NATIONAL ACADEMY OF SCIENCES
Colloquium Series
In 1991, the National Academy of Sciences inaugurated a series of scientific colloquia, five or six of which are scheduled each year under the guidance of the NAS Council’s Committee on Scientific Programs. Each colloquium addresses a scientific topic of broad and topical interest, cutting across two or more of the traditional disciplines. Typically two days long, colloquia are international in scope and bring together leading scientists in the field. Papers from colloquia are published in the Proceedings of the National Academy of Sciences (PNAS).
Proteolytic Processing and Physiological Regulation
A Colloquium sponsored by the National Academy of Sciences
February 20–21, 1999
PROGRAM
Saturday, February 20, 1999
Hans Neurath, University of Washington
Welcome and introduction: Proteolytic enzymes, past and future
David Agard, University of California, San Francisco
Kinetic stability and folding of proteases: twin paradigms for protease pro regions
Michael James, University of Alberta
Structural basis and mechanism of zymogen activation
David Matthews, Agouron Pharmaceuticals, Inc.
Structure-assisted design of mechanism based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
Christopher Walsh, Harvard University
Role of D, D-Peptidase in Vancomycin Resistance
Earl Davie, University of Washington
Introduction to Protease activated receptors
Shaun Coughlin, University of California, San Francisco
Thrombin signaling: Molecular mechanisms and roles in vivo
Vishva Dixit, Genentech, Inc.
Identification of components of the cell death pathway
Wolfram Bode, Max-Planck-Institute for Biochemistry
Structure of tryptase, a cage-like serine proteinase involved in asthma, allergic and inflammatory disorders
Philip Beachy, Johns Hopkins University
Hedgehog protein biogenesis and signaling
Marc Kirschner, Harvard University
The role of proteases in the regulation of cell cycle
Sunday, February 21, 1999
C.S.Craik, University of California, San Francisco
Introduction
Arthur Horwich, Yale University
Chaperone Rings in Protein Folding and Degradation
Robert Huber, Max-Planck-Institute for Biochemistry
Structure of the archaeal and yeast 20S proteasomes and of the eubacterial Analog HslV
Sukanto Sinha, Athena Neurosciences
Cellular mechanism of beta amyloid production and secretion
Michael Brown, University of Texas Southwestern Medical Center
A proteolytic system that controls cholesterol metabolism
Michael Brown
Introduction
Charles Craik, University of California, San Francisco
Reverse biochemistry-using protease inhibitors to dissect complex biochemical processes
Christine Debouck, Smith-Kline and Beecham Pharmaceuticals
From genomics to drugs—cathepsin K and osteoporosis
James McKerrow, University of California, San Francisco
Parasite proteases—windows on molecular evolution and targets for drug design
Joshua Boger, Vertex Pharmaceuticals
Recognizing a drug
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Table of Contents
Papers from a National Academy of Sciences Colloquium on Proteolytic Processing and Physiological Regulation
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Proteolytic enzymes, past and future |
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Caspase activation: The induced-proximity model |
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Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors |
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The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study |
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The structure of the human ßII-tryptase tetramer: Fo(u)r better or worse |
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Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched |
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Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes |
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Kinetic stability as a mechanism for protease longevity |
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Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target |
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How the protease thrombin talks to cells |
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VanX, a bacterial D-alanyl-D-alanine dipeptidase: Resistance, immunity, or survival function? |
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Chaperone rings in protein folding and degradation |
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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood |
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Cellular mechanisms of ß-amyloid production and secretion |
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Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue |
National Academy of Sciences Colloquia
Bound Reprints Available
In 1991, the National Academy of Sciences (NAS) inaugurated a series of scientific colloquia, several of which are held each year under the auspices of the NAS Coun cil Committee on Scientific Programs. These colloquia address scientific topics of broad and topical interest that cut across two or more traditional disciplines. Typically two days long, these colloquia are international in scope and bring together leading scientists in the field.
Papers presented at these colloquia are published in the Proceedings of the National Academy of Sciences (PNAS) and are available online (www.pnas.org). Because they have generated much interest, these papers are now available in the form of collected bound reprints, which may be ordered through the National Academy Press.
Currently available are:
Carbon Dioxide and Climate Change ($11)
Held November 13–15, 1995 (Irvine, CA)
Computational Biomolecular Science ($16)
Held September 12–13, 1997 (Irvine, CA)
Earthquake Prediction ($16)
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Elliptic Curves and Modular Forms ($7)
Held March 15–17, 1996 (Washington, DC)
Genetic Engineering of Viruses and Viral Vectors ($21)
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Genetics and the Origin of Species ($8)
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Geology, Mineralogy, and Human Welfare ($11)
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Neurobiology of Pain ($8)
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Neuroimaging of Human Brain Function ($17)
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Plants and Population: Is There Time? ($8)
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Protecting Our Food Supply: The Value of
Plant Genome Initiatives ($13)
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Science, Technology, and the Economy ($12)
Held November 20–22, 1995 (Irvine, CA)
The Age of the Universe, Dark Matter, and Structure Formation ($13)
Held March 21–23, 1997 (Irvine, CA)
Papers from future colloquia will be available for purchase after they appear in PNAS. Shipping and Handling Charges: In the U.S. and Canada please add $4.50 for the first reprint ordered and $0.95 for each additional reprint. Ordering Information: Telephone orders will be accepted only when charged to VISA, MasterCard, or American Express accounts. To order, call toll-free 1–800–624–6242 or order online at www.nap.edu and receive a 20% discount. |