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Respiratory syncytial virus

(Infants at earliest possible age)

Polypeptides produced by recombinant DNA technology

5

2

7

1

8

Attenuated live virus

5

2

7

1

8

Rotavirus

(Infants at earliest possible age. preferably with oral polio vaccine)

Attenuated high passage bovine rotavirus

2

2

4

1

5

Attenuated low passage bovine rotavirus

5

2

7

1

8

Rhesus monkey rotavirus

5

2

7

1

8

Salmonella typhi

(Children; young adults at risk; travelers from developed countries to endemic areas)

Attenuated ga1E mutant S. typhi strain TY21a

1

2

3

13

16

Aromatic amino acid dependent strains of S. typhi

6.5

2

8.5

13

21.5

Shigella spp.

(Infants at birth or earliest possible age; elderly for epidemic strains)

Probably plasmid mediated outer membrane protein invasion determinant (a small number of options need investigation to determine best approach)

10

2

12

1

13

Streptococcus A

(Children, < 3 to 4 years)

Synthetic M protein segment (excluding portions cross-reacting with human tissue)

7

3.5

10.5

9

19.5

Streptococcus pneumoniae

(Infants)

Conjugated polysaccharides, polyvalent

5

2

7

2

9

Vibrio cholera

(Children, especially < 2 years)

Genetically defined live mutant V. cholerae (A−B+ or A−B−) with respect to toxin subunit synthesis

6

2

8

2

10

Inactivated antigens

4

2

6

2

8

Yellow fever virus

(Young children)

Attenuated live virus produced in cell culture

3

2

5

14

19



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