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Appendix 31. Number of pregnancies terminating as spontaneous abortion, i.e., gest~- tion of less than or equal to 20 weeks 73 (Coded as 0 to 9. Multiples scored as 2, 3, etc., or in combination.) 32. Number of pregnancies terminating as induced abortions, i.e., gestation of less there or equal to 20 weeks. . 74 (Coded as 0 to 9.) 33. Number of pregnancies terminating ar multiple births (Coded as 0 to 9.) 34. Number of infarcts dying bef ore orze year of age 76 (Coded as 0 to 9.) 35. Defective terminations ire sibs 77-79 (Coded as:) Column 75 Child abnormal clinically*; negative 1 sibship history Child abnormal; negative sibship his- 2 tory with respect to this defect but other defect (NOTE: A history of another minor defect is scored 78-79.) Child abnormal; positive sibship his- tory with respect to this defect Child abnormal; positive sibship his- tory with respect to this defect and other defect present in sibship Child normal; sibship history negative Child normal; sibship history positive for defect 3 6 225 Column 36. Relationship of informant to in fant 80 (Coded as:) 1 Mother 2 Father 3 Maternal grandmother 4 Maternal grandfather 5 Paternal grandmother 6 Paternal grandfather 7 Not related 8 Other 9 Unknown A- Father and mother B Other combination Code Code Code Column 77 Column 78 Column 79 No. of sibs with other major de- fect, 1...9 as 2, column 77, with no entry in columns No. of sibs with same defect, in- cluding this sib- ling, 1...9 No. of sibs with same defect, in- cluding this sib- ling, 1...9 No. of sibs with major defect, 1. . .9 (NOTE: In the event a previous Long Form exists on this family, it will be indicated by an X in column 79 if some number other than 4 is entered in column 77. If 4 is entered in column 77, then M is to be punched in column 79.) * The term "abnormal" as used here does not apply to stillbirths or abortions, but only to visible defects. No. of sibs with other major de- fect, 1...9 CODING INSTRUCTIONS FOR PEDIATRICS FOLLOW-UP QUESTIONNAIRE Column 1. Genetics Questionnaire number... 1-6 (As item 1, columns 1-6 of Ge- netics Short-Form Code. Coded as: first digit indicates location; subse quent five, the case number.) Hiroshima H 00000 Nagasaki N 00000 Kure K 00000 Column

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226 Genetic Efects of Atomic Bombs Column 2. Mother's Master File number 7-12 (Coded as: first digit indicates loca tion. ) Hiroshima 2 00000 Nagasaki O 00000 Kure 5 00000 3. Parental age at time of termination;. 13-16 (As calculated from Genetics Short Form Code. Coded as 00 to 99; 99 is unknown; two columns for hus band, two for wife.) Parental radiation; history 17-30 (As items 5-15, columns 23-36, of Genetics Short-Form Code. Coded as ) (a) Location: (In Hiroshima or Nagasaki at time of bombing; yes or no for husband and wife. Coded as:) 1 Neither 2 Husband only in Hiro shima 3 Wife only in Hiroshima 4 Both in Hiroshima 5 Husband only in Naga saki 6 Wife only in Nagasaki 7 Both in Nagasaki 8 Husband in Hiroshima; wife in Nagasaki Wife in Hiroshima; husband in Nagasaki (b) Distance: (From hypocenter in hundreds of meters, with maximum coded as 98 and final entry be ing 99 or greater, two columns for husband, two for wife.) (c) Indoors or outside: (Coded as both if only one exposed.) Neither sheltered by hill 2 Both outside 3 Husband outside, wife indoors 4 Wife outside, husband indoors 5 Both indoors Husband sheltered by hill B Both outside C Husband outside, wife indoors 9 D Wife outside, husband indoors E Both indoors Wif e sheltered by hill K Both outside L Husband outside, wife indoors M Wife outside, husband indoors N Both indoors Both sheltered by hill S Both outside T Husband outside, wife indoors U Wife outside, husband indoors V Both indoors (d) Type of building: (Answered as Japanese or other, the latter including con- crete buildings of all types, brick. air raid shelters etc Coded as both if only one ex- posed. Coded as:) 1 Husband in Japanese type bldg., wife out- doors Husband in other type bldg., wife outdoors Wife in Japanese type bldg., husband outdoors 4 Wife in other type bldg., husband outdoors Both in Japanese type bldg. Both in bldg. 7 Husband in Japanese type bldg., wife in other type Husband in other type bldg., wife in Japanese type (e) Petechiae: 5 in other type (boded as both ll only one ex- posed. Coded as:) Husband Wife 1 yes yes 2 yes no 3 no yes 4 no no Column

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Appendix (f) Gingivitis: (Coded as both if only one ex- posed. Coded as:) Husband Wif e 1 yes yes 2 yes no 3 no yes 4 no no (g) Bloody diarrhea: (Coded as both if only one ex- posed. Coded as:) Husband Wif e 1 yes yes 2 yes no 3 no yes 4 no no (h) Epilatior~: (Coded as both if only one ex- posed. Coded as:) Husband Wif e 1 yes yes 2 yes no 3 no yes 4 no no (i) Fever: (Coded as both if only one ex- posed. Coded as:) Husband Wif e 1 yes yes 2 yes no 3 no yes 4 no no j ~ Burns: (Coded as both if only one ex posed. Coded as:) Husband Wife 1 yes yes 2 yes no 3 no yes 4 no no ,(k) Trauma: (Coded as both if only one ex posed. Coded as:) Hashand Wife Column 1 yes 2 yes 3 no 4 no 5. Date of birth 31-32 (As item 29, columns 59-60 of Genetics Short-Form Code. Coded as:) Month Year January 1 1948 1 yes no yes no 227 February March April May June July August 2 1949 3 1950 6 ~1951 5 1952 6 1953 7 1954 8 9 o X V Column 2 3 4 6 September October November December Duration of pregnancy in weeks . . . 33-34 (As item 30, columns 61-62 Of Genetics Short-Form Code. Coded as 00 to 99; 99 is unknown.) 7. Course of labor 35 (As item 32, column 64 of Genetics Short-Form Code. Coded as:) 1 Normal 2 Operative 3 Instrumental 4 Miscellaneous complications 8. Termination (As item 33, column 65 of Genetics Short-Form Code. Coded as: ~ 1 Livebirth after 38th week 2 Premature birth under or in eluding 38th week 3 Stillbirth 20 weeks or under 4 Stillbirth 21-29 weeks 5 Stillbirth 30-38 weeks 6 Stillbirth after 38th week 7 Unknown livebirth 8 Unknown stillbirth 10. 9. Sex ......................... (As item 35, column 67 of Genetics Short-Form Code. Coded as: 1 Male 2 Female 3 Undetermined (As item 36, columns 68-70, of Genetics Short-Form Code. Weight of newborn coded in tens of grams; 000 to 999; 999 is unknown.) (NOTE: Items 1 to 10 are to be a machine transfer from the Short- Form IBM card to the Pediatrics Follow-up IBM card.) 11. Master File number...... (Of infant as given on Pediatrics Follow-up form.) 36 37 38-40 ....... 41-46

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228 Genetic Efects of Atomic Bombs Column 12. Age 47-48 (At examination in months given on Pediatrics Follow-up form. Coded as 00 to 99; 99 is un- 3 known. ~ 13. Multiple birth 49 (Coded as:) 1 Single birth 2 First twin Second twin First triplet 5 Second triplet 6 Third triplet 14. Abnormali~y (As diagnosed either on home visit [initial], or when child is brought to clinic for confirmation of a diag nosis of malformation, or on 9 months follow-up but not autopsy diagnosis.) 1 Normal 2 Congenital disease 3 Birth injury 4 Major malformation 5 Minor malformation 6 Congenital disease, birth in ~ury Congenital disease, major malformation 8 Congenital disease, minor malformation 9 Birth injury, major malfor mation O Birth injury, minor malfor mation X Congenital disease, birth in jury, major malformation NT Congenital disease, birth in jury, minor malformation 15. Diagnosis on home visit arid follow up 5 1-74 (Maximum of four diagnoses each of six digits, first digit coded as:) 1 Home visit and/or Pediatrics Clinic diagnosis at early age of defects limited to one sys tem or region, confirmed on 9-months follow-up. 2 Home visit and/or Pediatrics Clinic diagnosis at early age of multiple defects, with most important defect coded first, and successive defects 50 A introduced by a 1..., con- firmed on 9-months follow- up. Home visit and/or Pediatrics Clinic diagnosis at early age of a complex and ill-defined defect, confirmed on 9- months follow-up. 4 Home visit and/or Pediatrics Clinic diagnosis at early age of a double monster or tera- toma, confirmed on 9-months follow-up. Home visit and/or Pediatrics Clinic diagnosis at early age of a 1. .., not confirmed on 9-months follow-up (child alive) . Home visit and/or Pediatrics Clinic diagnosis at early age of a 2. . ., not confirmed on 9-months follow-up (child alive); successive diagnoses introduced by A.... Home visit and/or Pediatrics Clinic diagnosis at early age of a 3. .., not confirmed on 9-months follow-up (child alive) . D Home visit and/or Pediatrics Clinic diagnosis at early age of a 4. . ., not confirmed on 9-months follow-up (child alive) . Home visit and/or Pediatrics Clinic diagnosis at early age of a 1..., cannot now be confirmed because child dead. : Home visit and/or Pediatrics Clinic diagnosis at early age of a 2..., cannot now be confirmed because child dead; successive diagnoses introduced by J.... Home visit and/or Pediatrics Clinic diagnosis at early age of a 3..., cannot now be confirmed because child dead. M Home visit and/or Pediatrics Clinic diagnosis at early age of a 4..., cannot now be Columns

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Appendix confirmed because child dead. Nine-months follow-up di- agnosis of a defect limited to one region or system not previously diagnosed. T Nine-months follow-up di- agnosis of multiple defects not previously diagnosed, most important coded first with diagnoses after the first introduced by S.... U Nine-months follow-up di- agnosis of a complex and ill- defined defect not previously diagnosed. V Nine-months follow-up di- agnosis of a double monster or teratoma not previously diagnosed. 16. Infant trod neo~zat~1 mortality. (Coded as:) 00 Under 1 day 01 1 day 02 2 days 03 3-6 days 04 7-13 days 05 1~20 days 06 21-~7 days 07 28-55 days 08 5~83 days 09 8~111 days 10 112-139days 11 140-167 days 168-195 days 19~223 days 22~251 days Column .... 75-76 15 252-279 days 16 280-307 days 17 308-325 days 18 326-353 days 19 Over 1 year 99 Unknown (see L. F. code) 229 Column 7. No punch seer; ir! clinic 77 (Coded asps 1 Dead on L. F. 2 Found dead by P. C. 3 Moved or unable to locate 4 Infant ill 3 successive weeks 5 Mother ill 3 successive weeks 6 Both or other P or F 7 Other reasons 1 8. Cor~sar~gninity . .. ... .... .. (Coded as:) 1 Not related 2 First cousins 3 One and one-half cousins 4 Second cousins 5 Other 6 Unknown 19. Exposure category ..... Father's Column 79 Mother's Column 80 .... 78 ........ 79-80 ~ The purpose of this item in the code is several- fold; but primarily it is designed to detect biases which might arise due to unequal attrition ratio among the exposure subclasses. It also affords some measure of the accuracy of the reports of death. Selec- tion was by terminal registration digit and hence some of the infants selected were known to be still- born or to have died during the neonatal period. For the latter cases, the statement at 9 months could be collated with the information available on the at-birth records.