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TABLE 1.6 Summary of Findings: Rankings of Various Vaccine Candidates Based on Their Potential Health Benefits Under a Variety of Assumptions and Resource Constraints




S. pneumoniae

Hepatitis B virus

Hepatitis A (either candidate)

Plasmodium spp. (malaria; both monovalent and circumsporozoite protein-based approaches)

H. influenzae type b

N. meningitidis

E. coli (either candidate)

Yellow fever virus

Rotavirus (all three candidates)

Streptococcus group A


S. typhi (Ty21a)

S. typhi (an aromatic amino acid-requiring strain)

Rabies (live vector virus)

Shigella spp.

M. leprae

Japanese encephalitis virus


V. cholerae (either candidate)



Respiratory syncytial virus (either candidate)






Rabies (vero cell derived or glycoprotein)


NOTE: Because certain vaccine candidates may enter different categories if other plausible assumptions are adopted, these assignments should not be regarded as definitive.

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