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Rotavirus

(Infants at earliest possible age, preferably with oral polio vaccine)

Attenuated high passage bovine rotavirus

Birth cohort: 115.1 million

Probable age of vaccination

(<1 year) to peak of disease (6–24 months) , i.e., approx. 1 year

Attenuated low passage bovine rotavirus

Rhesus monkey rotavirus

Salmonella typhi

(Children; young adults at risk; travelers from developed countries to endemic areas)

Attenuated ga1E mutant S. typhi strain TY21a

Birth cohort: 115.1 million

Probable age of vaccination

(<1 year) to midpoint of peak range of disease (approx. 14 yrs.), i.e., approx. 13 years

Aromatic amino acid dependent strains of S. typhi

Shigella spp.

(Infants at birth or earliest possible age; elderly for epidemic strains)

Probably plasmid mediated outer membrane protein invasion determinant (there are a small number of promising options needing investigation to determine best approach)

Birth cohort: 115.1 million

Probable age of vaccination

(<1 year) to peak of disease (6–24 months), i.e., approx. 1 year

Streptococcus A

(Children,<3 to 4 years)

Synthetic M protein segment

(excluding portions cross-reacting with human tissue)

Birth cohort: 115.1 million

Probable age of vaccination

(<1 year) to peak of severe disease and complications (10 years), i.e., approx. 9 years

Streptococcus pneumoniae

(Infants)

Conjugated polysaccharides, polyvalent

Birth cohort: 115.1 million

Frobable age of vaccination

(<1 year) to peak of disease (3 years?), i.e., approx. 2 years

Vibrio cholera

(Children, especially <2 years)

Genetically defined live mutant V. cholerae (A−B+ or A−B−) with respect to toxin subunit synthesis

Birth cohort in endemic areas: 22.2 million

Probable age of vaccination

(<1 year) to peak incidence of disease in endemic areas (2–4 years), i.e., approx. 2 years

Inactivated antigens

Yellow fever virus

(Young children)

Attenuated live virus produced in cell culture

Birth cohort in endemic areas: 24.8 million

Probable age of vaccination

(<1 year) to peak of disease (approx. 15, depending on area), i.e., approx. 14 years

aSee appropriate appendix for derivation.

bDengue hemorrhagic fever/dengue shock syndrome.



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