BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
2101 Constitution Avenue Washington, D.C. 20418
COMMITTEE ON TOXICOLOGY
Bureau of Medicine and Surgery
Dear Admiral Engel:
We are pleased to provide the enclosed report of the National ResearchCouncil's independent evaluation of the Navy Environmental HealthCenter's 1998 report Screening Level Air Human Health Risk Assessment, NAF Atsugi, Japan.The enclosed report was prepared by the Committee on Toxicology(COT) under Contract DAMD 17-89-C-9086 between the National Academyof Sciences and the Department of Defense. The COT members of thereview group were: Drs. Rogene Henderson (Chair), David Gaylor, CharlesFeigley, and Günter Oberdörster. The enclosed report was reviewed by Drs. DonaldGardner, Judith Graham, Loren Koller, and Joseph Rodricks. All membersof COT (see attached list) also reviewed the report.
We hope this report will be helpful to the Navy. Thank you againfor your support of the work of the Committee on Toxicology.
Committee on Toxicology
Toxicology and Risk Assessment
Board on Environmental Studies and Toxicology
Commission on Life Sciences
The National Research Council is the principal operating agency ofthe National Academy of Sciences and the National Academy of Engineeringto serve government and other organizations. The Board on EnvironmentalStudies and Toxicology is responsible to the National Research Councilthrough the Commission on Life Sciences and the Commission on Geosciences,Environment, and Resources.
EXPEDITED REVIEW GROUP
ROGENE F. HENDERSON (Chair),
Lovelace Biomedical and Environmental Research Institute, Albuquerque,New Mexico
CHARLES E. FEIGLEY,
University of South Carolina, Columbia, South Carolina
DAVID W. GAYLOR,
U.S. Food and Drug Administration, Jefferson, Arkansas
GÜNTER OBERDÖRSTER,
University of Rochester, Rochester, New York
Staff
KULBIR S. BAKSHI, Program Director for the Committee on Toxicology
SUSAN N.J. PANG, Project Director
RUTH E. CROSSGROVE, Editor
LINDA V. LEONARD, Senior Program Assistant
Sponsor: U.S. Department of Defense
COMMITTEEON TOXICOLOGY
ROGENE F. HENDERSON (Chair),
Lovelace Biomedical and Environmental Research Institute, Albuquerque,New Mexico
GERMAINE M. BUCK,
State University at Buffalo, Buffalo, New York
GARY P. CARLSON,
Purdue University, West Lafayette, Indiana
JACK H. DEAN,
Sanofi Research, Malverne, Pennsylvania
KEVIN E. DRISCOLL,
The Procter and Gamble Company, Cincinnati, Ohio
CHARLES E. FEIGLEY,
University of South Carolina, Columbia, South Carolina
PAUL M.D. FOSTER,
Chemical Industry Institute of Toxicology, Research Triangle Park,North Carolina
DAVID W. GAYLOR,
U.S. Food and Drug Administration, Jefferson, Arkansas
JOHN C. GERHART,
University of California, Berkeley, California
JUDITH A. GRAHAM,
U.S. Environmental Protection Agency, Research Triangle Park, NorthCarolina
IAN A. GREAVES,
University of Minnesota, Minneapolis, Minnesota
SIDNEY GREEN,
Covance Laboratories, Inc., Vienna, Virginia
WILLIAM E. HALPERIN,
National Institute for Occupational Safety and Health, Atlanta, Georgia
FLORENCE K. KINOSHITA,
Hercules Incorporated, Wilmington, Delaware
DANIEL KREWSKI,
University of Ottawa, Ottawa, Ontario
THOMAS E. MCKONE,
University of California, Berkeley, California
MICHELE A. MEDINSKY,
Chemical Industry Institute of Toxicology, Research Triangle Park,North Carolina
GÜNTER OBERDÖRSTER,
University of Rochester, Rochester, New York
JOHN L. O'DONOGHUE,
Eastman Kodak Company, Rochester, New York
GEORGE M. RUSCH,
AlliedSignal, Inc., Morristown, New Jersey
MARY E. VORE,
University of Kentucky, Lexington, Kentucky
BERNARD M. WAGNER, Consultant,
Short Hills, New Jersey
ANNETTA P. WATSON,
Oak Ridge National Laboratory, Oak Ridge, Tennessee
Staff
KULBIR S. BAKSHI, Program Director
SUSAN N.J. PANG, Research Associate
ABIGAIL STACK, Research Associate
RUTH E. CROSSGROVE, Production Manager
KATHRINE IVERSON, Manager of the Toxicology Information Center
CATHERINE M. KUBIK, Senior Program Assistant
LINDA V. LEONARD, Senior Program Assistant
LUCY V. FUSCO, Project Assistant
BOARDON ENVIRONMENTAL STUDIESAND TOXICOLOGY
GORDON ORIANS (Chair),
University of Washington, Seattle, Washington
DONALD MATTISON (Vice Chair),
University of Pittsburgh, Pittsburgh, Pennsylvania
MAY R. BERENBAUM,
University of Illinois, Urbana, Illinois
EULA BINGHAM,
University of Cincinnati, incinnati, Ohio
PAUL BUSCH,
Malcolm Pirnie, Inc., White Plains, New York
GEORGE P. DASTON,
The Procter and Gamble ompany, Cincinnati, Ohio
PETER L. DEFUR,
Virginia Commonwealth University, Richmond, Virginia
DAVID L. EATON,
University of Washington, Seattle, Washington
ROBERT A. FROSCH,
Harvard University, Cambridge, Massachusetts
MARK HARWELL,
University of Miami, Miami, Florida
BARBARA HULKA,
University of North Carolina, Chapel Hill, North Carolina
DANIEL KREWSKI,
University of Ottawa, Ottawa, Ontario
RAYMOND C. LOEHR,
University of Texas, Austin, Texas
JAMES A. MACMAHON,
Utah State University, Logan, Utah
MARIO J. MOLINA,
Massachusetts Institute of Technology, Cambridge, Massachusetts
WARREN MUIR,
Hampshire Research Institute, Alexandria, Virginia
GEOFFREY PLACE,
Hilton Head, South Carolina
MARGARET N. STRAND,
Bayh, Connaughton and Malone, Washington, D.C.
BAILUS WALKER, JR.,
Howard University, Washington, D.C.
DIANA WALL,
Colorado State University, Ft. Collins, Colorado
GERALD N. WOGAN,
Massachusetts Institute of Technology, Cambridge, Massachusetts
TERRY F. YOSIE,
Ruder Finn, Inc., Washington, D.C.
Staff
JAMES J. REISA, Director
DAVID J. POLICANSKY, Associate Director and Program Director for Applied Ecology
CAROL A. MACZKA, Program Director for Toxicology and Risk Assessment
LEE R. PAULSON, Program Director for Resource Management
RAYMOND A. WASSEL, Program Director for Environmental Sciences and Engineering
KULBIRS. BAKSHI, Program Director for the Committee on Toxicology
JAMIE YOUNG, Assistant to the Director
COMMISSIONON LIFE SCIENCES
THOMAS D. POLLARD (Chair),
The Salk Institute, La Jolla, California
FREDERICK R. ANDERSON,
Cadwalader, Wickersham & Taft, Washington, DC.
JOHN C. BAILAR III,
University of Chicago, Chicago, Illinois
PAUL BERG,
Stanford University School of Medicine, Stanford, California
JOANNA BURGER,
Rutgers University, Piscataway, New Jersey
SHARON L. DUNWOODY,
University of Wisconsin, Madison, Wisconsin
JOHN L. EMMERSON,
Portland, Oregon
NEAL L. FIRST,
University of Wisconsin, Madison, Wisconsin
URSULA W. GOODENOUGH,
Washington University, St. Louis, Missouri
HENRY W. HEIKKINEN,
University of Northern Colorado, Greeley, Colorado
HANS J. KENDE,
Michigan State University, East Lansing, Michigan
CYNTHIA J. KENYON,
University of California, San Francisco, California
DAVID M. LIVINGSTON,
Dana-Farber Cancer Institute, Boston, Massachusetts
THOMAS E. LOVEJOY,
Smithsonian Institution, Washington, D.C.
DONALD R. MATTISON,
University of Pittsburgh, Pittsburgh, Pennsylvania
JOSEPH E. MURRAY,
Wellesley Hills, Massachusetts
EDWARD E. PENHOET,
Chiron Corporation, meryville, California
MALCOLM C. PIKE,
University of Southern California, Los Angeles, California
JONATHAN M. SAMET,
The Johns Hopkins University, Baltimore, Maryland
CHARLES F. STEVENS,
The Salk Institute, La Jolla, California
JOHNL. VANDEBERG,
Southwest Foundation for Biomedical Research, San Antonio, Texas
PAUL GILMAN, Executive Director