. "Appendix C: The Burden of Disease Resulting from Diarrhea." New Vaccine Development: Establishing Priorities: Volume II, Diseases of Importance in Developing Countries. Washington, DC: The National Academies Press, 1986.
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New Vaccine Development: Establishing Priorities, Volume II, Diseases of Importance in Developing Countries
TABLE C.1 Annual Incidence of Diarrheal Diseasea (episodes per individual per year)
aModified from Programme for Control of Diarrhoeal Diseases (1984).
bUnder 5 years episodes are estimated to be distributed 0.7:0.3 between under 2 years and 2 to 4 years age groups.
TABLE C.2 Estimated 1984 Population for Regions Where Developing Countries Predominatea (thousands)
Age Group (years)
Region
Under 5
5–14
15–59
60 and Over
Total
Africa
96,802
141,459
265,451
27,288
531,000
Asia
343,700
666,402
1,472,242
179,656
2,662,000
Latin America
57,235
100,220
214,415
25,130
397,000
Oceania
822
1,285
2,620
273
5,000
Total
498,559
909,366
1,954,728
232,347
3,595,000
aDerived by applying the proportions of the 1980 population in various age groups to the mid-1984 population projections. See Chapter 4, Table 4.4, for the countries included.
million deaths). This total reasonably agrees with the estimated 3.5 million derived by the foregoing approach.
Tables C.6 and C.7 show the estimated distribution of the diarrheal disease burden by etiology. These estimates were derived from expert judgment after a review of available publications and from personal field experience. Only those etiologies for which vaccine prospects are reasonably promising were considered. Salmonella was subsequently dropped from consideration.
