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At the time of publication of this report, a vaccine candidate based on Salmonella typhi Ty21a was scheduled for a safety and antigenicity trial in children and a field trial for efficacy in children and adults. Another recombinant approach, an E. coli strain carrying the protective S. flexneri type 2A gene, also awaited human trials. In addition, attempts were under way to obtain, for testing in the United States, an apparently protective attenuated strain of S. flexneri developed as an oral vaccine in Rumania (National Institute of Allergy and Infectious Diseases, 1985).


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