DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis

Committee to Study New Research on Vaccines

Kathleen R. Stratton, Cynthia J. Howe, and Richard B. Johnston, Jr.,Editors

Division of Health Promotion and Disease Prevention

INSTITUTE OF MEDICINE

NATIONAL ACADEMY PRESS
Washington, D.C.
1994



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DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis Committee to Study New Research on Vaccines Kathleen R. Stratton, Cynthia J. Howe, and Richard B. Johnston, Jr.,Editors Division of Health Promotion and Disease Prevention INSTITUTE OF MEDICINE NATIONAL ACADEMY PRESS Washington, D.C. 1994

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DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis National Academy Press 2101 Constitution Avenue, N.W. Washington, D.C.20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this the Institute acts under the Academy's 1863 congressional charter responsibility to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth I. Shine is President of the Institute of Medicine. The project was supported by funds coordinated through the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (contract no. NO1-AI-15130). Copyright 1994 by the National Academy of Sciences. All rights reserved. Additional copies of this report are available in limited quantities from: Division of Health Promotion and Disease Prevention Institute of Medicine 2101 Constitution Avenue, N.W. Washington, D.C. 20418 Printed in the United States of America

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DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis COMMITTEE TO STUDY NEW RESEARCH ON VACCINES RICHARD B. JOHNSTON, JR. (Chair), Senior Vice President for Program and Medical Director, The March of Dimes Birth Defects Foundation, White Plains, New York; Adjunct Professor of Pediatrics, Yale University School of Medicine, New Haven, Connecticut E. RUSSELL ALEXANDER, Chief of Epidemiology, Seattle-King County Health Department, Seattle, Washington; Professor of Epidemiology, School of Public Health and Community Medicine, University of Washington RICHARD T. JOHNSON,* Professor and Director, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland MICHAEL S. KRAMER, Professor, Departments of Pediatrics and of Epidemiology and Biostatistics, McGill University Faculty of Medicine, Montreal, Quebec, Canada BENNETT A. SHAYWITZ, Professor, Department of Pediatrics, Neurology and Child Study Center, and Chief of Pediatric Neurology, Yale University School of Medicine, New Haven, Connecticut PAUL D. STOLLEY,* Professor and Chairman, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland Project Staff Kathleen R. Stratton, Project Director Cynthia J. Howe, Program Officer Dorothy R. Majewski, Project Assistant Michael A. Stoto, Director, Division of Health Promotion and Disease Prevention Michael A. Edington, Managing Editor Michael K. Hayes, Contract Editor *   Member, Institute of Medicine

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DPT Vaccine and Chronic Nervous System Dysfunction: A New Analysis Acknowledgments The committee would like to thank Professor David Miller, Dr. Gerald Golden, and Dr. John Menkes for their contributions to the committee deliberations. The committee would also like to thank the attendees at the public session held on 7 December 1993 for their interest in and concern for this project. Those attendees were: Regina Rabinovich, National Institutes of Health; John LaMontagne, National Institutes of Health; Christopher Howson, Institute of Medicine; Geoffrey Evans, Vaccine Injury Compensation Program; Marie Mann, Vaccine Injury Compensation Program; J. Anthony Morris, The Bell of Atri; Kathi Williams, National Vaccine Information Center/Dissatisfied Parents Together; Kristine Severyn, Ohio Parents for Vaccine Safety; Sharon Humiston, University of Rochester; Robert Chen, Centers for Disease Control and Prevention; Gerald Donlon, Food and Drug Administration; Carolyn Hardegree, Food and Drug Administration; Rebecca Devine, Food and Drug Administration; Drusilla Burns, Food and Drug Administration; and Suresh Rastogi, Food and Drug Administration.

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