and C. V. Beechey. 1985. Noncomplemen- tation phenomena and their bearing on nondisiunction- al effects, pp.363 376. In V. L. Dellarco, P. E. Voytek and A. Hollaender, Eds. Aneuploidy: Etiology and Mechanisms. New York: Plenum Press. Sega, G. A., and J. G. Owens. 1983. Methylation of DNA and protamine by methyl methanesulfonate in the germ cells of male mice. Mutat. Res.111:227- 244. Sega, G. A., and J. G. Owens. 1987. Binding of ethylene oxide in spermiogenic germ cell stages of the mouse after low-level inhalation exposure. Environ. Mol. Mutagen. 10:119-127. Sega, G. A., A. E. Sluder, L. S. McCoy, J. G. Owens, and E. E. Generoso. 1986. The use of alkaline elusion procedures to measure DNA damage in spermiogenic stages of mice exposed to methyl methanesulfonate. Mutat. Res. 159:55~3. Sengelaub, D. R., R. P. Dolan and R. L. Finlay. 1986. Cell generation, death, and retinal growth in the development of the hamster retinal ganglion cell layer. J. Comp. Neurol. 246:527-543. Seppalainen, A. 1978. Diagnostic utility of neuroelectric measures in environmental and occupational medicine, pp. 448 452. In D. A. Otto, Ed. Multidisciplinary Perspectives in Event Related Brain Potential Re- search. EPA600/9-77~43. Washington,D.C.: U.S. Environmental Protection Agency. Seppalainen, A., and S. Hernberg. 1980. Subclinical lead neuropathy. Am. J. Ind. Med. 1:413-420. Seppalainen, A., C. Raitta, and M. S. Huuskonen. 1979. n-Hexane-induced changes in visual evoked potentials and electroretino~yams of industrial workers. Electro- encephalogr. Clin. Neurophysiol. 47:492498. REFERENCES Seppalainen, A., K. Savolainen, and T. Kovala. 1981. Changes induced by xylene and alcohol in human evoked potentials. Electroencephalogr. Clin. Neuro- physiol. 51:14~155. Seshadri, R., E. Baker, and G. R. Sutherland. 1982. Sister-chromatid exchange (SCE) analysis in mothers exposed to DNA damaging agents and their newborn infants. Mutat. Res. 97:139-146. Setchell, B. P., and G. M. H. Waites. 1975. The blood- testis barrier, pp. 143-172. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Physiology, Section 7: Endocrinology. Volume V. Male Reproductive System. Washington,D.C.: American Physiological Society. Sever, J. L., and R. L. Brent. 1986. Teratogen Update. Environmentally Induced Birth Defect Risks. New York: Liss. 248 pp. Sever, L. W., and N. A. Hessol. 1985. Toxic effects of occupational and environmental chemicals on the testes, pp. 211-248. In J. A. Thomas, K. S. Korach and J. A. McLachlan, Eds. Endocrine Toxicology. Target Organ Toxicology Series. New York: Raven Press. Shackleton, C. H. L. 1986. Profiling steroid hormones and urinary steroids. J. Chromatogr. 379:91-156. Shaha, C., A. S. Liotta, D. T. Krieger, and C. W. Bardin. 1984. The ontogeny of immunoreactiveB-endorphin in fetal, neonatal, and pubertal testes from mouse and hamster. Endcrinology 114:1584 1591. Shalgi, R., J. Dor., E. Rudak, A. Lu sky, B. Goldman, S. Mashiach, and L. Nebel. 1985. Penetration of sperm from teratospennic men into zone-free hamster eggs. Int. J. Androl. 8:285-294. Shamsuddin, A. K. M., N. T. Sinopoli, K. Hemminki, R. R. Boesch, and C. C. Harris. 1985. Detection of benzoia~pyrene: DNA adducts in human white blood cells. Cancer Res. 45:66-68. Shangold, M. M., M. L. Gatz, and B. Thysen. 1981. Acute effects of exercise on plasma concentrations of prolactin and testosterone in recreational women runners. Fertil. Steril. 35:699-702. Shapiro, G., and S. Evron. 1980. A novel use of Spiro lactone: Treatment of hinutism. J. Clin. Endocrinol. Metab. 51:429-432. Shapiro, S. S., and P. Thiagarajan. 1982. Lupus antico- agulants. Prog. Hemost. Thromb. 6:263-285. Sheehan, H. L. 1968. Neurohypophysis and hypothala- mus, pp. 12-74. In J. M. B. Bloodworth, Jr., Ed. Endocrine Pathology. Baltimore, Md.: Williams & Wilkins. Shepard, T. H. 1986. Human teratogenicity. Adv. Pedi- atr. 33:225-268. Sherins, R. J., and S. S. Howards. 1986. Male infertility, pp. 64~697. In Campbell's Urology, 5th ed. Philadel- phia: W. B. Saunders Company. Sherins, R. J., D. Brightwell, and P. M. Sternthal. 1977. Longitudinal analysis of semen of fertile and infertile men' pp. 473488. In P. Troen and H. R. Nankin, Eds. The Testis in Normal and Infertile Men. New

REFERENCES York: Raven Press. Sherins, R. J., A. P. Patterson, D. Brightwell, R. Udels- man, and J. Sartor. 1982. Alterations in the plasma testosterone:estradiol ratio: An alternative to the inhibin hypothesis. Ann. N.Y. Acad. Sci. 383:295- 306. Sherman, B. M., and S. G. Korenman. 1975. Hormonal characteristics of the human manual We Tout reproductive life. J. Clin. Invest. 55:699-706. Sherman, B. M., J. H. West, and S. G. Korenman. 1976. The menopausal transition: Analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. Endrocinol. Metab. 42:629-636. Sherman, M. I., and L. R. Wudl. 1976. The implanting mouse blastocyst, pp. 81-125. In G. Poste and G. L. Nicolson, Eds. The Cell Surface in Animal Emb~yo- genesis and Development. Amsterdam: Elsevier- North Holland. Sherman, M. I., A. McLaren, and P. M. B. Walker. 1972. Mechanism of accumulation of DNA in giant cells of mouse trophoblast. Nature 238:175-176. Shiu, R. P. C., and H. G. Friesen. 1980. Mechanism of action of prolactin in the control of mammary gland function. Annul Rev. Physiol. 42:83-96. Short, R. V. 1962. Steroids in the follicular fluid and the corpus luteum of the mare. A "two-cell type" theory of ovarian steroid synthesis. J. Endocrinol. 24:59-63. Short, R. V. 1979. When conception fails to become a pregnancy, pp.377-387. In Maternal Recognition of Pregnancy. CIBA Foundation Symposium 64 (New Series). Amsterdam: Excerpta Medical Shum, S., N. M. Jensen, and D. W. Nebert. 1979. The murine Ah locus: In utero toxicity and teratogenesis associated with genetic differences in benzota]pyrene metabolism. Teratology 20:365-376. Sidman, R. L. 1961. Histogenesis of mouse retina studied with thyrnidine-H3, pp. 487-506. In G. K. Smelser, Ed. Structure of the Eye. New York: Academic Press. Sidman, R. L., I. L. Miale and N. Feder. 1959. Cell proliferation and migration in the primitive ependymal zone: An autoradiographic study of histogenesis in the nervous system. Exp. Neurol. 1:322-333. Sigler, A. T., B. H. Cohen, A. M. Lilienfeld, J. E. West- lalce, and W. H. Hetznecker. 1967. Reproductive and marital experience of parents of children with Down's Syndrome (mongolism). J. Pediatr. 70:608- 614. Silber, S. J., and L. J. Rodriguez-Rigau. 1981. Quantita- tive analysis of testicle biopsy Determination of partial obstruction and prediction of sperm count after surgery for obstruction. Fertil. Steril. 36:480-485. Silbergeld, E. K. 1983. Experimental studies of lead neurotoxicity: Implications for mechanisms, dose- response and reversibility, pp.191-216. In M. Rutter and R. Russell Jones, Eds. Lead Versus Health: Sources and Effects of Low Level Lead. New York: 363 John Wiley & Sons. Silbergeld, E. K. 1985. The relevance of animal models for neurotoxic disease states. Int. J. Mental Health 14:2~43. Silbergeld, E. K., and J. J. Chisolm, Jr. 1976. Lead poisoning Altered urinary catecholamine metabolites as indicators of intoxication in mice and children. Science 192~4235~:153-155. Silbergeld, E. K, and R. E. Hn~a. 1980. Neurochemical investigations of low lead exposure, pp. 135-152. In H. L. Needleman, Ed. Low Level Lead Exposure: The Clinical Implications of Current Research. New York: Raven Press. Silbergeld, E. K., J. Schwartz, and K. Mahaffey. 1988. Lead and Osteoporosis: Mobilization of lead from bone in postmenopausal women. Environ. Res. Silkworth, J. B., L. Antrim, and L. S. Kaminsly. 1984. Correlations between polychlorinated biphenyl im- munotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice. Toxicol. Appl. Pharmacol. 75:15 165. Simonds, J. F., and L. Aston. 1981. Relationship between minor physical anomalies, perinatal complications, and psychiatric diagnoses in children. Psychiatry Res. 4:181-188. Simpson, J. L., M. S. Golbus, A. O. Martin, and G. E. Sarto. 1982. Genetics in Obstetrics and Gynecology. New York: Grune & Stratton. 322 pp. Sims, D. G., and G. A. Neligan. 1975. Factors affecting the increasing incidence of severe non-hemolytic neonatal jaundice. Br. J. Obstet. Gyencol. 82:863- 867. Singhal, R. L., and J. A. Thomas, Eds. 1980. Lead Toxicity. Baltimore: Urban&Schwarzenberg. 514 PP Sinosich, M. J., J. G. Grudzinskas, and D. M. Saunders. 1985. Placental proteins in the diagnosis and evalua- tionofthe"elusive"earlypregnancy. Obstet.Gynecol. Sum. 40:273-282. Skare, J. A., and K. R. Schrotel. 1984. Alkaline elusion of rat testicular DNA: Detection of DNA strand breaks after in vrvo treatment with chemical mutagens. Mutat. Res. 130:283-294. Skinner, M. K., and M. D. Griswold. 1982. Secretion of testicular transferrin by cultured Sertoli cells is regulated by hormones and retinoids. Biol. Reprod. 27:211-221. Skinner, M. K., L. Cosand, and M. D. Griswold. 1984. Purification and characterization of testicular transfer- rin secreted by rat Sertoli cells. Biochem. J. 218:313- 320. Smalley, S. L., R. F. Asarnow, and M. A. Spence. 1988. Autism and genetics. A decade of research. Arch. Gen. Psychiatry 45:953-961. Smith, D. M., and A. E. Smith. 1971. Uptake and incor- poration of amino acids by cultured mouse embryos: Estrogen stimulation. Biol. Reprod. 4:66-73. Smith, F. W., A. H. Adam, and W. D. P. Phillips. 1983.

364 NMR imaging in pregnancy (letter). Lancet 1:61- 62. Smith, K. D., L. J. Rodriquez-Rigau, and E. Steinberger. 1977. Relation between indices of semen analysis and pregnancy rate in infertile couples. Fertil. Steril. 28:1314-1319. Smith, N. J. 1980. Excessive weight loss and food aver- sion in athletes simulating anorexia nervosa. Pediatrics 66:139-142. Smith, P. J. 1985. Behavioral toxicology: Evaluating cognitive function. Neurobehav. Toxicol. Teratol. 7:345-350. Snyder, S. H. 1984. Neurosciences: An integrated discipline. Science 225:1255-1257. Soares, M. J., and F. Talamantes. 1985. Placental lac- togen secretion in the mouse: In vitro responses and hormonal influences. J. Exp. Zool. 234:97-104. Soares, M. J., P. Colosi, and F. Talamantes. 1982. The development and characterization of a homologous radioimmunoassay for mouse placental lactogen. En- docrinology 110:668 670. Soares, M. J., J. A. Julian, and S. R. Glasser. 1985. Trophoblast giant cell release of placental lactogens: temporal and regional characteristics. Dev. Biol. 107:520-526. Soberon, J., J. J. Calderon, and J. W. Goldzieher. 1966. Relation of panty to age at menopause. Am. J. Obstet. Gynecol. 96:96-100. Sommer, B. 1978. Stress and menstrual distress. J. Hum. Stress 4~3~:5-10,4147. Sommer, G., T. Brosnan, Q. Cao, D. Nishimura, A. Macovski, and J. McNeal. 1988. Noise reduced pros- tatic MR imaging: Work in progress. Radiology 169:347-350. Song, B. J., H. V. Gelboin, S. S. Park, G. C. Tsokos, and F. K. Friedman. 1985. Monoclonal antibody- directed radioimmunoassay detects cytochrome P- 450 in human placenta and lymphocytes. Science 228~4698~:49~492. Soules, M. R., R. H. Wiebe, S. Aksel, and C. B. Ham- mond. 1977. The diagnosis and therapy of luteal phase deficiency. Fertil. Steril. 28:1033-1037. Soules, M. R., G. P. Sutton, C. B. Hammond, and A. F. Haney. 1980. Endocrine changes at operation under general anesthesia: Reproductive hormone fluctuations in young women. Fertil. Steril. 33:364 371. Soyka, L. F., and J. M. Joffe. 1980. Male mediated drug effects on offspring. Prog. Clin. Biol. Res. 36:49- 66. Speight, A. N. 1977. Floppy-infant syndrome and mater- nal diazepam and/or nitrazepam [letter]. Lancet 2:878. Speroff, C., R. H. Glass, and N. G. Kase. 1983. Clinical Gynecologic Endocrinology and Infertility. 3rd ed. Baltimore: Williams & Willcins. Spyker, J. M., S. B Sparber, and A. M. Goldberg. 1972. Subtle consequences of methylmercu~y exposure: Behavioral deviations in offspring of treated mothers. REFERENCES Science 177:621-623. Stamey, T. A., S. R. M. Bushby, and J. Bragonje. 1973. The concentration of trimethopnm in prostatic fluid: Nonionic diffusion or active transport? J. Infect. Dis. 128(Suppl.~:686 692. Stanker, L. H., A. Wyrobek, and R. Balhorn. 1987a. Monoclonal ant~odies to human protamines. Hybrid- oma 6:293-303. Stanker, L. H., B. Watkins, N. Rogers, and M. Vander- laan. 1987b. Monoclonal antibodies for dioxin: Antibody characterization and assay development. Toxicology 45:229-243. Stave,U. 1978. PennatalPhysiology. New York: Plen- um Medical Book. 851 pp. Steenhout, A., and M. Pourtois. 1981. Lead aca~mulation in teeth as a function of age with different exposures. Br. J. Ind. Med. 38:297-303. Steg, J., and J. L. Rapoport. 1975. Minor phyiscal anom- alies in normal neurotic, learning disabled, and severe- ly disturbed children. J. Autism Child Schizophr. 5:299-303. Steinberger, A., and E. Steinberger. 1976. Secretion of an FSH-inhibiting factor by cultured Sertoli cells. Endocrinology 99:91~921. Stewart, T. A., A. R. Bellve, and P. Leder. 1984. Trans- cription and promoter usage of the myc gene in normal somatic and spermatogenic cells. Science 226:707-710. Stock, R. J., J. B. Josimovich, B. Kosor, A. Klopper, and G. R. Wilson. 1971. The effect of chorionic gonado- tropin and chorionic somatomammotropin on steroido- genesis in the corpus luteum. J. Obstet. Gynaecol. Br. Commonw. 78:549-553. Stoetzer, H., A. Niggenschulze, W. Froe~e, and D. Elich. 1987. The action of methylthiouracil on the thyroid of rats of the F1 and F2 generation, pp. 109-120. In T. Fujii and P. M. Adams, Eds. Functional Terato- genesis: Functional Effects on the Offspring after Parental Drug Exposure. Tolyo: Teikyo University Press. Stone, M. L., L. J. Salerno, M. Green, and C. Zelson. 1971. Narcotic addiction in pregnancy. Am. J. Obstet. Gynecol. 109:71~723. Streissguth, A. P., H. M. Barr, and D. C. Martin. 1984. Alcohol exposure in utero and functional defilcits in children during the first four years of life, pp. 17 196. In Mechanisms of Alcohol Damage in utero. CIBA Foundation Symposium 105. London: Pitman. Strobino, B. R., J. Kline, and Z. Stein. 1978. Chemical and physical exposure of parents: Effects on human reproduction. Early Hum. Dev. 1:371-399. Stumpf, W. E., M. Sar, and L. D. Grant. 1980. Autora- diographic localization of 2~0Pb amid its decay products in rat forebrain. Neurotoxicology 1:593- 606. Suciu-Foca, N., E. Reed, C. Rohowsky, P. Kung, and D. W. King. 1983. Anti-idiotypic antibodies to anti- ~A receptors induced bypregancy. Proc. Natl. Acad. Sci. USA 80:830~34.

REFERENCES Surani, M. A. H. 1975. Hormonal regulation of proteins in the uterine secretion of ovariectm~zed rats and the implications for implantation and embryonic dia- pause. J. Reprod. Fertil. 43:411~17. Suskind, R. R. 1985. Chloracne, "the hallmark of dioxin intoxication". Scand. J. Work Environ. Health 11~3 Spec. No.~:165-171. Sutherland, J. M. 1959. Fatal cardiovascular collapse of infants receiving large amounts of chloramphenicol. A.M A. J. Dis. Child. 97:761-767. Suzuki, F., and T. Nagano. 1978. Regional differentiation of cell junctions in the excurrent duct epithelium of the rat testis as revealed by freeze-fracture. Anat. Rec. 191:503-519. Sved, A. F. 1983. Precursor control of the function of monoaminergic neurons, pp.223-275. In R. J. Wurt- man and J. J. Wurtman, Eds. Nutrition and the Brain, Vol.6. Physiological and Behavioral Effects of Food Constituents. New York: Raven Press. Swaab, D. F., and E. Fliers. 1985. A sexually dimorphic nucleus in the human brain. Science 228:1112-1115. Swerdloff, R. S., and P. C. Walsh. 1973. Testosterone and oestradiol suppression of LH and FSH in adult male rats: Duration of castration, duration of treat- ment and combined treatment. Acta Endocnnol. 73:11-21. Swierstra, E. E. 1971. Sperm production of boars as measured from epididymal sperm reserves and quan- titative testicular histology. J. Reprod. Fertil. 27:91- 99. Sylvan, P. E., D. T. MacLaughlin, G. S. Richardson, R. E. Scully, and N. Nikrui. 1981. Human uterine fluid proteins associated with secretory phase endometrium: Progesterone-induced products? Biol. Reprod.24:423 429. Sylvester, S. R., M. K. Skinner, and M. D. Griswold. 1984. A sulfated glycoprotein synthesized by Sertoli cells and by epididymal cells is a component of the sperm membrane. Biol. Reprod. 31:1087-1101. Talamantes, F., L. Ogren, E. Markoff, S. Woodward, and J. Madrid. 1980. Phylogenetic distribution, regula- tion of secretion, and prolactin-like effects of placental lactogens. Fed. Proc. 39:2582-2587. Tanner, J. M. A. 1981. A Histo~y of the Study of Human Growth. Cambridge: Cambridge University Press. Tate, S. S., and J. Orlando. 1979. Conversion of glutathi- one to glutathione disulfide, a catalytic function of gamma-glutamyl transpeptidase. J. Biol. Chem. 254:5573-5575. Tates, A. D., and P. deBoer. 1984. Further evaluation of a micronucleus method for detection of meiotic micronuclei in male germ cells of mammals. Mutat. Res. 140:187-191. Taylor, C., and W. P. Faulk. 1981. Prevention of recur- rent abortion with leucocyte transfusions. Lancet 2:6~70. Taylor, C., W. P. Faulk, and J. A. McIntyre. 1985. Prevention of recurrent spontaneous abortions by leuco~rte transfusion. J. R. Soc. Med. 78:623-627. 365 Templado, C., F. Vidal, J. Navarro, and J. Egozcue. 1986. Improved technique for the study of meiosis in ejaculate: Results of the first 50 consecutive cases. Hum. Genet. 72:275-277. Terasawa, E. 1985. Developmental changes in the posi- tive feedback effect of estrogen on lutein~zing hormone release in ovariectomized female rhesus monkeys. Endocrinology 117:249~2497. Teratology Society. 1987. Recomendations for Vitamin A use inpregnan~y. Teratology Society Position Paper. Teratology 35:269-275. Thau, R. B., Y. Yamamoto, M. Goldstein, P. H. Ehrlich, S. S. Witkin, G. N. Burrow, R. E. Canfield, and C. W. Bardin. 1983. Characterization of a human anti- hCG antiserum: A proposed standard for laboratories involved with the development of hCG vaccines. Contraception 27:627 637. Thiissen, J. H., J. Poortman, F. Schwa=, and F. de Waard. 1975. Post-menopausal estrogen production, with special reference to patients with mammary carcinoma. Front. Horm. Res. 3:45~2. Thomas, M. L., J. H. Harger, D. K Wagener, B. S. Rabin, and T. J. Gill, 3d. 1985. HLA sharing and spontane- ous abortion in humans. Am. J. Obstet. Gynecol. 151:1053-1058. Tice, R. R., B. Lambert, K Morimoto, end A. Hollaender. 1984. A review of the International Symposium on Sister Chromatid Exchanges: Twenty-f~ve years of experimental research. Environ. Mutagen. 6:737- 752. Tietz, N. W., O. Sheremeta, and E. Bukay. 1971. Gas chromatographic separation and determination of 17-ketosteroids, prenanediol and pregnanetriol, p. 525 537. In F. W. Sunderman, and F. W. Sunderman, Jr., Eds. Laborato~y Diag ~osis of Endocrine Disease. St. Louis, Mo.: Warren H. Green. Tilson, H. A., and D. C. Wright. 1985. Interpretation of behavioral teratology data. Neurobehav. Toncol. Teratol. 7:667 668. Tilson, H. A., G. J. Davis, J. A. McLachlan, and G. W. Lucier. 1979. The effects of polychlorinated biphenyls grven prenatally on the neurobehavioral development of mice. Environ. Res. 18:4~474. Timourian, H., J. B. Bishop, and A. J. Wyrobek. 1983. Sperm shape abnormalities in the offspring of male mice treated with triethylenemelamine (TEM). En- viron. Mutagen. 5:399. Tindall, D. J., V. Hansson, W. S. McLean, E. M. Ritzen, S. N. Nayfeh, and F. S. French. 1975. Androgen- binding proteins in rat epididymis: Properties of a cytoplasmic receptor for androgen similar to the andr~ gen receptor in ventral prostate and different from androgen-binding protein (ABP). Mol. Cell. Endocrin- ol. 3:83-101. Tinneberg, H. R., R. P. Staves, V. Hanf, W. Scholz, K. Semm, and L. Mettler. 1985. Use of a modified test system to determine early pregnancy factor (EPF) levels in patients with normal first trimester pregnancy and after therapeutic abortion. Ann. N.Y. Acad. Sci.

366 442:551-557. Tolls, G., D. Ruggere, D. R. Popkin, J. Chow, M. E. Boyd, A. De Leon, A. B. Lalonde, A. Asswad, M. Hendelman, V. Scali, R. Koby, G. Arronet, B. Yufe, F. J. Tweedie, P. R. Fournier, and F. Naftolin. 1979. Prolonged amenorrhea and oral contraceptives. Fertil. Steril. 32:265-268. Toman, Z., C. Dambly-Chaudiere, L. Tenenbaum, and M. Radman. 1985. A system for detection of genetic and epigenetic alterations in Escherichia cold induced by DNA-damaging agents. J. Mol. Biol.186:97-105. Toowicharanont, P., and M. Chulavatnatol. 1983. Meas- urement of anionic sites of rat epididymal spermatozoa using tritiated polycationized ferritin. J. Reprod. Fertil. 69:303-306. Torry, D. S., J. A. McIntyre, W. P. Faulk, and P. R. McConnachie. 1986. Inhibitors of complement- mediated cytotoxicity in normal and secondary aborter sera. Am. J. Reprod. Immunol. Microbiol. 10:53- 57. Trapp, M., V. Baukloh, H. G. Bohnet, and W. Heeschen. 1984. Pollutants in human follicular fluid. Fertil. Steril. 42:146-148. Trasler, J. M., B. F. Hales, and B. Robaire. 1985. Pater- nal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility. Nature 316:144-146. Trasler, J. M., B. F. Hales, and B. Robaire. 1986. Chronic low-dose cyclophosphamide treatment of adult male rats: Effects on fertility, pregnan~ outcome and progeny. Biol. Reprod. 34:275-283. Trasler, J. M., B. F. Hales, and B. Robaire. 1987. A time~urse study of chronic paternal cyclophosphamide treatment in rats: Effects on pregnancy outcome and the male reproductive and hematolog~c systems. Biol. Reprod. 37:317-326. Trasler, J. M., L. Hermo, and B. Robaire. 1988. Mor- phological changes in the testis and epididymis of rats treated with pyclophosphamide: A quantitative approach. Biol. Reprod. 38:463479. Treloar, A. E., R. E. Boynton, B. G. Behn, and B. W. Brown. 1970. Variation of the human menstrual cycle throughout reproduct*e life. Int. J. Fertil. 12:77- 126. Trillingsgaard, A., O. N. Hansen, and I. Bessel 1985. The Bender-Gestalt Test as a neurobehavioral measure of preclinical visual-motor integration deficits in chil- dren with low-level lead exposure, pp. 189-193. In Neurobehavioral Methods in Occupational and En- vironmental Health. WHO Environmental Health Document 3. Copenhagen: World Health Orgariiza- tion. Trimble, G. X., F. A. Finnerty, N. S. Assali, and S. L. Leiken. 1964. Thiazide and neonatal thrombocyto- penia (letter). N. Engl. J. Med. 271:160. Trounson, A. O., M. Mahadevan, J. Wood, and J. F. Leeton. 1980. Studies on the deep-freezing and artificial insemination of human semen, pp. 173- 185. In D. W. Richardson, D. Joyce, and E. M. REFERENCES Symonds, Eds. Frozen Human Semen. The Hague: Martinus Nijhoff. Tsai. S. P.. and C. P. Wen. 1986. A review of methodo- logical issues of the standard~zed mortality ratio (SMR) in occupational cohort studies. Int. J. Epidemiol. 15:8-21. Tsong, S. D., D. Phillips, N. Halmi, A. S. Liotta, A. Mar- gioris, C. W. Bardin, and D. T. Krieger. 1982a. ACTH and B-endorphin-related peptides are present in multi- ple sites in the reproductive tract of the male rat. Endocrinology 110:2204 2206. Tsong, S. D., D. M. Phillips, N. Halmi, D. Krieger, and C. W. Bardin. 1982b. B-endorphin is present in the male reproductive tract of f~ve species. Biol. Reprod. 27:755-764. Turk, J. L. 1975. Delayed Hypersensitivity, 2nd ed. Frontiers of Biology, Vol. 4. Amsterdam: North Holland. 319 pp. Turner, T. T. 1979. On the epididymis and its function. Invest. Urol. 16:311-321. Turner, T. T., and D. M. Cesarini. 1983. The ability of the rat epididymis to concentrate spermatozoa: Responsiveness to aldosterone. J. Androl. 4:197- 202. Turner, T. T., and R. D. Giles. 1982. Sperm motility- inhibiting factor in rat epididymis. Am. J. Physiol. 242:R199-R203. Turner,T. T., end S. S. Howards. 1985. The tenacity of the blood-testis and blood-epididymal barriers, pp.383-393. In T. J. Lobl and E. S. E. Hafez. Male Fertility and Its Regulation. New York: MIP Press. Turner, T. T., and A. D. Johnson. 1973. The metabolic activity of the bovine epididymis. I. Utilization of glucose and fructose. J. Reprod. Fertil. 34:201-213. Turner, T. T., R. D. Giles, and S. S. Howards. 1981. Effect of oestradiol valerate on the rat blood—testis and blood—epididymal barriers to [3H] inulin. J. Reprod. Fertil. 63:355-358. Turner, T. T., C. E. Jones, S. S. Howards, L. L. Ewing, B. Zegeye, and G. L. Gunsalus. 1984. On the andro- gen microenvironment of maturing spermatozoa. Endocrinology 115:1925-1932. Tyler, J. P. P., N. G. Crockett, and L. Driscoll. 1982. Studies of human seminal parameters with frequent ejaculation. I. Clinical characteristics. Clin. Reprod. Fertil. 1:273-285. Tzartos, S. J., and M. S. H. Surani. 1979. Affinity of uterine luminal proteins for rat blasto~sts. J. Reprod. Fertil. 56:579-586. Ullsa-Aguirre, A., and S. C. Chappel. 1982. Multiple species of follicle-stimulating hormone exist within the anterior pituitary gland of male golden hamsters. J. Endocrinol. 95:257-266. Ulstein, M. 1972. Sperm penetration of cewical mucus as a criterion of male fertility. Acta Obstet. Gynecol. Scand. 51:335-340. Unander, A. M., and L. B. Olding. 1983. Habitual abortion: Parental sharing of HIA antigens, absence of maternal blocking antibody, and suppression of

REFERENCES maternal lymphocytes. Am. J. Reprod. Immunol. 4:171-178. UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation). 1982. Report, Sources and Effects of Ionizing Radiation. New York: United Nations. U.S. EPA (United States Environmental Protection Agency). 1986. Air Quality Criteria for Lead. EPA- 600/8 83/028aF. Research Triangle Park N.C.: U.S. Environmental Protection Agency. 4 vols. U.S. EPA (United States Environmental Protection Agency). 1987. Health effects testing Reproduction and fertility effects. Code of Federal Regulations, Title 40, Chap. 1, Pt. 798, section 4700. Revised July 1, 1987. Washington, D.C.: U.S. Government Printing office. U.S. EPA (United States Environmental Protection Agency). 1989. Ambient Air Quality Criteria Docu- ment. 1989 Addendum. Washington, D.C.: U.S. Environmental Protection Agency. U.S. FDA (Food and Drug Administration). 1988. Good laborato~ypracticefornonclinicallaboratorystudies. Code of Federal Regulations, Title 21, Chap. 1, Pt. 58. Washington, D.C.: U.S. Government Printing Office. Usselman, M. C., and R. A. Cone. 1983. Rat sperm are mechanically immobilized in the caudal epidi~yrnis by "immobilin," a high molecular weight gl~rcoprotein. Biol. Reprod. 29:1241-1253. Uzman, L. L. 1960. The histogenesis of the mouse cerebellum as studied by its tritiated thymidine uptake. J. Comp. Neurol. 114:137-160. Vaitukaitis, J. L., G. D. Braunstein, and G. T. Ross. 1972. A radioimmuno~y which specifically measures human chorionic gonadotropin in the presence of human luteiruzi~ hormone. Am. J. Obstet. Gynecol. 113:751-758. Valenca, M. M., and A. Negro-Vilar. 1986. Pro-opiomel- anocortin-derived peptides in testicular interstitial fluid Characterization and changes in secretion after human chorionic gonadotropin or luteiru~ng hormone- releasinghormoneanalogtreatment. Endocrinology 118:32-37. Van Beurden-Lamers, W. M. O., A. O. Brinkmann, E. Mulder, and H. J. Van der Molen. 1974. High- affinity binding of oestradiol-17B by cytosols from testis interstitial tissue, pituitary, adrenal, liver and accessory sex glands of the male rat. Biochem. J. 140:495-502. Vanderlaan, M., J. Van Emon, B. Watkins, and L. Stan- ker. 1987. Monoclonal antibodies for the detection of trace chemicals, pp. 597 602. In R. Greenhalgh end T. R. Roberts, Eds. Pesticide Science and Biotech- nology. Blackwell Scientific Publications. van der Spuy, Z. M., D. L. Jones, C. S. Wright, B. Piura, D. B. Paintin, V. H. James, and H. S. Jacobs. 1985. Inhibition of 3-beta-hydroxy steroid dehydrogenase activity in fast trimester human pregnancy with trdos- tane and Win 32729. Clin. Endocrinol. (Oxf.) 19:521- 367 531. Van Dilla, M. A., and M. L. Mendelsohn. 1979. Intro- duction and resume of flow cytometry and sorting, pp. 11-37. In M. R. Melamed, P. F. Mullaney, and M. L. Mendelsohn, Eds. Flow Cytometry and Sorting. New York: John Wiley & Sons. van Dop, P. A., R. J. Scholtmeijer, P. H. J. Kurver, J. P. A. Baak, J. Oort, and L. A. M. Stolte. 1980a. A quantitative structural model of the testis of fertile mores with normal sperm counts. Int. J. Androl. 3:153- 169. van Dop, P. A., P. H. J. Kurver, R. J. Scholtmeijer, J. P. A. Baak, J. Oort, and L. A. M. Stolte. 1980b. Correlations between the quantitative morphology of the human testis and sperm production. Int. J. Androl. 3:170-176 Vanha-Perttula, T., J. P. Mather, C. W. Bardin, S. B. Moss, and A. R. Bellve. 1985. Localization of the angiotensin-converting enzyme activity in testis and epididymis. Biol. Reprod. 33:870-877. Van Keep, P. A., P. C. Brand, and P. H. Lehert. 1979. Factors affecting the age at menopause. J. Biosoc. Sci. 6(Suppl.~:37-55. Van Thiel, D. H., R. Lester, and R. J. Sherins. 1974. Hypogonadism in alcoholic liver disease: Evidence for a double defect. Gastroenterology67:1188 1199. van Zeeland, A. A. 1986. Molecular dosimet~y of alkylat- ing agents: Quantitative comparison of genetic effects on the basis of DNA-adduct formation. Un- published manuscript. Department of Radiation Genetics & Chemical Mutagenesis, Sylvius Laborator- ies, State University of Leiden. The Netherlands. (December) Venetianer A., D. L. Schiller, T. Magin, and W. W. Franke. 1983. Cessation of cytokeratin expression in a rat hepatoma cell line lacking differentiated functions. Nature 305:730-733. Verjans, H. L., F. H. de Jong, B. A. Cooke, H. J. Van der Molen, and K B. Eik-Nes. 1974. Effect of oestra- diol benzoate on pituitary and testis function in the normal and adult male rat. Acta Endocrinol. 77:63 642. Vermeulen, A., Lo Verdonch, M. Van der Straeten, and N. Orie. 1969. Capacity of the testosterone-binding globulin in human plasma and influence of specific binding of testosterone on its metabolic clearance rate. J. Clin. Endocrinol. Metab. 29:1470. Vermeulen, A., T. Stoica, and L. Verdonck. 1971. The apparent free testosterone concentration, an index of androgenicity. J. Clin. Endocrinol. Metab. 33:759- 767. Vernon, R. B., C. H. Muller, J. C. Herr, F. A. Feuchter, and E. M. Eddy. 1982. Epididymal secretion of a mouse sperm surface component recognized by a monoclonal antibody. Biol. Reprod. 26:523-535. Vernon, R. B., M. S. Hamilton, and E. M. Eddy. 1985. Effects of in vitro and in vitro fertilization environments on the expression of a surface antigen of the mouse sperm tail. Biol. Reprod. 32:669 680.

368 Vesell, E. S., G. T. Passananti, F. E. Greene, and J. G. Page. 1971. Genetic control of drug levels and of the induction of drug-metabolizing enzymes in man: Individual variability in the extent of allupunnol and nortriptyline inhibition of drug metabolism. Ann. N.Y. Acad. Sci 79:752-773. Vessel, M., R. Doll, R. Peto, B. Johnson, and P. W - ins. 1976. A long-term follow-up study of women using different methods of contraception: An interim report. J. Biosoc. Sci. 8:373-427. Vestel, R. E., and G. W. Dawson. 1985. Pharmacology and aging, pp. 74~819. In C. E. Finch and E. L. Schneider, Eds. Handbook of the Biology of Aging, 2nd ed. New York: Van Nostrand Reinhold. Vigersky, R. A., A. E. Andersen, R. H. Thompson, and D. L. Loriaux. 1977. Hypothalamic dysfunctionin secondary amenorrhea associatedwith simpleweight loss. N. Engl. J. Med. 297:1141-1145. Virji, N. 1985. LDH-C4 in human seminal plasma and its relationship to testicular function. I. Methodogical aspects. Int. J. Androl. 8:193-200. Vogel, F., and R. Rathenberg. 1975. Spontaneous muta- tion in man. Adv. Hum. Genet. 5:223-318. Voglmayr, J. K 1975. Metabolic changes in spermatozoa during epididymal transit, pp. 437451. In D. W. Hamilton and R. O. Greep, Eds. Handbook of Phys- iology, Section 7: Endocrinology. Volume V. Male ReproductiveSystem. Washington,D.C.: American Physiological Society. Voglmayr, J. K., and I. G. White. 1979. Effects of rete testis and epididymal fluid on the metabolism and motility of testicular and post-testicular spel'.~atozoa of the ram. Biol. Reprod. 20:288 293. Voisin, G., R. G. Kinsly, and H. T. Duc. 1972. Immune status of mice tolerant of living cells. II. Continous presence and nature of facilitation enhancing antibodies in tolerant animals. J. Exp. Med. 135:1185-1203. Vom Saal, F. S., and C. L. Moyer. 1985. Prenatal effects on reproductive capacity during aging in female mice. Biol. Reprod. 32:111~1126. Vorhees, C. V. 1983. Fetal anticonvulsant syndrome in rats: Dose- and period-response relationships of prenatal diphenylhydantoin, tnmethadione, and pheno- barbital exposure on the structural and functional development of the offspring. J. Pharmacol. Exp. Ther. 227:274-287. Vrbova, G., T. Gordon, and R. Jones. 1978. Nerve- Muscle Interaction. London: Chapman and Hall. 233 pp. Wald, N. J., and H. S. Buckle. 1980. Alpha fetoprotein in the antenatal diagnosis of open neural tube defects. Br. J. Hosp. Med. 23:473480. Waldrop, M., and C. Halverson. 1972. Minor physical anomalies: Their incidence and relation to behavior in a normal and deviant sample, pp. 14~156. In R. C. Smart and M. S. Smart, Eds. Readings in Child Development and Relationships. New York: Macmil- lan. Waldrop, M. F., F. A. Pederson, and R. Q. Bell. 1968. REFERENCES Minor physical anomalies and behavior in preschool children. Child Dev. 39:391 400. Waldrop, M. F., R. Q. Bell, and J. D. Goering. 1976. Minor physical anomalies and inliibited behavior in elementary school girls. J. Child Psychol. Psychiatry 17:113-122. Walker, J. S., H. Winet, and M. Freund. 1982. A com- parison of subjective and objective Sperm motility evaluation. J. Androl. 3:1~192. Walsh, P. C., and J. D. Wilson. 1976. The induction of prostatic hypertrophy in the dog with androstanediol. J. Clin. Invest. 57:1093-1097. Walsh, P. C., and J. D. Wilson. 1987. Impotence and infertility in men, pp.217-220. In Hamson's Principles of Internal Medicine, 11th ed. New York: McGraw Hill. Walters, M. R. W. Hunker, and A. W. Norman. 1982. 1, 2~dihydroxyvitamin D3 receptors: Exchange assurer and presence in reproductive tissues, pp. 91-93. In A. W. Norman, K. Schaefer, D. V. Herrath, H. G. Grigoleit, and W. de Gruyter, Eds. Vitamin D, Chemi- m1, Biochemical and Clinical Endomnolo~ of Calcium Metabolism. Berlin: W. de Gruyter. Ward, R. H. T., B. Modell, M. Petrou, F. Karagozlu, and E. Douratsos. 1983. Method of sampling chori- onic villi in first trimester of pregnancy under guidance of real time ultrasound. Br. Med.J.286:1542- 1544. Warkany, J. 1971. Congenital Malformations. Chicago: Year Book Medical Publishers. 1309 pp. Warkany, J. 1976. Warfarin emb~yopathy. Teratology 14:205-209. Warren, M. P. 1980. The effects of exercise on pubertal progression and reproductive function in girls. J. Clin. Endocrinol. Metab. 51:115~1157. Warren, M. P. 1982. The effects of altered nutritional states, stress, and systemic illness on reproduction in women, pp. 177-206. In J. L. Vaitukaitis, Ed. Clinical Reproductive Neuroendocrinolo~. New Yolk: Elsevier Biomedical. Warren, M. P. 1983. Effects of undernutrition on repro- ductive function in the human. Endocr. Rev. 4:363- 377. Warren, M. P., R. Jeweiewicz, I. DyTenfurth, R. Ans, S. Khalaf, and R. L. Vande Wiele. 1975. The sig- nif~cance of weight loss in the evaluation of pituitary response of LH-RH in women with secondary amenor- rhea. J. Clin. Endocrinol. Metab. 40:601~11. Wasmoen, T. L., C. B. Coulam, K. M Leiferman, and G. J. Gleich. 1987. Increases of plasma eosinophil major basic protein levels late in pregnancy predict onset of labor. Proc. Natl. Acad. Sci. USA 84:3029- 3032. Waters, S. H., R. J. Distel, and N. B. Hecht. 1985. Mouse testes contain two size classes of actin mRNA that are differentially expressed during q~ermatogene~ Mol. Cell Biol. 5:1649-1654. Watkins, W. B. 1978. Use of immunopytochemical tech- niques for the localization of human placental lactogen.

REFERENCES J. Histochem. Cytochem. 26:288 292. Watkins, W. B., and S. Reddy. 1980. Ovine placental lactogen in the cotyledonary and intercotyledonary placenta of the ewe. J. Reprod. Fertil. 58:411414. Weaver, D. D. 1988. Survey of prenatally diagnosed disorders. Clin. Obstet. Gynecol. 31:253-269. Webb, P. D., and S. R. Glasser. 1984. Implantation, pp. 341-364. In D. P. Wolf and M. M. Quigley, Eds. Human b' Vitro Fertilization and Embryo Transfer. New York: Plenum Press. Webster, M. A., S. L. Phipps, and M. D. Gillmer. 1985. Interruption of first trimester human pregnancy follow- ing Epostane therapy. Effect of prostaglandin in E2 pessaries. Br. J. Obstet. Gynaecol. 92:963-968. Wehmann, R. E., S. M. Harman, S. Birken, R. E. Can- field, and B. C. Nisula. 1981. Convenient radioim- munoassay for urinary human choriogonadotropin without interference by urinary human lutropin. Clin. Chem. 27:1997-2001. Weiss, B., and R. A. Doherty. 1975. Methylmercury poisoning. Teratology 12:311-313. Weissenberg, R., A. Eshkol, E. Rudak and B. Lunenfeld. 1983. Inability of round acrosomeless human qmmato- zoa to penetrate zone-free hamster ova. Arch. Androl. 11:167-169. Weitzman, E. D., R. M. B~yar, S. Kapen, and L. Hellman. 1975. The relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in man. Rec. Prog. Horm. Res. 31:399 446. Welch, L. S., S. M. Schrader, T. W. Turner, and M. R. Cullen. 1988. Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. Am. J. Ind. Med. 14:509-526. Welch, R. M, Y. E. Harrison, B. W. Gommi, P. J. Pop- pers, M. Finster, and A. H. Conney. 1969. Stimulatory effect of cigarette smoking on the hydroxylation of 3,4-ber~pyrene and the N-demeth~rlation of 3-methyl- 4-monomethylaminoazobenzene by enymes in human placenta. Clin. Pharmacol. Ther. 10:100109. Wells, M., B. L. Hsi, and W. P. Faulk. 1984a. Class I antigens of the major histocompatibility complex on cytotrophoblast of the human placental basal plate. Am. J. Reprod. Immunol. 6:167-174. Wells, M., B. L. Hsi, C. J. G. Yeh, and W. P. Faulk. 1984b. Spiral (uteroplacental) arteries of the human placental bed show the presence of amniotic basement membrane antigen~ Am. J. Obstet. Gynecol. 150:97 977. Werb, Z., M. J. Banda, and P. A. Jones. 1980. Degrada- tion of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins and collagen by proteases isolated from macrophages. J. Exp. Med 152: 134~1357. Werler, M. M., B. R. Pober, and L. B. Holmes. 1985. Smoking and pregnancy. Teratology 32:473~81. Wewer, U. M., M. Faber, L. A. Liotta, and R. Albrecht- son. 1985. Immunochemical and ultrastructural asses~nent of the nature of the pericellular basement membrane of human decidual cells. Lab. Invest. 369 53:62~633. Wheat, T. E., J. A. Shelton, V. Gonzales-Prevatt, and E. Goldberg. 1985. The antigenicity of synthetic peptide fragments of lactate dehydrogenase C4. Mol. Immunol. 22:1195-1199. White, T., R. A. Saltzman, R. K. Miller, R. Sutherland, P. A. diSant'Agnese, and P. Keng. 1988a. Human choriocarcinoma (JAr) cells grown as multicellular spheriods: A system for studying the trophoblast. Placenta (in press). White, T., P. A. di Sant'Agnese, and R. K. Miller. 1988b. Coculture of three dimensional trophoblast cultures with human endometrial cells. Trophoblast Research (in press). Whitfield, C. R. 1976. Rhesus haemolytic disease. J. Clin. Pathol. 10:54-62. Whitlock, J. P. 1986. The regulation of cytochrome P450 gene ~prcssion. Annul Rev. Pharn~L T~coL 26:333-369. Whittaker, P. G., A. Taylor, and T. Lind. 1983. Un- suspected pregnancy loss in healthy women. Lancet 1~8334~:1126-1127. WHO (World Health Organization). 1980a. LaboratoIy Manual for the Examination of Human Semen and Semen-Cen~cal Mucus Interaction. Singapore: Press Concern. WHO (World Health Organization). 1980b. A Retro- spective Analysis of Steroid Glucuronide Excretion in Ovulatory Women. Spemal Prog~amme of Research Devel~nent and Researdl Training in Human Rep~ auction. Project No. 77930. WHO (World Health Organization). 1986. Effects of Oca~pational Health Hazards on Reproductive Fun~ tions. Geneva: Office of Oca~pational Health, World Health Organization. WHO (World Health Organization). 1987. Laboratory Manual for the Examination of Human Semen and Semen~enricalMucusInteraction. Cambridge: Cam- bridge University Press. Whorton, D., R. M. Krauss, S. MarshalL and T. H. Milby. 1977. Infertilityin male pesticide workers. Lancet 2(8051):1259-1261. Whorton, D., T. H. Mil~y, R. M Krauss, and H. A. Stubbs. 1979. Testicular function in DBCP exposed pesticide workers. J. Occup. Med. 21:161-166. Whorton, M. D., and C. R. Meyer. 1984. Sperm count results from 861 American chemical/agricultural workers from 14 s~parate studies. Fertil. Sterd. 42 86. Wide, L. 1962. An immunological method for the assay of human chorionic gonadotropin Acta EndocrinoL 41(Suppl. 70):1-111. Wide, L. 1981. Male and female forms of human follicle- stimulatinghormonesin serum. J. Clin. Endocrinol. Metab. 55:682 687. Wide, L., and C. A. Gemzell. 1960. An ~mmunological pregnancy test. Acta. Endocrinol. 35:261-267. Wieben, E. D. 1981. Regulation of the synthesis of lactate dehydrogenase X during spermatogenesis in

370 the mouse. J. Cell. Biol. 88:492498. Wilcox, A. J., C. R. Weinberg, R. E. Wehmann, E. G. Armstrong, R. E. Canfield, and B. C. Nisula. 1985. Measuring early pregnancy loss: Laboratory and field methods. Fertil. Steril. 44:36~374. Wilcox, A. J., C. R. Weinberg, E. G. Armstrong, and R. E. Canfield. 1987a. Urinary human chorionic gonadotropin among intrauterine device users: Detect lion with a highly specific and sensitive assay. Fertil. Steril. 47:265-269. Wilcox, A. J., D. D. Baird, C. R. Weinberg, E. G. Arm- strong, P. I. Musey, R. E. Wehmann, and R. E. Can- f~eld. 1987b. The use of biochemical assurers in epidem- iologic studies of reproduction. Environ. Health Perspect. 75:29-35. Wildt, K., R. Eliasson, and M. Berlin. 1983. Effects of occupational exposure to lead on sperm and semen, pp. 279-300. In T. W. Clarkson, G. F. Norberg, and P. R. Sager, Eds. Reproductive and Developmental Toxicity of Metals. New York: Plenum. Wilkinson, C. F. 1987. Being more realistic about chemi- cal carcinogenesis. Environ. Sci. Technol. 21:843- 847. Williams, G. M. 1977. Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures. Cancer Res. 37:1845-1851. Wilson, E. M., and F. S. French. 1980. Biochemical homology between rat dorsal prostate and coagulating gland. Purification of a major androgen-induced protein. J. Biol. Chem. 2551:10946 10953. Wilson, E. M., D. H. Viskochil, R. J. Bartlett, O. A. Lea, C. M. Noyes, P. Entrust, D. W. Stafford, and F. S. French. 1981. Model systems for studies on androgen- dependent gene expression in the rat prostate, pp. 351-380. In G. P. Murphy, A. A. Sandberg, and J. P. Karr, Eds. The Prostatic Cell: Structure and Function Part A. Morphologic, Secretory, and Bio- chemical Aspects. New York: Liss. Wilson, G. S., R. McCrea~y, J. Kean, and J. C. Baxter. 1979. The development of preschool children of heroin-addicted mothers: A controlled study. Pedia- trics 63:135-141. Wilson, J. G. 1954. Differentiation and the reaction of rat embryos to radiation. J. Cell. Comp. Physiol. 43(Suppl. 1~:11-38. Wilson, J. G. 1973. Environment and Birth Defects. New York: Academic Press. 305 pp. Wilson, R. S., W. Smead, and F. Char. 1978. Dipheneyl- hydantoin teratogenicity: Ocular manifestations and related deformities. J. Pediatr. Ophthal. Stabismus. 15:137-140. Winder, C., L. L. Garten, and P. D. Lewis. 1983. The morphological effects of lead on the developing central nervous system. Neuropathol. Appl. Neurobiol. 9:87- 108. Wing, T.-Y., and A. K Chnstensen. 1982. Morphometric studies on rat seminiferous tubules. Am. J. Anat. 165:13-25. Winneke, G., G. Foder, and H. Schlipkoter. 1978. Car- REFERENCES bon monoxide, trichloroethylene, and alcohol: Relia- bility and validity of neurobehavioral effects, pp.461- 469. In D. A. Otto, Ed. Multidisciplinary Perspectives in Event Related Brain Potential Research. EPA 600/9-77 043. Washington, D.C.: U.S. Emrironmental Protection Agency. Witkin, S. S., J. M. Richards, and J. M. Bedford. 1983. Influence of epididymal maturation on the capacity of hamster and rabbit spermatozoa for complement activation. J. Reprod. Fertil. 69:517-521. Wogan, G. N. 1988. Detection of DNA damage in studies on cancer etiology and prevention, pp. 32- 54. In H. Bartsch, K. Hemminki, and I. K. O'Neill, Eds. Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention. L\RC Scientific Publications, No. 89. Lyon: International Agency for Research on Cancer. Wogan, G. N., and N. J. Gorelick. 1985. Chemical and biochemical dosimet~y of exposure to genoto~c chemi- cals. Environ. Health Perspect. 62:5-18. Wolf, D. P., and S. Mastroianni, Jr. 1975. Protein com- position of human uterine fluid. Fertil. Steril. 26:240-247. Wong, D. F., H. N. Wagner, Jr., L. E. Tune, R. F. Dan- nals, G. D. Pearlson, J. M. Links, C. A. Tamminga, E. P. Broussolle, H. T. Ravert, and A. A. Wilson. 1986. Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234:155~1563. Wong, O., M. D. Utidjian, and V. S. Karten. 1979. Retrospective evaluation of reproductive performance of workers exposed to ethylene dibromide (EDB). J. Occup. Med. 21:98-102. Wong, P. Y. D., and W. M. Lee. 1982. Effects of spiro- nolactone (aldosterone antagonist) on electrolytes and water content of the cauda epididymidis and fertility of male rats. Biol. Reprod. 27:771-777. Wong, P. Y. D., and C. H. Yeung. 1977. Hormonal regulation of fluid reabsorption in isolated rat cauda epididymis. Endocrinology 101:1391-1397. Wong, T. K, R. B. Everson, and S-T. Hsu. 1985a. Potent induction of human placental monmo'cygenase activity by previous dietary exposure to polychlorinated bi- phenyls and their thermal degradation production. Lancet 1:721-724. Wong, T. K., T. E. Blanton, C. K. Hunnicutt, and R. B. Everson. 1985b. Quantification of aryl hydrocarbon lydrc~ase and 7 eth~ycoumann 0~ activity in human placentae: Development of aprotocol suit- able for studying effects of environmental exposures on human metabolism. Placenta 6:297-310. Wooding, F. B. P. 1981. Localization of ovine placental lactogen in sheep placentomes by electron microscope immunocytochemistry. J. Reprod. Fertil. 62:15-19. Wooding, F. B. P. 1982. The role of the binucleate cell in ruminant placental structure. J. Reprod. Fertil. 31(Suppl.~:32-39. Working, P. K., and M. E. Hurtt. 1987. Computerized

REFERENCES videomicrographic analysis of rat sperm motility. J. Androl. 8:33~337. Wramsby, H., K. Fregda, and P. Liedholm. 1987. Chro- mosome analysis of human oocytes recovered from preovulatory follicles in stimulated cycles. N. Engl. J. Med. 316:121-124. Wright, W. W., N. A. Musto, J. P. Mather, and C. W. Bardin. 1981. Sertoli cells secrete both testi~specific and serum proteins. Proc. Natl. Acad. Scat. USA 78:7565-7569 Wyrobek, A. J., and D. Pinkel. 1986. Detecting chromo- somes in human sperm by fluorescent hybridization. Am. J. Hum. Genet. 39:A102. (Abstract.) Wyrobek, A. J., G. Watchmaker, L. Gordon, K. Wong, D. H. Moore II, and D. Whorton. 1981. Sperm shape abnormalities in carba~yl~cposed employees. Environ. Health Perspect. 40:255-265. Wyrobek, A. J., L. A. Gordon, G. Watchmaker, and D. H. Moore II. 1982. Human sperm morphology testing Description of a reliable method and its statistical power, pp. 527-541. In B. A. Bridges, B. E. Butter- worth, and I. B. Weinstein, Eds. Banbury Report 13: Indicators of Genotoxic Exposure. [Cold Spring Harbor, N.Y.~: Cold Spring Harbor Laboratory. Wyrobek, A. J., L. A. Gordon, J. G. Burkhart, M. W. Francis, R. W. Kapp, G. Letz, H. V. Mailing, J. C. Topham, and M. D. Whorton. 1983a. An evaluation of human sperm as indicators of chemically induced alterations of spermatogenic function. A report of the U. S. Environmental Protection Agency Gene- Tox Program. Mutat. Res. 115:73-148. Wyrobek, A. J., L. A. Gordon, J. G. Burkhart, M. W. Francis, R. W. Kapp, Jr., G. Letz, H. V. Mailing, J. C. Topham, and M. D. Whorton. 1983b. An evalua- tion of the mouse sperm morphology test and other sperm tests in non-human mammals. A report of the U. S. Environmental Protection Agency Gene- Tox Program. Mutat. Res. 115:1-72. Wyrobek, A. J., G. Watchmaker, and L. Gordon. 1984. An evaluation of sperm tests as indicators of germ- cell damage in men exposed to chemical or physical agents, pp. 385~05. In Reproduction: The New Frontier in Occupational and Environmental Health Research. New York: Liss. Wyrobel;, A. J., P. Buffler, D. Houston, and T. Connor. In press. Antifertility effects, mutagenicity, and adverse reproductive outcomes in animals and human beings exposed to dibromochloropropane. Am. J. Indust. Med. Yager, J. W., C. J. Hines, and R. C. Spear. 1983. Ex- posure to ethylene oxide at work increases sister chromatic exchanges in human peripheral lymphocytes. Science 29:1221-1223. Yanagimachi, R., H. Yanagimachi, and B. J. Rogers. 1976. The use of zone-free animal ova as a test- system for the assessment of the fertilizing capacity of human spermatozoa. Biol. Reprod. 15:471-476. Yanagimachi, R. 1984. Zona-free hamster eggs: Their use in assessing fertilizing capacity and examining 371 chromosomes of human spermatozoa. Gamete Res. 10:187-232. Yeh, C. J. G., B. L. Hsi, and W. P. Faulk. 1984. Hm tocompatibility antigens, transferrin receptors and extra-emb~yonic markers of human amniotic epithelial cells in vitro. Placenta 4:361-368. Yelick, P. C., R. Balhorn, P. A. Johnson, M. Corzett, C. H. Mazrimas, K. C. Kleene, and N. B. Hecht. 1987. Mouse protamine 2 is synthesized as a precursor whereas mouse protamine 1 is not. Mol. Cell. Biol. 7:2173-2179. Yen, S. S. C. 1977. The biology of menopause. J. Re- prod. Med. 18:287-296. Yodaiken, R. E. 1986. Surveillance, monitoring, and regulatory concerns. J. Occup. Med. 28:569-571. Yoneda, T., and R. M. Pratt. 1981. Mensenchymal cells from the human embryonic palate are hi mponsve to epidermal growth factors. Science 213:563-565. Yoshimi, T., C. A. Strott, J. R. Marshall, and M. B. Lipsett. 1969. Corpus luteum function in early prey nancy. J. Clin. Endocrinol. 29:225. Younes, M. A., and C. G. Pierrepoint. 1981. Androgen steroid-receptor binding in the canine epididymis. Prostate 2:133-142. Younes, M., B. A. J. Evans, N. Chaisiri, Y. Valotaire, and C. G. Pierrepoint. 1979. Steroids receptors in the canine epididymis. J. Reprod. Fertil. 56:45-52. Young, M. D., and W. P. Blackmore. 1977. The use of danazol in the management of endometriosis. J. Int. Med. Res. 5(Suppl. 3~:8~91. Young, R. W. 1985. Cell proliferation during postnatal development of the retina in the mouse. Brain Res. 353:229-239. Younglai, E. V., and R. V. Short. 1970. Pathways of steroid biosynthesis in the intact Graafian follicle of mares in oestrus. J. Endocrinol. 47:321-331. Yule, Q., R. Lansdown, I. B. Millar, and M. A. Urbane wicz. 1981. The relationship between blood lead concentrations, intelligence and attainment in a school population: A pilot study. Dev. Med. Child Neurol. 23:567-576. Yussman, M. A., and M. L. Taymor. 1970. Serum levels of follicle stimulating hormone and lutaniang hormone and of plasma progesterone related to oblation by corpus luteum biopsy. J. Clin. Endocrinol. Metab. 30:39~399. Zamenhof, S., E. Van Marthens, and L. Grauel. 1972. DNA (cell number) and protein in rat brain. Second generation (F2) alteration by maternal (F0) dietary protein restriction. Nutr. Metab. 14:262-270. Zaneveld, L. J. D. 1978. The biology of human sper- matozoa. Obstet. Gynecol. Annul 7:15 40. Zappoli, R., G. Giuliano, L. Rosy M. Papini, O. Ronchi, A. Ragazoni, and A. Amantini. 1978. CNV and SEP in shoe industryworkerswith neuropathy resulting from toxic effect of adhesive solvents, pp. 476 480. In D. A. Otto, Ed. Multidisciplinary Perspectives in Event Related Brain Potential Research. EPA 600/9-77~43. Washington, D.C.: U.S. Environmental

372 Protection Agency. Zec, R. F., and D. R. Weinberger. 1986. Relationship between CT scan findings and neuropsychological performance in chronic schizophrenia. Psychiatr. Clin. North Am. 9:49-61. Zeisler, R., S. H. Harrison, and S. A. Wise, Eds. 1983. The Pilot National Environmental Specimen Bank: Analysis of Human Liver. National Bureau of Standards Special Publication 656. Washington, D.C.: U.S. Department of Commerce, National Bureau of Standards. 128 pp. Zelson, C., E. Rubio, and E. Wasserman. 1971. Neonatal narcotic addiction: 10 year observation. Pediatrics 48:17~189. Zenick, H., and E. D. Cleeg. 1989. Assessment of male reproductive toxicity: A risk assessment approach, pp. 275-310. In A. W. Hayes, Ed. Principles and Methods in Toxicology, 2nd ed. New York: Raven Press. Zenz, C. 1988. Occupational Medicine. Principles and Practical Applications, 2nd ed. Chicago: Year Book Medical Publishers. Zhu, L.P., D. Chen, S. Z. Zhang, and S. L. Liu. 1985. Study on the effect of calf thymic peptides preparation (TP) on human B lymphocytes. Immunol. Invest. 14:115-129. Zirkin, B. R., and J. D. Strandberg. 1984. Quantitative changes in the morphology of the aging canine pros- tate. Anat. Rec. 208:207-214. Zirkin, B. R., L. L. Ewing, N. Kromann, and R. C. Coch- ran. 1980. Testosterone secretion by rat, rabbit, guinea pig, dog, and hamster testes perfused invitro: correlation with L~ydig cell ultra~ructure. Endocrinol- ogy 107:1867-1874. Zirkin, B. R., R. Gross, and L. L. Ewing. 1985a. Effects of lead acetate on male rat reproduction, pp. 13 145. In F. Homburger and A. M. Goldberg, Eds. In vitro EmbIyto~city and Teratogenicity Tests. Concepts in Toxicology, Vol. 3. Basel: S. Karger. Zirkin, B. R., D. A. Soucek, T. S. K. Chang, and S. D. Perreault. 1985b. In vitro and in vivo studies of mammalian sperm nuclear decondensation. Res. Gamete 11:349-365. REFERENCES Zorn, J. R., M. Roger, M. Savale, and J. Grenier. 1982. Steroid hormone levels in peritoneal fluid during the periovulatory period. Fertil. Steril. 38:162-165. Zukerman, Z., L. J. Rodriguez-Rigau, K. D. Smith, and E. Steinberger. l9T7. Frequency distn~ution of sperm counts in fertile and infertile males. Fertil. Steril. 28:131~1313.