Appendix A



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Permissible Exposure Levels for Selected Military Fuel Vapors Appendix A

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Permissible Exposure Levels for Selected Military Fuel Vapors This page in the original is blank.

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Permissible Exposure Levels for Selected Military Fuel Vapors PROGRAM: MODEL FOR TWO VOLATILE ORGANICS (PEL.CSL) 'PHYSIOLOGICALLY BASED MODELING OF HEXANE' 'AND TOLUENE FOR SUBCOMMITTEE ON PERMISSIBLE' 'EXPOSURE LEVELS FOR MILITARY FUELS' 'THIS PROGRAM DESCRIBES COMPETITIVE, NONCOMPETITIVE,' 'AND UNCOMPETITIVE INHIBITION IN THE METABOLISM OF TWO' 'VOLATILE ORGANIC CHEMICALS, HEXANE AND TOLUENE' INITIAL 'Physiological parameters' CONSTANT QPC=15. CONSTANT QCC=15. CONSTANT VLC=0.04 CONSTANT VFC=0.20 CONSTANT QLC=0.25 CONSTANT QFC=0.09 CONSTANT BW=80 'Partition coefficients; 1=HEXANE, 2=TOLUENE' CONSTANT PL1=2.27 CONSTANT PL2=4.64 CONSTANT PF1=69.4 CONSTANT PF2=56.7 CONSTANT PS1=1.27 CONSTANT PS2=1.54 CONSTANT PR1=2.27 CONSTANT PR2=4.64 CONSTANT PB1=2.29 CONSTANT PB2=18 'Biochemical Parameters; 1=HEXANE 2=TOLUENE' CONSTANT VMAXC1=3.0 CONSTANT VMAXC2=7.5 CONSTANT KM1=0.3 CONSTANT KM2=0.3 CONSTANT KMI1=0.3 CONSTANT KMI2=0.3 CONSTANT KM21=1E6 CONSTANT KM12=1E6 CONSTANT CONC1=150. $'Concentration in mg/m3 or ug/L' CONSTANT CONC2=150. CONSTANT MW1=88 CONSTANT MW2=92 CONSTANT KL1=0.

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Permissible Exposure Levels for Selected Military Fuel Vapors CONSTANT KL2=0. AIO1=CONC1/MW1 $'Initial concentration in umoles/L' AIO2=CONC2/MW2   '** TIMING COMMANDS' SCHEDULE DS1 .AT. TCHNG CIZONE=1. CONSTANT TCHNG=8. CONSTANT TSTOP=48. CONSTANT POINTS=50. CINT=TSTOP/POINTS 'SCALED PARAMETERS' QC = QCC*BW**0.74 QP = QPC*BW**0.74 VMAX1 = VMAXC1*BW**0.7 VMAX2 = VSAXC2*BW**0.7 QL = QLC*QC QF = QFC*QC QS = 0.24*QC-QF QR = 0.76*QC-QL VL = VLC*BW VS = 0.82*BW-VF VR = 0.09*BW-VL END $'END OF INITIAL' DYNAMIC ALGORITHM IALG=2 DISCRETE DS1 CIZONE=0 CALL LOGD (.TRUE.) END DERIVATIVE 'COMPOUND 1' 'CI = CONCENTRATION IN INHALED AIR (UMOLE/L)' RAI1 = QP*CI1 AI1 = INTEG(RAI1,0.)

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Permissible Exposure Levels for Selected Military Fuel Vapors CI1 = AIO1*CZONE 'AB = AMOUNT IN LUNG BLOOD COMPARTMENT (UMOLE)' CA1 = (QC*CV1+QP*CI1)/(QP/PB1+QC) CX1 = CA1/PB1 AUCB1= INTEG(CA1,.0001) 'AX = AMOUNT EXHALED (UMOLE)' RAX1 = QP*CX1 AX1 = INTEG(RAX1,.0001) 'AF = AMOUNT IN FAT COMPARTMENT (UMOLE)' RAF1 = QF*(CA1-CVF1) AF1 = INTEG(RAF1,.0001) CVF1 = AF1/(VF*PF1) CF1 = AF1/VF 'AL = AMOUNT IN LIVER COMPARTMENT (UMOLE)' RAL1 = QL*(CA1-CVL1)-RAM1 AL1 = INTEG(RAL1,.0001) CVL1 = AL1/ (VL*PL1) CL1 = AL1/VL 'AS = AMOUNT IN SLOWELY PERFUSED TISSUES (UMOLE)' RAS1 = QS*(CA1-CVS1) AS1 = INTEG(RAS1,.0001) CVS1 = AS1/(VS*PS1) CS1 = AS1/VS 'AR = AMOUNT IN RAPIDLY PERFUSED TISSUES (UMOLE)' RAR1 = QR* (CA1-CVR1) AR1 = INTEG(RAR1,.0001) CVR1 = AR1/(VR*PR1) CR1 = AR1/VR 'AM = AMOUNT METABOLIZED (UMOLE)' RAM1 = (VAMX1*CVL1)/KM1*DEN1+CVL1*DEN2) DEN1 = 1.+CVL2/KMI2 DEN2 = 1.+CVL2/KM21 AM1 = INTEG(RAM1,.0001) 'CV = MIXED VEMOUS BLOOD CONCENTRATION (UMOLE)' CV1 = (QF*CVF1 + QL*CVL1 + QS*CVS1 + QR*CVR1)/QC 'COMPOUND 1' 'CI = CONCENTRATION IN INHALED AIR (UMOLE/L)' RAI2 = QP*CI2

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Permissible Exposure Levels for Selected Military Fuel Vapors AI2 = INTEG(RAI2,0.) CI2 = AIO2*CZONE 'AB = AMOUNT IN LUNG BLOOD COMPARTMENT (UMOLE)' CA2 = (QC*CV2+QP*CI2)/(QP/PB2+QC) CX2 = CA2/PB2 AUCB2= INTEG(CA2,.0001) 'AX = AMOUNT EXHALED (UMOLE)' RAX2 = QP*CX2 AX2 = INTEG(RAX2, .0001) 'AF = AMOUNT IN FAT COMPARTMENT (UMOLE)' RAF2 = QF* (CA2-CVF2) AF2 = INTEG(RAF2,.0001) CVF2 = AF2/(VF*PF2) CF2 = AF2/VF 'AL = AMOUNT IN LIVER COMPARTMENT (UMOLE)' RAL2 = QL*(CA2-CVL2)-RAM2 AL2 = INTEG(RAL2, .0001) CVL2 = AL2/(VL*PL2) CL2 = AL2/VL 'AS = AMOUNT IN SLOWELY PERFUSED TISSUES (UMOLE)' RAS2 = QS*(CA2-CVS2) AS2 = INTEG(RAS2,.0001) CVS2 = AS2/(VS*PS2) CS2 = AS2/VS 'AR = AMOUNT IN RAPIDLY PERFUSED TISSUES (UMOLE)' RAR2 = QR*(CA2-CVR2) AR2 = INTEG(RAR2,.0001) CVR2 = AR2/(VR*PR2) CR2 = AR2/VR 'AM = AMOUNT METABOLIZED (UMOLE)' RAM2 = (VAMX2*CVL2)/KM2*DEN3+CVL2*DEN4) DEN3 = 1.+CVL1/KMI1 DEN4 = 1.+CVL1/KM12 AM2 = INTEG(RAM2,.0001) 'CV = MIXED VEMOUS BLOOD CONCENTRATION (UMOLE)' CV2 = (QF*CVF2 + QL*CVL2 + QS*CVS2 + QR*CVR2)/QC TERMT(T.GT.TSTOP) END $'END OF DERIVATIVE' END $'END OF DYNAMIC' END $'END OF PROGRAM'