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Ending Neglect: The Elimination of Tuberculosis in the United States (2000)
Institute of Medicine (IOM)

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. "Appendix F Approval Dates for Existing and Prospects for Development of New Antituberculosis Drugs and Vaccines." Ending Neglect: The Elimination of Tuberculosis in the United States. Washington, DC: The National Academies Press, 2000.

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Page 249

1) Activity: mole for mole as active as INH

2) Orally active

3) Bactericidal

4) Active vs. nongrowing organisms (e.g., M. tuberculosis cultured under anaerobic conditions)

5) Now in initial stages of testing

Ribozyme Pharmaceuticals

0

0

0

0

Sequella Corp.

  • Ethambutol analogs (3 candidates)

Clinical testing probably

Clinical testing probably

Vaccine: Has license for new experimental vaccine (Nature 400[6741]:269; 1999)

  • Shikemic acid pathway

0

0

(inhibitor)

  • New diagnostic being studied: A patch test that may be positive in patients with active disease but not in individuals with prior infection

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249
Front Matter (R1-R18)
Executive Summary (1-12)
1 Fundamentals of Tuberculosis and Tuberculosis Control (13-22)
2 The Current Situation and How We Got Here (23-50)
3 Tuberculosis Elimination and the Changing Role of Tuberculosis Control Programs (51-85)
4 Advancing Toward Elimination (86-121)
5 Developing the Tools for Tuberculosis Elimination (122-148)
6 The U.S. Role in Global Tuberculosis Control (149-158)
7 Mobilizing for Elimination (159-168)
Appendix A Statement of Task (169-172)
Appendix B Public Session Agendas (173-181)
Appendix C Site Visit Summaries (182-204)
Appendix D Role of Public Health Laboratories in the Control of Tuberculosis (205-233)
Appendix E Estimating the Number of Tuberculosis Cases That Can Be Prevented by a Program of Screening and Preventive Therapy of Newly Arrived Immigrants to the United States from Countries with a High Rate of Tuberculosis a (234-243)
Appendix F Approval Dates for Existing and Prospects for Development of New Antituberculosis Drugs and Vaccines (244-249)
Appendix G Committee Biographies (250-256)
Index (257-269)