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H
Report of the International Symposium on
"Severe Infectious Diseases: Epidemiology, Express-Diagnostics,
and Prevention"
Nizhne-Ivkino, Kirov Oblast
June 16-20, 1997
The participants from a number of countries emphasized the importance of the topics discussed during the
symposium, which are set forth in the attached agenda.
The problem of emerging and reemerging infections should be considered a top priority at both the
national and international levels. The consequences of unpredictable epidemics which could be caused by
these infections are very serious.
The urgent nature of the problem is based on the evolving nature of the genome and biological (e.g.,
antigenic) characteristics of pathogens. Such changes are the result of dramatic alterations in social and
environmental conditions at both local and global levels. The natural migration of animals, the increasing
movement of people, and modifications in ecosystems due to anthropogenic activities also contribute to the
global spread of numerous zoonoses and zooanthroponoses. It is necessary to anticipate and predict such
situations and conduct monitoring at the national and international levels in order to~prevent and reduce the
scope of epidemic events.
in the case of emergency epidemic situations, it is necessary to ensure adequate and timely diagnostics, as
well as reliable vaccines and antimicrobials, including antivirals, and other preparations for saving human
and animal lives. in this regard, the following approaches should be directed to the diseases of greatest
concern (see Table ~ for examples of diseases):
a) Identify organisms for which vaccines, antiviral preparations, and antibiotics should be developed
and specify groups which require immunization.
b) Employ the tremendous power of modern molecular microbiology and immunology toward the
conception and design of the most effective, innovative vaccines against the most dangerous pathogens.
c) Apply the new knowledge obtained from basic molecular microbiologic research toward rapid
vaccine production technology and effective distribution for the global prevention and control of
catastrophic disease episodes.
d) Develop highly sensitive and specific methods of rapid diagnostics.
These areas were discussed in the reports during the symposium.
The reported experiments and data reflected the substantial progress which has been achieved in
diagnosing and preventing emerging and reemerging infections. At the same time, a wide range of
problems was identified. In some cases, solutions to these problems were proposed.
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In addition to reports on fundamental research highlighting the basic pathogenesis of highly dangerous
infections, molecular and genetic characteristics of their causative agents, and mechanisms of
immunogenesis, attention also focused on results obtained from applied research. Such studies are aimed
at improving techniques and methods of rapid diagnostics of highly dangerous infections and indication
and identification of relevant pathogens, as well as developing new research efforts in the design of
immunological and biological preparations.
The participants recognized the special contributions to public health which defense scientists can make
and urged them to direct their efforts to improved prophylaxis, detection, and treatment of highly
dangerous pathogens.
The participants of the symposium enthusiastically supported the idea of exchanges of specialists from
different countries. it would facilitate the sharing of research results and the search for areas of mutually
beneficial scientific cooperation and would provide a basis for joint research.
Expanded educational programs are needed to improve understanding among both health practitioners and
the general public about practical measures that can be taken to reduce the risks of infections from
dangerous pathogens.
Modern information and communications technologies are providing unprecedented opportunities for
direct communications among scientists throughout the world. Governments and private organizations
should ensure that these technologies are made available to scientists working on dangerous pathogens.
A continuing high level of attention should be given to all aspects of safe handling of dangerous
pathogens, including the safe disposal of contaminated wastes.
Thus, it is clear that scientists must support the battle against epidemics which result in tremendous
disasters inflicted on the worms population and cause ~ 6 million deaths every year.
The participants expressed their sincere gratitude to the U.S. National Academy of Sciences and the
international Science and Technology Center, which cosponsored the symposium, to the Volga-Vyatka
State Scientific Center of Applied Biotechnology, which organized the event, and to the governor of Kirov
Region, Academician V.N. Sergeenkov, for his special interest in the symposium.
The participants had an opportunity to visit the Kirov Biochemical Plant, the Vyatka Chamber of
Commerce and industry, and the facilities of the Sanitary Epidemiological Service and the Committee on
Ecology in Kirov. Also, the participants welcomed the proposal of the Volgo-Vyatka State Scientific
Center for Applied Biotechnology to serve as a point of contact for future cooperation with the region in
fields related to the topics discussed at the symposium.
June 20, 1997
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CONFERENCE LIST OF PARTICIPANTS
KIROV, RUSSIA, JUNE 1997
Abramov, Vyacheslav M.
Institute of Immunology
Anderson, George W., LTC
USAMRIID
Baskevitch, Pierre Paul
French Embassy
Bektimirov, Tagir A.
L.A. Tarasevich State Research Institute for Standards and Control of Medical Biological
Preparations
Biketov, Sergei F.
State Research Center for Applied Microbiology
Bragintseva, Lidia
Scientific and Industrial Enterprise
Buravtseva, Nina P.
Stavropol Plague Scientific Research Institute
Byrne, W. Russell, COL
USAMRIID
Cassell, Gail H.
University of Alabama at Birmingham
Cherkassky, Benyamin L.
Central Research Institute of Epidemiology
Dobritza, Valery P.
Anti-Plague Research Institute
Efremenko, Vitaly I.
Stavropol Plague Scientific Research Institute
Farina, Francisco
International Science and Technology Center
Fokin, Valet G.
Administration of Kirov Region
Girdany, Martha J.
Office of the Secretary of Defense
Glukhov, Alexander I.
Moscow Scientific Research Institute of Medical Ecology
Committee on Health Care
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Gordeev, Sergei A.
All Russian Scientific Center of Molecular Diagnostics and Treatment
Gryazanova, Elena A.
International Science and Technology Center
Hiroaki, Okumo
National Institute of Bioscience and Human-Technology
Howson, Christopher P.
IOM, NAS
Jaax, Gerald P., COL
USAMRIID
Jahrling, Peter B.
USAMRIID
Kalachev, Igor Ya.
State Research Center for Applied Microbiology
Kirillin, Yuri V.
Scientific Research Institute of Biotechnical Industry
Kondratenkov, Yuri B.
International Science and Technology Center
Kondratov, Vasily M.
Vyatka State Technical University
Krikorian, Debra J.
U.S. Department of State, Bureau of Political-Military Affairs
L'vov, Dmitry K.
D. 1. Ivanovsky Institute of Virology
Lipatnikov, Nikolai M.
Vyatka Chamber of Commerce and Industry of Kirov Region
Loktev, Valery B.
"Vector" State Research Center of Virology and Biotechnology
Molton, Peter M.
Battelle Pacific Northwest National Laboratories
Murphy, Frederick A.
University of California-Davis, Schoo] of Veterinary Medicine
Nietzold, Dieter E.
Tnternational Science and Technology Center
Noskov, Anatoly N.
State Research Center for Applied Microbiology
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Ogura, Shinichiro
International Science and Technology Center
Okuno, Hiroaki
National Institute of Bioscience and Human Technology
Osin, Nikolai S.
GosNII of Biological Instrument Making
Pobedimskaya, Diana D.
International Science and Technology Center
Robbins, Kelly L.
NRC
Ruban, Eugene A.
Russian Federal Research and Technological Institute of Biotechnology Industry
Schweitzer, Glenn E.
NRC
Shemyakin, Igor G.
State Research Center for Applied Microbiology
Shiyan, Yuri
Russian Academy of Sciences
Stepanov, Alexei V.
State Research Center for Applied Microbiology
Svetiova, Anastasia V.
International Science and Technology Center
Takeda, Yoskhifumi
Research Institute, International Medical Center of Japan
Toshitada, Takemori
Research Institute, International Medical Center of Japan
National Institute of Infectious Diseases
Tulyankin, Gennady M.
Volgo-Vyatka State Scientific Center of Applied Technology
Voronov, Alexander V.
All Russian Scientific Center of Molecular Diagnostics
and Treatment
Weber, Andrew
Office of the Secretary of Defense, International Security Policy
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Yukimatsu, Yasuhiro
Embassy of Japan
Zav'yalov, Vladimir P.
Institute of Immunology
ZIobin, Vladimir N.
State Scientific Research institute of Biological Engineering
NOTE: This list does not include unregistered exhibitors at the conference.
Representative terms from entire chapter:
international science