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OCR for page 182
182 PART III. ABNORMAL HEMOGLOI3INS esls technique against all abnormal types of hemoglobin in an effort to demon- . . ~ . strafe antlgenIc speclilclty. In summary, it may be stated that except for Hb F. no immunologic specif- icity exists between the other forms of human hemoglobins examined to date. The lack of specificity may be due to identical surface configurations of the protein moiety, or to the masking of minimal alterations by a larger common antigenic structure. REFEREN CES I. Darrow, R. R., Nowakovsky, S., and Austin, M. H.: Specificity of fetal and of adult human hemoglobin precipitins, Arch. Path. 30: 873-880, 1940. 2. Vecchio, F~., and Barbagallo, E.: Ricerche sierologiche sul potere antigene di taluni tipi di emoglobina umana normal) et patologici. I. L'emoglobina dell'anemia di Cooley e dell'anemia drepanocitica, Pediatria 58: 481~96, 1950. 3. Goodman, M., and Campbell, D. H.: Differences in antigenic specificity of human normal adult, fetal, and sickle cell anemia hemoglobins, Blood 8: 422033, 1953. 4. Chernoff, A. I.: Immunologic studies of hemoglobins. I. Production of anti- hemoglobin sera and their immunologic characteristics, Blood 8: 399012, 1953. Aksoy, M.: Anti-hemoglobin serum production and its relationship to etal and adult hemoglobin, Acta Haematologica 13: 226-234, 1955. 6. Ingram, V. M.: A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobins, Nature 178: 792-794, 1956. 7. Ouchterlony, O.: Antigen-antibody reactions in gels, Acta Path. et Microbiol. Scandinav. 26: 507-515, 1949. 8. lluggieri, P., and Marchi, M.: Ricerche sulfa specificita antigene delle emoglobine umane normal) ( adulta e fetale ) mediante precipitazione in agar, Estratto dalla Rivista dell'Istituto Sieroterapico Italiano 30: 405013, 1955. 5. DISCUSSION Dr. S. J. Singer: I am not entirely familiar with the work of Campbell arid Goodman, but I had the impression that by quantitative cross reaction pre- cipitin testing, some difference was found between sickle and normal hemo- globins. Dr. Chernoff: Very minor. Dr. Si~zger: Small, but distinct.