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296 PART V. CLIN I CAL CF1ARACTERISTICS are not yet in a position always to distinguish between the thalassemia effect and the interaction effect. Concerning this question, I would just like to report to you that the family with Hb C-thalassemia combination has since produced several other off- spring. One of them has a thalassemia-like picture which on clinical and hematological grounds is quite indistinguishable from the case of the sibling we reported as lIb C-thalassemia. However, this individual does not happen to have Hb C, so I think at the present time it is a reasonable assump- tion to attribute the severity of the disease in that particular family to the thalassemia gene rather than to interactions, as such. CLOSING REMARKS Dr. G. E. Cartwright: Is there anyone else who would like to comment? If not, this will close the sessions. }for the closing remarks, I should like to call on Dr. Carl Moore, Chairman of the Subcommittee on Blood and Related Problems of the National Academy of Sciences-National Research Council. Dr. Carl Moore: I feel as if I am being called on to pronounce the bene- diction or something of the sort. Yesterday morning tribute was quite properly paid to the Division staff for their work in arranging this Conference, and to the National Institutes of Health for underwriting it. I am sure it is abundantly clear to all of you by this time that a statement of thanks is also due to Drs. John Edsall, Irving London, and George Cartwright, who not only served as chairmen of your meetings, but who also really planned the Conference and put it together. If the exchange of ideas which has gone on in this room and outside it during the last two days has done anything at all to accelerate our understanding and progress in these various areas, I am sure all of you will agree that these two days have been well spent. With that, I wish that you would consider that the benediction has been pronounced, the hallelujas sung, and that school is out.