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TABLE 9.5 Sensitivity Analysis: Effect of Discount Rate on Annualized Present Value of Potential Health Benefits for Various Vaccine Candidates

 

Discount Rate

 

Central Analysis, 0.05

0.02

0.10

Vaccine

Rank

Value (IME Units)

Rank

Value (IME Units)

Rank

Value (IME Units)

S. pneumoniae

1

1,363,943

1

1,770,510

1

897,358

Rotavirus (HPBRV)

2

521,852

5

603,244

2

413,552

Malaria (monovalent)

3

475,205

3

663,218

5

278,319

Rotavirus (LPBRV)

4

450,795

6

568,450

3

310,708

Rotavirus (RMRV)

4

450,795

6

568,450

4

310,708

S. typhi (Ty21a)

6

431,471

2

686,085

7

204,973

Malaria (multivalent)

7

426,640

4

640,191

6

222,440

Shigella

8

222,096

10

323,742

9

121,310

Hepatitis B

9

213,192

8

554,897

15

45,926

H. influenzae b

10

210,943

12

281,875

8

132,474

S. typhi (aa-strain)

11

194,745

9

363,189

12

71,630

Streptococcus group A

12

180,513

11

317,684

11

72,869

E. coli (attenuated live)

13

145,260

13

211,741

10

79,342

E. coli (purified antigens)

14

126,454

14

184,238

13

69,070

V. cholera (attenuated live)

15

94,986

16

126,925

14

59,652

M. leprae

16

88,481

17

162,639

19

33,310

V. cholera (inactivated)

17

65,548

17

82,656

16

45,179

RSV (attenuated live virus)

18

59,559

18

75,104

17

41,051

RSV (glycoprotein)

19

52,412

19

66,092

18

36,125

Parainfluenza viruses

20

43,692

20

60,101

22

26,192

Rabies (Vero cell derived)

21

41,910

21

52,088

20

29,566

Rabies (glycoprotein)

22

37,983

22

47,207

21

26,795

Hepatitis A (attenuated live virus)

23

15,112

23

20,787

23

9,059

Hepatitis A (polypeptide)

24

14,392

24

20,379

24

8,235

N. meningitidis

25

13,754

25

20,049

25

7,513

Yellow fever virus

26

11,127

26

19,301

26

4,598

Dengue virus

27

9,558

27

15,646

27

4,334

Rabies (live vector virus)

28

8,260

28

5,630

28

2,969

Japanese encephalitis virus

29

3,232

29

5,215

29

1,500



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