U.S. federal and private sponsors to conduct a workshop to evaluate current international efforts in malaria vaccine research and development and to make recommendations on how the U.S. federal government can help expedite more rapid and efficient development of promising malaria vaccine candidates. To accomplish this task, the IOM convened the Committee on Malaria Vaccines, a group of six members reflecting a broad range of expertise in microbiology, parasitology, vaccine research and development, molecular biology, epidemiology, and the conduct of vaccine field trials and related issues. The committee met on 7 July 1995 to review the project charge and develop the agenda for the international workshop. The workshop, which was subsequently held on 19–20 October 1995 in Washin, D.C. (see the Appendix for the agenda), addressed two key questions: what are the current incentives and disincentives to fuller participation of the industrial sector in malaria vaccine development, and how can the U.S. federal and industrial sectors and the international community work together more efficiently toward the common goal of developing effective malaria vaccines? This report summarizes the findings of the 19–20 October 1995 workshop.

ORGANIZATION OF THE REPORT

The report contains six chapters and one appendix. Chapter 1 summarizes the findings and recommendations of the workshop. Chapter 2 provides an overview of the global extent, causative agents, and mode of transmission of malaria; the health impact of malaria on the U.S. population; the economic and developmental impact of malaria; current strategies for malaria control; the rationale for developing a malaria vaccine; and the goals and target populations of malaria vaccine efforts to date. Chapter 3 focuses on the scientific and organizational elements that are in place and provides a rationale and basis for accelerated malaria vaccine development. Chapter 4 describes the current scientific and organizational obstacles that need to be addressed in developing a coherent plan of action, and Chapter 5 and Chapter 6 offer ways to surmount these obstacles. The Appendix provides the workshop agenda.

FINDINGS AND RECOMMENDATIONS

Workshop participants agreed that the successful development and widespread application of a vaccine that can prevent the illness and death of malaria could be one of the most important advances in medicine, with the potential for improving the lives of hundreds of millions of people. The successful completion of this task, however, will require an extraordinary level of effort in the scientific, public health, and industrial sectors, as well as coordination of these efforts. The following findings and recommendations of



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