. "B: Health Risk Assessment for the Nerve Agent GB." Review of the U.S. Army's Health Risk Assessments for Oral Exposure to Six Chemical-Warfare Agents. Washington, DC: The National Academies Press, 1999.
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Review of the U.S. Army's Health Risk Assessments for Oral Exposure to Six Chemical-Warfare Agents
GB Type II - RBC Cholinesterase Inhibition in Female Ratsa (ANOVA and Dunnett's Comparison)
Oral Dose (µg/kg/day)
Week
-1
1
3
7
13
0
ns/
ns/
ns/
ns/
75
_/ns
ns/ns
ns/ns
ns/ns
ns/ns
150
_/ns
S/S
S/ns
S/S
ns/S
300
_/ns
S/S
S/S
S/S
ns/S
Source: Re-evaluation of data from Bucci and Parker, 1992.
a Six animals/dose group
b Comparison to pre-exposure value (week -1)/comparison to control (0 µg/kg/day) value.
ns. Not statistically significant.
S. Statistically significant at p <0.05.
GB Type II - RBC Cholinesterase Inhibition in Male Ratsa (ANOVA and Dunnett's Comparison)
Oral Dose (µg/kg/day)
Week
-1
1
3
7
13
0
0
ns/
ns/
ns/
ns/
75
_/ns
S/S
S/S
S/S
ns/ns
150
_/ns
S/S
S/S
S/S
S/ns
300
_/ns
S/S
S/S
S/S
S/ns
Source: Re-evaluation of data from Bucci and Parker, 1992.
a Six animals/dose group
b Comparison to pre-exposure value (week -1)/comparison to control (0 µg/kg/day) value.
