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Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects (1986)
Commission on Life Sciences (CLS)

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. "14 Cardiovascular System." Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects. Washington, DC: The National Academies Press, 1986.

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Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects

TABLE 14–2 Resting Acute Cardiovascular Effects in Nondiseased Humans of Exposure to Environmental Tobacco Smoke

Authors

Study Population

Conditions

Results

Measured Variable

Before

After

Luguette et al., 1970

40 children

Room: 9 m3

No. cig.: 6

Time: 15 min

Heart rate

Blood pressure

89

116/67

97

120/72

Harke and Bleichert, 1972

10

Room: n.g.

No. cig.: 150

Time: 20 min

Heart rate

Blood pressure

Skin temperature (−°C/min)

72±8

123/84

0

74±12

121/84

0.0273

Rummel et al., 1975

56

Room: 30 m3

No. cig.: 6–8

Time: 20 min

Heart rate

Blood pressure

72±10

117/71

71±11

117/71

Hurshman et al., 1978

8

Room: n.g.

No. cig.: 2–6

Time: 10 min

Heart rate

Blood pressure

73

107/67

79

114/68

Pimm et al., 1978

10 males

10 females

Age=22.3

Room: 14.6 m3

No. cig.: 7

Time: 2 h

Heart rate

84(F)

77(M)

80(F)

70(M)

CO, or ETS need to be separately studied. In addition, consideration needs to be given to persons of different sensitivity or vulnerability.

Healthy Subjects

Table 14–2 lists studies that report on the consequences of exposure of nondiseased individuals to ETS for periods up to 2 hours under experimental, resting conditions. There were no significant changes noted in heart rate or blood pressure in school-aged children or in adult men and women.

Two studies evaluated the physiologic responses to exercise with and without exposure to ETS. In the first, Pimm et al. (1978) (see also Table 14–2) had subjects perform a 7-minute progressive exercise test on an electronic bicycle ergometer. During exercise, the women had higher heart rates after exposure to ETS when compared with control conditions (differences of 6.3 beats per minute at 2 minutes and 4.5 beats per minute at 7 minutes, p<0.01). The recovery heart rates were not significantly different. The men, however, showed little difference between test and

Page
259
Front Matter (R1-R8)
Contents (R9-R14)
Executive Summary (1-12)
1 Introduction (13-22)
Part I: Physicochemical and Toxicological Studies of Environmental Tobacco Smoke (23-24)
2 The Physicochemical Nature of Sidestream Smoke and Environmental Tobacco Smoke (25-53)
3 In Vivo and In Vitro Assays to Assess the Health Effects of Environmental Tobacco Smoke (54-62)
Part II: Assessing Exosures to Environmental Tobacco Smoke (63-64)
4 Introduction (65-68)
5 Assessubg /Exposures to Environmental Tobacco Smoke in the External Environment (69-100)
6 Assessing Exposures to Enviromental Tobacco Smoke Using Questionnaires (101-119)
7 Exposure-Dose Relationship for Environmental Tobacco Smoke (120-132)
8 Assessing Exposures to Environmental Tobacco Smoke Using Biological Markers (133-160)
Part III: Health Effects Possibly Associated with Exposure to Environmental Tobacco Smoke by Nonsmokers (161-162)
9 Introduction (163-165)
10 Sensory Reactions To and Irritation Effects of Environmental Tobacco Smoke (166-181)
11 Effects of Exposure to Environmental Tobacco Smoke on Lung Function and Respiratory Symptoms (182-222)
12 Exposure to Environmental Tobacco Smoke and Lung Cancer (223-249)
13 Cancers Other than Lung Cancer (250-256)
14 Cardiovascular System (257-268)
15 Other Health Considerations in Children (269-276)
Appendixes (277-278)
Appendix A: Guidelines for Public and Occupational Chemical Exposures to Materials that are Also Found in Environmental Tobacco Smoke (279-283)
Appendix B: Method of Combining Data From Studies of Environmental Tobacco Smoke Exposure and Lung Cancer (284-288)
Appendix C: Adjusments to Epidemiologic Estimates of Excess Lung Cancer in Persons Exposed to Environmental Tobacco Smoke (289-293)
Appendix D: Risk Assessment- Exposure to Environmental Tobacco Smoke and Lung Cancer (294-338)