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Methyl Bromide Risk Characterization in California (2000)

Chapter: Appendix B: Public Access Materials

« Previous: Appendix A: Biographical Information on the Subcommittee for the Review of the Risk Assessment of Methyl Bromide
Suggested Citation:"Appendix B: Public Access Materials." National Research Council. 2000. Methyl Bromide Risk Characterization in California. Washington, DC: The National Academies Press. doi: 10.17226/9849.
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Page 87
Suggested Citation:"Appendix B: Public Access Materials." National Research Council. 2000. Methyl Bromide Risk Characterization in California. Washington, DC: The National Academies Press. doi: 10.17226/9849.
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Page 88
Suggested Citation:"Appendix B: Public Access Materials." National Research Council. 2000. Methyl Bromide Risk Characterization in California. Washington, DC: The National Academies Press. doi: 10.17226/9849.
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Page 89

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Appendix B Public Access Materials The following materials (written documents) were made available to the committee at or after its first meeting, October 4, 1999, Beckman Center: . California Environmental Protection Agency, Nepal lment of Pesticide Regulation. 1999. Methyl Bromide: Risk Characterization Document for Inhalation Exposure. Draft. March I, 1999. 149 pp. with 9 appendi- ces. Memorandum from Lori Lim and Stephen Rinkus, California Depart- ment of Pesticide Regulation to Gary Patterson, California Department of Pesticide Regulation. Subject: Methyl Bromide Assignment #98- 0507. Dated September25, 1998. 23pp. Methyl Bromide industry Panel. ~ 998. Toxicological Endpoint Evaluation and Exposure Assessment for Methyl Bromide. August ~ 8, 1998. 33 pp. With 2-pa cover letter from David Weinberg to James Wells, Department of Pesticide Regulation. 4. Comments on the Department of Pesticide Regulation's Draft Risk Characterization Document for Inhalation Exposure to the Active Ingre- dient Methyl Bromide. From Anna M. Fan, California Office of Envi- ronmental Health Hazard Assessment, to Gary T. Patterson, California Department of Pesticide Regulation, dated September 1, 1999. 21 pp. 87

88 METHYL BROMIDE RISK CHARACTERIZATIONIN CALIFORNIA Risk Assessment of Methyl Bromide. Presented by Lori O. Lim and Thomas Thongsinthusak, California Department of Pesticide Regulation. October 4, 1999. 29 pp. 6. Chemical Manufacturers Association, Methyl Bromide Industry Panel. Presented by Vincent Piccirillo, NPC, Inc. October 4, 1999. 28 pp. Methyl Bromide Use in California: Public Health Concerns for Resi- dents near Fumigated Agricultural Fields. Presented by Bill Walker, Environmental Working Group. October 4, ~ 999. ~ 35 pp. 8. Public Health Concerns in the Methyl Bromide Reassessment. Pre- sented by Amy Kyle, Consulting Scientist for the California Rural Legal Assistance Foundation. October 4, 1999. 19 pp. 9. California Environmental Protection Agency, Department of Pesticide Regulation. 1999. Methyl Bromide: Risk Characterization Document for Inhalation Exposure. Draft. October 1999. 467 pp. 10. Letter from lames N. Seiber, University of Nevada, to Douglas Okumura, California Department of Pesticide Regulation, dated May 5, ~ 999. Comments on report "Evaluation of Charcoal Tube and SUMMA Canister Recoveries for Methyl Bromide Air Monitoring." 54 pp. 11. Heinz's responses to~imSeiber's comments. Draft. Undated. 3pp. 12. Mini-Memo from Terri Barry to Kean Goh, dated May ~ 9, ~ 999. Draft. Responses to comments on statistical aspects of the report entitled "Evaluation of Charcoal Tube and SUMMA Canister Recoveries for Methyl Bromide Air Sampling." 4 pp. 13. U.S. EPA. 1991. Guidelines for Developmental Toxicity Risk Assess- ment. U.S. Environmental Protection Agency, Office of Research and Development, Risk Assessment Forum. EPA/600/FR-91/001. 67 pp. 14. Letter from Courtney Price, Vice President CHEMSTAR, on behalf of the Chemical Manufacturers Association's Methyl Bromide Industry Panel to Dr. Charles Hobbs, NRC Subcommittee on Methyl Bromide. Dated November 8, 1999. ~ pp. with 2 attachments of published article by Medinsky et al. (1985) and bar chart.

PUBLIC ACCESS MA TERIALS 89 15. California Rural Legal Assistance Foundation. 1999. Letter From Anne Katten and I. Felix de la Torre of the CRLAF to Roberta Wedge, NRC, regarding review of California Department of Pesticide Regulation Risk Characterization for Methyl Bromide. Dated December 23, 1999. 2 pp. With attachment "Technical Comments of California Rural Legal Assis- tance Foundation: The NAS Review of the CDPR Methyl Bromide Risk Characterization, December 1999." 10 pp. 16. Letter from Gary T. Patter, Division of Registration and Health Evalua- tion, California Department of Pesticide Registration to Roberta Wedge, NRC, regarding an issue paper submitted by the Methyl Bromide Indus- try Panel (MBIP) on the pharmacokinetics and metabolism of methyl bromide. Dated January 7, 2000. 2pp. With 3 attachments including; 1) the issue paper, 2) review and comments of the issue paper by the DPR staff; and 3) questions posed by DPR to the MBIP at a meeting where the issue paper was presented. 17. Letter from loci Kuhn, Methyl Bromide Industry Panel (MBIP) to Roberta Wedge, NRC with comments from the MBIP to the California Department of Pesticide Regulation. Dated January 2l, 2000. ~ pg. With an attached letter from MBIP to Paul Helliker, CDPR, dated Janu- ary 11, 2000 (1 pa) and a 3 page attachment entitled "Methyl Bromide: Supplemental Information on Metabolism." 18. Memorandum from Lori Lim, Department of Pesticide Regulation (DPR), to Gary Patterson, DPR, regarding methyl bromide assignment #98-0408. Dated July 3, 1998. 2 pp. With an attached memorandum from Linnea I. Hansen, U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances, Health Effects Divi- sion, to Margaret Stasikowski, Health Effects Division, entitled "Methyl Bromide: Review of Draft Toxicology and Hazard Identification Docu- ment Prepared by the Department of Pesticide Regulation, California Environmental Protection Agency. Dated June ~ I, ~ 998. 6 pp. 19. Letter from Cindy Tuck, Law Offices of William Thomas, Sacramento, CA, to Roberta Wedge, NRC, regarding methyl bromide recovery rate: new document for review by NRC subcommittee on methyl bromide. With an attached memorandum from Jay Gan, ARS USDA, to Dr. Duafain on DPR study and methyl bromide recovery rates. Dated March 21, 2000. 5 pp.

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Methyl bromide is gaseous pesticide used to fumigate soil, crops, commodity warehouses, and commodity-shipping facilities. Up to 17 million pounds of methyl bromide are used annually in California to treat grapes, almonds, strawberries, and other crops. Methyl bromide is also a known stratospheric ozone depleter and, as such, is scheduled to be phased out of use in the United States by 2005 under the United Nations Montreal Protocol. In California, the use of methyl bromide is regulated by the Department of Pesticide Regulation (DPR), which is responsible for establishing the permit conditions that govern the application of methyl bromide for pest control. The actual permits for use are issued on a site-specific basis by the local county agricultural commissioners. Because of concern for potential adverse health effects, in 1999 DPR developed a draft risk characterization document for inhalation exposure to methyl bromide. The DPR document is intended to support new regulations regarding the agricultural use of this pesticide. The proposed regulations encompass changes to protect children in nearby schools, establish minimum buffer zones around application sites, require notification of nearby residents, and set new limits on hours that fumigation employees may work. The State of California requires that DPR arrange for an external peer review of the scientific basis for all regulations. To this end, the National Research Council (NRC) was asked to review independently the draft risk characterization document prepared by DPR for inhalation exposure to methyl bromide.

The task given to NRC's subcommittee on methyl bromide states the following: The subcommittee will perform an independent scientific review of the California Environmental Protection Agency's risk assessment document on methyl bromide. The subcommittee will (1) determine whether all relevant data were considered, (2) determine the appropriateness of the critical studies, (3) consider the mode of action of methyl bromide and its implications in risk assessment, and (4) determine the appropriateness of the exposure assessment and mathematical models used. The subcommittee will also identify data gaps and make recommendations for further research relevant to setting exposure limits for methyl bromide.

This report evaluates the toxicological and exposure data on methyl bromide that characterize risks at current exposure levels for field workers and nearby residents. The remainder of this report contains the subcommittee's analysis of DPR's risk characterization for methyl bromide. In Chapter 2, the critical toxicological studies and endpoints identified in the DPR document are evaluated. Chapter 3 summarizes DPR's exposure assessment, and the data quality and modeling techniques employed in its assessment are critiqued. Chapter 4 provides a review of DPR's risk assessment, including the adequacy of the toxicological database DPR used for hazard identification, an analysis of the margin-of-exposure data, and appropriateness of uncertainty factors used by DPR. Chapter 5 contains the subcommittee's conclusions about DPR's risk characterization, highlights data gaps, and makes recommendations for future research.

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