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A ppendix CODING INSTRUCTIONS FOR GENETICS FOLLOW-UP QUESTIONNAIRES 1. Genetics number .............. (As item 1, columns 1 to 6, of Ge- netics Short-Form Code, i.e., first digit indicates location, subsequent five, the case number.) Parental radiation history........ (Asitems5,6, 9, loandl2'col- umns 23, 24-27, 30, 31, and 33 of the Genetics Short-Form Code.) (a) Location: (In Hiroshima or Nagasaki at time of bombing. Yes or no for husband and wife.) 1 Neither 2 Husband only in Hiro- shima 3 Wife only in Hiroshima 4 Both in Hiroshima 5 Husband only in Naga- saki 6 Wife only in Nagasaki 7 Both in Nagasaki 8 Husband in Hiroshima wife in Nagasaki 9 Wife in Hiroshima; husband in Nagasaki (b) Distance: (Distance from hypocenter in hundreds of meters, with maximum coded 98 and final entry being 99 or greater, two columns for husband, two for wife.) (c) Petechiae: (Coded as both if only one exposed.) Husband Wife 1 yes yes 2 yes no 3 no yes 4 no no (d) Gingivitis: (Coded as both if only one exposed.) Husband Wife 1 yes yes 2 yes no 3 no yes 4 no no (e) Ep~lation: (Coded as both if only one exposed.) 221 Column 1-6 7-14 3. Wife yes no yes no Wife yes no yes no Husband 1 yes 2 yes 3 no 4 no Wife yes no yes no Column Date of child's birth 15-16 (As item 29, columns 59-60 of Genetics Short-Form Code. Coded as:) Montl' January 1 February 2 March 3 April 4 May 5 June 6 July 7 August 8 September 9 October 0 November X December ~ 4 O2~ra~io'2 of pregnancy ire weeks. Year 1948 1 1949 2 1950 3 1951 4 1952 5 1953 6 1954 7 , ~v , .. 17 - 18 (As item 30, columns 6-1-62 of Genetics Short-Form Code. Coded as 00 to 99; 99 is unknown.) 5. Onset of labor................. (As item 31, column 63 of Genetics Short-Form Code. Coded as:) 1 Spontaneous less than 24 hours 2 Spontaneous more than 24 hours 3 Induced less than 24 hours 4 Induced more than 24 hours 5 Operative 6. Termir'~tion.................. (As item 33, column 65 of Genetics Short-Form Code. Coded as:) 1 Livebirth after 38th week 2 Premature birth under or in- cluding 38th week 3 Stillbirth 20 weeks or under 4 Stillbirth 21-29 weeks 5 Stillbirth 30-38 weeks 6 Stillbirth after 38th week 7 Unknown livebirth 8 Unknown stillbirth 19 20

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222 Genetic Efects of Atomic Bombs 5 Column 7. Sex 21 (As item 35, column 67 of Genetics Short-Form Code. Coded as:) 1 Male 2 Female 3 Unknown S. Weight 22-24 (As item 36, column 68 to 70, of Genetics Short-Form Code. Weight of newborn coded in tens of grams. 999 for unknown.) (NOTE: Items 1 to 8 were punched on the Long Form IBM card by machine transfer from the Short-Form IBM card.) 9. Multiple binh 25 (Coded as:) 1 Single birth 2 First twin 3 Second twin 4 First triplet Second triplet 6 Third triplet 3 10. Abnormality 26 C (Coded as:) A Normal to clinical examina tion and autopsy 1 Normal to clinical examina tion Congenital disease (includ ing autopsy data) 3 Birth injury (clinical diag nosis only) 4 Major malformation clini cal or autopsy diagnosis 5 Minor malformation clini cal or autopsy diagnosis 6 Congenital disease, birth in ~ury 7 Congenital disease, malformation Congenital disease, malformation 9 Birth injury, major mation O Birth injury, minor mation X Congenital disease, birth in jury, major malformation V Congenital disease, birth in jury, minor malformation major minor malfor malfor Col~mn 11. Clinical and Autopsy diagnosis.... 27-44 (Maximum of three diagnoses of 6 digits; first digit of each diagnosis coded as:) 1 Clinical diagnosis of defect limited to one region or sys- tem Clinical diagnosis of multiple defects, with most important defect coded first, and succes- sive diagnoses introduced by a 1. . . Clinical diagnosis of a com- plex and ill-defined defect Clinical diagnosis of a double monster A Autopsy confirmation of 1. ., coded as A followed by five diagnostic digits Autopsy confirmation of 2. ., coded as B followed by five diagnostic digits; successive diagnoses as A. .. Autopsy confirmation of 3. ., coded as C followed by five diagnostic digits D Autopsy confirmation of 4. ., coded as D followed by five diagnostic digits Autopsy diagnosis alone of a 1.., coded as .J followed by five diagnostic digits : Autopsy diagnosis alone of a 2. ., coded as K followed by five diagnostic digits; succes- sive diagnoses as J... L Autopsy diagnosis alone of a 3.., coded as L followed by five diagnostic digits M Autopsy diagnosis alone of a 4. ., coded as M followed by five diagnostic digits Autopsy fails to confirm a clinical diagnosis of a 1.., coded as S followed by five diagnostic digits T Autopsy fails to confirm a clinical diagnosis of a 2.., coded as T followed by five diagnostic digits; successive diagnoses as S. .. S

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Appendix Column U Autopsy fails to confirm a clinical diagnosis of a 3.., coded as U followed by Eve diagnostic digits V Autopsy fails to confirm a clinical diagnosis of a 4.., coded as V followed by five diagnostic digits 12. Neonatal and infant death 45~6 (Coded as age at death; 99 is un known.) 00 Under 1 day 01 1 day 02 2 days 03 3-6 days 04 7-13 days 05 14-20 days 06 21-27 days 07 1 month 08 2 months 09 3 months etc. to 11 months 223 Column 3 One and one-half cousins 4 Second cousins 5 Other 6 Unknown 16. Consanguinity of grar~dlparents 51 (Coded as:) 1 Both negative 2 Paternal positive, maternal negative Paternal negative, maternal positive 4 Paternal and maternal posi tive Paternal unknown, maternal positive 6 Paternal negative 7 Paternal positive, maternal unknown 8 Paternal negative, unknown 9 Paternal unknown, 13. Age of father at termination; of unknown pregnancy 47-48 17. Economic status . . . . . . . . . . . . . . . 52 (Coded as 00 to 99. Unknown (Coded as:) coded as 99.) 1 Very poor 2 Poor 3 Average 4 Well-to-do 5 Rich 6 Not indicated 18. Age of mother at termination of pregnancy 53-54 (Coded as 00 to 99. Unknown coded as 99.) 19. Family history of mother (Coded as:) 1 Negative family history 2 Mother alone with same de fect 3 Mother alone with other de fect 4 Other maternal relatives with same defect 5 Other maternal relatives with other defect 6 Mother and other maternal relatives with same defect , Mother with same defect, maternal relatives with other defect Mother with other defect, maternal relatives with same defe* 5 unknown, maternal 14. Family history of father 49 (Coded as:) 1 ~ T . ~ 1 1 . _ . 2 3 Negative family nlsrory Father alone with same defect Father alone with other de- fect 4 Other paternal relatives with same defect 5 Other paternal relatives with other defect 6 Father and other paternal relatives with same defect 7 Father same defect, paternal relatives with other defect 8 Father with other defect, pa- ternal relatives with same de- fect 9 Father and paternal relatives with other defect 0 Unknown (NOTE: Same or other defect refers to the same or a different defect from that present in the infant.) ~5. Consanguinity of parents...... (Coded as:) 1 None 2 First cousins .. 50 maternal maternal

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224 Genetic Efects of Atomic Bombs Column 9 Mother and maternal rela- 25. fives with other defect 0 Unknown (NOTE: Same or other defect refers to the same or a different defect from that present in the infant.) 20. Menstrual history 1 Age of onset in years to near est year, coded as 00 to 99; 99 is unknown 56-57 26. 2 Duration in days, coded as 0 to 9 (no entry is unknown; greater than 9 coded as 9) . . 58 3 Internal in days between peri ods coded as 00 to 39 (coded as 00 if entry is "irregular," 99 if unknown) 59-60 21. Irregularity of menstruation 61 (Coded as:) 1 None 2 Periods of amenorrhea ex ceeding 90 days 3 Periods of amenorrhea of less than 90 days 4 Cycles of 3 weeks or less 5 Ill-defined or nature not stated 22. Pelvic operations, treatment, or dis eases 62 (Coded as:) 1 None 2 Pelvic operations, abdominal approach Pelvic operations, D and C Radium or X-ray therapy Other Pelvic operations, D and C, and abdominal 7 Unknown Illness daring pregnancy (Coded as:) 1 None 2 Febrile disease, clearly de- 29. fined 3 Other illness, may be febrile but no clear indication 4 Unknown 24. Uterine bleeding during first six 30. months of pregr~ancy 64 (Coded as:) 1 None 2 Present 3 Unknown 3 5 6 63 Column Presentation 65 (Coded as:) 1 Occiput 2 Face 3 Breech 4 Footling 5 Arm 6 Cesarean section 7 Unknown M~rterrzal and infant serology (NoTE: For Nagasaki, the pre partum lIokensho serological tests are coded as the alphabetical equiva lents of 1 to 8. The prepartum serology is to be coded if post partum testing by ABCC did not occur.) 1 Mother negative, child un tested 2 Mother negative, child nega tive 3 Mother negative, child posi tive Mother tested 5 Mother positive, child nega tive 6 Mother live 7 Mother and child untested 8 Mother doubtful, child un tested Total number marriage (Coded ~s 27. positive, child un positive, child posi of pregnancies this ................. 67-68 `_ _ ~ 00 to 99. Multiples scored as one pregnancy; 99 is un -known.) 28. Number of liveborn infants 69-70 (Coded as 00 to 99. Multiples scored as 2, 3, etc., or in combina tion. Number of premature infants 7 (Liveborn or stillborn exclusive of abortions, coded as 0 to 9. Multi ples scored as 2, 3, etc., or in com bination.) Number of stillborn infarcts (Coded as 0 to 9. Multiples scored as 2, 3, etc., or in combination; artificial interruption after 20 weeks ending in stillborn fetus is scored as stillborn infant.) 72