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New Vaccine Development: Establishing Priorities: Volume II, Diseases of Importance in Developing Countries (1986)
Board on Population Health and Public Health Practice (BPH)

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. "Appendix D-3: The Prospects for Immunizing Against Hemophilus influenzae Type b." New Vaccine Development: Establishing Priorities: Volume II, Diseases of Importance in Developing Countries. Washington, DC: The National Academies Press, 1986.

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New Vaccine Development: Establishing Priorities, Volume II, Diseases of Importance in Developing Countries

Cochi, S.L. 1983. Personal communication. Centers for Disease Control, Atlanta, Ga.


Egan, W.M., F.-P.Tsui, and G.Zon. 1982. Structural studies of the Haemophilus influenzae capsular polysaccharides. Pp. 185–196 in Haemophilus influenzae, S.H.Sell and P.P.Wright, eds. New York: Elsevier Science.

Eskola, J., H.Peltola, P.H.Mäkelä, H.Käyhty, V.Karanko, J.Samuelson, and L.K.Gordon. 1985. Antibody levels achieved in infants by course of Haemophilus influenzae type b polysaccharide/ diphtheria toxoid conjugate vaccine. Lancet I:1184–1186.


Fothergill, L.D., and J.Wright. 1933. Influenzal meningitis; relation of age incidence to the bactericidal power of blood against the causal organism. J. Immunol. 24:273–284.


Gordon, L.K. 1985. Personal communication, Connaught Research Institute, Ontario, Canada.

Griffiss, J.M. 1985. Personal communication, School of Medicine, University of California, San Francisco.


Hansen, E.J., C.F.Frisch, K.H.Johnston. 1982a. Cell envelope proteins of Haemophilus influenzae type b: Potential vaccination candidates. Pp. 197–206 in Haemophilus influenzae, S.H.Sell and P.F.Wright, eds. New York: Elsevier Science.

Hansen, E.J., S.M.Robertson, P.A.Gulig, C.F.Frisch, E.J.Haanes. 1982b. Immunoprotection of rats against Haemophilus influenzae type b disease mediated by monoclonal antibody against a Haemophilus outer-membrane protein. Lancet I (8268):366–368.

Hill, J.C. 1983. Summary of a workshop on Haemophilus influenzaetype b vaccines. J. Infect. Dis. 148:167–175.


Institute of Medicine. 1985. New Vaccine Development: Establishing Priorities, Volume I. Diseases of Importance in the United States. Washington, D.C.: National Academy Press.


King, S.D., A.Ramlal, H.Wynter, K.Moodie, D.Castle, J.S.C.Kuo, L. Barnes, and C.L.Williams. 1981. Safety and immunogenicity of a new Haemophilus influenzae type b vaccine in infants under one year of age. Lancet II (8249):705–709.


Lepow, M.L., J.S.Samuelson, and L.K.Gordon. 1985. Safety and immunogenicity of Haemophilus influenzae type b-polysaccharide diphtheria toxoid conjugate vaccine in infants 9 to 15 months of age. J. Pediatrics 106:185–189.

Loeb, M.R., and D.H.Smith. 1980. Outer membrane protein composition in disease isolates of Haemophilus influenzae: Pathogenic and epidemiological implication. Infect. Immun. 30(3):709–717.


Mäkelä, P.H., J.Peltola, H.Käyhty, H.Jousimies, O.Pettay, E. Ruoslahti, A.Sivonen, and O.-V.Renkonen. 1977. Polysaccharide vaccine of group A Neisseria meningtitidis and Haemophilus influenzae type b: Field trial in Finland. J.Infect. Dis. 136(Suppl.):S43–50.

Myerowitz, R.L., and C.W.Norden. 1977. Immunology of the infant rat experimental model of Haemophilus influenzae type b meningitis. Infect. Immun. 16 (1):218–225.

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Front Matter (R1-R16)
1. Summary (1-18)
2. Priority Setting for Health-Related Investments: A Review of Methods (19-29)
3. Overview of the Analytic Approach (30-43)
4. Comparison of Disease Burdens (44-62)
5. Predictions of Vaccine Development (63-75)
6. Assessing the Likely Utilization of New Vaccines (76-81)
7. Calculation and Comparison of the Health Benefits and Differential Costs Associated with Candidate Vaccines (82-105)
8. Additional Issues in the Selection of Priorities for Accelerated Vaccine Development (106-120)
9. Findings, Conclusions, and Recommendations (121-142)
Appendix A: Selection of Vaccine Candidates for Accelerated Development (143-148)
Appendix B: The Burden of Disease Resulting from Acute Respiratory Illness (149-158)
Appendix C: The Burden of Disease Resulting from Diarrhea (159-169)
Appendix D-1: The Prospects for Immunizing Against Dengue Virus (170-177)
Appendix D-2: The Prospects for Immunizing Against Escherichia coli (178-185)
Appendix D-3: The Prospects for Immunizing Against Hemophilus influenzae Type b (186-196)
Appendix D-4: The Prospects for Immunizing Against Hepatitis A Virus (197-207)
Appendix D-5: The Prospects for Immunizing Against Hepatitis B Virus (208-222)
Appendix D-6: The Prospects for Immunizing Against Japanese Encephalitis Virus (223-240)
Appendix D-7: The Prospects for Immunizing Against Mycobacterium leprae (241-250)
Appendix D-8: The Prospects for Immunizing Against Neisseria meningitidis (251-266)
Appendix D-9: The Prospects for Immunizing Against Parainfluenza Viruses (267-274)
Appendix D-10: The Prospects for Immunizing Against Plasmodium spp. (275-286)
Appendix D-11: The Prospects for Immunizing Against Rabies Virus (287-298)
Appendix D-12: The Prospects for Immunizing Against Respiratory Syncytial Virus (299-307)
Appendix D-13: The Prospects for Immunizing Against Rotavirus (308-318)
Appendix D-14: The Prospects for Immunizing Against Salmonella typhi (319-328)
Appendix D-15: The Prospects for Immunizing Against Shigella spp. (329-337)
Appendix D-16: The Prospects for Immunizing Against Streptococcus Group A (338-356)
Appendix D-17: The Prospects for Immunizing Against Streptococcus pneumoniae (357-375)
Appendix D-18: The Prospects for Immunizing Against Vibrio cholerae (376-389)
Appendix D-19: The Prospects for Immunizing Against Yellow Fever (390-402)
Appendix E: Questionnaire for Assessing Morbidity-Mortality Trade-Offs (403-411)
Appendix F: Technical Notes (412-412)
Appendix G: Biographical Notes on Committee Members (413-417)
Appendix H: Additional Sources of Advice to the Committee (418-419)
Appendix I: Contents of Supplement to Volume II (420-420)
Appendix J: Preface to Volume I (421-422)
Appendix K: Contents to Volume I (423-423)
Index (424-432)