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TABLE 9.2 Benefits and Affordability of Various Vaccine Candidates

Vaccine

Annualized Present Value of Potential Health Benefits (IME units)

Vaccine

Annualized Present Value of Potential Expenditures ($ millions)

S. pneumoniae

1,363,943

Rabies (live vector virus)

15.5

Rotavirus (HPBRV)

521,852

V. cholera (attenuated live)

23.8

Malaria (monovalent)

475,205

V. cholera (inactivated)

43.6

Rotavirus (LPBRV)

450,795

E. coli (attenuated live)

69.2

Rotavirus (RMRV)

450,795

Shigella

91.6

S. typhi (Ty21a)

431,471

Yellow fever

93.0

Malaria (multivalent)

426,640

Rabies (glycoprotein)

138.7

Shigella

222,096

Rabies (Vero cell derived)

146.8

Hepatitis B

213,192

S. typhi (aa-strain)

152.2

H. influenzae b

210,943

Dengue

241.8

S. typhi (aa-strain)

194,745

M. leprae

270.6

Streptococcus group A

180,513

S. typhi (Ty21a)

358.0

E. coli (attenuated live)

145,260

H. influenzae b

526.6

E. coli (purified antigens)

126,454

Streptococcus group A

554.2

V. cholera (attenuated live)

94,986

Japanese encephalitis

614.0

M. leprae

88,481

Rotavirus (LPBVR)

655.4

V. cholera (inactivated)

65,548

Rotavirus (RMRV)

655.9

RSV (attenuated live virus)

59,559

N. meningitidis

708.1

RSV (glycoprotein)

52,412

E. coli (purified antigens)

722.3

Parainfluenza viruses

43,692

Rotavirus (HPBRV)

852.7

Rabies (Vero cell derived)

41,910

Malaria (multivalent)

856.8

Rabies (glycoprotein)

37,983

Malaria (monovalent)

967.3

Hepatitis A (attenuated live virus)

15,112

RSV (attenuated live)

982.8

Hepatitis A (polypeptide)

14,392

Hepatitis A (attenuated live)

1,058.0

N. meningitidis

13,754

Streptococcus pneumoniae

1,310.3

Yellow fever virus

11,127

Parainfluenza

1,697.1

Dengue virus

9,558

RSV (glycoprotein)

1,964.4

Rabies (live vector virus)

8,260

Hepatitis A (polypeptide)

4,029.0

Japanese encephalitis virus

3,232

Hepatitis B

8,859.3

Health benefits are expressed in units equivalent in undesirability to the death of an infant (IMEs) and are calculated using the median of IME perspectives from responding health professionals in developing countries.



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