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RISK ASSESSMENT IN THE FEDERAL GOVERNMENT: MANAGING llIE PROCESS WORItING PAPERS Prepared for . Committee on the Institutional Means for As ses seen t of Ri sks to Pub! ic Health Commission on Life Sciences NATIONAL RE SEARCH COUNC IL NATION AL ACADEMY PRESS April 1983

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PREFACE This volume contains papers that were originally prepared for the use of the National Research Council's Committee on the Institutional Means for Assessment of Risks to Public Health. The Committee, in conducting a congressionally mandated study of ways to improve the scientific basis of risk assessment in the federal government, commiss toned the work as pa rt of a larger analysis of federal experience. Me Committee' s final report, Risk Assessment in the Federal Government: Managing_the Process, was released in March 1983. ~=~ reflect ehe judgment or position of the Committee or the National Research Council. They 'cave not been subjected to the internal review procedures that apply to reports prepared by ARC committees. Ire three case studies have been reviewed by individuals outside the study project who are directly familiar with the federal analyses and decisions that are described; however, responsibility for them res ts wi th cue authors . The purpose of the case s tudies was to summarize issues raised by others in pas ~ decisions on particular substances, but t'ney are not intended to present independent positions or interpretations on scientific or policy matters. Lawrence E. McC ray Pro jec t Direc For April 29, 1983 ~

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TABLE OF CONTENTS FORMALDEHYDE The Consumer Product Safety Commission' Risk Assessment for Formaldehyde William M. Stigliani NITRITE Catherine St. Hilaire ASBESTOS Part I - Environmental Protec t ion Agency Part II - Occupational Safety and Health Agency/National Institite for Occupat tonal Safety and Real th William M. Stigliani AN ANATOMY OF RI SK ASSESSMENT: S(:IENTIFIC AND EXTRA-SCIENTIFIC COMPONENTS IN IRE ASSESSMENT OF SCIENTIFIC DATA ON CANCER RISKS Lawrence E. McCray FEDERAL RI SK ASSESSMENTS FOR POTENTIAL CARCINOGENS: AN EMP [RICAL REVIEW Robert ~ . F ie Id Lawrence E. McCray 1 39 S5 69 83 103

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