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Rotavirus
(Infants at earliest possible age, preferably with oral polio vaccine)
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Attenuated high passage bovine rotavirus
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Birth cohort: 115.1 million
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Probable age of vaccination
(<1 year) to peak of disease (6–24 months) , i.e., approx. 1 year
|
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Attenuated low passage bovine rotavirus
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Rhesus monkey rotavirus
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Salmonella typhi
(Children; young adults at risk; travelers from developed countries to endemic areas)
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Attenuated ga1E mutant S. typhi strain TY21a
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Birth cohort: 115.1 million
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Probable age of vaccination
(<1 year) to midpoint of peak range of disease (approx. 14 yrs.), i.e., approx. 13 years
|
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Aromatic amino acid dependent strains of S. typhi
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Shigella spp.
(Infants at birth or earliest possible age; elderly for epidemic strains)
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Probably plasmid mediated outer membrane protein invasion determinant (there are a small number of promising options needing investigation to determine best approach)
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Birth cohort: 115.1 million
|
Probable age of vaccination
(<1 year) to peak of disease (6–24 months), i.e., approx. 1 year
|
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Streptococcus A
(Children,<3 to 4 years)
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Synthetic M protein segment
(excluding portions cross-reacting with human tissue)
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Birth cohort: 115.1 million
|
Probable age of vaccination
(<1 year) to peak of severe disease and complications (10 years), i.e., approx. 9 years
|
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Streptococcus pneumoniae
(Infants)
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Conjugated polysaccharides, polyvalent
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Birth cohort: 115.1 million
|
Frobable age of vaccination
(<1 year) to peak of disease (3 years?), i.e., approx. 2 years
|
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Vibrio cholera
(Children, especially <2 years)
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Genetically defined live mutant V. cholerae (A−B+ or A−B−) with respect to toxin subunit synthesis
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Birth cohort in endemic areas: 22.2 million
|
Probable age of vaccination
(<1 year) to peak incidence of disease in endemic areas (2–4 years), i.e., approx. 2 years
|
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Inactivated antigens
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Yellow fever virus
(Young children)
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Attenuated live virus produced in cell culture
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Birth cohort in endemic areas: 24.8 million
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Probable age of vaccination
(<1 year) to peak of disease (approx. 15, depending on area), i.e., approx. 14 years
|
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aSee appropriate appendix for derivation.
bDengue hemorrhagic fever/dengue shock syndrome.
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