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TABLE 4.9 Morbidity and Mortality Burdens Resulting from Various Diseases

Disease

Total Disease Burden Valuea (IME units)b

Normalized (percent)

Dengue virus

34,365

0.52

Escherichia coli

978,248

14.79

 

(550,248)c

(8.32)

Hemophilus influenzae type b

471,336

7.13

Hepatitis A virus

30,229

0.46

Hepatitis B virus

2,394,256

36.21

Japanese encephalitis virus

18,075

0.27

Mycobacterium leprae

657,349

9.94

Neisseria meningitidis

68,252

1.03

Parainfluenza virus

145,954

2.21

Plasmodium spp.

2,111,795

31.94

Rabies virus

67,821

1.03

Respiratory syncytial virus

183,326

2.77

Rotavirus

925,042

13.99

 

(488,542)c

(7.39)

Salmonella typhi

1,308,121

19.78

Shigella spp.

828,068

12.52

Streptococcus Group A

811,477

12.27

Streptococcus pneumoniae

6,612,261

100.00

Vibrio cholera

229,217

3.47

Yellow fever virus

32,887

0.50

aSee Appendixes D-1 through D-19 for derivations of disease burden estimates used to calculate TDBVs.

bInfant mortality equivalence units.

cValues in parentheses represent the anticipated disease burden from certain diarrheal pathogens if a plausible increase in oral rehydration therapy is assumed (see Appendix C).

development is described in Appendixes D-1 through D-19. Various assumptions were entailed in deriving such estimates. Table 4.9 shows the total disease burden values calculated for each disease (using disease burden estimates and the median of perspectives from public health professionals in developing countries). Use of these total disease burden values to rank the diseases is demonstrated in Table 4.10.

Chapter 7 describes application of the disease comparison system to the calculation of potential health benefits from candidate vaccines.

LIMITATIONS OF THE PROPOSED SYSTEM

The proposed system assesses the most obvious feature of infectious diseases, morbidity, and mortality. The aggregate nature of the total



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