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Biographies DONALD R. MATTISON, Chairman, Subcommittee on Reproductive and Neurodevelopmental Toxicology, is professor of obstetrics and gynecology at the University of Arkansas for Medical Sciences and medical officer at the National Center for Toxicological Research. His research interests, as reflected in his numerous publications, include reproductive pharmacology and toxicology, nuclear magnetic resonance imaging and spectroscopy, and risk assessment. He has served on committees for the National Research Council, the National Institutes of Health, the U.S. Environmental Protection Agency, and the U.S. Food and Drug Administration. Dr. Mattison also serves on the editorial board of Reproductive Toxicology, Developmental Pharmacology and Toxicology, and Risk Analysis. JUDITH L. BUELKE-SAM is an associate within the Department of Genetic and Developmental toxicology at Lilly Research Laboratories, Eli Lilly and Company, where she is involved in the design, conduct, and interpretation of preclinical toxicity studies for Japanese submission. She is the current president of the Behavioral Teratology Society, a member of the Behavioral Toxicology Task Force of the Drug Safety Subsection, Phar- maceutical Manufacturers' Association, and on the editorial advisory board of Neurotoxicology and Teratology. Ms. Buelke-Sam was an organizer and principal investigator for the collaborative behavioral teratology study, coordinated by the National Center for Toxicological Research, for which she received the FDA Commissioner's Special Citation. -- ~ evaluation in characterizing the pharmacology and toxicology of new pharmaceutical agents. Her current research addresses the role of behavioral ROBERT E. CANFIELD is professor of medicine and director of the Irving Center for Clinical Research at the Columbia-Presbyterian Medical Center in New York. Dr. Canfield~s primary research interests include the chemistry and immunology of gonadotropin hormones and fibrinogen, as well as research related to metabolic bone disease. He is an author or coauthor of many research publications in all three fields. J. DAVID ERICKSON has been at the Centers for Disease Control since 1974, serving first as an epidemiologist and later, Chief in the Birth Defects Branch, Chief of the Etiologic Studies Section, Director of the Agent Orange Projects, Chief of the 373

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374 BIOGRAPHIES Cancer Branch, and most recently, as Chief of the Birth Defects and Genetic Diseases Branch. He has also served on numerous professional and government advisory committees, including the National Institute of Occupational Safety and Health Committee on Reproductive Effects of the Workplace, the Surgeon General's Advisory Committee on the Health Consequences of Using Smokeless Tobacco, and the Veterans Administration Advisory Committee on Health-Related Effects of Herbicides. He has also served on the Panel on Reproductive and Developmental Toxicology of the National Research Council and was a recent editor of the epidemiology section in the publication Teratology. He is currently chairman of the International Clearinghouse for Birth Defects Monitoring Programs. Dr. Erickson's research interests include the causes and prevention of human birth defects and human genetics. Board certified by the American Board of Dental Public Health, he belongs to numerous professional societies, including the American Epidemio- logical Society, the American College of Epidemiology, the Society for Epidemiologic Research, the American Society of Human Genetics, and the Teratology Society. He holds a D.D.S. degree from the University of Alberta, an M.P.H. degree from the University of Minnesota, and a Ph.D. degree from the University of Washington. LARRY L. EWING, chairman of the male reproductive toxicology panel, is a professor of Population Dynamics at the Johns Hopkins University School of Hygiene and Public Health. Dr. Ewing has served as editor-in-chief of Biology of Reproduction, associate editor of The Physiology of Reproduction, and editorial board member of the professional journals, American Journal of Physiology, Endocrinology, Biology of Reproduction, and the Journal of Andrology. Dr. Ewing has served as president of the Society of the Study of Reproduction and the American Society of Andrology and was a member of the Reproductive Biology Section for the National Institutes of Health. He is presently chairman of Subcommittee 3 of the Clinical Sciences Study Section. He has also served on the National Research Council of the National Academy of Sciences and with numerous federal advisory groups that include the U. S. Environmental Protection Agency, the Department of Agriculture, the Veterans Administration, the Office of Technology Assessment, and the Food and Drug Administration. His current research is in male reproductive biology. W. PAGE FAULK is director of experimental pathology at the Center for Reproduction and Transplantation Immunology at Methodist Hospital, Indianapolis, Indiana. He was formerly professor of immunology at the University of Nice and director of research at the Royal College of Surgeons' Blond-McIndoe Transolantation Institute at East _ _ . , Grinstead, Sussex, England. His career in pregnancy immunology research has included positions with the World Health Or~nni7.ntinn ~nr1 the British M~1inn1 R~c~nrnh tail ~ ~ ~ . . .. . . . _ _ _ . . and professorships at the Medical University of South Carolina, the University of Texas, and Brisbane University. He is cofounder, and for many years, coeditor of Placenta. His research is primarily concerned with interlocking aspects of immunolog- ical responses in pregnancy, organ transplantation, and cancer. CALEB E. FINCH is ARCO/William F. Kieschnick Professor in the Department of Neurobiology of Aging at the Andrus Gerontology Center of the University of Southern California. He is a neurobiologist with major interests in the neuroendocrinology of aging and in Alzheimer's disease. Dr. Finch is also on the National Advisory Council to the National Institute on Aging. WALDERICO M. GENEROSO is a senior scientist in the biology division of the Oak Ridge National Laboratory in Tennessee. His research includes the mechanisms for induction of heritable mutations in mice, genetic risk evaluation, and understanding the etiology of mutagen-induced developmental anomalies. He was leader of the U.S. Environmental

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BIOGRAPHIES 375 Protection Agency Gene-Tox Working Group on Heritable Translocation Tests in Mice and of the International Group on Commission for Protection Against Environmental Mutagens and Carcinogens Working Group on Dominant-Lethal Tests in Rodents. He served as a member of the EPA Gene-Tox Committee on Risk Assessment, the National Academy of Sciences/National Research Council Panel on Anticholinesterase Chemicals and their Panel on Cholinesterase Reactivators. Dr. Generoso has also served as councilor of the Environmental Mutagen Society. He is a member of the editorial boards of Mutation Research and Teratogenesis, Carcinogenesis, and Mutagenesis, and was senior editor of the book, DNA Repair and Mutagenesis in Eukaryotes. He also served as coeditor of the books, Molecular and Cellular Mechanisms of Mutagenesis and Cellular Mutation, Cancer, and Malformation. JAMES E. GIBSON is director of toxicology affairs, the Dow Chemical Company, Midland, Michigan and has been, until recently, vice-president and director of research for the Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina. He also serves as an adjunct professor in toxicology at the University of North Carolina and North Carolina State University, and in pharmacology at the Duke University Medical Center. Dr. Gibson holds an undergraduate degree from Drake University and M.S. and Ph.D degrees in pharmacology from the University of Iowa. He is a Diplomate, Academy of Toxicological Sciences, and holds leadership posts in many professional societies. He also serves in editorial and advisory capacities for many professional publications. In addition, Dr. Gibson serves on numerous professional, industry, and government advisory boards, the most recent of which include the Scientific Review Panel of the National Library of Medicine, the Science Advisory Board of the Environmen- tal Protection Agency, the Environmental Health Sciences Review Committee of the National Institute of Environmental Health Sciences, the Scientific Board of Scientific Directors, ILSI Risk Science Institute, and the Advisory Committee for the Joint Industry Research Project on Benzene. Dr. Gibson was also a panelist on the National Academy of Sciences/National Research Council's Subcommittee on Toxicology, Safe Drinking Water Committee. STANLEY R. GLASSER is a faculty member in the Department of Cell Biology and Center for Population Research and Studies in Reproductive Biology at the Baylor College of Medicine. His laboratory is charged with the analysis of the cellular and molecular biological mechanisms that regulate the reciprocal relationships between the early mammalian embryo and individual cell types of the uterine endometrium that allow their temporally circumscribed interaction. Dr. Glasser received a B.A. degree in zoology and a B.S. degree in animal husbandry from Cornell University, and a Ph.D. degree from Rutgers University. He was a member of the radiation biology faculty at the University of Rochester Medical School and in the obstetrics and gynecology faculty at Vanderbilt Medical School. He has also been a fellow of the Weizmann Institute and has served on advisory panels of Task Force III of the National Institute of Environmental Health Sciences and the National Science Foundation. Dr. Glasser has organized a number of international symposia focusing on early mammalian development and has served on the editorial boards of his scientific societies. His publications include two books devoted to the regulatory biology of early pregnancy. BERNARD D. GOLDSTEIN is chairman of the Department of Environmental and Community Medicine at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School. He is also director of the Environmental and Occupational Health Sciences Institute, director of the graduate program in public health, and director of an NIEHS Center of Excellence, all joint programs of Rutgers University and UMDNJ. Dr. Goldstein, a physician board-certified in internal medicine and hematology,

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376 BIOGRAPHIES was a faculty member in the departments of Environmental Medicine and Medicine at New York University Medical Center until 1980, when he joined the staff of the UMDNJ. From 1983 to 1985, Dr. Goldstein was assistant administrator for research and development of the U.S. Environmental Protection Agency. He has been a member and chairman of the National Institutes of Health Toxicology Study Section and of EPA's Clean Air Scientific Advisory Committee. He was also chairman of the National Academy of Sciences Institute of Medicine Committee on the Role of the Physician in Occupational and Environmental Medicine, and currently chairs the NRC Committee on the Biomarkers in Environmental Health Research. ARTHUR F. HANEY is an associate professor and the director of the Division of Reproduc- tive Endocrinology and Infertility in the Department of Obstetrics and Gynecology with a joint appointment in Radiology at the Duke University Medical Center, Durham, North Carolina. He has served as a consultant for the National Institutes of Health, the Environmental Protection Agency, and the National Toxicology Program. He serves as an examiner for the American Board of Obstetrics and Gynecology and represented the United States in a scientific exchange with the People Republic of China. He is an active clinician, primarily involved in the assisted reproductive technologies. His research interests include the evaluation of reproductive toxicity with in vitro systems, the characteriza- tion of genital tract teratogenicity, the reproductive consequences of prenatal diethylstilbestrol exposure, and treatments for infertility. MAUREEN C. HATCH is assistant professor of epidemiology at the Columbia University School of Public Health. She is also affiliated with the Gertrude H. Sergievsky Center at Columbia and the Columbia Comprehensive Cancer Center. Dr. Hatch has also served on expert and research review groups for the National Institute for Occupational Safetv and Health, the U. S. Environmental Protection A~encv. the National Institute for Child health and Human Development, and the task force on environmental cancer and heart and lung disease. Her current research is on stress in pregnancy and low- level radiation and cancer. She is co-editor, with Dr. Zena Stein, of Reproductive Problems in the Workplace. ROGENE F. HENDERSON is a senior~scientist and supervisor of the Chemistry and Biochemical Toxicology Group at the Lovelace Inhalation Toxicology Research Institute in Albuquer- que, New Mexico. She has done extensive research on the analysis of bronchoalveolar ravage fluid to evaluate lung injury in animal toxicology studies. She has also headed up studies on the disposition and metabolic fate of inhaled vapors to aid in planning and interpretation of long-term carcinogenicity studies in rodents. Dr. Henderson has been a member of the Committee on Tcxicology of the Board on Environmen- tal Studies and Toxicology of the National Research Council since 1985. JOHN E. HOBBIE is director of the Ecosystems Center of the Marine Biological Laboratory, Woods Hole, Massachusetts. He is past president of the American Society for Limnology and Oceanography and of the Association of Ecosystem Research Centers. He currently serves on the Board of Trustees of the Marine Biological Laboratory. During 1988-89 he holds the Tage Erlander Visiting Professorship of the National Research Council of Sweden. His current research is on models of ecosystem response to global change, on the processes in arctic ecosystems, and on the use of stable isotopes in ecological research. PHILIP J. LANDRIGAN is professor of Community Medicine and director of the Division of Environmental and Occupational Medicine at Mt. Sinai School of Medicine where he is responsible for directing a research program in environmental and occupational l

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BIOGRAPHIES 377 medicine, for the training of residents, and for the teaching of medical students. Dr. Landrigan also holds a professorship in pediatrics at Mt. Sinai. He obtained his medical degree from the Harvard Medical School, interned at Cleveland Metropolitan General Hospital, and completed a residency in pediatrics at the Children's Hospital Medical Center in Boston. From 1970-1985, Dr. Landrigan, as a commissioned officer in the United States Public Health Service, served as a medical epidemiologist with the Centers for Disease Control. In this capacity, he established and directed the Environmental Hazards Branch of the Cancer and Birth Defects Division of the Bureau of Epidemiology. From 1979- 1985, as director of the Division of Surveillance, Hazard Evaluations and Field Studies of the National Institute for Occupational Safety and Health, he directed the national program in occupational epidemiology. Dr. Landrigan has a long-standing research interest in the clinical and epidemiologic evaluation of human diseases caused by toxic environmental and occupational exposures. His research has included studies of heavy metal poisoning, pesticide poisoning, solvent neuropathy, chronic lung disease, chemically induced renal disease, and occupational carcinogenesis. LAWRENCE D. LONGO is professor of physiology, professor of obstetrics and gynecology, and head of the Division of Perinatal Biology, Loma Linda University, Loma Linda, California. Under Dr. Longo's leadership, this division has grown into a prolific and well-regarded national research center for fetal and newborn biology. His primary areas of research have involved the dynamics and regulation of fetal oxygenation and the neuroendocrine regulation of the fetus. As a result of his investigation of maternal-fetal carbon monoxide exchange, he was asked to write the Surgeon General's report enumerating the negative effect of maternal cigarette smoking on the fetus. Dr. Longo has published numerous papers, review articles, and book chapters as a result of his research. RICHARD K. MILLER (Chairman, Panel on Pregnancy) is professor of obstetrics and gynecology and of toxicology at the University of Rochester, School of Medicine and Dentistry. He is also director of the Division of Research at the same institution. He has had appointments as an NIH Fogarty Senior International Fellow and a Fulbright Distinguished Professor. He is also a member of the Board of Scientific Counselors for the National Toxicology Program and serves on numerous committees for the U.S. Environmental Protection Agency, the U.S. National Institutes of Health, and the National Library of Medicine. Dr. Miller is currently editor-in-chief of the profes- sional journal, Trophoblast Research, and has served on the editorial boards of Placenta, Reproductive Toxicology, and Teratology. His numerous books and research publications are concerned with reproduction, placental function, teratology, and reproductive pharmacology and toxicology. HERBERT L. NEEDLEMAN is professor of psychiatry and associate professor of pediatrics at the University of Pittsburgh School of Medicine. He is medical director of the Allegheny County Lead Screening Program, and director of lead research at the university. He has served as consultant to the World Health Organization in designing studies of low level lead toxicity and on many advisory boards in environmental health. C. ALVIN PAULSEN, MD, is professor of medicine and the director of the Population Center for Research in Reproduction at the University of Washington School of Medicine, Seattle, Washington. He has served as chief of research at the U.S. Public Health Service Pacific Medical Center, where he currently holds the position of chief of endocrinology. He received his BA in 1947 from the University of Washington and his MD in 1952 from the University of Oregon. Following service in the U.S. Navy,

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378 BIOGRAPHIES he became director of laboratories at the Pacific Northwest Research Foundation. Dr. Paulsen's research has concentrated on studies of the male reproductive system with major research contributions that have included the recognition of sex chromosomal mosaicism and its concomitant clinical and pathologic manifestations in patients with Klinefelter's Syndrome, the delineation of the clinical characteristics and treatment modalities of patients with hypogonadotropic enunochoidism, and documentation of the relationship between varicocele and abnormal spermatogenesis with infertility. In these studies, Dr. Paulsen and his colleagues demonstrated the details of testicular function in those men with varicocele who remained fertile. Dr. Paulsen has contributed numerous articles to professional and scientific journals and has served on advisory boards for the National Institute of Health and on the Male Task Force for the World Health Organization. He is past president of the Pacific Coast Fertility Society, the American Society of Andrology, and the American Fertility Society. FREDERICA PERERA is associate professor in the Division of Environmental Sciences at the Columbia University School of Public Health. She is project director of several molecular epidemiology studies of chemical carcinogenesis in humans and has published extensively in the areas of molecular epidemiology, biomonitoring, risk assessment, and public health policy. Dr. Perera has served on numerous committees including those of the National Research Council, the National Toxicology Program, and the U.S. Environmental Protection Agency. EMIL PFITZER is assistant vice-president and group director of the Department of Toxicology and Pathology at Hoffmann-LaRoche Inc., where he is responsible for the design, conduct, and interpretation of toxicologic chemicals. He holds appointments as adjunct professor at Rutgers University and the New York University Institute of Environmental Medicine. He was president of the Society of Toxicology in 1985- 1986 and is a member of a number of national scientific organizations. He was certified in general toxicology by the American Board of Toxicology, Inc., in 1980. In addition to his work at Hoffmann-LaRoche Inc., he has served on the National Institute of Environmental Health Sciences Training Grant Review Committee, on advisory boards for the national Center for Toxicological Research and the Brookhaven National Laboratory Medical Department, and on several National Research Council committees. Dr. Pfitzer's publications include several book chapters on the principles of dose- effect and dose-response relationships. BERNARD ROBAIRE is professor of pharmacology and therapeutics at McGill University, Montreal, Quebec, Canada. He is also appointed in the McGill Department of Obstetrics and Gynecology. From 1982-1987 he served as director of the McGill Centre for the Study of Reproduction. Dr. Robaire has held offices in several learned societies and in 1988 he was president of the Canadian Fertility and Andrology Society. His scientific publications have focused on the regulation of epididymal functions, steroidal regulation of the hypothalamic pituitary testicular axis and male mediated teratogenesis. NEENA B. SCHWARTZ is William Deering Professor of Biological Sciences and director of the Center for Reproductive Science at Northwestern University, Evanston, Illinois. She has served as president of the Society for the Study of Reproduction and of the Endocrine Society. In 1985, she received the Williams Distinguished Service Award of the Endocrine Society, and is a fellow of the American Association for the Advancement of Science. She has served on the NICHD population research and training committee and is presently a member of the National Institutes of Health endocrinology study section. Her research focuses on the control of gonadotropin control hormone secretion

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BIOGRAPHIES 379 by the anterior pituitary as it is regulated by brain neuropeptides and gonadal steroid and peptide hormone feedback. RICHARD J. SHERINS, M.D., a specialist in male reproduction and andrology, is director of the Division of Andrology at the Genetics & IVF Institute in Fairfax, Virginia. He was formerly the Chief of the Section on Reproductive Endocrinology in the Developmen- tal Endocrinology Branch of the National Institute of Child Health and Human Development, the National Institutes of Health. He holds an undergraduate degree from UCLA and a medical degree from University of California, San Francisco Medical School. He received his clinical training in internal medicine at UCLA and served a fellowship in endocrinology at the University of Washington. Dr. Sherins has served on the editorial boards of numerous professional and scientific publications and has been adviser to industry and government organizations, He holds wide membership in professional societies and organizations and has served as president of the American Society of Andrology and chairman of the male reoroduction/urolo~v committee of the American Fertility Society. _ . ~ . _ . . ~ . ~ ~ . . Bits current research interests are In the hormonal regulation ot human spermatogenesis, male infertility, and sperm biology. ELLEN K. SILBERGELD is chief scientist of the Toxicological Branch for the Environmental Defense Fund in Washington, DC and serves as a neuropharmacologist with the National Institutes of Health Division of Communicable Disorders and Stroke. She also serves as an adjunct professor at the University of Maryland in the toxicology program and is on the faculty of Johns Hopkins University in the Department of Health Policy Management at the School of Hygiene and Public Health, the Johns Hopkins Medical Institute. Her professional appointments include the Science Advisory Board for the Environmental Protection Agency, the Scientific Advisory Panel for the Michigan Agent Orange Commission, and the Scientific Advisory Panel for the International Joint Commission on the Great Lakes. Among the many professional societies and organizations to which Dr. Silbergeld belongs are the American Public Health Associa- tion, the Association of Women in Science, the Society for Occupational and Environmental Health, the Society for Neuroscience and the Society of Toxicology. She has published extensively in scientific journals and is currently preparing a book for the World Health Organization on the health problems of lead in the environment. Dr. Silbergeld holds a Ph.D degree from the Johns Hopkins University in environmental engineering sciences. RICHARD G. SKALKO is professor and chairman of the Department of Anatomy at the Quillen- Dishner College of Medicine, East Tennessee State University. He has served as director of the embryology laboratory at the Birth Defects Institute, New York State Department of Health, and was professor of anatomy and toxicology at the Albany Medical College. He has also taught anatomy and toxicology at the Louisiana State and Cornell University Medical Centers. Dr. Skalko received undergraduate degrees from Providence College and St. John's University, and his Ph.D. from the University of Florida. His professional activities include membership in the Science Advisory Board for the National Center for Toxicolog- ical Research, in the Reproductive and Developmental Toxicology Review Committee for the National Toxicology Program, and in the Toxicology Study Section of the National Institutes of Health. He also serves as a member of the editorial boards of professional journals and as president of the Reproductive and Developmental Toxicology Specialty Section of the Society of Toxicology. STEPHEN P. SPIELBERG is associate professor of pediatrics and pharmacology at the University of Toronto and director of the Division of Clinical Pharmacology and

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380 SHIES Toxicology at the Hospital for Sick Children. He also serves director of the University of Toronto Centre for Drug Safety Research. He has served on pharmacology and toxicology grant review panels of both the National Institutes of Health and the Medical Research Council of Canada, as well as on the Committee on Drugs of the American Academy of Pediatrics. Dr. Spielberg also holds a Scholarship from the Medical Research Council of Canada. His research interests include the mechanisms of adverse effects of drugs and environ- mental chemicals in the human population, pharmacogenetics, and the development of biological markers of chemical exposure and toxicity. Current research activities include investigation of the mechanisms of toxicity and pharmacogenetic susceptibility to adverse reactions from sulfonamides and aromatic anticonvulsants as well as from environmental chemicals such as the polychlorinated biphenyls and dioxins. ANDREW WYROBEK is senior staff biophysicist in the Molecular Biology Section of the Biomedical Sciences Division at the Lawrence Livermore National Laboratory in Livermore, California. He received his B.S. in physics in 1970 from the University of Notre Dame and his Ph.D. in 1975 in medical biophysics from the University of Toronto, Canada. He was a commissioned officer in the U.S. Air Force and served at the Medical Research Laboratories at Wright-Patterson Air Force Base, in Dayton, Ohio. Dr. Wyrobek has been a member of numerous national science committees, advisory groups, and editorial boards. His research has included investigations of the effects of toxic chemicals and ionizing radiation on sperm production, and he developed quantitative morphometric approaches for human semen analysis. At Lawrence Livermore National Laboratory, he directs three research projects for developing new molecular methods to detect male reproductive toxicity as well as human somatic and germinal mutations.