TABLE 12.1 Conclusions1


Conditions recommended for treatment in clinical trials of smoked marijuana

Promising targets for cannabinoid drugs

Recommended research on potential harms of marijuana and cannabinoids?

Use of whole and/or smoked marijuana as medicine

Primary goals of cannabinoid drug development

Institute of Medicine2

Various, including nausea and vomiting, wasting, pain

Various, including nausea and vomiting, wasting, pain

Yes, especially on smoking-related harms

Whole marijuana is not a modern medicine

Safe, reliable, rapid-onset delivery method for cannabinoids

House of Lords (U.K.)3

Multiple sclerosis, chronic pain

Not discussed

None recommended

Hazards of marijuana smoke noted

Rapid-onset, smoke-free delivery systems (e.g., inhalation, under the tongue, and rectal suppositories)

World Health Organization4

Not discussed

Nausea and vomiting; muscle spasticity

Various, including infertility, respiratory damage, immune dysfunction, schizophrenia, and “amotivational syndrome”

Hazards of marijuana smoke noted

Not discussed

National Institutes of Health5 (U.S.)

Wasting, chemotherapy-induced nausea and vomiting, neurological and movement disorders, glaucoma

Nausea and vomiting, neuropathy, possibly muscle spasticity, certain dystonias and epilepsy

None recommended

Should be held to same standards of safety and efficacy as other FDA-approved drugs

Smoke-free inhaled delivery systems for marijuana and cannabinoids

British Medical Association6

Not discussed

Muscle spasticity, neurodegenerative disorders, epilepsy

None recommended

Cigarettes and crude marijuana preparations should not be used

Novel cannabinoid analogs for new uses

American Medical Association7

Various, including AIDS, wasting, chemotherapy-induced nausea and vomiting, MS, spinal cord injury, neuropathy

Not discussed

None recommended

Not recommended

Smoke-free inhaled delivery system for marijuana and cannabinoids

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