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OCR for page R1
Colloqium on Proteolytic Processing and Physiological Regulation
COLLOQUIUM ON PROTEOLYTIC PROCESSING AND PHYSIOLOGICAL REGULATION
NATIONAL ACADEMY OF SCIENCES
WASHINGTON, D.C. 1999
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Colloqium on Proteolytic Processing and Physiological Regulation
NATIONAL ACADEMY OF SCIENCES
Colloquium Series
In 1991, the National Academy of Sciences inaugurated a series of scientific colloquia, five or six of which are scheduled each year under the guidance of the NAS Council’s Committee on Scientific Programs. Each colloquium addresses a scientific topic of broad and topical interest, cutting across two or more of the traditional disciplines. Typically two days long, colloquia are international in scope and bring together leading scientists in the field. Papers from colloquia are published in the Proceedings of the National Academy of Sciences (PNAS).
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Colloqium on Proteolytic Processing and Physiological Regulation
Proteolytic Processing and Physiological Regulation
A Colloquium sponsored by the National Academy of Sciences
February 20–21, 1999
PROGRAM
Saturday, February 20, 1999
Hans Neurath, University of Washington
Welcome and introduction: Proteolytic enzymes, past and future
David Agard, University of California, San Francisco
Kinetic stability and folding of proteases: twin paradigms for protease pro regions
Michael James, University of Alberta
Structural basis and mechanism of zymogen activation
David Matthews, Agouron Pharmaceuticals, Inc.
Structure-assisted design of mechanism based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Christopher Walsh, Harvard University
Role of D, D-Peptidase in Vancomycin Resistance
Earl Davie, University of Washington
Introduction to Protease activated receptors
Shaun Coughlin, University of California, San Francisco
Thrombin signaling: Molecular mechanisms and roles in vivo
Vishva Dixit, Genentech, Inc.
Identification of components of the cell death pathway
Wolfram Bode, Max-Planck-Institute for Biochemistry
Structure of tryptase, a cage-like serine proteinase involved in asthma, allergic and inflammatory disorders
Philip Beachy, Johns Hopkins University
Hedgehog protein biogenesis and signaling
Marc Kirschner, Harvard University
The role of proteases in the regulation of cell cycle
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Colloqium on Proteolytic Processing and Physiological Regulation
Sunday, February 21, 1999
C.S.Craik, University of California, San Francisco
Introduction
Arthur Horwich, Yale University
Chaperone Rings in Protein Folding and Degradation
Robert Huber, Max-Planck-Institute for Biochemistry
Structure of the archaeal and yeast 20S proteasomes and of the eubacterial Analog HslV
Sukanto Sinha, Athena Neurosciences
Cellular mechanism of beta amyloid production and secretion
Michael Brown, University of Texas Southwestern Medical Center
A proteolytic system that controls cholesterol metabolism
Michael Brown
Introduction
Charles Craik, University of California, San Francisco
Reverse biochemistry-using protease inhibitors to dissect complex biochemical processes
Christine Debouck, Smith-Kline and Beecham Pharmaceuticals
From genomics to drugs—cathepsin K and osteoporosis
James McKerrow, University of California, San Francisco
Parasite proteases—windows on molecular evolution and targets for drug design
Joshua Boger, Vertex Pharmaceuticals
Recognizing a drug
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Colloqium on Proteolytic Processing and Physiological Regulation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Table of Contents
Papers from a National Academy of Sciences Colloquium on Proteolytic Processing and Physiological Regulation
Proteolytic enzymes, past and future
Hans Neurath
10962–10963
Caspase activation: The induced-proximity model
Guy S.Salvesen and Vishva M.Dixit
10964–10967
Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors
Amir R.Khan, Nina Khazanovich-Bernstein, Ernst M.Bergmann, and Michael N.G.James
10968–10975
The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study
Michael Groll, Wolfgang Heinemeyer, Sibylle Jäger, Tobias Ullrich, Matthias Bochtler, Dieter H.Wolf, and Robert Huber
10976–10983
The structure of the human ßII-tryptase tetramer: Fo(u)r better or worse
Christian P.Sommerhoff, Wolfram Bode, Pedro J.B.Pereira, Milton T.Stubbs, Jörg Stürzebecher, Gerd P.Piechottka, Gabriele Matschiner, and Andreas Bergner
10984–10991
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
Naoyuki Fuse, Tapan Maiti, Baolin Wang, Jeffery A.Porter, Traci M.Tanaka Hall, Daniel J.Leahy, and Philip A.Beachy
10992–10999
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
D.A.Matthews, P.S.Dragovich, S.E.Webber, S.A.Fuhrman, A.K.Patick, L.S.Zalman, T.F.Hendrickson, R.A.Love, T.J.Prins, J.T.Marakovits, R.Zhou, J.Tikhe, C.E.Ford, J.W.Meador, R.A.Ferre, E.L.Brown, S.L.Binford, M.A.Brothers, D.M.DeLisle, and S.T.Worland
11000–11007
Kinetic stability as a mechanism for protease longevity
Erin L.Cunningham, Sheila S.Jaswal, Julie L.Sohl, and David A.Agard
11008–11014
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
Paul M.Selzer, Sabine Pingel, Ivy Hsieh, Bernhard Ugele, Victor J.Chan, Juan C.Engel, Matthew Bogyo, David G.Russell, Judy A.Sakanari, and James H.McKerrow
11015–11022
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Colloqium on Proteolytic Processing and Physiological Regulation
How the protease thrombin talks to cells
Shaun R.Coughlin
11023–11027
VanX, a bacterial D-alanyl-D-alanine dipeptidase: Resistance, immunity, or survival function?
Ivan A.D.Lessard and Christopher T.Walsh
11028–11032
Chaperone rings in protein folding and degradation
Arthur L.Horwich, Eilika U.Weber-Ban, and Daniel Finley
11033–11040
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
Michael S.Brown and Joseph L.Goldstein
11041–11048
Cellular mechanisms of ß-amyloid production and secretion
Sukanto Sinha and Ivan Lieberburg
11049–11053
Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue
Toshihiko Takeuchi, Marc A.Shuman, and Charles S.Craik
11054–11061
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Colloqium on Proteolytic Processing and Physiological Regulation
National Academy of Sciences Colloquia
Bound Reprints Available
In 1991, the National Academy of Sciences (NAS) inaugurated a series of scientific colloquia, several of which are held each year under the auspices of the NAS Coun cil Committee on Scientific Programs. These colloquia address scientific topics of broad and topical interest that cut across two or more traditional disciplines. Typically two days long, these colloquia are international in scope and bring together leading scientists in the field.
Papers presented at these colloquia are published in the Proceedings of the National Academy of Sciences (PNAS) and are available online (www.pnas.org). Because they have generated much interest, these papers are now available in the form of collected bound reprints, which may be ordered through the National Academy Press.
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