Cover Image

Not for Sale

View/Hide Left Panel
Click for next page ( 131

The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement

Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page 130
130 PART II. BIOSYNTHESIS OF HEMOGLOBIN methionine. II. Conversion of methionine sulfur to taurine sulfur in dogs and rats. III. Distribution of sulfur in the proteins of animals fed sulfur or methion- ine. IV. Experiments in vitro with sulfur and hydrogen sulfide, J. Biol. Chem. 146: 69, 1942. 52. Drabkin, D. L.: Metabolism of the hemin chromoproteins, Physiol. Rev. 31: 345, 1951. 53. Borsook, H., Abrams, A., and Lowy, P. H.: Pructose-amino acids in liver: Stimuli of amino acid incorporation in rvilro, J. Biol. Chem. 215: 111, 1955. 54. Abrams, H., Lowy, P. H., and Borsook, H.: Preparation of 1-amino-1-deoxy-2- ketohexoses from aldohexoses and a-amino acids. I., J. Amer. Chem. Soc. 77: 4794, 1955. 55. Lowy, P. H., and Borsook, H.: Preparation of N-substituted 1-amino-1-deoxy-D- arabino-hexuloses of arginine, histidine and lysine, J. Amer. Chem. Soc. 78: 3175, 1956. 56. Altman, K. I., Casarett, G. W., Masters, R. E., Noonan, T. R., and Salomon, K.: Hemoglobin synthesis from glycine labeled with radioactive carbon in its u- carbon atom, J. Biol. Chem. 2~76: 319, 1948. 57. Salomon, K., Altman, K. I., Casarett, G. W., and Noonan, T. R.: Effect of x-ray radiation and of starvation on hemoglobin synthesis in the rat, Federation Proc. 8: 247, 1949. 58. Richmond, J. E., Altman, K. I., and Salomon, K.: The effect of x-radiation on the biosynthesis of hemoglobin, J. Biol. Chem. 190: 817, 1951. 59. London, I. M., et al. See these Proceedings. DISCUSSION Dr. Peratz: I should like to comment on Dr. Borsook's observation that globin synthesis is inhibited in the absence of a supply of RNA despite the very large reservoir of RNA present in the cell. I wondered whether one might think of two kinds of RNA in the cell- one which is structural, as it were, and forms the template for the formation of globin and is therefore not avail- able, and another part of RNA which is metabolic and which has to be con- tinuously resynthesized in order that globin synthesis can be carried on.