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Problems to be Overcome

Major economic, political, and social problems may hamper efforts to evaluate potential vaccine candidates for leprosy. Research and field studies to determine which vaccines are most appropriate for specific populations will be expensive. Some areas of the developing world that possess the field and clinical expertise to participate in vaccine trials and evaluations lack the national political commitment to initiate and carry out essential background work. The most significant social question will be whether the identification of an effective vaccine for leprosy and the development of suitable delivery systems can overcome the universal stigma associated with the disease.

REFERENCES

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Bloom, B.R., and V.Mehra. 1984. Vaccine strategies for the eradication of leprosy. Pp. 368–389 in New Approaches to Vaccine Development, R.Bell and G.Torrigiani, eds. Basel, Switzerland: Schwabe and Co. AG.


Convit, J., M.Aranzazu, M.Pinardi, and M.Ulrich. 1979. Immunological changes observed in indeterminate and lepromatous leprosy patients and Mitsuda-negative contacts after the inoculation of a mixture of Mycobacterium leprae and BCG. Clin. Exp. Immuno. 36:214,

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Gill, H.K., A.S.Mustafa, and T.Godal. In press. Sensitization of normal human volunteers with a candidate vaccine against leprosy. Bull. WHO.


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Mehra, V., and B.R.Bloom. 1979. Induction of cell mediated immunity to Mycobacterium leprae in guinea pigs. Infect. Immun. 23:787–794.


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