Vaccines Against Malaria: Hope in a Gathering Storm

Committee on Malaria Vaccines

Board on International Health

Board on Health Promotion and Disease Prevention

INSTITUTE OF MEDICINE

Philip K. Russell and Christopher P. Howson, Editors

NATIONAL ACADEMY PRESS
Washington, D.C.
1996



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement



Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm Vaccines Against Malaria: Hope in a Gathering Storm Committee on Malaria Vaccines Board on International Health Board on Health Promotion and Disease Prevention INSTITUTE OF MEDICINE Philip K. Russell and Christopher P. Howson, Editors NATIONAL ACADEMY PRESS Washington, D.C. 1996

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm NATIONAL ACADEMY PRESS 2101 Constitution Avenue, N.W. Washington, DC 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this, the Institute acts under both the Academy's 1863 congressional charter responsibility to be an adviser to the federal government and its own initiative in identifying issues of medical care, research, and education. Dr. Kenneth I. Shine is president of the Institute of Medicine. This study was supported in part by the MacArthur Foundation, the Rockefeller Foundation, the Burroughs Wellcome Fund, the National Institutes of Health, and the Navy Medical Research Institute. The views presented in this report are those of the Committee on Malaria Vaccines and are not necessarily those of the funding organizations. Additional copies of this report are available in limited quantities from: Board on International Health Institute of Medicine 2101 Constitution Avenue, N.W. Washington, DC 20418 Copyright 1996 by the National Academy of Sciences. All rights reserved. Printed in the United States of America The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The image adopted as a logotype by the Institute of Medicine is based on a relief carving from ancient Greece, now held by the Staatlichemuseen in Berlin.

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm COMMITTEE ON MALARIA VACCINES PHILIP K. RUSSELL (Chair), Department of International Health, School of Hygiene and Public Health, Johns Hopkins University STANLEY O. FOSTER, Department of International Health, Rollins School of Public Health, Emory University MAURICE R. HILLEMAN,* Institute for Therapeutic Research, Merck Research Labs, West Point, Pennsylvania RUSSELL J. HOWARD, AFFYMAX Research Institute, Santa Clara, California JEFFREY V. RAVETCH, Sloan-Kettering Institute, New York HARRISON C. SPENCER, London School of Hygiene and Tropical Medicine, University of London Staff CHRISTOPHER P. HOWSON, Project Director KIMBERLY A. BREWER, Research Assistant DELORES H. SUTTON, Project Assistant STEPHANIE Y. SMITH, Project Assistant MICHAEL A. STOTO, Director, Division of Health Promotion and Disease Prevention KATHLEEN R. STRATTON, Associate Director, Division of Health Promotion and Disease Prevention MONA R. BRINEGAR, Financial Associate *Member, National Academy of Sciences.

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm BOARD ON INTERNATIONAL HEALTH BARRY R. BLOOM (Cochair),* Howard Hughes Medical Institute, Albert Einstein College of Medicine, Yeshiva University HARVEY V. FINEBERG (Cochair),* Harvard School of Public Health JOHN H. BRYANT,* Moscow, Vermont JACQUELYN CAMPBELL, The Johns Hopkins University School of Nursing RICHARD G. A. FEACHEM, London School of Hygiene and Tropical Medicine, University of London JULIO FRENK,* Fundación Mexicana para la Salud, San Jerónimo Líce, Mexico DEAN JAMISON,* University of California, Los Angeles EILEEN T. KENNEDY, Center for Nutrition Policy and Promotion, Washington, D.C. ARTHUR KLEINMAN,* Harvard Medical School WILLIAM E. PAUL,* National Institute of Allergy and Infectious Diseases and Office of AIDS Research, National Institutes of Health, Rockville, Maryland PATRICIA ROSENFIELD, The Carnegie Corporation of New York, New York City THOMAS J. RYAN, Boston University School of Medicine and Boston University Medical Center SUSAN C. M. SCRIMSHAW,* University of Illinois School of Public Health, Chicago JUNE E. OSBORN (Institute of Medicine Liaison),* The University of Michigan School of Public Health WILLIAM H. FOEGE (Ex Officio),* Carter Center, Emory University DAVID P. RALL (Institute of Medicine Foreign Secretary),* National Institute of Environmental Health Sciences (retired), Washington, D.C. Staff CHRISTOPHER P. HOWSON, Director KIMBERLY A. BREWER, Research Assistant STEPHANIE Y. SMITH, Project Assistant MONA R. BRINEGAR, Financial Associate *Member, Institute of Medicine.

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm BOARD ON HEALTH PROMOTION AND DISEASE PREVENTION DONALD R. MATTISON (Chair), University of Pittsburgh M. JOYCELYN ELDERS, University of Arkansas for Medical Sciences, Little Rock DOUGLAS C. EWBANK, University of Pennsylvania CLAIRE M. FAGIN,* University of Pennsylvania PAUL S. FRAME,* Tri-County Family Medicine, Cohocton, New York ROBERT E. FULLILOVE, Columbia University School of Public Health KRISTINE M. GEBBIE,* Columbia University School of Nursing JEAN GOEPPINGER, University of North Carolina, Chapel Hill ANTONIO M. GOTTO, Jr.,* The Methodist Hospital, Houston ELLEN R. GRITZ, M. D. Anderson Cancer Center, The University of Texas,Houston RUTH T. GROSS,* Stanford University (retired), Longboat, Florida RICHARD B. JOHNSTON,Jr., The March of Dimes Birth Defects Foundation, White Plains, New York MARIE McCORMICK, Harvard School of Public Health RICARDO F. MUÑOZ, University of California at San Francisco and San Francisco General Hospital ELENA O. NIGHTINGALE,* Scholar-in-Residence, National Academy of Sciences, Washington, D.C. DIANA B. PETITTI, Kaiser Permanente Medical Care Program, Pasadena, California HUGH H. TILSON, Glaxo Wellcome Company, Research Triangle Park, North Carolina ROBERT B. WALLACE, University of Iowa Cancer Center KENNETH E. WARNER, University of Michigan School of Public Health ROBIN WEISS, Private Practice in Psychiatry, Baltimore, Maryland DONALD WHORTON, Private Practice, Alameda, California Staff MICHAEL A. STOTO, Director, Division of Health Promotion and Disease Prevention CYNTHIA ABEL, Program Officer DONNA THOMPSON, Division Assistant * Member, Institute of Medicine

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm This page in the original is blank.

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm ◆ ◆ ◆ ◆ ◆ Acknowledgments The committee is grateful to the many individuals who made substantive and productive contributions to this project. Particular thanks are in order to the following workshop presenters, whose effective efforts provided important information bearing on the topic of this report: W. R. Ballou, Walter Reed Army Institute of Research Center; William Bancroft, U.S. Army Medical Research and Materiel Command; Ian Bathurst, LXR Biotechnology; W. Neal Burnette, Molecular Pharmaceutics Corporation; Graham Brown, The Walter and Eliza Hall Institute of Medical Research; Daniel Colley, Centers for Disease Control and Prevention; Michael Davies, Medical Research Council; Carter Diggs, U.S. Agency for International Development; Howard Engers, World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases; Kenneth Guito, Connaught Laboratories; Lee Hall, National Institute of Allergy and Infectious Diseases; Stephen Hoffman, Naval Medical Research Institute; Palle Jakobsen, Danish International Development Agency (DANIDA) and Commission of European Communities; David Kaslow, National Institute of Allergy and Infectious Diseases; Wenceslaus Kilama, National Medical Research Council of Tanzania and the African Malaria Vaccine Testing Network; Donald Krogstad, Tulane University School of Public Health and Tropical Medicine; Louis Miller, National Institute of Allergy and Infectious Diseases; Ruth Nussenzweig, New York University Medical Center; Adeoye Olukotun, Bristol-Myers Squibb Company; Jerald Sadoff, Merck Research Laboratories; and John Tine, Virogenetics Corporation. In addition, the committee is indebted to the following persons for their substantive contributions to the workshop: Finley Austin, Burroughs Wellcome Fund; Constance Carrino, U.S. Agency for International Development; Salvatore Cirome, Office of the Assistant Secretary of Defense; Mary Galinski, The Malaria Foundation, Inc.; Charles Hoke, Jr., Walter Reed Army Institute of Research; Stephanie James, National Institute of Allergy and Infectious Diseases; Surayanarayan Ramachandran, Fogarty International Center for Advanced Study in the Health Sciences; Barry Silverman, Cambridge Consulting Company; and John Tomaro, U.S. Agency for International Development. The committee also owes special thanks to Donald Krogstad for ensuring the completeness and accuracy of Chapter 2, and to Michael Katz, The March of Dimes, and Robert Eisinger, NIH Office of AIDS Research, for providing helpful background information for the report.

OCR for page R1
Vaccines Against Malaria: Hope in a Gathering Storm The committee expresses its appreciation to the IOM staff who facilitated its work: Christopher Howson, study director; Kimberly Brewer, research assistant; Delores Sutton, project assistant; Stephanie Smith, project assistant beginning May 1996; Mona Brinegar, financial associate; Michael Edington, managing editor; and Claudia Carl, administrative associate. The committee also thanks Michael Stoto, director, and Kathleen Stratton, associate director, Division of Health Promotion and Disease Prevention, for their substantive input into the project and report, and Gregory Pearson, for his vision and hard work in realizing this project. This project was funded by the MacArthur Foundation, the Rockefeller Foundation, The Burroughs Wellcome Fund, the U.S. Public Health Service, and the Naval Medical Research Institute of the Department of Defense. The committee and staff are deeply appreciative of their support.