world. In addition, various parties have expressed interest in licensing BIBAC technology; these queries are directed to the Cornell Research Foundation. A US patent has been issued for the BIBAC vector, and foreign patents are pending. The Center for Advanced Technology/Biotechnology at Cornell University supported the construction and maintains a BIBAC Web site in support of BIBAC technology.

NRI Award:

1995; Evalustion and Applicaton of a New BAC Library Vector Designed for Transfer of Large DNA Inserts; 3 years.


March 31, 1998; C.M.Hamilton; Binary BAC vector.

  • Hamilton, C.M., A.Frary, Y.Xu, S.D.Tanksley, and H.B.Zhang. 1999. Construction of tomato genomic DNA libraries in a binary-BAC (BIBAC) vector. The Plant Journal 18(2):223–229.

  • Hamilton, C.M. 1998. BIBAC technology: progress and prospects. AgBiotech News and Information 10(1):23N-28N.

  • Hamilton, C.M. 1997. A binary-BAC system for plant transformation with high-molecular-weight DNA. Gene 200:107–116.

  • Hamilton, C.M., A.Frary, C.Lewis and S.D.Tanksley. 1996. Stable transfer of intact high molecular weight DNA into plant chromosomes. Proceedings of the National Academy of Sciences 93:9975–9979.

Additional Information:

Hamilton was funded in 1995 as an NRI new investigator at Cornell University with additional support from the National Science Foundation and the Department of Energy. She is now employed at Paradigm Genetics, Inc., in Research Triangle Park, North Carolina. The Center for Advanced Technology/Biotechnology maintains a BIBAC Web site at, that includes how to obtain BIBAC materials, general information, restriction maps, and several detailed protocols. Hamilton replies to all BIBAC correspondence and can be reached at

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