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glycoproteins of all three PIV types should be a priority. Finally, detailed information on both the HN and the fusion proteins of all three types should be made available through studies of the glycoproteins themselves, their purification, and their chemistry.

Some recent progress toward PIV vaccines has been reported by the National Institute of Allergy and Infectious Diseases (1985). Purified HN and F glycoproteins from PIV 3 have been developed by the University of Alabama as a candidate vaccine. Cold adapted PIV 3 mutants have been developed by investigators at Marshall College of Medicine, and tests in humans are planned. In addition, approaches using purified viral fusion proteins are being investigated (National Institute of Allergy and Infectious Diseases, 1985).

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Chanock, R.M., R.H.Parrott, A.Z.Kapikian, H.W.Kim, and C.D.Brandt. 1968. Possible role of immunological factors in the pathogenesis of RS virus lower respiratory tract disease. Perspect. Virol. VI:125–139.

Clyde, W.A., and F.W.Denny, eds. 1983. Workshop on acute respiratory diseases among children of the world. Pediatr. Res. 17:1023–1076.


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