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130 PART II. BIOSYNTHESIS OF HEMOGLOBIN methionine. II. Conversion of methionine sulfur to taurine sulfur in dogs and rats. III. Distribution of sulfur in the proteins of animals fed sulfur or methion- ine. IV. Experiments in vitro with sulfur and hydrogen sulfide, J. Biol. Chem. 146: 69, 1942. 52. Drabkin, D. L.: Metabolism of the hemin chromoproteins, Physiol. Rev. 31: 345, 1951. 53. Borsook, H., Abrams, A., and Lowy, P. H.: Pructose-amino acids in liver: Stimuli of amino acid incorporation in rvilro, J. Biol. Chem. 215: 111, 1955. 54. Abrams, H., Lowy, P. H., and Borsook, H.: Preparation of 1-amino-1-deoxy-2- ketohexoses from aldohexoses and a-amino acids. I., J. Amer. Chem. Soc. 77: 4794, 1955. 55. Lowy, P. H., and Borsook, H.: Preparation of N-substituted 1-amino-1-deoxy-D- arabino-hexuloses of arginine, histidine and lysine, J. Amer. Chem. Soc. 78: 3175, 1956. 56. Altman, K. I., Casarett, G. W., Masters, R. E., Noonan, T. R., and Salomon, K.: Hemoglobin synthesis from glycine labeled with radioactive carbon in its u- carbon atom, J. Biol. Chem. 2~76: 319, 1948. 57. Salomon, K., Altman, K. I., Casarett, G. W., and Noonan, T. R.: Effect of x-ray radiation and of starvation on hemoglobin synthesis in the rat, Federation Proc. 8: 247, 1949. 58. Richmond, J. E., Altman, K. I., and Salomon, K.: The effect of x-radiation on the biosynthesis of hemoglobin, J. Biol. Chem. 190: 817, 1951. 59. London, I. M., et al. See these Proceedings. DISCUSSION Dr. Peratz: I should like to comment on Dr. Borsook's observation that globin synthesis is inhibited in the absence of a supply of RNA despite the very large reservoir of RNA present in the cell. I wondered whether one might think of two kinds of RNA in the cell- one which is structural, as it were, and forms the template for the formation of globin and is therefore not avail- able, and another part of RNA which is metabolic and which has to be con- tinuously resynthesized in order that globin synthesis can be carried on.