Moderate localized pain and/or mild systemic reaction or impairment requiring minor change in normal activities, and associated with some restriction of work activity.
Moderate pain and/or moderate impairment requiring moderate change in normal activities, e.g., house-bound or in bed, and associated with temporary loss of ability to work.
Severe pain, severe short-term impairment, or hospitalization
Mild chronic disability (not requiring hospitalization, institutionalization, or other major limitation of normal activity, and resulting in minor limitation of ability to work).
Moderate to severe chronic disability (requiring hospitalization, special care, or other major limitation of normal activity, and seriously restricting ability to work).
Reproductive impairment resulting in infertility.
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Appendix E: Questionnaire for Assessing Morbidity-Mortality Trade-Offs ."
New Vaccine Development: Establishing Priorities: Volume II, Diseases of Importance in Developing Countries . Washington, DC: The National Academies Press,
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