TABLE 9.5 Sensitivity Analysis: Effect of Discount Rate on Annualized Present Value of Potential Health Benefits for Various Vaccine Candidates
|
|
Discount Rate |
|||||
|
|
Central Analysis, 0.05 |
0.02 |
0.10 |
|||
|
Vaccine |
Rank |
Value (IME Units) |
Rank |
Value (IME Units) |
Rank |
Value (IME Units) |
|
S. pneumoniae |
1 |
1,363,943 |
1 |
1,770,510 |
1 |
897,358 |
|
Rotavirus (HPBRV) |
2 |
521,852 |
5 |
603,244 |
2 |
413,552 |
|
Malaria (monovalent) |
3 |
475,205 |
3 |
663,218 |
5 |
278,319 |
|
Rotavirus (LPBRV) |
4 |
450,795 |
6 |
568,450 |
3 |
310,708 |
|
Rotavirus (RMRV) |
4 |
450,795 |
6 |
568,450 |
4 |
310,708 |
|
S. typhi (Ty21a) |
6 |
431,471 |
2 |
686,085 |
7 |
204,973 |
|
Malaria (multivalent) |
7 |
426,640 |
4 |
640,191 |
6 |
222,440 |
|
Shigella |
8 |
222,096 |
10 |
323,742 |
9 |
121,310 |
|
Hepatitis B |
9 |
213,192 |
8 |
554,897 |
15 |
45,926 |
|
H. influenzae b |
10 |
210,943 |
12 |
281,875 |
8 |
132,474 |
|
S. typhi (aa-strain) |
11 |
194,745 |
9 |
363,189 |
12 |
71,630 |
|
Streptococcus group A |
12 |
180,513 |
11 |
317,684 |
11 |
72,869 |
|
E. coli (attenuated live) |
13 |
145,260 |
13 |
211,741 |
10 |
79,342 |
|
E. coli (purified antigens) |
14 |
126,454 |
14 |
184,238 |
13 |
69,070 |
|
V. cholera (attenuated live) |
15 |
94,986 |
16 |
126,925 |
14 |
59,652 |
|
M. leprae |
16 |
88,481 |
17 |
162,639 |
19 |
33,310 |
|
V. cholera (inactivated) |
17 |
65,548 |
17 |
82,656 |
16 |
45,179 |
|
RSV (attenuated live virus) |
18 |
59,559 |
18 |
75,104 |
17 |
41,051 |
|
RSV (glycoprotein) |
19 |
52,412 |
19 |
66,092 |
18 |
36,125 |
|
Parainfluenza viruses |
20 |
43,692 |
20 |
60,101 |
22 |
26,192 |
|
Rabies (Vero cell derived) |
21 |
41,910 |
21 |
52,088 |
20 |
29,566 |
|
Rabies (glycoprotein) |
22 |
37,983 |
22 |
47,207 |
21 |
26,795 |
|
Hepatitis A (attenuated live virus) |
23 |
15,112 |
23 |
20,787 |
23 |
9,059 |
|
Hepatitis A (polypeptide) |
24 |
14,392 |
24 |
20,379 |
24 |
8,235 |
|
N. meningitidis |
25 |
13,754 |
25 |
20,049 |
25 |
7,513 |
|
Yellow fever virus |
26 |
11,127 |
26 |
19,301 |
26 |
4,598 |
|
Dengue virus |
27 |
9,558 |
27 |
15,646 |
27 |
4,334 |
|
Rabies (live vector virus) |
28 |
8,260 |
28 |
5,630 |
28 |
2,969 |
|
Japanese encephalitis virus |
29 |
3,232 |
29 |
5,215 |
29 |
1,500 |