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Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan

Committee on Toxicology

Board on Environmental Studies and Toxicology

Commission on Life Sciences

National Research Council

June 1998



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Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan Committee on Toxicology Board on Environmental Studies and Toxicology Commission on Life Sciences National Research Council June 1998

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Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan NATIONAL RESEARCH COUNCIL BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY 2101 Constitution Avenue Washington, D.C. 20418 COMMITTEE ON TOXICOLOGY TEL: (202) 334-2897 FAX: (202) 334-1393 June 12, 1998 Rear Admiral Joan M. Engel Assistant Chief, Operational Medicine and Fleet Support Bureau of Medicine and Surgery 2300 E Street, NW Washington, DC 20372-5300 Dear Admiral Engel: We are pleased to provide the enclosed report of the National ResearchCouncil's independent evaluation of the Navy Environmental HealthCenter's 1998 report Screening Level Air Human Health Risk Assessment, NAF Atsugi, Japan.The enclosed report was prepared by the Committee on Toxicology(COT) under Contract DAMD 17-89-C-9086 between the National Academyof Sciences and the Department of Defense. The COT members of thereview group were: Drs. Rogene Henderson (Chair), David Gaylor, CharlesFeigley, and Günter Oberdörster. The enclosed report was reviewed by Drs. DonaldGardner, Judith Graham, Loren Koller, and Joseph Rodricks. All membersof COT (see attached list) also reviewed the report. We hope this report will be helpful to the Navy. Thank you againfor your support of the work of the Committee on Toxicology. Sincerely, Kulbir S. Bakshi, Ph.D. Program Director Committee on Toxicology Carol A. Maczka, Ph.D. Director Toxicology and Risk Assessment James J. Reisa, Ph.D. Director Board on Environmental Studies and Toxicology Paul Gilman, Ph.D. Executive Director Commission on Life Sciences cc: MAJ Steve Channel CAPT David Macys COL Francis O'Donnell CAPT Henry Spolnicki CAPT Kenneth Still COL David Wilder The National Research Council is the principal operating agency ofthe National Academy of Sciences and the National Academy of Engineeringto serve government and other organizations. The Board on EnvironmentalStudies and Toxicology is responsible to the National Research Councilthrough the Commission on Life Sciences and the Commission on Geosciences,Environment, and Resources.

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Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan EXPEDITED REVIEW GROUP ROGENE F. HENDERSON (Chair), Lovelace Biomedical and Environmental Research Institute, Albuquerque,New Mexico CHARLES E. FEIGLEY, University of South Carolina, Columbia, South Carolina DAVID W. GAYLOR, U.S. Food and Drug Administration, Jefferson, Arkansas GÜNTER OBERDÖRSTER, University of Rochester, Rochester, New York Staff KULBIR S. BAKSHI, Program Director for the Committee on Toxicology SUSAN N.J. PANG, Project Director RUTH E. CROSSGROVE, Editor LINDA V. LEONARD, Senior Program Assistant Sponsor: U.S. Department of Defense

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Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan COMMITTEEON TOXICOLOGY ROGENE F. HENDERSON (Chair), Lovelace Biomedical and Environmental Research Institute, Albuquerque,New Mexico GERMAINE M. BUCK, State University at Buffalo, Buffalo, New York GARY P. CARLSON, Purdue University, West Lafayette, Indiana JACK H. DEAN, Sanofi Research, Malverne, Pennsylvania KEVIN E. DRISCOLL, The Procter and Gamble Company, Cincinnati, Ohio CHARLES E. FEIGLEY, University of South Carolina, Columbia, South Carolina PAUL M.D. FOSTER, Chemical Industry Institute of Toxicology, Research Triangle Park,North Carolina DAVID W. GAYLOR, U.S. Food and Drug Administration, Jefferson, Arkansas JOHN C. GERHART, University of California, Berkeley, California JUDITH A. GRAHAM, U.S. Environmental Protection Agency, Research Triangle Park, NorthCarolina IAN A. GREAVES, University of Minnesota, Minneapolis, Minnesota SIDNEY GREEN, Covance Laboratories, Inc., Vienna, Virginia WILLIAM E. HALPERIN, National Institute for Occupational Safety and Health, Atlanta, Georgia FLORENCE K. KINOSHITA, Hercules Incorporated, Wilmington, Delaware DANIEL KREWSKI, University of Ottawa, Ottawa, Ontario THOMAS E. MCKONE, University of California, Berkeley, California MICHELE A. MEDINSKY, Chemical Industry Institute of Toxicology, Research Triangle Park,North Carolina GÜNTER OBERDÖRSTER, University of Rochester, Rochester, New York JOHN L. O'DONOGHUE, Eastman Kodak Company, Rochester, New York GEORGE M. RUSCH, AlliedSignal, Inc., Morristown, New Jersey MARY E. VORE, University of Kentucky, Lexington, Kentucky BERNARD M. WAGNER, Consultant, Short Hills, New Jersey ANNETTA P. WATSON, Oak Ridge National Laboratory, Oak Ridge, Tennessee Staff KULBIR S. BAKSHI, Program Director SUSAN N.J. PANG, Research Associate ABIGAIL STACK, Research Associate RUTH E. CROSSGROVE, Production Manager KATHRINE IVERSON, Manager of the Toxicology Information Center CATHERINE M. KUBIK, Senior Program Assistant LINDA V. LEONARD, Senior Program Assistant LUCY V. FUSCO, Project Assistant

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Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan BOARDON ENVIRONMENTAL STUDIESAND TOXICOLOGY GORDON ORIANS (Chair), University of Washington, Seattle, Washington DONALD MATTISON (Vice Chair), University of Pittsburgh, Pittsburgh, Pennsylvania MAY R. BERENBAUM, University of Illinois, Urbana, Illinois EULA BINGHAM, University of Cincinnati, incinnati, Ohio PAUL BUSCH, Malcolm Pirnie, Inc., White Plains, New York GEORGE P. DASTON, The Procter and Gamble ompany, Cincinnati, Ohio PETER L. DEFUR, Virginia Commonwealth University, Richmond, Virginia DAVID L. EATON, University of Washington, Seattle, Washington ROBERT A. FROSCH, Harvard University, Cambridge, Massachusetts MARK HARWELL, University of Miami, Miami, Florida BARBARA HULKA, University of North Carolina, Chapel Hill, North Carolina DANIEL KREWSKI, University of Ottawa, Ottawa, Ontario RAYMOND C. LOEHR, University of Texas, Austin, Texas JAMES A. MACMAHON, Utah State University, Logan, Utah MARIO J. MOLINA, Massachusetts Institute of Technology, Cambridge, Massachusetts WARREN MUIR, Hampshire Research Institute, Alexandria, Virginia GEOFFREY PLACE, Hilton Head, South Carolina MARGARET N. STRAND, Bayh, Connaughton and Malone, Washington, D.C. BAILUS WALKER, JR., Howard University, Washington, D.C. DIANA WALL, Colorado State University, Ft. Collins, Colorado GERALD N. WOGAN, Massachusetts Institute of Technology, Cambridge, Massachusetts TERRY F. YOSIE, Ruder Finn, Inc., Washington, D.C. Staff JAMES J. REISA, Director DAVID J. POLICANSKY, Associate Director and Program Director for Applied Ecology CAROL A. MACZKA, Program Director for Toxicology and Risk Assessment LEE R. PAULSON, Program Director for Resource Management RAYMOND A. WASSEL, Program Director for Environmental Sciences and Engineering KULBIRS. BAKSHI, Program Director for the Committee on Toxicology JAMIE YOUNG, Assistant to the Director

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Review of a Screening Level Risk Assessment for the Naval Air Facilityat Atsugi, Japan COMMISSIONON LIFE SCIENCES THOMAS D. POLLARD (Chair), The Salk Institute, La Jolla, California FREDERICK R. ANDERSON, Cadwalader, Wickersham & Taft, Washington, DC. JOHN C. BAILAR III, University of Chicago, Chicago, Illinois PAUL BERG, Stanford University School of Medicine, Stanford, California JOANNA BURGER, Rutgers University, Piscataway, New Jersey SHARON L. DUNWOODY, University of Wisconsin, Madison, Wisconsin JOHN L. EMMERSON, Portland, Oregon NEAL L. FIRST, University of Wisconsin, Madison, Wisconsin URSULA W. GOODENOUGH, Washington University, St. Louis, Missouri HENRY W. HEIKKINEN, University of Northern Colorado, Greeley, Colorado HANS J. KENDE, Michigan State University, East Lansing, Michigan CYNTHIA J. KENYON, University of California, San Francisco, California DAVID M. LIVINGSTON, Dana-Farber Cancer Institute, Boston, Massachusetts THOMAS E. LOVEJOY, Smithsonian Institution, Washington, D.C. DONALD R. MATTISON, University of Pittsburgh, Pittsburgh, Pennsylvania JOSEPH E. MURRAY, Wellesley Hills, Massachusetts EDWARD E. PENHOET, Chiron Corporation, meryville, California MALCOLM C. PIKE, University of Southern California, Los Angeles, California JONATHAN M. SAMET, The Johns Hopkins University, Baltimore, Maryland CHARLES F. STEVENS, The Salk Institute, La Jolla, California JOHNL. VANDEBERG, Southwest Foundation for Biomedical Research, San Antonio, Texas PAUL GILMAN, Executive Director