NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this, the Institute acts under both the Academy’s 1863 congressional charter responsibility to be an adviser to the federal government and its own initiative in identifying issues of medical care, research, and education.

The work on which this publication is based was initiated and funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under contract No. NO1-AI-22678. The U.S. Agency for International Development, through the Public Health Service’s Vaccine Development and Health Research Participating Agency Services Agreement No. 000001-04-S5, also provided valuable financial support.

Library of Congress Cataloging-in-Publication Data

(Revised for vol. 2)

New vaccine development.

Prepared for the National Institute of Allergy and Infectious Diseases.

Includes bibliographies and index.

Contents: v. 1. Diseases of importance in the United States—v. 2. Diseases of importance in developing countries.

1. Vaccines—Research—Government policy. 2. Communicable diseases—United States—Preventive inoculation. 3. Communicable diseases—Developing countries—Preventive inoculation. I. Institute of Medicine (U.S.). Committee on Issues and Priorities for New Vaccine Development. II. National Institute of Allergy and Infectious Diseases (U.S.)

RA638.N49 1985 614.4’7’0973 84–62037