Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

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Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000)
Institute of Medicine (IOM)

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. "6 Vitamin E." Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: The National Academies Press, 2000.

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DRI DIETARY REFERENCE INTAKES FOR Vitamin C, Vitamin E, Selenium, and Carotenoids

Genetic Abnormalities in α-TPP^a Gene	Histological/Biochemical Features
Found no mutations or polymorphisms in the α-TTP gene	Low serum vitamin E concentration: 0.05–1.18 µmol/L (0.02–0.51 µg/mL) (normal: 12–46 µmol/L [5–20 µg/mL])
Found no mutations in the frataxin gene	Low serum vitamin E concentration: 2.8 and 5.3 µmol/L (1.2 and 2.3 µg/mL) (normal: 12–37 µmol/L [5–16 µg/mL]) Slightly low sensory action potentials
Homozygous for 513insTT mutation	Low serum vitamin E concentration: <5 µmol/L (2 µg/mL) (normal: 10–42 µmol/L [4–18 µg/mL])

^c ADP = adenosine diphosphate.

^d O = oxygen.

^e TBARS = thiobarbituric acid reactive substances.

^f This was the only report of any cardiomyopathy.

ethyl)-6-hydroxychroman (α-CEHC) were excreted in the urine when a plasma threshold of 30 µmol/L (1,290 µg/dL) of α-tocopherol was exceeded. However, the α-CEHC metabolite represents only a small fraction of the α-tocopherol consumed daily, and there are few data concerning its formation. Therefore, α-CEHC excretion has not been used as a basis for assessing the α-tocopherol requirement.