• Front Matter R1-R2

• Contents R7-R13

• Preface R3-R4

• Foreword R5-R6

• Opening Remarks R14-R14

• Part I. Structure of Hemoglobin: Current Concepts of Structure of Hemoglobin 1-13

• Individual Velocity Constants in the Chain of Reaction of Sheep Hemoglobin with Dissolved Gases 14-26

• Discussion 27-32

• A Survey of the Evidence For and Against a Crevice Configuration for the Heme in Hemoglobin 33-47

• Discussion 48-49

• X-Ray Analysis of Haemoglobin 50-60

• Discussion 61-65

• Part II. Biosynthesis of Hemoglobin: The Biosynthesis of Porphyrin 66-73

• The Enzymatic Synthesis of Uroporphyrinogens from Porphobilinogen 74-83

• Enzymatic Studies of Protoporphyrin Synthesis 84-91

• Discussion 92-94

• The Role of Iron in Hemoglobin Synthesis 95-99

• The Role of Copper in Erythropoiesis 100-109

• Discussion 110-110

• Hemoglobin Synthesis in Vitro in Rabbit Reticulocytes 111-129

• Discussion 130-130

• The Incorporation of Glycine into Globin and the Synthesis of Heme in Duck Erythrocytes and Rabbit Reticulocytes 131-139

• Discussion 140-143

• Part III. Abnormal Hemoglobins: Electrophoretic Analyses of Abnormal Human Hemoglobins 144-153

• Discussion 154-156

• Zone Electrophoresis and the Minor Hemoglobin Components of Normal Human Blood 157-161

• Discussion 162-164

• A Method for the Characterization of Abnormal Human Hemoglobins Based Upon Differences in Chromatographic Behavior on Amberlite IRC 50 165-165

• Discussion 166-171

• The Alkali Denaturation Procedures 172-175

• Discussion 176-178

• Immunologic Aspects of the Human Hemoglobin 179-181

• Discussion 182-182

• Studies on the Heterogeneity of Adult and Fetal Hemoglobins by Salting-Out, Alkali Denaturation and Moving Boundary Electrophoresis 183-198

• Discussion 199-200

• Heterogeneity of Hemoglobin and Methods of Isotopic Biosynthesis 201-211

• Starch Electrophoresis of Hemoglobin: Findings in Thalessemia Syndrome 212-214

• Discussion 215-219

• Observations on the Amino Acid Composition of Human Hemoglobins 220-224

• Discussion 225-226

• The Structural Basis of Difference in Electrophoretic Behavior of Human Hemoglobins 227-231

• Discussion 232-232

• The Chemical Difference Between Normal Human and Sickle Cell Anaemia Haemoglobins 233-237

• Discussion 238-252

• Part IV. Genetic Aspects of Abnormal Hemoglobins: Genetic Aspects of Hemoglobin 253-271

• Discussion 272-275

• Part V. Clinical Characteristics Associated with Abnormal Hemoglobins: Clinical Manifestations of Sickle Cell Disease 276-282

• The Thalassemia Syndromes 283-286

• Hemoglobin C. Diseases 287-294

• Discussion 295-295

• Closing Remarks 296-296

• Attendance List 297-302

• Index of Authors and Discussions 303-304

" Observations on the Amino Acid Composition of Human Hemoglobins ." CONFERENCE ON HEMOGLOBIN 2-3 MAY 1957 . Washington, DC: The National Academies Press, 1958 .

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